71d5ac0942efe164be084a59e0f77444 pmc_9708456.pdf db526cc221878fd8050f5642b181b00db0ca37d2 pmc_9708456.pdf 2e0a2036158bb761cf98253c13001f978e5e3f94ffab1c1391810803d1a01e4e pmc_9708456.pdf Title: Association of fecal and serum microRNA profiles with gastrointestinal cancer and chronic inflammatory enteropathy in dogs Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 11.0 (Windows) CreationDate: Mon Nov 28 17:04:00 2022 CET ModDate: Mon Nov 28 17:04:00 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1160253 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NPCONL+AdvTT6071803a.B Type 1C WinAnsi yes yes no 712 0 NPDCOE+AdvTTa9c1b374 Type 1C WinAnsi yes yes no 713 0 NPDCOF+AdvOT8608a8d1 Type 1C WinAnsi yes yes no 714 0 NPDCPF+AdvOT8608a8d1+20 Type 1C WinAnsi yes yes no 715 0 NPDCPG+AdvTTeb5f0e55.I Type 1C WinAnsi yes yes no 716 0 NPDJEB+AdvTTa9c1b374+20 Type 1C Custom yes yes yes 717 0 NPDJIA+AdvP4C4E59 Type 1C Custom yes yes yes 383 0 NPDKGO+AdvOT8608a8d1+03 Type 1C Custom yes yes yes 384 0 NPDKFM+AdvTTa9c1b374+22 Type 1C Custom yes yes yes 385 0 NPDKFN+AdvP4C4E74 Type 1C Custom yes yes yes 386 0 NPDLBK+AdvOT8608a8d1+02 Type 1C Custom yes yes yes 42 0 NPDLBL+AdvTTa9c1b374+02 Type 1C MacRoman yes yes no 387 0 NPDPJB+AdvTTfac587ca.B Type 1C WinAnsi yes yes no 388 0 NPDPKC+AdvTT9c438aa4.BI Type 1C WinAnsi yes yes no 389 0 NPEEPC+Calibri-Bold Type 1C Custom yes yes yes 85 0 NPEEPD+Calibri Type 1C Custom yes yes yes 86 0 Calibri-Italic Type 1C WinAnsi yes no no 87 0 NPEHPD+HelveticaLTStd-Bold Type 1C WinAnsi yes yes no 129 0 NPEHPE+HelveticaLTStd-Obl Type 1C WinAnsi yes yes no 130 0 NPEIAE+HelveticaLTStd-Roman Type 1C WinAnsi yes yes no 131 0 NPFCHF+AdvP4C4E40 Type 1C WinAnsi yes yes no 159 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-12-15 02:30:26 CET RepresentationInformation: pmc_9708456.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-12-08 02:16:47 CET Size: 1160253 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 732 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Association of fecal and serum microRNA profiles with gastrointestinal cancer and chronic inflammatory enteropathy in dogs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Children: Item: Title: 1 INTRODUCTION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: 2 MATERIALS AND METHODS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Children: Item: Title: 2.1 Study design and ethics approval Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: 2.2 Dog recruitment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: 2.3 Sample collection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: 2.4 RNA isolation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: 2.5 Small RNAseq and data analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: 2.6 Validation of candidate miRNAs using RT-qPCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: 2.7 Data analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: 2.7.1 Clinical data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: 2.7.2 RT-qPCR data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 3 RESULTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Children: Item: Title: 3.1 Dog characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Children: Item: Title: 3.1.1 RNA isolation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: 3.1.2 Small RNAseq screening of feces and serum from dogs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 3.1.3 RT-qPCR identification of GIC biomarkers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 3.1.4 Diagnostic performance of fecal and serum miRNAs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 4 DISCUSSION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: ACKNOWLEDGMENT Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: CONFLICT OF INTEREST DECLARATION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: OFF-LABEL ANTIMICROBIAL DECLARATION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: INSTITUTIONAL ANIMAL CARE AND USE COMMITTEE (IACUC) OR OTHER APPROVAL DECLARATION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: HUMAN ETHICS APPROVAL DECLARATION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Children: Item: Title: DATA AVAILABILITY STATEMENT Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: REFERENCES Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Info: Title: Association of fecal and serum microRNA profiles with gastrointestinal cancer and chronic inflammatory enteropathy in dogs Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 11.0 (Windows) CreationDate: Mon Nov 28 17:34:00 CET 2022 ModDate: Mon Nov 28 17:34:00 CET 2022 ID: 0xee08b1ff5279584c8ac3d2caf96d5a6d, 0x2690a7b3c6718d315c190f645822f980 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: NPDKGO+AdvOT8608a8d1+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: NPDKGO+AdvOT8608a8d1+03 Flags: Symbolic FontBBox: -479, -364, 854, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NPDKFM+AdvTTa9c1b374+22 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: NPDKFM+AdvTTa9c1b374+22 Flags: Symbolic FontBBox: 0, -166, 677, 854 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NPEHPD+HelveticaLTStd-Bold FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: NPEHPD+HelveticaLTStd-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NPDKFN+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 106 FontDescriptor: FontName: NPDKFN+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NPEHPE+HelveticaLTStd-Obl FontSubset: true FirstChar: 80 LastChar: 112 FontDescriptor: FontName: NPEHPE+HelveticaLTStd-Obl Flags: Nonsymbolic, Italic FontBBox: -170, -225, 1116, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NPDLBL+AdvTTa9c1b374+02 FontSubset: true FirstChar: 247 LastChar: 255 FontDescriptor: FontName: NPDLBL+AdvTTa9c1b374+02 Flags: Nonsymbolic FontBBox: -104, -250, 1000, 989 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: NPEIAE+HelveticaLTStd-Roman FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: NPEIAE+HelveticaLTStd-Roman Flags: Nonsymbolic FontBBox: -166, -225, 1000, 931 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NPDPJB+AdvTTfac587ca.B FontSubset: true FirstChar: 49 LastChar: 85 FontDescriptor: FontName: NPDPJB+AdvTTfac587ca.B Flags: Nonsymbolic FontBBox: -72, -177, 1062, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NPDPKC+AdvTT9c438aa4.BI FontSubset: true FirstChar: 80 LastChar: 114 FontDescriptor: FontName: NPDPKC+AdvTT9c438aa4.BI Flags: Nonsymbolic FontBBox: -83, -177, 1010, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NPCONL+AdvTT6071803a.B FontSubset: true FirstChar: 37 LastChar: 248 FontDescriptor: FontName: NPCONL+AdvTT6071803a.B Flags: Nonsymbolic FontBBox: -52, -177, 1041, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NPDCOE+AdvTTa9c1b374 FontSubset: true FirstChar: 33 LastChar: 252 FontDescriptor: FontName: NPDCOE+AdvTTa9c1b374 Flags: Nonsymbolic FontBBox: -41, -177, 1010, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NPDCOF+AdvOT8608a8d1 FontSubset: true FirstChar: 230 LastChar: 230 FontDescriptor: FontName: NPDCOF+AdvOT8608a8d1 Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NPDLBK+AdvOT8608a8d1+02 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: NPDLBK+AdvOT8608a8d1+02 Flags: Symbolic FontBBox: -62, -302, 843, 843 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NPDCPF+AdvOT8608a8d1+20 FontSubset: true FirstChar: 147 LastChar: 148 FontDescriptor: FontName: NPDCPF+AdvOT8608a8d1+20 Flags: Nonsymbolic FontBBox: -968, -333, 2000, 1020 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NPDCPG+AdvTTeb5f0e55.I FontSubset: true FirstChar: 39 LastChar: 248 FontDescriptor: FontName: NPDCPG+AdvTTeb5f0e55.I Flags: Nonsymbolic FontBBox: -83, -177, 989, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NPDJEB+AdvTTa9c1b374+20 FontSubset: true FirstChar: 2 LastChar: 151 FontDescriptor: FontName: NPDJEB+AdvTTa9c1b374+20 Flags: Symbolic FontBBox: -239, -218, 1166, 937 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NPEEPC+Calibri-Bold FontSubset: true FirstChar: 2 LastChar: 147 FontDescriptor: FontName: NPEEPC+Calibri-Bold Flags: Symbolic FontBBox: -519, -349, 1263, 1039 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NPEEPD+Calibri FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: NPEEPD+Calibri Flags: Serif, Symbolic FontBBox: -503, -312, 1240, 1026 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: Calibri-Italic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Calibri-Italic Flags: Nonsymbolic, Italic FontBBox: -725, -276, 1260, 1026 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NPDJIA+AdvP4C4E59 FontSubset: true FirstChar: 2 LastChar: 61 FontDescriptor: FontName: NPDJIA+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NPFCHF+AdvP4C4E40 FontSubset: true FirstChar: 43 LastChar: 43 FontDescriptor: FontName: NPFCHF+AdvP4C4E40 Flags: Nonsymbolic FontBBox: -52, -239, 1156, 750 FontFile3: true Encoding: WinAnsiEncoding XMP: VoR 10.1111/jvim.16530 10.1111/jvim.16530 10.1111/(ISSN)1939-1676 3 Association of fecal and serum microRNA profiles with gastrointestinal cancer and chronic inflammatory enteropathy in dogs Pages: Page: Label: 1989 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 132, 574, 137, 586 Destination: 632 Annotation: Subtype: Link Rect: 140, 573, 148, 581 Annotation: Subtype: Link Rect: 242, 574, 261, 586 Destination: 632 Annotation: Subtype: Link Rect: 374, 574, 379, 586 Destination: 632 Annotation: Subtype: Link Rect: 382, 573, 390, 581 Annotation: Subtype: Link Rect: 176, 557, 181, 568 Destination: 632 Annotation: Subtype: Link Rect: 183, 555, 192, 563 Annotation: Subtype: Link Rect: 312, 557, 317, 568 Destination: 632 Annotation: Subtype: Link Rect: 319, 555, 328, 563 Annotation: Subtype: Link Rect: 428, 557, 433, 568 Destination: 632 Annotation: Subtype: Link Rect: 121, 538, 126, 550 Destination: 632 Annotation: Subtype: Link Rect: 128, 537, 137, 545 Annotation: Subtype: Link Rect: 236, 538, 241, 550 Destination: 632 Annotation: Subtype: Link Rect: 382, 538, 387, 550 Destination: 632 Annotation: Subtype: Link Rect: 390, 537, 398, 545 Annotation: Subtype: Link Rect: 494, 538, 499, 550 Destination: 632 Annotation: Subtype: Link Rect: 134, 521, 146, 532 Destination: 632 Annotation: Subtype: Link Rect: 288, 521, 293, 532 Destination: 632 Annotation: Subtype: Link Rect: 295, 519, 304, 527 Annotation: Subtype: Link Rect: 410, 521, 415, 532 Destination: 632 Annotation: Subtype: Link Rect: 417, 519, 426, 527 Annotation: Subtype: Link Rect: 532, 521, 537, 532 Destination: 632 Annotation: Subtype: Link Rect: 539, 519, 548, 527 Annotation: Subtype: Link Rect: 65, 308, 142, 315 Annotation: Subtype: Link Rect: 205, 72, 382, 79 Annotation: Subtype: Link Rect: 410, 32, 518, 39 Thumb: true Page: Label: 1990 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 178, 399, 182, 407 Destination: 168 Annotation: Subtype: Link Rect: 65, 308, 69, 316 Destination: 168 Annotation: Subtype: Link Rect: 268, 282, 272, 290 Destination: 168 Annotation: Subtype: Link Rect: 220, 256, 228, 264 Destination: 168 Annotation: Subtype: Link Rect: 130, 87, 143, 95 Destination: 168 Annotation: Subtype: Link Rect: 165, 61, 181, 69 Destination: 248 Annotation: Subtype: Link Rect: 542, 425, 549, 433 Destination: 248 Annotation: Subtype: Link Rect: 412, 399, 426, 407 Destination: 248 Annotation: Subtype: Link Rect: 457, 386, 463, 394 Destination: 248 Annotation: Subtype: Link Rect: 341, 373, 347, 381 Destination: 248 Annotation: Subtype: Link Rect: 487, 373, 501, 381 Destination: 248 Thumb: true Page: Label: 1991 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 251, 360, 258, 368 Destination: 248 Annotation: Subtype: Link Rect: 209, 334, 223, 342 Destination: 248 Annotation: Subtype: Link Rect: 242, 295, 249, 303 Destination: 248 Annotation: Subtype: Link Rect: 117, 269, 132, 277 Destination: 248 Annotation: Subtype: Link Rect: 137, 243, 144, 251 Destination: 248 Annotation: Subtype: Link Rect: 213, 87, 227, 95 Destination: 248 Annotation: Subtype: Link Rect: 535, 542, 549, 550 Destination: 248 Annotation: Subtype: Link Rect: 500, 490, 514, 498 Destination: 248 Annotation: Subtype: Link Rect: 540, 399, 546, 407 Destination: 248 Annotation: Subtype: Link Rect: 433, 139, 449, 147 Destination: 248 Thumb: true Page: Label: 1992 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 56, 282, 63, 290 Destination: 248 Annotation: Subtype: Link Rect: 110, 282, 117, 290 Destination: 248 Annotation: Subtype: Link Rect: 330, 136, 334, 144 Destination: 51 Thumb: true Page: Label: 1993 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 282, 84, 286, 92 Destination: 68 Annotation: Subtype: Link Rect: 543, 97, 547, 105 Destination: 68 Annotation: Subtype: Link Rect: 539, 708, 542, 716 Destination: 51 Annotation: Subtype: Link Rect: 107, 665, 110, 673 Destination: 51 Annotation: Subtype: Link Rect: 118, 637, 121, 645 Destination: 51 Annotation: Subtype: Link Rect: 139, 609, 142, 617 Destination: 51 Annotation: Subtype: Link Rect: 105, 511, 109, 519 Destination: 51 Annotation: Subtype: Link Rect: 115, 413, 118, 421 Destination: 51 Annotation: Subtype: Link Rect: 101, 399, 103, 407 Destination: 51 Annotation: Subtype: Link Rect: 74, 385, 76, 393 Destination: 51 Thumb: true Page: Label: 1994 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 344, 672, 360, 680 Destination: 248 Annotation: Subtype: Link Rect: 496, 620, 512, 628 Destination: 248 Annotation: Subtype: Link Rect: 469, 526, 473, 534 Destination: 106 Annotation: Subtype: Link Rect: 501, 526, 511, 534 Destination: 126 Annotation: Subtype: Link Rect: 330, 487, 335, 495 Destination: 106 Annotation: Subtype: Link Rect: 364, 487, 374, 495 Destination: 126 Annotation: Subtype: Link Rect: 333, 435, 338, 443 Destination: 106 Annotation: Subtype: Link Rect: 373, 435, 383, 443 Destination: 126 Annotation: Subtype: Link Rect: 418, 409, 423, 417 Destination: 106 Annotation: Subtype: Link Rect: 452, 409, 462, 417 Destination: 126 Annotation: Subtype: Link Rect: 543, 383, 547, 391 Destination: 106 Annotation: Subtype: Link Rect: 469, 201, 473, 209 Destination: 126 Annotation: Subtype: Link Rect: 500, 201, 505, 209 Destination: 150 Annotation: Subtype: Link Rect: 451, 136, 456, 144 Destination: 150 Thumb: true Page: Label: 1995 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 128, 308, 144, 316 Destination: 303 Annotation: Subtype: Link Rect: 274, 295, 288, 303 Destination: 303 Annotation: Subtype: Link Rect: 159, 230, 166, 238 Destination: 303 Annotation: Subtype: Link Rect: 77, 87, 84, 95 Destination: 303 Annotation: Subtype: Link Rect: 66, 61, 73, 69 Destination: 303 Annotation: Subtype: Link Rect: 478, 438, 485, 446 Destination: 303 Annotation: Subtype: Link Rect: 397, 412, 412, 420 Destination: 303 Annotation: Subtype: Link Rect: 450, 373, 465, 381 Destination: 248 Annotation: Subtype: Link Rect: 534, 373, 549, 381 Destination: 303 Annotation: Subtype: Link Rect: 474, 644, 477, 652 Destination: 106 Annotation: Subtype: Link Rect: 474, 630, 477, 638 Destination: 106 Annotation: Subtype: Link Rect: 143, 560, 145, 568 Destination: 106 Annotation: Subtype: Link Rect: 143, 546, 145, 554 Destination: 106 Thumb: true Page: Label: 1996 Sequence: 8 Thumb: true Page: Label: 1997 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 130, 464, 137, 472 Destination: 303 Annotation: Subtype: Link Rect: 177, 334, 192, 342 Destination: 303 Annotation: Subtype: Link Rect: 61, 269, 68, 277 Destination: 303 Annotation: Subtype: Link Rect: 203, 230, 217, 238 Destination: 303 Annotation: Subtype: Link Rect: 204, 74, 211, 82 Destination: 248 Annotation: Subtype: Link Rect: 228, 48, 234, 56 Destination: 248 Thumb: true Page: Label: 1998 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 114, 724, 130, 732 Destination: 303 Annotation: Subtype: Link Rect: 224, 685, 231, 693 Destination: 303 Annotation: Subtype: Link Rect: 203, 490, 219, 498 Destination: 303 Annotation: Subtype: Link Rect: 114, 412, 121, 420 Destination: 365 Annotation: Subtype: Link Rect: 141, 386, 148, 394 Destination: 248 Annotation: Subtype: Link Rect: 196, 386, 202, 394 Destination: 248 Annotation: Subtype: Link Rect: 264, 360, 288, 368 Destination: 248 Annotation: Subtype: Link Rect: 281, 308, 288, 316 Destination: 303 Annotation: Subtype: Link Rect: 335, 526, 444, 534 Annotation: Subtype: Link Rect: 362, 484, 371, 492 Annotation: Subtype: Link Rect: 373, 482, 516, 490 Annotation: Subtype: Link Rect: 361, 471, 369, 479 Annotation: Subtype: Link Rect: 371, 469, 514, 477 Annotation: Subtype: Link Rect: 388, 458, 397, 466 Annotation: Subtype: Link Rect: 399, 456, 542, 464 Annotation: Subtype: Link Rect: 364, 445, 373, 453 Annotation: Subtype: Link Rect: 375, 443, 518, 451 Annotation: Subtype: Link Rect: 355, 432, 363, 440 Annotation: Subtype: Link Rect: 365, 430, 508, 438 Annotation: Subtype: Link Rect: 379, 419, 388, 427 Annotation: Subtype: Link Rect: 390, 417, 533, 425 Annotation: Subtype: Link Rect: 379, 406, 387, 414 Annotation: Subtype: Link Rect: 389, 404, 532, 412 Annotation: Subtype: Link Rect: 358, 393, 366, 401 Annotation: Subtype: Link Rect: 368, 391, 511, 399 Annotation: Subtype: Link Rect: 356, 380, 365, 388 Annotation: Subtype: Link Rect: 367, 378, 510, 386 Annotation: Subtype: Link Rect: 515, 318, 549, 326 Annotation: Subtype: Link Rect: 322, 308, 413, 315 Annotation: Subtype: Link Rect: 412, 276, 531, 284 Annotation: Subtype: Link Rect: 470, 234, 532, 242 Annotation: Subtype: Link Rect: 334, 192, 423, 200 Annotation: Subtype: Link Rect: 444, 171, 549, 179 Annotation: Subtype: Link Rect: 322, 161, 347, 168 Annotation: Subtype: Link Rect: 409, 129, 512, 137 Annotation: Subtype: Link Rect: 430, 87, 515, 95 Annotation: Subtype: Link Rect: 366, 45, 457, 53 Thumb: true Page: Label: 1999 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 218, 690, 285, 698 Annotation: Subtype: Link Rect: 143, 648, 211, 655 Annotation: Subtype: Link Rect: 254, 616, 288, 624 Annotation: Subtype: Link Rect: 61, 606, 125, 613 Annotation: Subtype: Link Rect: 152, 574, 219, 582 Annotation: Subtype: Link Rect: 278, 543, 288, 550 Annotation: Subtype: Link Rect: 61, 532, 153, 540 Annotation: Subtype: Link Rect: 73, 501, 211, 508 Annotation: Subtype: Link Rect: 124, 469, 190, 477 Annotation: Subtype: Link Rect: 154, 438, 235, 446 Annotation: Subtype: Link Rect: 157, 417, 264, 424 Annotation: Subtype: Link Rect: 212, 385, 288, 393 Annotation: Subtype: Link Rect: 61, 375, 81, 382 Annotation: Subtype: Link Rect: 165, 343, 231, 351 Annotation: Subtype: Link Rect: 161, 312, 286, 319 Annotation: Subtype: Link Rect: 243, 302, 288, 309 Annotation: Subtype: Link Rect: 61, 291, 273, 298 Annotation: Subtype: Link Rect: 61, 280, 90, 288 Annotation: Subtype: Link Rect: 278, 249, 288, 256 Annotation: Subtype: Link Rect: 61, 238, 165, 246 Annotation: Subtype: Link Rect: 190, 207, 257, 214 Annotation: Subtype: Link Rect: 161, 186, 205, 194 Annotation: Subtype: Link Rect: 128, 154, 195, 162 Annotation: Subtype: Link Rect: 277, 102, 288, 109 Annotation: Subtype: Link Rect: 61, 91, 146, 99 Annotation: Subtype: Link Rect: 73, 50, 188, 57 Annotation: Subtype: Link Rect: 385, 701, 451, 708 Annotation: Subtype: Link Rect: 539, 679, 549, 687 Annotation: Subtype: Link Rect: 322, 669, 384, 676 Annotation: Subtype: Link Rect: 432, 637, 523, 645 Annotation: Subtype: Link Rect: 356, 574, 430, 582 Annotation: Subtype: Link Rect: 538, 543, 549, 550 Annotation: Subtype: Link Rect: 322, 532, 384, 540 Annotation: Subtype: Link Rect: 374, 501, 472, 508 Annotation: Subtype: Link Rect: 322, 438, 413, 446 Annotation: Subtype: Link Rect: 478, 417, 549, 424 Annotation: Subtype: Link Rect: 322, 406, 342, 414 Annotation: Subtype: Link Rect: 355, 354, 472, 361 Annotation: Subtype: Link Rect: 334, 312, 455, 319 Annotation: Subtype: Link Rect: 500, 280, 549, 288 Annotation: Subtype: Link Rect: 322, 270, 389, 277 Annotation: Subtype: Link Rect: 483, 249, 549, 256 Annotation: Subtype: Link Rect: 322, 238, 344, 246 Annotation: Subtype: Link Rect: 491, 207, 549, 214 Annotation: Subtype: Link Rect: 322, 197, 364, 204 Annotation: Subtype: Link Rect: 539, 165, 549, 172 Annotation: Subtype: Link Rect: 322, 154, 378, 162 Annotation: Subtype: Link Rect: 355, 81, 429, 89 Thumb: true Page: Label: 2000 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 258, 721, 288, 729 Annotation: Subtype: Link Rect: 61, 711, 102, 718 Annotation: Subtype: Link Rect: 98, 679, 192, 687 Annotation: Subtype: Link Rect: 254, 648, 288, 655 Annotation: Subtype: Link Rect: 61, 637, 119, 645 Annotation: Subtype: Link Rect: 229, 606, 288, 613 Annotation: Subtype: Link Rect: 61, 596, 86, 603 Annotation: Subtype: Link Rect: 218, 564, 288, 571 Annotation: Subtype: Link Rect: 61, 554, 82, 561 Annotation: Subtype: Link Rect: 215, 511, 288, 519 Annotation: Subtype: Link Rect: 61, 501, 105, 508 Annotation: Subtype: Link Rect: 98, 469, 164, 477 Annotation: Subtype: Link Rect: 210, 438, 288, 446 Annotation: Subtype: Link Rect: 61, 427, 85, 435 Annotation: Subtype: Link Rect: 257, 396, 288, 403 Annotation: Subtype: Link Rect: 61, 385, 146, 393 Annotation: Subtype: Link Rect: 248, 364, 288, 372 Annotation: Subtype: Link Rect: 61, 354, 97, 361 Annotation: Subtype: Link Rect: 278, 322, 288, 330 Annotation: Subtype: Link Rect: 61, 312, 154, 319 Annotation: Subtype: Link Rect: 142, 280, 264, 288 Annotation: Subtype: Link Rect: 61, 238, 137, 246 Annotation: Subtype: Link Rect: 98, 197, 188, 204 Annotation: Subtype: Link Rect: 192, 165, 288, 172 Annotation: Subtype: Link Rect: 61, 154, 91, 162 Annotation: Subtype: Link Rect: 170, 123, 239, 130 Annotation: Subtype: Link Rect: 147, 81, 217, 89 Annotation: Subtype: Link Rect: 278, 60, 288, 67 Annotation: Subtype: Link Rect: 61, 50, 131, 57 Annotation: Subtype: Link Rect: 430, 701, 513, 708 Annotation: Subtype: Link Rect: 491, 669, 549, 676 Annotation: Subtype: Link Rect: 322, 658, 362, 666 Annotation: Subtype: Link Rect: 425, 627, 522, 634 Annotation: Subtype: Link Rect: 351, 585, 420, 593 Annotation: Subtype: Link Rect: 359, 543, 436, 550 Annotation: Subtype: Link Rect: 389, 511, 468, 519 Annotation: Subtype: Link Rect: 482, 480, 549, 488 Annotation: Subtype: Link Rect: 322, 469, 344, 477 Annotation: Subtype: Link Rect: 420, 438, 518, 446 Annotation: Subtype: Link Rect: 518, 406, 549, 414 Annotation: Subtype: Link Rect: 322, 396, 390, 403 Annotation: Subtype: Link Rect: 425, 364, 524, 372 Annotation: Subtype: Link Rect: 518, 333, 549, 341 Annotation: Subtype: Link Rect: 322, 322, 355, 330 Annotation: Subtype: Link Rect: 510, 302, 549, 309 Annotation: Subtype: Link Rect: 322, 291, 354, 298 Annotation: Subtype: Link Rect: 509, 249, 549, 256 Annotation: Subtype: Link Rect: 322, 238, 358, 246 Annotation: Subtype: Link Rect: 516, 197, 549, 204 Annotation: Subtype: Link Rect: 322, 186, 362, 194 Annotation: Subtype: Link Rect: 516, 154, 549, 162 Annotation: Subtype: Link Rect: 322, 144, 370, 151 Annotation: Subtype: Link Rect: 518, 112, 549, 120 Annotation: Subtype: Link Rect: 322, 102, 394, 109 Annotation: Subtype: Link Rect: 334, 50, 401, 57 Thumb: true Page: Label: 2001 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 278, 701, 288, 708 Annotation: Subtype: Link Rect: 61, 690, 137, 698 Annotation: Subtype: Link Rect: 73, 648, 142, 655 Annotation: Subtype: Link Rect: 152, 616, 264, 624 Annotation: Subtype: Link Rect: 90, 585, 162, 593 Annotation: Subtype: Link Rect: 227, 554, 288, 561 Annotation: Subtype: Link Rect: 61, 543, 103, 550 Annotation: Subtype: Link Rect: 475, 701, 549, 708 Annotation: Subtype: Link Rect: 322, 690, 346, 698 Annotation: Subtype: Link Rect: 504, 559, 514, 567 Annotation: Subtype: Link Rect: 319, 546, 380, 554 Thumb: true Checksum: 40f61d51 Type: CRC32 Checksum: 71d5ac0942efe164be084a59e0f77444 Type: MD5 Checksum: db526cc221878fd8050f5642b181b00db0ca37d2 Type: SHA-1