887b2c5d312dae8838631abe31c24d8b pmc_9674680.pdf 7a176056d24edf81b2282f039522c700f7dbb4c4 pmc_9674680.pdf 531b6a053ef7b11b392098475758e5323c5eeb3a339ca7c885188258d27f743b pmc_9674680.pdf Title: Radiation dose estimation with time-since-exposure uncertainty using the -H2AX biomarker Subject: Scientific Reports, https://doi.org/10.1038/s41598-022-24331-1 Author: Dorota Młynarczyk Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Nov 18 11:07:52 2022 CET ModDate: Fri Nov 18 19:39:23 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2253047 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OVYQNB+RMTMIB Type 1C Custom yes yes no 1127 0 EPTVHM+Wingdings-Regular 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Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1202 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Radiation dose estimation with time-since-exposure uncertainty using the -H2AX biomarker Children: Item: Title: Statistical models Children: Item: Title: Calibration. Item: Title: Estimation. Item: Title: Materials and results Item: Title: Discussion Item: Title: References Info: Title: Radiation dose estimation with time-since-exposure uncertainty using the -H2AX biomarker Author: Dorota Młynarczyk Subject: Scientific Reports, https://doi.org/10.1038/s41598-022-24331-1 Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Nov 18 11:37:52 CET 2022 ModDate: Fri Nov 18 19:39:23 CET 2022 ID: 0x34c3df9ddb49975a53ee4b0e7961b3d4, 0x49b90c0d49de87a46387fde86bdf1185 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2032 ImageHeight: 802 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 969 ImageHeight: 707 ColorSpace: RGB BitsPerSample: 8 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FontBBox: 0, -181, 256, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: INSLCN+MTMI26 FontSubset: true FirstChar: 27 LastChar: 33 FontDescriptor: FontName: INSLCN+MTMI26 Flags: Symbolic FontBBox: 0, -206, 700, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FZCJST+MinionPro-Bold9 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: FZCJST+MinionPro-Bold9 Flags: Symbolic, SmallCap FontBBox: -7, -245, 654, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GYRPGR+MinionPro-It31 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: GYRPGR+MinionPro-It31 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: VXTESN+MTSYN21 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: VXTESN+MTSYN21 Flags: Symbolic FontBBox: 0, -181, 256, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VXTESN+MTSYN23 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: VXTESN+MTSYN23 Flags: Symbolic FontBBox: 0, -181, 256, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: GYRPGR+MinionPro-Regular14 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: GYRPGR+MinionPro-Regular14 Flags: Symbolic, SmallCap FontBBox: 0, -257, 796, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GYRPGR+MinionPro-Regular13 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: GYRPGR+MinionPro-Regular13 Flags: Symbolic, SmallCap FontBBox: 0, -257, 796, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true 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BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: APPFAD+MathPackTen FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: APPFAD+MathPackTen Flags: Symbolic FontBBox: 0, -11, 479, 713 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: VFCWIN+CMEX102 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: VFCWIN+CMEX102 Flags: Symbolic FontBBox: 0, -1400, 1387, 0 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: FZCJST+MinionPro-Bold2 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: FZCJST+MinionPro-Bold2 Flags: Symbolic, SmallCap FontBBox: -7, -245, 654, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BOELOB+MathPackTwelve2 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: BOELOB+MathPackTwelve2 Flags: Symbolic FontBBox: 0, -24, 482, 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Symbolic FontBBox: 0, -206, 700, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: APPFAD+MathPackTen2 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: APPFAD+MathPackTen2 Flags: Symbolic FontBBox: 0, -11, 479, 713 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: INSLCN+MTMI7 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: INSLCN+MTMI7 Flags: Symbolic FontBBox: 0, -206, 700, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: GYRPGR+MinionPro-Regular4 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: GYRPGR+MinionPro-Regular4 Flags: Symbolic, SmallCap FontBBox: 0, -257, 796, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: VXTESN+MTSYN4 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: VXTESN+MTSYN4 Flags: Symbolic FontBBox: 0, -181, 256, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionPro-It6 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MinionPro-It6 Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: GYRPGR+MinionPro-It13 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: GYRPGR+MinionPro-It13 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: VFCWIN+CMEX10 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: VFCWIN+CMEX10 Flags: Symbolic FontBBox: 0, -1400, 1387, 0 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GYRPGR+MinionPro-It9 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: GYRPGR+MinionPro-It9 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GYRPGR+MinionPro-It7 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: GYRPGR+MinionPro-It7 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: VXTESN+MTSYN3 FontSubset: true FirstChar: 28 LastChar: 33 FontDescriptor: FontName: VXTESN+MTSYN3 Flags: Symbolic FontBBox: 0, -181, 256, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: INSLCN+MTMI6 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: INSLCN+MTMI6 Flags: Symbolic FontBBox: 0, -206, 700, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: GYRPGR+MinionPro-Regular3 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: GYRPGR+MinionPro-Regular3 Flags: Symbolic, SmallCap FontBBox: 0, -257, 796, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: OVYQNB+RMTMIB FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: OVYQNB+RMTMIB Flags: Symbolic FontBBox: 0, -206, 559, 462 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GYRPGR+MinionPro-It8 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: GYRPGR+MinionPro-It8 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: EPTVHM+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: EPTVHM+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: 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BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: BOELOB+MathPackTwelve FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: BOELOB+MathPackTwelve Flags: Symbolic FontBBox: 0, -24, 482, 702 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: VXTESN+MTSYN11 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: VXTESN+MTSYN11 Flags: Symbolic FontBBox: 0, -181, 256, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FZCJST+MinionPro-Bold5 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: FZCJST+MinionPro-Bold5 Flags: Symbolic, SmallCap FontBBox: -7, -245, 654, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: VXTESN+MTSYN12 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: VXTESN+MTSYN12 Flags: Symbolic FontBBox: 0, -181, 256, 668 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: OVYQNB+RMTMIB7 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: OVYQNB+RMTMIB7 Flags: Symbolic FontBBox: 0, -206, 559, 462 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GYRPGR+MinionPro-Regular10 FontSubset: true FirstChar: 25 LastChar: 33 FontDescriptor: FontName: GYRPGR+MinionPro-Regular10 Flags: Symbolic, SmallCap FontBBox: 0, -257, 796, 700 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: INSLCN+MTMI12 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: INSLCN+MTMI12 Flags: Symbolic FontBBox: 0, -206, 700, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NJXVAD+CMSY9 FontSubset: true FirstChar: 31 LastChar: 33 FontDescriptor: FontName: NJXVAD+CMSY9 Flags: 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FontName: OVYQNB+RMTMIB3 Flags: Symbolic FontBBox: 0, -206, 559, 462 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GYRPGR+MinionPro-It18 FontSubset: true FirstChar: 20 LastChar: 33 FontDescriptor: FontName: GYRPGR+MinionPro-It18 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GYRPGR+MinionPro-It29 FontSubset: true FirstChar: 29 LastChar: 33 FontDescriptor: FontName: GYRPGR+MinionPro-It29 Flags: Symbolic FontBBox: -142, -257, 760, 712 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: INSLCN+MTMI35 FontSubset: true FirstChar: 30 LastChar: 33 FontDescriptor: FontName: INSLCN+MTMI35 Flags: Symbolic FontBBox: 0, -206, 700, 676 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VFCWIN+CMEX103 FontSubset: true FirstChar: 30 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FirstChar: 32 LastChar: 118 FontDescriptor: FontName: OLGWOB+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: RINJXV+Corbel CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RINJXV+Corbel Flags: Symbolic FontBBox: -553, -239, 1110, 952 FontFile2: true Font: BaseFont: BRMQNB+Corbel-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: BRMQNB+Corbel-Bold Flags: Symbolic FontBBox: -556, -240, 1155, 952 FontFile2: true XMP: 2022-11-18T15:37:52+05:30 Springer 2022-11-18T19:39:23+01:00 2022-11-18T19:39:23+01:00 application/pdf https://doi.org/10.1038/s41598-022-24331-1 Nature Publishing Group UK Scientific Reports, https://doi.org/10.1038/s41598-022-24331-1 Radiation dose estimation with time-since-exposure uncertainty using the -H2AX biomarker Dorota Młynarczyk Pedro Puig Carmen Armero Virgilio Gómez-Rubio Joan F. Barquinero Mònica Pujol-Canadell 10.1038/s41598-022-24331-1 2010-04-23 true springer.com springerlink.com https://doi.org/10.1038/s41598-022-24331-1 10.1038/s41598-022-24331-1 2045-2322 journal Scientific Reports The Author(s) 2010-04-23 true 10.1038/s41598-022-24331-1 noindex springer.com springerlink.com VoR uuid:65e13eb0-702e-437e-8e75-d16960640998 uuid:e5fe65a4-8ed3-4591-973e-30f2f582f34a default 1 converted uuid:6671f95b-f843-47dd-8948-5b57a71be7fc converted to PDF/A-2b pdfToolbox 2022-11-18T15:39:26+05:30 converted uuid:2bbacf7a-24c8-4a06-aa33-9f6d782e07ce converted to PDF/A-2b pdfToolbox 2022-11-18T15:40:12+05:30 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. 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For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). 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