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     Item: 
      Title: Loss of seryl-­tRNA synthetase (SARS1) causes complex spastic paraplegia and cellular senescence
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       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Materials and methods
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         Item: 
          Title: Patients and samples
         Item: 
          Title: Whole-exome sequencing analysis
         Item: 
          Title: Evolutionary conservation of SARS1
         Item: 
          Title: Three-dimensional modelling
         Item: 
          Title: Fibroblast cultures
         Item: 
          Title: RT-PCR and qRT-PCR
         Item: 
          Title: Immunofluorescence
         Item: 
          Title: Western blot analysis
         Item: 
          Title: β-Galactosidase staining
         Item: 
          Title: Construction, culture and analysis of S. cerevisiae yeast strains
         Item: 
          Title: In vitro analysis of SARS1 activity
         Item: 
          Title: S. cerevisiae yeast S100 preparation
         Item: 
          Title: Fibroblast S100 preparation
         Item: 
          Title: Data availability
       Item: 
        Title: Results
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         Item: 
          Title: Clinical description and genetic findings
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          Title: Structural and functional characterisation
         Item: 
          Title: Analysis of hSARS and its mutant in S. cerevisiae yeast revealed dominant-negative effects
         Item: 
          Title: Loss of SARS1 activity causes cellular senescence
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        Title: Discussion
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        Title: References
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       Rect: 376, 232, 422, 224
      Annotation: 
       Subtype: Link
       Rect: 351, 205, 367, 197
      Annotation: 
       Subtype: Link
       Rect: 434, 169, 480, 160
  Checksum: 84f252bf
   Type: CRC32
  Checksum: 2c4ce13ddbd896358cb58a9a6b3a16a1
   Type: MD5
  Checksum: c56a0c14377b3d13ccfcd1053419049ab5dc92d1
   Type: SHA-1