4f0791ab9b0c0122cf6c5323979d7cfc pmc_9701481.pdf a87e30d73918a0f66f606cfaa28b0cf3825960bd pmc_9701481.pdf 3d66e894ce013a1391a360cd120610b84da2b1dc112a429cf9b356dc7684cac7 pmc_9701481.pdf Title: Non-invasive predictors of clinically-significant portal hypertension in NASH cirrhosis Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Sat Nov 5 10:15:27 2022 CET ModDate: Sat Nov 5 10:15:36 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1133121 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SEONDI+ArialMT CID TrueType Identity-H yes yes yes 324 0 SEONDI+Arial-BoldMT TrueType WinAnsi yes yes yes 325 0 DFBBBM+ArialMT TrueType WinAnsi yes yes yes 326 0 NCZELS+Arial-ItalicMT TrueType WinAnsi yes yes yes 327 0 DFBBBM+ArialMT TrueType WinAnsi yes yes yes 208 0 DFBBBM+ArialMT TrueType WinAnsi yes yes yes 209 0 NCZELS+Arial-BoldItalicMT TrueType WinAnsi yes yes yes 206 0 NCZELS+STIX-Bold Type 1C WinAnsi yes yes yes 161 0 YDMSJW+STIX-Regular Type 1C Custom yes yes yes 207 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-10 02:37:38 CET RepresentationInformation: pmc_9701481.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-12-08 02:17:08 CET Size: 1133121 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 343 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Noninvasive predictors of clinically significant portal hypertension in NASH cirrhosis: Validation of ANTICIPATE models and development of a lab-­based model Children: Item: Title: Abstract Item: Title: INTRODUCTION Item: Title: METHODS Children: Item: Title: Participants Item: Title: Predicted outcome Item: Title: Models Item: Title: Variables Item: Title: Statistical analysis Item: Title: RESULTS Children: Item: Title: AIM 1: External validation of ANTICIPATE and ANTICIPATE-­NASH models Children: Item: Title: ANTICIPATE model Item: Title: ANTICIPATE-­NASH model Item: Title: AIM 2: Development of a model using only laboratory values Item: Title: DISCUSSION Children: Item: Title: Aim 1: Validation of ANTICIPATE models Item: Title: Aim 2: Development of FIB4+ model Item: Title: Strengths and limitations of our study Item: Title: Conclusions Item: Title: ACKNOWLEDGMENT Item: Title: FUNDING INFORMATION Item: Title: CONFLICT OF INTEREST Item: Title: REFERENCES Info: Title: Non-invasive predictors of clinically-significant portal hypertension in NASH cirrhosis Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Sat Nov 05 10:45:27 CET 2022 ModDate: Sat Nov 05 10:45:36 CET 2022 ID: 0x0abc65a52855c14b98baabb38f286b5c, 0xafd0093306b603206e75712e19f51f30 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1103 ImageHeight: 1218 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2074 ImageHeight: 1177 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2095 ImageHeight: 1177 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2083 ImageHeight: 2231 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1866 ImageHeight: 757 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: SEONDI+ArialMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: NCZELS+STIX-Bold FontSubset: true FirstChar: 43 LastChar: 43 FontDescriptor: FontName: NCZELS+STIX-Bold Flags: Serif, Nonsymbolic FontBBox: -998, -552, 2000, 1055 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: YDMSJW+STIX-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: YDMSJW+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: SEONDI+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 124 FontDescriptor: FontName: SEONDI+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: DFBBBM+ArialMT FontSubset: true FirstChar: 32 LastChar: 242 FontDescriptor: FontName: DFBBBM+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: NCZELS+Arial-ItalicMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: NCZELS+Arial-ItalicMT Flags: Nonsymbolic, Italic FontBBox: -517, -325, 1359, 998 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: NCZELS+Arial-BoldItalicMT FontSubset: true FirstChar: 112 LastChar: 112 FontDescriptor: FontName: NCZELS+Arial-BoldItalicMT Flags: Nonsymbolic, Italic FontBBox: -560, -376, 1390, 1018 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: SEONDI+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: SEONDI+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1040 FontFile2: true XMP: VoR 10.1002/hep4.2091 10.1002/hep4.2091 10.1002/(ISSN)2471-254X 3 Non-invasive predictors of clinically-significant portal hypertension in NASH cirrhosis Pages: Page: Label: 3324 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 77, 39, 190, 30 Annotation: Subtype: Link Rect: 132, 585, 136, 568 ActionDest: 280 Annotation: Subtype: Link Rect: 136, 583, 149, 570 Annotation: Subtype: Link Rect: 257, 585, 262, 568 ActionDest: 280 Annotation: Subtype: Link Rect: 377, 585, 382, 568 ActionDest: 280 Annotation: Subtype: Link Rect: 483, 585, 488, 568 ActionDest: 280 Annotation: Subtype: Link Rect: 119, 567, 124, 550 ActionDest: 280 Annotation: Subtype: Link Rect: 232, 567, 244, 550 ActionDest: 280 Annotation: Subtype: Link Rect: 244, 565, 256, 552 Annotation: Subtype: Link Rect: 413, 567, 413, 550 Annotation: Subtype: Link Rect: 413, 567, 425, 550 ActionDest: 280 Annotation: Subtype: Link Rect: 214, 86, 397, 77 Annotation: Subtype: Link Rect: 67, 279, 173, 269 Page: Label: 3325 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 282, 602, 286, 589 ActionDest: 179 Annotation: Subtype: Link Rect: 234, 506, 238, 493 ActionDest: 179 Annotation: Subtype: Link Rect: 134, 434, 147, 421 ActionDest: 179 Annotation: Subtype: Link Rect: 203, 326, 207, 313 ActionDest: 179 Annotation: Subtype: Link Rect: 157, 290, 162, 277 ActionDest: 179 Annotation: Subtype: Link Rect: 192, 206, 196, 193 ActionDest: 179 Annotation: Subtype: Link Rect: 503, 662, 507, 649 ActionDest: 179 Annotation: Subtype: Link Rect: 432, 602, 436, 589 ActionDest: 179 Annotation: Subtype: Link Rect: 450, 350, 454, 337 ActionDest: 179 Annotation: Subtype: Link Rect: 502, 182, 506, 169 ActionDest: 179 Page: Label: 3326 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 151, 710, 154, 697 ActionDest: 179 Annotation: Subtype: Link Rect: 248, 626, 252, 613 ActionDest: 179 Annotation: Subtype: Link Rect: 96, 542, 116, 529 ActionDest: 179 Annotation: Subtype: Link Rect: 158, 530, 166, 517 ActionDest: 179 Annotation: Subtype: Link Rect: 109, 506, 119, 493 ActionDest: 179 Annotation: Subtype: Link Rect: 154, 506, 162, 493 ActionDest: 179 Annotation: Subtype: Link Rect: 240, 458, 247, 445 ActionDest: 179 Annotation: Subtype: Link Rect: 112, 446, 120, 433 ActionDest: 179 Annotation: Subtype: Link Rect: 60, 410, 73, 397 ActionDest: 179 Annotation: Subtype: Link Rect: 68, 206, 75, 193 ActionDest: 179 Annotation: Subtype: Link Rect: 134, 194, 141, 181 ActionDest: 179 Annotation: Subtype: Link Rect: 404, 686, 412, 673 ActionDest: 179 Annotation: Subtype: Link Rect: 540, 662, 547, 649 ActionDest: 179 Annotation: Subtype: Link Rect: 416, 542, 424, 529 ActionDest: 179 Annotation: Subtype: Link Rect: 364, 290, 546, 277 Annotation: Subtype: Link Rect: 343, 158, 348, 145 ActionDest: 65 Annotation: Subtype: Link Rect: 404, 110, 409, 97 ActionDest: 65 Annotation: Subtype: Link Rect: 424, 86, 428, 73 ActionDest: 179 Annotation: Subtype: Link Rect: 392, 62, 396, 49 ActionDest: 179 Annotation: Subtype: Link Rect: 431, 62, 443, 49 ActionDest: 197 Page: Label: 3327 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 392, 602, 398, 589 ActionDest: 83 Annotation: Subtype: Link Rect: 477, 434, 488, 421 ActionDest: 197 Annotation: Subtype: Link Rect: 423, 386, 435, 373 ActionDest: 197 Annotation: Subtype: Link Rect: 134, 322, 137, 311 ActionDest: 65 Annotation: Subtype: Link Rect: 116, 279, 119, 268 ActionDest: 65 Annotation: Subtype: Link Rect: 66, 154, 69, 144 ActionDest: 65 Annotation: Subtype: Link Rect: 90, 113, 93, 102 ActionDest: 65 Page: Label: 3328 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 166, 230, 178, 217 ActionDest: 197 Annotation: Subtype: Link Rect: 414, 350, 419, 337 ActionDest: 101 Annotation: Subtype: Link Rect: 479, 194, 484, 181 ActionDest: 65 Annotation: Subtype: Link Rect: 382, 170, 388, 157 ActionDest: 101 Annotation: Subtype: Link Rect: 327, 122, 337, 109 ActionDest: 179 Annotation: Subtype: Link Rect: 361, 98, 373, 85 ActionDest: 197 Annotation: Subtype: Link Rect: 376, 62, 388, 49 ActionDest: 197 Page: Label: 3329 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 415, 86, 421, 73 ActionDest: 117 Annotation: Subtype: Link Rect: 134, 386, 137, 375 ActionDest: 101 Annotation: Subtype: Link Rect: 116, 343, 119, 332 ActionDest: 101 Annotation: Subtype: Link Rect: 66, 218, 69, 208 ActionDest: 101 Annotation: Subtype: Link Rect: 90, 177, 93, 166 ActionDest: 101 Annotation: Subtype: Link Rect: 89, 163, 93, 152 ActionDest: 101 Page: Label: 3330 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 156, 110, 161, 97 ActionDest: 117 Page: Label: 3331 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 255, 482, 261, 469 ActionDest: 123 Annotation: Subtype: Link Rect: 214, 386, 230, 373 ActionDest: 197 Annotation: Subtype: Link Rect: 259, 230, 266, 217 ActionDest: 197 Annotation: Subtype: Link Rect: 135, 194, 143, 181 ActionDest: 197 Annotation: Subtype: Link Rect: 395, 686, 399, 673 ActionDest: 179 Annotation: Subtype: Link Rect: 457, 674, 461, 661 ActionDest: 179 Annotation: Subtype: Link Rect: 521, 590, 547, 577 ActionDest: 179 Annotation: Subtype: Link Rect: 340, 434, 358, 421 ActionDest: 197 Annotation: Subtype: Link Rect: 365, 182, 377, 169 ActionDest: 197 Page: Label: 3332 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 168, 722, 178, 709 ActionDest: 179 Annotation: Subtype: Link Rect: 62, 542, 70, 529 ActionDest: 197 Annotation: Subtype: Link Rect: 226, 494, 234, 481 ActionDest: 197 Annotation: Subtype: Link Rect: 193, 470, 200, 457 ActionDest: 179 Annotation: Subtype: Link Rect: 150, 434, 158, 421 ActionDest: 179 Annotation: Subtype: Link Rect: 66, 386, 73, 373 ActionDest: 179 Annotation: Subtype: Link Rect: 238, 386, 242, 373 ActionDest: 179 Annotation: Subtype: Link Rect: 209, 326, 219, 313 ActionDest: 179 Annotation: Subtype: Link Rect: 107, 242, 111, 229 ActionDest: 179 Annotation: Subtype: Link Rect: 392, 638, 397, 625 ActionDest: 123 Annotation: Subtype: Link Rect: 524, 602, 549, 589 Annotation: Subtype: Link Rect: 306, 590, 387, 577 Annotation: Subtype: Link Rect: 333, 494, 341, 481 ActionDest: 197 Annotation: Subtype: Link Rect: 539, 434, 547, 421 ActionDest: 197 Page: Label: 3333 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 115, 110, 127, 98 Annotation: Subtype: Link Rect: 128, 110, 182, 97 Annotation: Subtype: Link Rect: 45, 98, 165, 85 Annotation: Subtype: Link Rect: 111, 86, 123, 74 Annotation: Subtype: Link Rect: 124, 86, 178, 73 Annotation: Subtype: Link Rect: 45, 74, 165, 61 Page: Label: 3334 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 376, 413, 524, 400 Checksum: bebfe3ad Type: CRC32 Checksum: 4f0791ab9b0c0122cf6c5323979d7cfc Type: MD5 Checksum: a87e30d73918a0f66f606cfaa28b0cf3825960bd Type: SHA-1