9792d24479e9a76d819a2ac687f9ec34 pmc_9636649.pdf 86d4bb965213dbfb564f65a806a5fe600f3d231a pmc_9636649.pdf 4bf572320094d7b90b618b4347ca318d56ef0acaaf3cad715b85c88e6cc4f501 pmc_9636649.pdf Creator: Adobe InDesign 16.0 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Mon Oct 31 08:23:15 2022 CET ModDate: Fri Nov 4 20:25:26 2022 CET Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1707175 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Light Type 1C Custom yes no yes 28 0 MyriadPro-Regular Type 1C Custom yes no yes 23 0 MyriadPro-Semibold Type 1C Custom yes no yes 26 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 25 0 MyriadPro-It Type 1C WinAnsi yes no yes 590 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 637 0 WarnockPro-Regular Type 1C Custom yes no yes 24 0 MinionPro-Regular Type 1C WinAnsi yes no yes 27 0 MyriadPro-Regular Type 1C WinAnsi yes no yes 34 0 MyriadPro-It Type 1C WinAnsi yes no yes 37 0 UHJSJK+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 48 0 SymbolStd Type 1C Custom yes no yes 49 0 MyriadPro-Regular Type 1C WinAnsi yes no yes 154 0 MyriadPro-It Type 1C WinAnsi yes no yes 150 0 WarnockPro-It Type 1C Custom yes no yes 70 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-11-30 02:46:23 CET RepresentationInformation: pmc_9636649.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-11-17 02:11:57 CET Size: 1707175 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 681 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: In the presence of non-neutralising maternally derived antibodies, intradermal and intramuscular vaccination with a modified live vaccine against porcine reproductive and respiratory syndrome virus 1 (PRRSV-1) induce similar levels of neutralising antibo Children: Item: Title: Abstract Item: Title: Background Item: Title: Results Children: Item: Title: Clinical follow-up Item: Title: Vaccine-induced viremia Item: Title: Development of antibodies Item: Title: Lymphoproliferation Item: Title: IFN-γ secreting cells Item: Title: Cytokine production Item: Title: Discussion Item: Title: Conclusion Item: Title: Materials and methods Children: Item: Title: Animals and experimental design Item: Title: Sampling and sample processing Item: Title: Serological analysis Item: Title: Quantification of PRRSV RNA Item: Title: IFN-γ ELISPOT Item: Title: Cytokine ELISA in culture supernatant and serum Item: Title: Statistical analysis Item: Title: References Info: Creator: Adobe InDesign 16.0 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Mon Oct 31 08:23:15 CET 2022 ModDate: Fri Nov 04 20:25:26 CET 2022 ID: 0x545a3ed6ea2f20c50eede0bf00918108, 0xc6981f7b65bda01cc439ea958f8b8ba6 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1254 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1164 BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1488 ImageHeight: 870 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2008 ImageHeight: 622 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2008 ImageHeight: 637 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric ImageMask: true Decode: 0, 1 Name: X Fonts: Type1: Font: BaseFont: SymbolStd FirstChar: 0 LastChar: 255 FontDescriptor: FontName: SymbolStd Flags: Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WarnockPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -222, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WarnockPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Regular Flags: Serif, Nonsymbolic FontBBox: -177, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Light Flags: Nonsymbolic FontBBox: -49, -250, 1046, 883 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true TrueType: Font: BaseFont: UHJSJK+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 32 FontDescriptor: FontName: UHJSJK+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true XMP: uuid:2e0f1d9c-7b20-4d21-b72f-c8b98656c3ef adobe:docid:indd:aca9e6a3-b7bc-11dd-9b31-8d92eded7c31 xmp.id:54c3476b-0db6-1c40-8db4-ccfa47cb74fc proof:pdf 1 xmp.iid:686043fa-bb33-0446-b2db-64b303f4bd45 xmp.did:b3e9c3a3-3bfe-2b49-8015-883794ed7939 default converted from application/x-indesign to application/pdf Adobe InDesign 16.0 (Windows) 2022-10-31T08:23:15+01:00 converted uuid:c5b24832-8b86-415b-a82f-6a3e167ae7a6 converted to PDF/A-2b pdfToolbox 2022-10-31T08:29:15+01:00 2022-10-31T08:23:15+01:00 2022-11-04T20:25:26+01:00 2022-11-04T20:25:26+01:00 Adobe InDesign 16.0 (Windows) journal 10.1186/s40813-022-00289-4 2010-04-23 true springer.com springerlink.com 2010-04-23 true 10.1186/s40813-022-00289-4 springer.com springerlink.com VoR application/pdf Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) False 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef internal An unordered array of references to resources that were incorporated, by inclusion or reference, into this document. Ingredients Bag ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text internal Mirrors crossmark:DOI doi Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 415, 83, 527, 75 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 317, 75, 449, 67 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 508, 682, 540, 649 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 59, 443, 64, 430 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 70, 443, 75, 430 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 237, 431, 241, 418 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 263, 215, 268, 202 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 232, 191, 237, 178 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 176, 167, 186, 154 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 351, 623, 361, 610 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 365, 623, 375, 610 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 369, 587, 374, 574 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 380, 587, 385, 574 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 333, 131, 338, 118 Flags: Print AppearanceDictionary: true Destination: 40 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 95, 143, 100, 130 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 418, 203, 422, 190 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 325, 143, 329, 130 Flags: Print AppearanceDictionary: true Destination: 52 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 204, 119, 209, 106 Flags: Print AppearanceDictionary: true Destination: 62 Annotation: Subtype: Link Rect: 357, 107, 362, 94 Flags: Print AppearanceDictionary: true Destination: 62 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 432, 179, 442, 166 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 329, 95, 339, 82 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 388, 71, 398, 58 Flags: Print AppearanceDictionary: true Destination: 117 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 59, 647, 64, 634 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 70, 647, 75, 634 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 80, 647, 90, 634 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 226, 551, 231, 538 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 283, 431, 288, 418 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 56, 419, 66, 406 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 71, 419, 80, 406 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 166, 347, 176, 334 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 247, 107, 257, 94 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 262, 107, 272, 94 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 505, 551, 515, 538 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 520, 551, 529, 538 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 470, 515, 475, 502 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 480, 515, 490, 502 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 530, 467, 535, 454 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 326, 287, 336, 274 Flags: Print AppearanceDictionary: true Destination: 117 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 97, 515, 106, 502 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 410, 599, 420, 586 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 307, 431, 317, 418 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 499, 155, 509, 142 Flags: Print AppearanceDictionary: true Destination: 117 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 104, 359, 114, 346 Flags: Print AppearanceDictionary: true Destination: 117 Annotation: Subtype: Link Rect: 512, 479, 517, 466 Flags: Print AppearanceDictionary: true Destination: 107 Annotation: Subtype: Link Rect: 496, 275, 529, 266 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 266, 404, 257 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 9 Thumb: true Checksum: e1b66a26 Type: CRC32 Checksum: 9792d24479e9a76d819a2ac687f9ec34 Type: MD5 Checksum: 86d4bb965213dbfb564f65a806a5fe600f3d231a Type: SHA-1