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Title:          Detailed stratified GWAS analysis for severe COVID-19 in four European populations
Subject:        AcademicSubjects/SCI01140, DOI: 10.1093/hmg/ddac158, Human Molecular Genetics, 31, 23, 15 07 2022. Abstract: Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung. 
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    Subject: AcademicSubjects/SCI01140, DOI: 10.1093/hmg/ddac158, Human Molecular Genetics, 31, 23, 15 07 2022. Abstract: Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung. 
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<dc:description>AcademicSubjects/SCI01140, DOI: 10.1093/hmg/ddac158, Human Molecular Genetics, 31, 23, 15 07 2022. Abstract: Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12&#x2009;488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a &#x007E;0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung. </dc:description>
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<dc:rights>&#x00A9; The Author(s) 2022. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com</dc:rights>
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       Rect: 303, 426, 313, 431
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 303, 382, 313, 387
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 303, 338, 313, 344
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 303, 284, 313, 289
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 303, 262, 313, 267
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 411, 226, 492, 236
      Annotation: 
       Subtype: Link
       Rect: 303, 218, 313, 223
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 303, 152, 313, 157
       Destination: 169
      Annotation: 
       Subtype: Link
       Rect: 303, 97, 313, 103
       Destination: 169
  Checksum: 077f7a8b
   Type: CRC32
  Checksum: 1363e86beb79319997ab95e266a66bf8
   Type: MD5
  Checksum: 69049321e8a193d29313013b645bb5df248b4388
   Type: SHA-1