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found Offset: 7546232 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B14' cannot be found Offset: 7546232 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B49' cannot be found Offset: 7546232 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B50' cannot be found Offset: 7546232 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 693 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Remodeling the bladder tumor immune microenvironment by mycobacterial species with changes in their cell envelope composition Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Bacterial Strains and BC Cell Line Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Orthotopic model of BC and intravesical treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Bladder tissue processing and staining Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Flow cytometry analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Monocyte compartment is skewed towards a reparative phenotype after M. brumae treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Mycobacterial cell envelope composition lead to global changes in the immune microenvironment in bladder tumors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: BCG and M. brumae treatments induce differential lymphoid T and non-T-cell bladder immune cell infiltration profiles, whereas 洀礀挀漀戀愀挀琀攀爀椀愀氀 挀甀氀琀甀爀攀 挀漀渀搀椀琀椀漀渀猀 栀愀瘀攀 愀 洀愀樀漀爀 椀洀瀀愀挀琀 漀渀 琀栀攀 琀甀洀漀爀 䈀ⴀ挀攀氀氀 挀漀洀瀀漀猀椀琀椀漀温㸾൥湤潢樍㘹ㄠ〠潢樼㰯偡牥湴‶㜸‰⁒⽎數琠㘹〠〠刯䑥獴⣾＀猀㌀开㈩⽐牥瘠㘷㤠〠刯呩瑬攨Mycobacterial cell envelope composition lead to global changes in the immune microenvironment in bladder tumors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: BCG and M. brumae as well as their cell envelope composition alter the maturation profile of tumor-infiltrating CD4+ and CD8+ 吀ⴀ挀攀氀氀猩㸾൥湤潢樍㘹〠〠潢樼㰯偡牥湴‶㜸‰⁒⽎數琠㘸㤠〠刯䑥獴⣾＀猀㌀开㌩⽐牥瘠㘹ㄠ〠刯呩瑬攨BCG and M. brumae treatments induce differential lymphoid T and non-T-cell bladder immune cell infiltration profiles, whereas 洀礀挀漀戀愀挀琀攀爀椀愀氀 挀甀氀琀甀爀攀 挀漀渀搀椀琀椀漀渀猀 栀愀瘀攀 愀 洀愀樀漀爀 椀洀瀀愀挀琀 漀渀 琀栀攀 琀甀洀漀爀 䈀ⴀ挀攀氀氀 挀漀洀瀀漀猀椀琀椀漀温㸾൥湤潢樍㘹ㄠ〠潢樼㰯偡牥湴‶㜸‰⁒⽎數琠㘹〠〠刯䑥獴⣾＀猀㌀开㈩⽐牥瘠㘷㤠〠刯呩瑬攨Mycobacterial cell envelope composition lead to global changes in the immune microenvironment in bladder tumors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Immunosuppressive tumor microenvironment is modulated by changes in mycobacterial culture conditions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Mycobacterial treatment shapes the tumor-infiltrating myeloid compartment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Monocyte compartment is skewed towards a reparative phenotype after M. brumae treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Supplementary material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Info: Title: Remodeling the bladder tumor immune microenvironment by mycobacterial species with changes in their cell envelope composition Author: Jordi Senserrich; Sandra  Guallar-Garrido; Elisabet Gomez-Mora; Victor Urrea; Bonaventura Clotet; Esther Julián; Cecilia Cabrera Subject: Intravesical BCG instillation after bladder tumor resection is the standard treatment for non-muscle invasive bladder cancer; however, it is not always effective and frequently has undesirable side effects Keywords: non-muscle invasive bladder cancer, BCG, Mycobacterium brumae, immunotherapy, intravesical mycobacterial treatment, tumor immune microenvironment Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Sat Oct 08 00:51:32 CEST 2022 ModDate: Sat Oct 08 00:51:32 CEST 2022 ID: 0x526950b11c114c43b2ca024a65502139, 0x47a2dfa94c78674baa62f76a7e8e0030 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2756 ImageHeight: 2361 ColorSpace: RGB 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