fb1ec7f33a04053dadb313478f88999e pmc_9633277.pdf 86170b3e4386e10f8324d8c27b195e7264ce53be pmc_9633277.pdf 460d507eb7eaab194eb89744c6ca4846df6724411c65155bcf9836f102d55ecf pmc_9633277.pdf Title: Subject: Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 22.0 (Windows); modified using iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version) CreationDate: Thu Nov 3 08:56:47 2022 CET ModDate: Thu Nov 3 08:56:59 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 5 Encrypted: no Page size: 595.274 x 782.286 pts Page rot: 0 File size: 1631443 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IBMMHB+CaeciliaLTStd-Light Type 1C Custom yes yes yes 399 0 IBMMLA+CaeciliaLTStd-Italic Type 1C Custom yes yes yes 400 0 IBMMMB+CaeciliaLTStd-Roman Type 1C Custom yes yes yes 401 0 IBMMMC+CaeciliaLTStd-Bold Type 1C Custom yes yes yes 402 0 IBNCHA+MTSY Type 1C Custom yes yes yes 403 0 IBNCHB+CaeciliaLTStd-Heavy Type 1C Custom yes yes yes 404 0 IBNCJB+CaeciliaLTStd-LightItalic Type 1C Custom yes yes yes 438 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-13 02:31:17 CEST RepresentationInformation: pmc_9633277.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-11-10 02:20:46 CET Size: 1631443 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: ISO PDF/A-1, Level B PDFMetadata: Objects: 568 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Info: Title: Author: Subject: Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 22.0 (Windows); modified using iTextSharp™ 5.5.10 ©2000-2016 iText Group NV (AGPL-version) CreationDate: Thu Nov 03 09:26:47 CET 2022 ModDate: Thu Nov 03 09:26:59 CET 2022 ID: 0xffa619a4377e0b9463af20dfdc56488d, 0x5dba7caf17f7c3d1719ef0de6016d498 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 962 ImageHeight: 76 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 32 ImageHeight: 16 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 21 ImageHeight: 17 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 962 ImageHeight: 337 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 962 ImageHeight: 89 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 7 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 23 ImageHeight: 7 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 17 ImageHeight: 7 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 19 ImageHeight: 7 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 18 ImageHeight: 7 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 14 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 8 ImageHeight: 17 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 7 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 164 ImageHeight: 164 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 21 ImageHeight: 7 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 20 ImageHeight: 7 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 183 ImageHeight: 173 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 215 ImageHeight: 175 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 203 ImageHeight: 258 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 172 ImageHeight: 172 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 398 ImageHeight: 169 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 278 ImageHeight: 260 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 207 ImageHeight: 207 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 207 ImageHeight: 207 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 170 ImageHeight: 171 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 207 ImageHeight: 207 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: IBMMLA+CaeciliaLTStd-Italic FontSubset: true FirstChar: 66 LastChar: 121 FontDescriptor: FontName: IBMMLA+CaeciliaLTStd-Italic Flags: Serif, Symbolic, Italic FontBBox: -166, -270, 1053, 915 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IBMMMB+CaeciliaLTStd-Roman FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: IBMMMB+CaeciliaLTStd-Roman Flags: Serif, Symbolic FontBBox: -167, -270, 1136, 926 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IBMMMC+CaeciliaLTStd-Bold FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: IBMMMC+CaeciliaLTStd-Bold Flags: Serif, Symbolic, ForceBold FontBBox: -166, -273, 1141, 938 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IBNCHA+MTSY FontSubset: true FirstChar: 2 LastChar: 3 FontDescriptor: FontName: IBNCHA+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IBNCHB+CaeciliaLTStd-Heavy FontSubset: true FirstChar: 49 LastChar: 144 FontDescriptor: FontName: IBNCHB+CaeciliaLTStd-Heavy Flags: Serif, Symbolic, ForceBold FontBBox: -170, -277, 1146, 970 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IBNCJB+CaeciliaLTStd-LightItalic FontSubset: true FirstChar: 2 LastChar: 142 FontDescriptor: FontName: IBNCJB+CaeciliaLTStd-LightItalic Flags: Serif, Symbolic, Italic FontBBox: -166, -267, 1033, 909 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: IBMMHB+CaeciliaLTStd-Light FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: IBMMHB+CaeciliaLTStd-Light Flags: Serif, Symbolic FontBBox: -164, -266, 1130, 908 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 113, 622, 123, 633 Annotation: Subtype: Link Rect: 121, 625, 126, 633 Destination: 3 Annotation: Subtype: Link Rect: 126, 622, 131, 633 Destination: 3 Annotation: Subtype: Link Rect: 197, 622, 207, 633 Annotation: Subtype: Link Rect: 205, 625, 210, 633 Destination: 3 Annotation: Subtype: Link Rect: 264, 622, 273, 633 Annotation: Subtype: Link Rect: 271, 625, 276, 633 Destination: 3 Annotation: Subtype: Link Rect: 322, 622, 332, 633 Annotation: Subtype: Link Rect: 330, 625, 335, 633 Destination: 3 Annotation: Subtype: Link Rect: 492, 622, 501, 633 Annotation: Subtype: Link Rect: 499, 625, 504, 633 Destination: 3 Annotation: Subtype: Link Rect: 504, 625, 509, 633 Destination: 3 Annotation: Subtype: Link Rect: 149, 609, 159, 620 Annotation: Subtype: Link Rect: 157, 612, 162, 620 Destination: 3 Annotation: Subtype: Link Rect: 161, 612, 166, 620 Destination: 3 Annotation: Subtype: Link Rect: 234, 609, 244, 620 Annotation: Subtype: Link Rect: 242, 612, 247, 620 Destination: 3 Annotation: Subtype: Link Rect: 337, 609, 347, 620 Annotation: Subtype: Link Rect: 345, 612, 350, 620 Destination: 3 Annotation: Subtype: Link Rect: 435, 609, 445, 620 Annotation: Subtype: Link Rect: 443, 612, 448, 620 Destination: 3 Annotation: Subtype: Link Rect: 448, 612, 453, 620 Destination: 3 Annotation: Subtype: Link Rect: 505, 609, 515, 620 Annotation: Subtype: Link Rect: 513, 612, 518, 620 Destination: 3 Annotation: Subtype: Link Rect: 104, 596, 114, 606 Annotation: Subtype: Link Rect: 112, 599, 117, 607 Destination: 3 Annotation: Subtype: Link Rect: 181, 596, 191, 606 Annotation: Subtype: Link Rect: 189, 599, 194, 607 Destination: 3 Annotation: Subtype: Link Rect: 264, 596, 274, 606 Annotation: Subtype: Link Rect: 272, 599, 277, 607 Destination: 3 Annotation: Subtype: Link Rect: 347, 596, 356, 606 Annotation: Subtype: Link Rect: 354, 599, 359, 607 Destination: 3 Annotation: Subtype: Link Rect: 435, 596, 445, 606 Annotation: Subtype: Link Rect: 443, 599, 451, 607 Destination: 3 Annotation: Subtype: Link Rect: 499, 596, 509, 606 Annotation: Subtype: Link Rect: 507, 599, 515, 607 Destination: 3 Annotation: Subtype: Link Rect: 91, 582, 100, 593 Annotation: Subtype: Link Rect: 98, 586, 106, 594 Destination: 3 Annotation: Subtype: Link Rect: 185, 582, 195, 593 Annotation: Subtype: Link Rect: 193, 586, 201, 594 Destination: 3 Annotation: Subtype: Link Rect: 200, 586, 208, 594 Destination: 3 Annotation: Subtype: Link Rect: 208, 586, 216, 594 Destination: 3 Annotation: Subtype: Link Rect: 339, 582, 349, 593 Annotation: Subtype: Link Rect: 347, 586, 355, 594 Destination: 3 Annotation: Subtype: Link Rect: 445, 582, 454, 593 Annotation: Subtype: Link Rect: 452, 586, 460, 594 Destination: 3 Annotation: Subtype: Link Rect: 121, 570, 130, 581 Annotation: Subtype: Link Rect: 128, 573, 136, 581 Destination: 3 Annotation: Subtype: Link Rect: 212, 570, 221, 581 Annotation: Subtype: Link Rect: 219, 573, 227, 581 Destination: 3 Annotation: Subtype: Link Rect: 321, 573, 329, 581 Destination: 3 Annotation: Subtype: Link Rect: 371, 570, 381, 581 Annotation: Subtype: Link Rect: 379, 573, 387, 581 Destination: 3 Annotation: Subtype: Link Rect: 475, 570, 485, 581 Annotation: Subtype: Link Rect: 483, 573, 491, 581 Destination: 3 Annotation: Subtype: Link Rect: 102, 557, 112, 567 Annotation: Subtype: Link Rect: 110, 560, 118, 568 Destination: 3 Annotation: Subtype: Link Rect: 188, 557, 198, 567 Annotation: Subtype: Link Rect: 196, 560, 204, 568 Destination: 3 Annotation: Subtype: Link Rect: 296, 557, 305, 567 Annotation: Subtype: Link Rect: 303, 560, 311, 568 Destination: 3 Annotation: Subtype: Link Rect: 375, 557, 385, 567 Annotation: Subtype: Link Rect: 383, 560, 391, 568 Destination: 3 Annotation: Subtype: Link Rect: 466, 557, 475, 567 Annotation: Subtype: Link Rect: 473, 560, 482, 568 Destination: 3 Annotation: Subtype: Link Rect: 105, 544, 115, 555 Annotation: Subtype: Link Rect: 113, 548, 121, 556 Destination: 3 Annotation: Subtype: Link Rect: 184, 544, 194, 555 Annotation: Subtype: Link Rect: 192, 548, 200, 556 Destination: 3 Annotation: Subtype: Link Rect: 258, 544, 268, 555 Annotation: Subtype: Link Rect: 266, 548, 274, 556 Destination: 3 Annotation: Subtype: Link Rect: 335, 544, 344, 555 Annotation: Subtype: Link Rect: 342, 548, 350, 556 Destination: 3 Annotation: Subtype: Link Rect: 413, 544, 423, 555 Annotation: Subtype: Link Rect: 421, 548, 429, 556 Destination: 3 Annotation: Subtype: Link Rect: 528, 544, 538, 555 Annotation: Subtype: Link Rect: 536, 548, 544, 556 Destination: 3 Annotation: Subtype: Link Rect: 158, 531, 168, 542 Annotation: Subtype: Link Rect: 166, 535, 174, 543 Destination: 3 Annotation: Subtype: Link Rect: 247, 531, 257, 542 Annotation: Subtype: Link Rect: 255, 535, 263, 543 Destination: 3 Annotation: Subtype: Link Rect: 262, 535, 270, 543 Destination: 3 Annotation: Subtype: Link Rect: 346, 531, 355, 542 Annotation: Subtype: Link Rect: 353, 535, 361, 543 Destination: 3 Annotation: Subtype: Link Rect: 361, 535, 369, 543 Destination: 3 Annotation: Subtype: Link Rect: 458, 531, 468, 542 Annotation: Subtype: Link Rect: 466, 535, 474, 543 Destination: 3 Annotation: Subtype: Link Rect: 127, 518, 137, 529 Annotation: Subtype: Link Rect: 135, 521, 143, 530 Destination: 3 Annotation: Subtype: Link Rect: 206, 518, 216, 529 Annotation: Subtype: Link Rect: 214, 521, 222, 530 Destination: 3 Annotation: Subtype: Link Rect: 321, 518, 330, 529 Annotation: Subtype: Link Rect: 328, 521, 337, 530 Destination: 3 Annotation: Subtype: Link Rect: 412, 518, 422, 529 Annotation: Subtype: Link Rect: 420, 521, 428, 530 Destination: 3 Annotation: Subtype: Link Rect: 427, 521, 435, 530 Destination: 3 Annotation: Subtype: Link Rect: 502, 518, 512, 529 Annotation: Subtype: Link Rect: 510, 521, 518, 530 Destination: 3 Annotation: Subtype: Link Rect: 517, 521, 525, 530 Destination: 3 Annotation: Subtype: Link Rect: 105, 510, 110, 519 Destination: 3 Annotation: Subtype: Link Rect: 382, 159, 478, 168 Annotation: Subtype: Link Rect: 112, 45, 258, 55 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 276, 115, 282, 126 Destination: 427 Annotation: Subtype: Link Rect: 453, 401, 459, 412 Destination: 425 Annotation: Subtype: Link Rect: 464, 401, 470, 412 Destination: 427 Annotation: Subtype: Link Rect: 490, 106, 496, 116 Destination: 427 Annotation: Subtype: Link Rect: 305, 40, 311, 50 Destination: 427 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 140, 374, 147, 384 Destination: 427 Annotation: Subtype: Link Rect: 272, 253, 278, 263 Destination: 427 Annotation: Subtype: Link Rect: 183, 176, 189, 186 Destination: 427 Annotation: Subtype: Link Rect: 117, 110, 123, 120 Destination: 427 Annotation: Subtype: Link Rect: 175, 110, 181, 120 Destination: 427 Annotation: Subtype: Link Rect: 459, 275, 465, 285 Destination: 427 Annotation: Subtype: Link Rect: 310, 187, 321, 197 Destination: 427 Annotation: Subtype: Link Rect: 517, 55, 528, 65 Destination: 427 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 223, 641, 234, 652 Destination: 427 Annotation: Subtype: Link Rect: 302, 190, 419, 200 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 323, 625, 554, 649 Annotation: Subtype: Link Rect: 332, 571, 463, 582 Annotation: Subtype: Link Rect: 323, 527, 554, 550 Annotation: Subtype: Link Rect: 323, 472, 554, 495 Annotation: Subtype: Link Rect: 323, 417, 554, 440 Annotation: Subtype: Link Rect: 323, 373, 554, 397 Annotation: Subtype: Link Rect: 323, 329, 554, 353 Annotation: Subtype: Link Rect: 323, 297, 554, 320 Annotation: Subtype: Link Rect: 383, 254, 514, 264 Annotation: Subtype: Link Rect: 383, 199, 514, 209 Annotation: Subtype: Link Rect: 323, 154, 554, 177 Annotation: Subtype: Link Rect: 323, 110, 554, 134 Checksum: 98b9f062 Type: CRC32 Checksum: fb1ec7f33a04053dadb313478f88999e Type: MD5 Checksum: 86170b3e4386e10f8324d8c27b195e7264ce53be Type: SHA-1