db0da17b4f714a0507e72685307300e1 pmc_9617215.pdf d062288ee98254fe16d7a0581322f37b3ccd7748 pmc_9617215.pdf 95637e8c23be547c17152056ca4bd1f95a3ccc385de15e536b5510704a452204 pmc_9617215.pdf Title: Subject: Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 22.0 (Windows); modified using iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version) CreationDate: Sat Oct 29 07:36:23 2022 CEST ModDate: Sat Oct 29 07:37:50 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 594 x 783 pts Page rot: 0 File size: 1769449 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EBHLIA+MinionPro-Regular Type 1C Custom yes yes yes 69 0 EBHMDN+MinionPro-It Type 1C Custom yes yes yes 70 0 EBHMEN+GillSansStd Type 1C Custom yes yes yes 71 0 EBHMEO+PerpetuaStd Type 1C Custom yes yes yes 72 0 EBHMHO+CMSY10 Type 1C Custom yes yes yes 73 0 EBHMLO+MTSY Type 1C Custom yes yes yes 74 0 EBHNCM+GillSansStd-Bold Type 1C Custom yes yes yes 75 0 EBHNEM+GillSansStd-Italic Type 1C Custom yes yes yes 133 0 EBHPMO+RMTMI Type 1C Custom yes yes yes 134 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-07 02:39:17 CEST RepresentationInformation: pmc_9617215.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-11-10 02:22:10 CET Size: 1769449 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: ISO PDF/A-1, Level B PDFMetadata: Objects: 574 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Info: Title: Author: Subject: Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 22.0 (Windows); modified using iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version) CreationDate: Sat Oct 29 08:06:23 CEST 2022 ModDate: Sat Oct 29 08:07:50 CEST 2022 ID: 0x5c61cc52fd73ef86eedf6e9510fc1a13, 0xc41d72db56cdcfcee2b0bbc543055401 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 3301 ImageHeight: 389 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1103 ImageHeight: 1398 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2301 ImageHeight: 634 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2301 ImageHeight: 1368 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1998 ImageHeight: 974 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1323 ImageHeight: 729 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: EBHLIA+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: EBHLIA+MinionPro-Regular Flags: Serif, Symbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EBHNEM+GillSansStd-Italic FontSubset: true FirstChar: 44 LastChar: 122 FontDescriptor: FontName: EBHNEM+GillSansStd-Italic Flags: Symbolic, Italic FontBBox: -201, -250, 1009, 909 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EBHMDN+MinionPro-It FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: EBHMDN+MinionPro-It Flags: Serif, Symbolic, Italic FontBBox: -201, -360, 1684, 919 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EBHPMO+RMTMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: EBHPMO+RMTMI Flags: Symbolic, Italic FontBBox: 0, -213, 987, 680 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EBHMEN+GillSansStd FontSubset: true FirstChar: 2 LastChar: 182 FontDescriptor: FontName: EBHMEN+GillSansStd Flags: Symbolic FontBBox: -162, -250, 1041, 911 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EBHMEO+PerpetuaStd FontSubset: true FirstChar: 2 LastChar: 119 FontDescriptor: FontName: EBHMEO+PerpetuaStd Flags: Serif, Symbolic FontBBox: -152, -303, 1006, 806 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EBHMHO+CMSY10 FontSubset: true FirstChar: 130 LastChar: 130 FontDescriptor: FontName: EBHMHO+CMSY10 Flags: Symbolic, Italic FontBBox: -29, -960, 1116, 775 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EBHMLO+MTSY FontSubset: true FirstChar: 2 LastChar: 124 FontDescriptor: FontName: EBHMLO+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EBHNCM+GillSansStd-Bold FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: EBHNCM+GillSansStd-Bold Flags: Symbolic, ForceBold FontBBox: -177, -250, 1167, 929 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Pages: Page: Label: 1061 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 158, 610, 169, 624 Annotation: Subtype: Link Rect: 167, 615, 173, 626 Destination: 3 Annotation: Subtype: Link Rect: 172, 615, 178, 626 Destination: 3 Annotation: Subtype: Link Rect: 177, 615, 183, 626 Destination: 3 Annotation: Subtype: Link Rect: 250, 615, 256, 626 Destination: 3 Annotation: Subtype: Link Rect: 320, 610, 331, 624 Annotation: Subtype: Link Rect: 329, 615, 335, 626 Destination: 3 Annotation: Subtype: Link Rect: 389, 615, 396, 626 Destination: 3 Annotation: Subtype: Link Rect: 471, 610, 482, 624 Annotation: Subtype: Link Rect: 480, 615, 487, 626 Destination: 3 Annotation: Subtype: Link Rect: 133, 601, 140, 612 Destination: 3 Annotation: Subtype: Link Rect: 247, 601, 256, 612 Destination: 3 Annotation: Subtype: Link Rect: 92, 396, 219, 408 Annotation: Subtype: Link Rect: 57, 136, 291, 163 Destination: 333 Annotation: Subtype: Link Rect: 62, 99, 144, 112 Destination: 331 Annotation: Subtype: Link Rect: 148, 99, 230, 112 Destination: 332 Annotation: Subtype: Link Rect: 234, 99, 289, 112 Destination: 333 Annotation: Subtype: Link Rect: 302, 187, 421, 200 Destination: 333 Annotation: Subtype: Link Rect: 473, 149, 531, 162 Destination: 332 Annotation: Subtype: Link Rect: 302, 137, 356, 150 Destination: 332 Annotation: Subtype: Link Rect: 360, 137, 442, 150 Destination: 332 Annotation: Subtype: Link Rect: 343, 59, 489, 70 Page: Label: 1062 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 121, 659, 193, 672 Destination: 333 Annotation: Subtype: Link Rect: 106, 646, 158, 659 Destination: 332 Annotation: Subtype: Link Rect: 63, 559, 115, 572 Destination: 332 Annotation: Subtype: Link Rect: 118, 559, 196, 572 Destination: 332 Annotation: Subtype: Link Rect: 144, 522, 195, 535 Destination: 332 Annotation: Subtype: Link Rect: 197, 522, 285, 535 Destination: 331 Annotation: Subtype: Link Rect: 186, 235, 288, 248 Destination: 332 Annotation: Subtype: Link Rect: 60, 223, 140, 236 Destination: 332 Annotation: Subtype: Link Rect: 59, 197, 292, 224 Destination: 332 Annotation: Subtype: Link Rect: 59, 172, 292, 199 Destination: 332 Annotation: Subtype: Link Rect: 106, 123, 139, 136 Destination: 99 Annotation: Subtype: Link Rect: 510, 389, 529, 400 Destination: 314 Annotation: Subtype: Link Rect: 303, 197, 536, 224 Destination: 333 Annotation: Subtype: Link Rect: 521, 173, 528, 186 Destination: 98 Annotation: Subtype: Link Rect: 333, 160, 384, 173 Destination: 332 Annotation: Subtype: Link Rect: 516, 86, 523, 99 Destination: 98 Annotation: Subtype: Link Rect: 429, 61, 512, 74 Destination: 333 Page: Label: 1063 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 57, 474, 290, 501 Destination: 332 Annotation: Subtype: Link Rect: 83, 475, 142, 488 Destination: 332 Annotation: Subtype: Link Rect: 209, 450, 287, 463 Destination: 333 Annotation: Subtype: Link Rect: 58, 437, 80, 450 Destination: 333 Annotation: Subtype: Link Rect: 62, 238, 114, 251 Destination: 332 Annotation: Subtype: Link Rect: 116, 238, 138, 251 Destination: 332 Annotation: Subtype: Link Rect: 338, 369, 419, 382 Destination: 332 Annotation: Subtype: Link Rect: 301, 344, 535, 371 Destination: 331 Annotation: Subtype: Link Rect: 301, 319, 535, 346 Destination: 332 Annotation: Subtype: Link Rect: 392, 282, 528, 295 Destination: 331 Annotation: Subtype: Link Rect: 455, 208, 508, 221 Destination: 332 Annotation: Subtype: Link Rect: 452, 170, 485, 183 Destination: 100 Annotation: Subtype: Link Rect: 488, 83, 495, 96 Destination: 98 Page: Label: 1064 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 405, 566, 426, 576 Destination: 332 Annotation: Subtype: Link Rect: 424, 566, 445, 576 Destination: 332 Annotation: Subtype: Link Rect: 330, 360, 371, 371 Destination: 332 Annotation: Subtype: Link Rect: 369, 360, 371, 371 Destination: 332 Annotation: Subtype: Link Rect: 59, 213, 292, 241 Destination: 332 Annotation: Subtype: Link Rect: 146, 202, 265, 215 Destination: 332 Annotation: Subtype: Link Rect: 59, 176, 292, 203 Destination: 331 Annotation: Subtype: Link Rect: 85, 177, 161, 190 Destination: 333 Annotation: Subtype: Link Rect: 146, 164, 232, 177 Destination: 333 Annotation: Subtype: Link Rect: 59, 101, 292, 128 Destination: 333 Annotation: Subtype: Link Rect: 59, 76, 292, 104 Destination: 333 Annotation: Subtype: Link Rect: 307, 301, 389, 314 Destination: 332 Annotation: Subtype: Link Rect: 369, 251, 438, 264 Destination: 331 Annotation: Subtype: Link Rect: 331, 202, 405, 215 Destination: 333 Annotation: Subtype: Link Rect: 451, 127, 529, 140 Destination: 331 Annotation: Subtype: Link Rect: 438, 114, 512, 127 Destination: 332 Annotation: Subtype: Link Rect: 379, 90, 427, 103 Destination: 332 Annotation: Subtype: Link Rect: 303, 64, 536, 91 Destination: 332 Page: Label: 1065 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 144, 498, 222, 511 Destination: 333 Annotation: Subtype: Link Rect: 57, 472, 290, 499 Destination: 331 Annotation: Subtype: Link Rect: 165, 461, 259, 474 Destination: 333 Annotation: Subtype: Link Rect: 253, 286, 287, 299 Destination: 99 Annotation: Subtype: Link Rect: 58, 273, 151, 286 Destination: 333 Annotation: Subtype: Link Rect: 62, 248, 142, 261 Destination: 333 Annotation: Subtype: Link Rect: 57, 222, 290, 250 Destination: 331 Annotation: Subtype: Link Rect: 391, 709, 473, 722 Destination: 333 Annotation: Subtype: Link Rect: 405, 696, 480, 709 Destination: 331 Annotation: Subtype: Link Rect: 423, 671, 488, 684 Destination: 333 Annotation: Subtype: Link Rect: 382, 646, 457, 659 Destination: 332 Annotation: Subtype: Link Rect: 353, 596, 432, 609 Destination: 332 Annotation: Subtype: Link Rect: 338, 360, 416, 373 Destination: 333 Annotation: Subtype: Link Rect: 419, 360, 488, 373 Destination: 333 Annotation: Subtype: Link Rect: 500, 322, 528, 335 Destination: 314 Annotation: Subtype: Link Rect: 301, 272, 535, 299 Destination: 333 Annotation: Subtype: Link Rect: 331, 273, 493, 286 Destination: 331 Annotation: Subtype: Link Rect: 349, 235, 435, 248 Destination: 332 Annotation: Subtype: Link Rect: 301, 110, 535, 137 Destination: 332 Annotation: Subtype: Link Rect: 384, 98, 480, 111 Destination: 332 Annotation: Subtype: Link Rect: 450, 86, 528, 99 Destination: 333 Annotation: Subtype: Link Rect: 382, 48, 453, 61 Destination: 333 Page: Label: 1066 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 91, 483, 158, 496 Destination: 333 Annotation: Subtype: Link Rect: 198, 446, 246, 459 Destination: 332 Annotation: Subtype: Link Rect: 59, 433, 292, 460 Destination: 333 Annotation: Subtype: Link Rect: 97, 434, 217, 447 Destination: 333 Annotation: Subtype: Link Rect: 105, 384, 178, 397 Destination: 331 Annotation: Subtype: Link Rect: 59, 321, 292, 348 Destination: 331 Annotation: Subtype: Link Rect: 106, 322, 191, 335 Destination: 332 Annotation: Subtype: Link Rect: 210, 33, 241, 46 Destination: 100 Annotation: Subtype: Link Rect: 304, 646, 398, 659 Destination: 332 Annotation: Subtype: Link Rect: 400, 646, 479, 659 Destination: 332 Annotation: Subtype: Link Rect: 331, 609, 443, 622 Destination: 332 Annotation: Subtype: Link Rect: 427, 71, 503, 84 Destination: 333 Annotation: Subtype: Link Rect: 303, 32, 536, 60 Destination: 333 Page: Label: 1067 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 90, 709, 188, 722 Destination: 333 Annotation: Subtype: Link Rect: 57, 346, 290, 374 Destination: 333 Annotation: Subtype: Link Rect: 158, 173, 249, 186 Destination: 333 Annotation: Subtype: Link Rect: 57, 122, 290, 149 Destination: 333 Annotation: Subtype: Link Rect: 127, 48, 207, 61 Destination: 332 Annotation: Subtype: Link Rect: 378, 509, 468, 522 Destination: 331 Annotation: Subtype: Link Rect: 477, 313, 528, 326 Destination: 331 Page: Label: 1068 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 111, 709, 191, 722 Destination: 332 Annotation: Subtype: Link Rect: 59, 110, 292, 137 Destination: 332 Annotation: Subtype: Link Rect: 307, 696, 359, 709 Destination: 332 Annotation: Subtype: Link Rect: 303, 633, 536, 660 Destination: 332 Annotation: Subtype: Link Rect: 405, 596, 482, 609 Destination: 331 Annotation: Subtype: Link Rect: 303, 583, 536, 610 Destination: 332 Annotation: Subtype: Link Rect: 381, 547, 477, 560 Destination: 332 Annotation: Subtype: Link Rect: 303, 533, 536, 561 Destination: 332 Annotation: Subtype: Link Rect: 307, 484, 387, 497 Destination: 333 Annotation: Subtype: Link Rect: 303, 222, 536, 249 Destination: 332 Annotation: Subtype: Link Rect: 327, 173, 432, 186 Destination: 332 Annotation: Subtype: Link Rect: 435, 173, 493, 186 Destination: 332 Annotation: Subtype: Link Rect: 405, 111, 485, 124 Destination: 332 Annotation: Subtype: Link Rect: 322, 86, 354, 99 Destination: 100 Annotation: Subtype: Link Rect: 404, 61, 516, 74 Destination: 332 Page: Label: 1069 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 69, 659, 93, 672 Destination: 314 Annotation: Subtype: Link Rect: 76, 646, 83, 659 Destination: 98 Annotation: Subtype: Link Rect: 275, 447, 282, 460 Destination: 98 Annotation: Subtype: Link Rect: 57, 384, 290, 411 Destination: 332 Annotation: Subtype: Link Rect: 165, 347, 269, 360 Destination: 332 Annotation: Subtype: Link Rect: 153, 298, 160, 311 Destination: 98 Annotation: Subtype: Link Rect: 390, 185, 421, 198 Destination: 100 Page: Label: 1070 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 59, 474, 292, 502 Destination: 332 Annotation: Subtype: Link Rect: 236, 475, 267, 488 Destination: 100 Annotation: Subtype: Link Rect: 98, 286, 125, 299 Destination: 106 Annotation: Subtype: Link Rect: 60, 274, 144, 287 Annotation: Subtype: Link Rect: 151, 274, 231, 287 Annotation: Subtype: Link Rect: 149, 224, 183, 237 Destination: 99 Annotation: Subtype: Link Rect: 246, 199, 274, 212 Destination: 314 Annotation: Subtype: Link Rect: 59, 98, 292, 126 Destination: 100 Annotation: Subtype: Link Rect: 227, 87, 256, 100 Destination: 314 Annotation: Subtype: Link Rect: 63, 62, 95, 75 Destination: 100 Annotation: Subtype: Link Rect: 480, 422, 529, 435 Destination: 331 Annotation: Subtype: Link Rect: 483, 410, 529, 423 Destination: 332 Annotation: Subtype: Link Rect: 307, 385, 401, 398 Destination: 332 Annotation: Subtype: Link Rect: 438, 285, 507, 298 Destination: 333 Annotation: Subtype: Link Rect: 327, 248, 405, 261 Destination: 333 Annotation: Subtype: Link Rect: 472, 198, 503, 211 Destination: 100 Annotation: Subtype: Link Rect: 429, 99, 506, 112 Destination: 331 Annotation: Subtype: Link Rect: 303, 85, 536, 113 Destination: 331 Annotation: Subtype: Link Rect: 307, 61, 397, 74 Destination: 331 Page: Label: 1071 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 57, 300, 290, 328 Destination: 333 Annotation: Subtype: Link Rect: 57, 201, 290, 228 Destination: 332 Annotation: Subtype: Link Rect: 86, 189, 192, 202 Destination: 332 Annotation: Subtype: Link Rect: 329, 252, 354, 265 Destination: 330 Page: Label: 1072 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 195, 461, 267, 474 Destination: 332 Annotation: Subtype: Link Rect: 405, 187, 489, 200 Destination: 332 Annotation: Subtype: Link Rect: 382, 150, 471, 163 Destination: 331 Page: Label: 1073 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 195, 627, 213, 640 Page: Label: 1074 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 68, 500, 292, 525 Annotation: Subtype: Link Rect: 332, 666, 463, 677 Annotation: Subtype: Link Rect: 312, 522, 536, 546 Annotation: Subtype: Link Rect: 312, 424, 536, 448 Annotation: Subtype: Link Rect: 312, 336, 536, 360 Annotation: Subtype: Link Rect: 312, 270, 536, 294 Annotation: Subtype: Link Rect: 312, 237, 536, 262 Page: Label: 1075 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 67, 589, 166, 600 Annotation: Subtype: Link Rect: 123, 567, 230, 578 Checksum: a8ee3d9c Type: CRC32 Checksum: db0da17b4f714a0507e72685307300e1 Type: MD5 Checksum: d062288ee98254fe16d7a0581322f37b3ccd7748 Type: SHA-1