ff31f44aafff31523acbedfcd158245f  pmc_9650905.pdf
a30c01b56808b008cb568ad8d8a053e3288e57a0  pmc_9650905.pdf
99f34b5176ac8a780b93f4477c546f2204344c46ee4293bf7d8c887e0a6cf7ef  pmc_9650905.pdf

Title:          Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients
Subject:        Arthritis Research & Therapy, https://doi.org/10.1186/s13075-022-02942-3
Keywords:       Functional MRI;Pain sensitization;Fibromyalgia;Knee osteoarthritis;Somatosensory cortex;Insular cortex
Author:          Jesus Pujol
Creator:        Adobe InDesign 15.1 (Windows)
Producer:       Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:   Fri Nov 11 00:36:27 2022 CET
ModDate:        Fri Nov 11 07:49:14 2022 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          13
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      1804443 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     65  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes     69  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     67  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     68  0
MyriadPro-Light                      Type 1C           Custom           yes no  yes    128  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     66  0
MyriadPro-SemiboldIt                 Type 1C           WinAnsi          yes no  yes     96  0
GPEETL+MTSY                          Type 1C           Custom           yes yes yes     97  0
MyriadPro-Regular2                   Type 1C           WinAnsi          yes no  yes    301  0
BRIGGX+WarnockPro-It                 Type 1C           WinAnsi          yes yes yes    118  0
YPKIWP+MyriadPro-LightIt             Type 1C           WinAnsi          yes yes yes    127  0
MyriadPro-Regular3                   Type 1C           WinAnsi          yes no  yes    278  0
XESJVT+OpenSans-Light                Type 1C           Custom           yes yes no     285  0
XESJVT+OpenSans-Extrabold            Type 1C           WinAnsi          yes yes no     281  0
XESJVT+OregonLDOBookSinistral        Type 1C           WinAnsi          yes yes no     291  0
XESJVT+OpenSans-Bold                 Type 1C           WinAnsi          yes yes no     288  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2022-11-26 02:35:01 CET
 RepresentationInformation: pmc_9650905.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2022-11-23 02:11:30 CET
  Size: 1804443
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 438
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background: 
         Item: 
          Title: Methods: 
         Item: 
          Title: Results: 
         Item: 
          Title: Conclusions: 
       Item: 
        Title: Background
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Study design
         Item: 
          Title: Study populations
         Item: 
          Title: Clinical assessments
          Children: 
           Item: 
            Title: Osteoarthritis samples
           Item: 
            Title: Fibromyalgia samples
         Item: 
          Title: MRI acquisition
         Item: 
          Title: Iso-distant average correlation (IDAC) maps
         Item: 
          Title: Statistical analysis
          Children: 
           Item: 
            Title: Sample size
       Item: 
        Title: Results
       Item: 
        Title: Discussion
       Item: 
        Title: Conclusions
       Item: 
        Title: References
   Info: 
    Title: Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients
    Author:  Jesus Pujol
    Subject: Arthritis Research & Therapy, https://doi.org/10.1186/s13075-022-02942-3
    Keywords: Functional MRI;Pain sensitization;Fibromyalgia;Knee osteoarthritis;Somatosensory cortex;Insular cortex
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Fri Nov 11 00:36:27 CET 2022
    ModDate: Fri Nov 11 07:49:14 CET 2022
   ID: 0x64953b60b60a913a2abb543dba89171c, 0x066bd8771145b3030a3aeea7bb1be281
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 39
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 74
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 81
      ImageHeight: 84
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 665
      ImageHeight: 100
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 76
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 40
      ImageHeight: 76
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1418
      ImageHeight: 906
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1946
      ImageHeight: 1470
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1181
      ImageHeight: 960
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1418
      ImageHeight: 1809
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1418
      ImageHeight: 1252
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -193, -250, 1164, 972
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GPEETL+MTSY
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: GPEETL+MTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: BRIGGX+WarnockPro-It
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: BRIGGX+WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -221, -533, 1474, 950
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: YPKIWP+MyriadPro-LightIt
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: YPKIWP+MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -121, -250, 1007, 863
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2022-11-10T23:36:27</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.1 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2022-11-11T07:49:14+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2022-11-11T07:49:14+01:00</xmp:MetadataDate>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Keywords>Functional MRI;Pain sensitization;Fibromyalgia;Knee osteoarthritis;Somatosensory cortex;Insular cortex</pdf:Keywords>
         <pdf:Trapped>False</pdf:Trapped>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1186/s13075-022-02942-3</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BioMed Central</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Arthritis Research &amp; Therapy, https://doi.org/10.1186/s13075-022-02942-3</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Functional MRI</rdf:li>
               <rdf:li>Pain sensitization</rdf:li>
               <rdf:li>Fibromyalgia</rdf:li>
               <rdf:li>Knee osteoarthritis</rdf:li>
               <rdf:li>Somatosensory cortex</rdf:li>
               <rdf:li>Insular cortex</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li> Jesus Pujol</rdf:li>
               <rdf:li> Laura Blanco-Hinojo</rdf:li>
               <rdf:li> Andrea Doreste</rdf:li>
               <rdf:li> Fabiola Ojeda</rdf:li>
               <rdf:li> Gerard Martínez-Vilavella</rdf:li>
               <rdf:li> Víctor Pérez-Sola</rdf:li>
               <rdf:li> Joan Deus</rdf:li>
               <rdf:li> Jordi Monfort</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1186/s13075-022-02942-3</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1186/s13075-022-02942-3</prism:url>
         <prism:doi>10.1186/s13075-022-02942-3</prism:doi>
         <prism:issn>1478-6362</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Arthritis Research &amp; Therapy</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s13075-022-02942-3</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmpMM:DocumentID>uuid:7c71e8e6-1a73-4aec-80d4-1a8108f43e89</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:86213b2b-f324-4be1-81e0-a77a0eee9450</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:7c71e8e6-1a73-4aec-80d4-1a8108f43e89</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2022-11-10T23:57:16Z</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 212, 66, 330, 58
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 486, 66, 530, 58
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 58, 276, 50
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 368, 172, 373, 160
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 378, 172, 383, 160
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 507, 683, 540, 650
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 136, 692, 141, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 90, 632, 95, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 99, 632, 104, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 59, 596, 64, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 70, 596, 80, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 88, 572, 92, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 99, 560, 104, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 109, 560, 113, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 118, 560, 128, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 234, 548, 244, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 203, 536, 208, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 214, 536, 224, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 230, 536, 240, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 165, 524, 170, 512
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 177, 524, 186, 512
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 193, 524, 203, 512
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 209, 512, 214, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 219, 512, 229, 500
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 59, 488, 69, 476
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 59, 476, 69, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 189, 464, 194, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 199, 464, 204, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 102, 368, 112, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 156, 224, 166, 212
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 275, 212, 285, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 119, 200, 128, 188
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 530, 392, 535, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 392, 368, 402, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 398, 248, 403, 236
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 409, 248, 419, 236
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 425, 248, 435, 236
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 461, 212, 471, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 307, 176, 312, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 319, 176, 329, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 506, 152, 516, 140
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 382, 104, 392, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 102, 583, 112, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 80, 559, 85, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 90, 559, 95, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 280, 535, 285, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 258, 487, 268, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 129, 463, 139, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 250, 377, 260, 365
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 275, 341, 285, 329
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 278, 317, 288, 305
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 56, 305, 66, 293
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 158, 281, 168, 269
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 504, 463, 514, 451
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 531, 451, 536, 439
       Flags: Print
       AppearanceDictionary: true
       Destination: 237
      Annotation: 
       Subtype: Link
       Rect: 453, 355, 463, 343
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 429, 259, 434, 247
       Flags: Print
       AppearanceDictionary: true
       Destination: 237
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 176, 681, 181, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 204, 681, 209, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 173
      Annotation: 
       Subtype: Link
       Rect: 229, 489, 239, 476
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 118, 261, 128, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 81, 81, 86, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 122
      Annotation: 
       Subtype: Link
       Rect: 513, 537, 518, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 237
      Annotation: 
       Subtype: Link
       Rect: 365, 429, 370, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 237
      Annotation: 
       Subtype: Link
       Rect: 329, 369, 334, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 122
      Annotation: 
       Subtype: Link
       Rect: 356, 369, 360, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 443, 321, 448, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 377, 225, 382, 212
       Flags: Print
       AppearanceDictionary: true
       Destination: 237
      Annotation: 
       Subtype: Link
       Rect: 421, 225, 426, 212
       Flags: Print
       AppearanceDictionary: true
       Destination: 146
      Annotation: 
       Subtype: Link
       Rect: 372, 141, 377, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 173
     Thumb: true
    Page: 
     Sequence: 5
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 283, 196, 288, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 230, 184, 235, 172
       Flags: Print
       AppearanceDictionary: true
       Destination: 237
      Annotation: 
       Subtype: Link
       Rect: 436, 268, 440, 256
       Flags: Print
       AppearanceDictionary: true
       Destination: 237
      Annotation: 
       Subtype: Link
       Rect: 329, 88, 339, 76
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 158, 345, 163, 333
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 167, 345, 172, 333
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 253, 321, 257, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 263, 321, 268, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 259, 309, 269, 297
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 275, 309, 285, 297
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 59, 249, 69, 237
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 75, 249, 85, 237
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 225, 189, 234, 177
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 275, 117, 285, 105
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 491, 381, 500, 369
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 362, 333, 372, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 307, 177, 317, 165
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 323, 177, 333, 165
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 494, 129, 504, 117
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 508, 129, 518, 117
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 523, 129, 533, 117
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 526, 105, 536, 93
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 304, 93, 314, 81
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 217, 69, 205
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 257, 205, 267, 193
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 275, 157, 285, 145
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 275, 121, 285, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 381, 217, 391, 205
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 307, 157, 317, 145
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 323, 157, 333, 145
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 339, 157, 349, 145
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 523, 133, 533, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 80, 282, 90, 269
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 274, 270, 285, 257
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 236, 234, 246, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 251, 234, 261, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 118, 222, 129, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 229, 222, 239, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 106, 210, 116, 197
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 122, 210, 132, 197
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 145, 198, 155, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 161, 198, 171, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 177, 198, 187, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 193, 198, 203, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 59, 186, 70, 173
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 75, 186, 85, 173
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 90, 186, 100, 173
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 59, 162, 70, 149
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 75, 162, 85, 149
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 91, 162, 101, 149
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 259, 150, 269, 137
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 274, 150, 284, 137
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 422, 294, 431, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 439, 294, 448, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 398, 234, 408, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 412, 234, 422, 221
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 469, 174, 479, 161
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 486, 174, 495, 161
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 402, 150, 412, 137
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 307, 126, 317, 113
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 473, 114, 483, 101
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 495, 78, 504, 65
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 510, 78, 520, 65
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 113, 657, 123, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 266
      Annotation: 
       Subtype: Link
       Rect: 129, 657, 139, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 270
      Annotation: 
       Subtype: Link
       Rect: 203, 381, 208, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 214, 381, 224, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 256
      Annotation: 
       Subtype: Link
       Rect: 496, 549, 529, 540
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 540, 404, 531
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 122, 577, 282, 569
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 568, 160, 555
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 12
     Thumb: true
    Page: 
     Sequence: 13
     Thumb: true
  Checksum: 54bbade9
   Type: CRC32
  Checksum: ff31f44aafff31523acbedfcd158245f
   Type: MD5
  Checksum: a30c01b56808b008cb568ad8d8a053e3288e57a0
   Type: SHA-1