fadae95ae176c4d55fb5fffabca8ddc1 pmc_9691095.pdf 0b66c2be2e99497cf558f3b4fc58087e351ac714 pmc_9691095.pdf 1e8cc66d236eb95dd34e6c89c00b59e7b886bf4e1067e0a8f898bd85d3e08623 pmc_9691095.pdf Title: Heterogeneity in Response to MCT and Psychoeducation: A Feasibility Study Using Latent Class Mixed Models in First-Episode Psychosis Subject: Metacognitive training (MCT) is an effective treatment for psychosis. Longitudinal trajectories of treatment response are unknown but could point to strategies to maximize treatment efficacy during the first episodes. This work aims to explore the possible benefit of using latent class mixed models (LCMMs) to understand how treatment response differs between metacognitive training and psychoeducation. We conducted LCMMs in 28 patients that received MCT and 34 patients that received psychoeducation. We found that MCT is effective in improving cognitive insight in all patients but that these effects wane at follow-up. In contrast, psychoeducation does not improve cognitive insight, and may increase self-certainty in a group of patients. These results suggest that LCMMs are valuable tools that can aid in treatment prescription and in predicting response to specific treatments. Keywords: first-episode psychosis; social cognition; metacognition; latent class mixed models; metacognitive training; psychoeducation Author: Marta Ferrer-Quintero, Daniel Fernández, Raquel López-Carrilero, Luciana Díaz-Cutraro, Marina Verdaguer-Rodríguez, Helena García-Mieres, Elena Huerta-Ramos, Juana Gómez-Benito, Trini Peláez, Irene Birulés, Ana Barajas, Esther Pousa, Marisa Barrigón, Alfonso Gutiérrez-Zotes, Eva Grasa, Isabel Ruiz-Delgado, Esther Lorente-Rovira, Jordi Cid, on behalf of the Spanish Metacognition Study Group and Susana Ochoa Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Nov 10 17:06:12 2022 CET ModDate: Thu Nov 10 17:13:33 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1986786 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OOYTGH+VnURWPalladioL Type 1 Custom yes yes no 10 0 WQYPNU+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 DOJYZN+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 IUUWSW+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 XAOEUN+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 CNXSVA+CMSY10 Type 1 Builtin yes yes no 71 0 MKHHVF+EURB10 Type 1 Builtin yes yes no 78 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 82 0 HFHJOE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 102 0 HFHJOG+PalatinoLinotype TrueType WinAnsi yes yes no 105 0 HFHJOI+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 108 0 JLZORU+EURM10 Type 1 Builtin yes yes no 116 0 HFHJOE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 127 0 HFHJOF+PalatinoLinotype CID TrueType Identity-H yes yes yes 130 0 HFHJOG+PalatinoLinotype TrueType WinAnsi yes yes no 136 0 HFHJOI+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 139 0 HFHJOE+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 153 0 HFHJOG+PalatinoLinotype TrueType WinAnsi yes yes no 156 0 HFHJOI+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 159 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-12-02 02:29:30 CET RepresentationInformation: pmc_9691095.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-12-01 02:19:22 CET Size: 1986786 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 365 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4923ab24 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Cognitive Insight Trajectories in the MCT Group Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Children: Item: Title: Self-Reflectivity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Self-Certainty Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Cognitive Insight Trajectories in the Psychoeducation Group Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Self-Reflectivity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Self-Certainty Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Info: Title: Heterogeneity in Response to MCT and Psychoeducation: A Feasibility Study Using Latent Class Mixed Models in First-Episode Psychosis Author: Marta Ferrer-Quintero, Daniel Fernández, Raquel López-Carrilero, Luciana Díaz-Cutraro, Marina Verdaguer-Rodríguez, Helena García-Mieres, Elena Huerta-Ramos, Juana Gómez-Benito, Trini Peláez, Irene Birulés, Ana Barajas, Esther Pousa, Marisa Barrigón, Alfonso Gutiérrez-Zotes, Eva Grasa, Isabel Ruiz-Delgado, Esther Lorente-Rovira, Jordi Cid, on behalf of the Spanish Metacognition Study Group and Susana Ochoa Subject: Metacognitive training (MCT) is an effective treatment for psychosis. Longitudinal trajectories of treatment response are unknown but could point to strategies to maximize treatment efficacy during the first episodes. This work aims to explore the possible benefit of using latent class mixed models (LCMMs) to understand how treatment response differs between metacognitive training and psychoeducation. We conducted LCMMs in 28 patients that received MCT and 34 patients that received psychoeducation. We found that MCT is effective in improving cognitive insight in all patients but that these effects wane at follow-up. In contrast, psychoeducation does not improve cognitive insight, and may increase self-certainty in a group of patients. These results suggest that LCMMs are valuable tools that can aid in treatment prescription and in predicting response to specific treatments. 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