b12a9fe4160261d28f8738fb7f5f4e27 pmc_9718344.pdf 03e72946c293e2c842faa7b1598b578718d82956 pmc_9718344.pdf de4ff50ea63bb218e1d8710463fa350cbff309df58994e9f548d119b47617cde pmc_9718344.pdf Title: Synovial tissue metabolomic profiling reveal biomarkers of synovial inflammation in patients with osteoarthritis Subject: Osteoarthritis and Cartilage Open, 4 (2022) 100295. doi:10.1016/j.ocarto.2022.100295 Author: Jessica D. Murillo-Saich Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Aug 10 09:57:25 2022 CEST ModDate: Wed Aug 10 09:58:29 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2439760 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GNHIIC+AdvTTe692faf0 Type 1C WinAnsi yes yes no 874 0 GNHIID+AdvTTe692faf0+fb Type 1C Custom yes yes yes 879 0 GNHIIE+AdvTT47f7fe79.I Type 1C WinAnsi yes yes no 881 0 GNHIJF+AdvTTc9617e0c.B Type 1C WinAnsi yes yes no 884 0 GNHIJG+AdvOTb0c9bf5d+20 Type 1C WinAnsi yes yes no 887 0 GNHJAE+AdvPSA35D Type 1C WinAnsi yes yes no 893 0 GNHJBF+AdvOTb0c9bf5d Type 1C WinAnsi yes yes no 895 0 GNHJEJ+AdvTTc9617e0c.B+fb Type 1C Custom yes yes yes 615 0 GNHJDF+AdvP4C4E74 Type 1C Custom yes yes yes 616 0 GNHJDG+AdvOTb0c9bf5d+03 Type 1C Custom yes yes yes 620 0 GNHJDH+AdvTT5843c571 Type 1C WinAnsi yes yes no 631 0 GNHJDI+AdvP4C4E51 Type 1C WinAnsi yes yes no 634 0 GNHJFK+AdvTT47f7fe79.I+fb Type 1C Custom yes yes yes 639 0 GNIIBA+AdvP4C4E3A Type 1C WinAnsi yes yes no 647 0 GNIICB+AdvOTe3b1fbf3.B Type 1C WinAnsi yes yes no 645 0 GNIICC+AdvOTe3b1fbf3.B+03 Type 1C Custom yes yes yes 648 0 GNJCHD+AdvTTe692faf0+20 Type 1C WinAnsi yes yes no 660 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-24 02:37:00 CEST RepresentationInformation: pmc_9718344.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-12-15 02:13:52 CET Size: 2439760 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib10' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib13' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib13' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib24' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib25' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib27' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib28' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib29' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib30' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib24' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib31' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib36' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib37' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib38' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib39' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib43' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib44' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib45' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib46' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib47' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib48' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib49' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib50' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib51' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib52' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib51' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib53' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib54' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib55' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib56' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib57' cannot be found Offset: 2408597 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib58' cannot be found Offset: 2408597 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 944 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Synovial tissue metabolomic profiling reveal biomarkers of synovial inflammation in patients with osteoarthritis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: 1. Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: 2. Method Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: 3.1. Histological classification of ST samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: 3.2. Metabolomic profile of synovial tissue in inflamed and non-inflamed synovial samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 3.3. Correlation between synovial fluid and synovial tissue metabolic profiles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 3.4. Inflammatory mediators and metabolites in synovial tissue and synovial fluid reflect tissue histologic features Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 3.5. Synovial fluid as predictor of inflammation in synovial tissue Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Authors contribution Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Declaration of funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Role of funding source Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Declaration of competing interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Appendix A. Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Info: Title: Synovial tissue metabolomic profiling reveal biomarkers of synovial inflammation in patients with osteoarthritis Author: Jessica D. Murillo-Saich Subject: Osteoarthritis and Cartilage Open, 4 (2022) 100295. doi:10.1016/j.ocarto.2022.100295 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Aug 10 10:27:25 CEST 2022 ModDate: Wed Aug 10 10:28:29 CEST 2022 ID: 0xaa4068f2fb03f43b1344b80fdeed2732, 0x790911eaa6772b4986d0e7dbdc295168 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 249 ImageHeight: 272 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 237 ImageHeight: 299 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2155 ImageHeight: 1000 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1836 ImageHeight: 736 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1836 ImageHeight: 1473 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1836 ImageHeight: 1597 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2154 ImageHeight: 766 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: GNIICB+AdvOTe3b1fbf3.B FontSubset: true FirstChar: 60 LastChar: 177 FontDescriptor: FontName: GNIICB+AdvOTe3b1fbf3.B Flags: Nonsymbolic FontBBox: -62, -208, 979, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GNHJEJ+AdvTTc9617e0c.B+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: GNHJEJ+AdvTTc9617e0c.B+fb Flags: Symbolic FontBBox: 19, 0, 989, 875 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GNIIBA+AdvP4C4E3A FontSubset: true FirstChar: 188 LastChar: 188 FontDescriptor: FontName: GNIIBA+AdvP4C4E3A Flags: Nonsymbolic FontBBox: -20, -937, 1322, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GNHJDF+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 254 FontDescriptor: FontName: GNHJDF+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GNIICC+AdvOTe3b1fbf3.B+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: GNIICC+AdvOTe3b1fbf3.B+03 Flags: Symbolic FontBBox: -500, -416, 916, 937 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GNHIIC+AdvTTe692faf0 FontSubset: true FirstChar: 35 LastChar: 122 FontDescriptor: FontName: GNHIIC+AdvTTe692faf0 Flags: Serif, Nonsymbolic FontBBox: -72, -250, 916, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GNHJDG+AdvOTb0c9bf5d+03 FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: GNHJDG+AdvOTb0c9bf5d+03 Flags: Symbolic FontBBox: -479, -364, 854, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GNHIID+AdvTTe692faf0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: GNHIID+AdvTTe692faf0+fb Flags: Symbolic FontBBox: 19, 0, 916, 875 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GNHIIE+AdvTT47f7fe79.I FontSubset: true FirstChar: 40 LastChar: 237 FontDescriptor: FontName: GNHIIE+AdvTT47f7fe79.I Flags: Serif, Nonsymbolic FontBBox: -156, -250, 1000, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GNHIJF+AdvTTc9617e0c.B FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: GNHIJF+AdvTTc9617e0c.B Flags: Nonsymbolic FontBBox: -83, -250, 947, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GNJCHD+AdvTTe692faf0+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: GNJCHD+AdvTTe692faf0+20 Flags: Nonsymbolic FontBBox: -468, -302, 1093, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GNHIJG+AdvOTb0c9bf5d+20 FontSubset: true FirstChar: 147 LastChar: 150 FontDescriptor: FontName: GNHIJG+AdvOTb0c9bf5d+20 Flags: Nonsymbolic FontBBox: 0, 200, 500, 676 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GNHJDH+AdvTT5843c571 FontSubset: true FirstChar: 38 LastChar: 38 FontDescriptor: FontName: GNHJDH+AdvTT5843c571 Flags: Nonsymbolic FontBBox: -72, -208, 927, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GNHJDI+AdvP4C4E51 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: GNHJDI+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GNHJAE+AdvPSA35D FontSubset: true FirstChar: 45 LastChar: 119 FontDescriptor: FontName: GNHJAE+AdvPSA35D Flags: Nonsymbolic FontBBox: -166, -239, 989, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GNHJBF+AdvOTb0c9bf5d FontSubset: true FirstChar: 169 LastChar: 169 FontDescriptor: FontName: GNHJBF+AdvOTb0c9bf5d Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GNHJFK+AdvTT47f7fe79.I+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: GNHJFK+AdvTT47f7fe79.I+fb Flags: Symbolic FontBBox: -125, -218, 906, 875 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1016/j.ocarto.2022.100295 Synovial tissue metabolomic profiling reveal biomarkers of synovial inflammation in patients with osteoarthritis Jessica D. Murillo-Saich Roxana Coras Robert Meyer Cristina Llorente Nancy E. Lane Monica Guma Inflammation Fibrosis Metabolomic Synovial fluid Osteoarthritis and Cartilage Open, 4 (2022) 100295. doi:10.1016/j.ocarto.2022.100295 The Authors journal Osteoarthritis and Cartilage Open © 2022 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International (OARSI). 2665-9131 4 3 September 2022 100295 100295 10.1016/j.ocarto.2022.100295 https://doi.org/10.1016/j.ocarto.2022.100295 2010-04-23 true 10.1016/j.ocarto.2022.100295 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.ocarto.2022.100295 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2022-08-10T13:27:25+05:30 2022-08-10T13:28:29+05:30 2022-08-10T13:28:29+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:97b6f886-b53b-4e7c-a1c5-81d5ea08cf94 uuid:d3dd0b81-8c61-4ef3-bef1-d9cc72d1a956 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 149, 576, 153, 586 Destination: 816 Annotation: Subtype: Link Rect: 223, 576, 227, 586 Destination: 816 Annotation: Subtype: Link Rect: 230, 576, 234, 586 Destination: 816 Annotation: Subtype: Link Rect: 305, 576, 309, 586 Destination: 816 Annotation: Subtype: Link Rect: 312, 576, 315, 586 Destination: 816 Annotation: Subtype: Link Rect: 399, 576, 403, 586 Destination: 816 Annotation: Subtype: Link Rect: 476, 576, 481, 586 Destination: 816 Annotation: Subtype: Link Rect: 104, 563, 108, 573 Destination: 816 Annotation: Subtype: Link Rect: 111, 563, 115, 573 Destination: 816 Annotation: Subtype: Link Rect: 118, 563, 122, 573 Destination: 816 Annotation: Subtype: Link Rect: 125, 565, 129, 571 Destination: 816 Annotation: Subtype: Link Rect: 262, 221, 266, 229 Destination: 156 Annotation: Subtype: Link Rect: 127, 189, 132, 197 Destination: 156 Annotation: Subtype: Link Rect: 219, 158, 223, 166 Destination: 156 Annotation: Subtype: Link Rect: 227, 158, 232, 166 Destination: 156 Annotation: Subtype: Link Rect: 366, 242, 370, 250 Destination: 156 Annotation: Subtype: Link Rect: 379, 158, 384, 166 Destination: 156 Annotation: Subtype: Link Rect: 549, 148, 554, 156 Destination: 156 Annotation: Subtype: Link Rect: 97, 104, 177, 111 Annotation: Subtype: Link Rect: 501, 598, 529, 626 Annotation: Subtype: Link Rect: 321, 722, 368, 730 Annotation: Subtype: Link Rect: 201, 667, 469, 675 Annotation: Subtype: Link Rect: 37, 87, 186, 94 Annotation: Subtype: Link Rect: 110, 59, 276, 66 Annotation: Subtype: Link Rect: 215, 749, 379, 757 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 148, 730, 152, 738 Destination: 156 Annotation: Subtype: Link Rect: 244, 709, 249, 717 Destination: 156 Annotation: Subtype: Link Rect: 251, 709, 260, 717 Destination: null Annotation: Subtype: Link Rect: 40, 668, 49, 676 Destination: null Annotation: Subtype: Link Rect: 178, 647, 187, 655 Destination: null Annotation: Subtype: Link Rect: 189, 647, 198, 655 Destination: null Annotation: Subtype: Link Rect: 263, 605, 272, 613 Destination: null Annotation: Subtype: Link Rect: 274, 605, 283, 613 Destination: null Annotation: Subtype: Link Rect: 237, 563, 246, 571 Destination: null Annotation: Subtype: Link Rect: 250, 563, 259, 571 Destination: null Annotation: Subtype: Link Rect: 123, 542, 132, 550 Destination: null Annotation: Subtype: Link Rect: 147, 521, 156, 529 Destination: null Annotation: Subtype: Link Rect: 154, 500, 163, 508 Destination: null Annotation: Subtype: Link Rect: 241, 500, 249, 508 Destination: null Annotation: Subtype: Link Rect: 252, 500, 261, 508 Destination: null Annotation: Subtype: Link Rect: 63, 490, 72, 498 Destination: null Annotation: Subtype: Link Rect: 124, 490, 133, 498 Destination: null Annotation: Subtype: Link Rect: 220, 374, 229, 382 Destination: null Annotation: Subtype: Link Rect: 180, 217, 189, 225 Destination: null Annotation: Subtype: Link Rect: 218, 113, 227, 121 Destination: null Annotation: Subtype: Link Rect: 229, 113, 238, 121 Destination: null Annotation: Subtype: Link Rect: 441, 542, 450, 550 Destination: null Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 78, 605, 283, 613 Annotation: Subtype: Link Rect: 254, 573, 288, 581 Annotation: Subtype: Link Rect: 37, 563, 238, 571 Annotation: Subtype: Link Rect: 261, 553, 288, 561 Annotation: Subtype: Link Rect: 37, 542, 220, 550 Annotation: Subtype: Link Rect: 250, 490, 288, 498 Annotation: Subtype: Link Rect: 37, 479, 206, 487 Annotation: Subtype: Link Rect: 269, 372, 288, 380 Destination: 27 Annotation: Subtype: Link Rect: 53, 362, 136, 370 Destination: null Annotation: Subtype: Link Rect: 390, 730, 471, 738 Destination: null Annotation: Subtype: Link Rect: 471, 709, 552, 717 Destination: null Annotation: Subtype: Link Rect: 499, 689, 526, 696 Destination: 64 Annotation: Subtype: Link Rect: 531, 689, 557, 696 Destination: null Annotation: Subtype: Link Rect: 306, 678, 364, 686 Destination: null Annotation: Subtype: Link Rect: 435, 647, 454, 655 Destination: 27 Annotation: Subtype: Link Rect: 485, 573, 512, 581 Destination: 64 Annotation: Subtype: Link Rect: 531, 573, 557, 581 Destination: null Annotation: Subtype: Link Rect: 306, 563, 364, 571 Destination: null Annotation: Subtype: Link Rect: 505, 467, 557, 474 Destination: null Annotation: Subtype: Link Rect: 306, 456, 343, 464 Destination: null Annotation: Subtype: Link Rect: 462, 435, 552, 443 Destination: null Annotation: Subtype: Link Rect: 450, 383, 552, 391 Destination: null Annotation: Subtype: Link Rect: 531, 372, 557, 380 Destination: null Annotation: Subtype: Link Rect: 306, 362, 374, 370 Destination: null Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 192, 60, 283, 68 Destination: null Annotation: Subtype: Link Rect: 392, 60, 483, 68 Destination: null Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 236, 730, 288, 738 Destination: null Annotation: Subtype: Link Rect: 37, 720, 72, 728 Destination: null Annotation: Subtype: Link Rect: 263, 615, 288, 623 Destination: 64 Annotation: Subtype: Link Rect: 53, 605, 134, 613 Destination: null Annotation: Subtype: Link Rect: 216, 594, 243, 602 Destination: 64 Annotation: Subtype: Link Rect: 262, 594, 288, 602 Destination: null Annotation: Subtype: Link Rect: 37, 584, 97, 592 Destination: null Annotation: Subtype: Link Rect: 113, 573, 197, 581 Destination: null Annotation: Subtype: Link Rect: 262, 553, 288, 561 Destination: null Annotation: Subtype: Link Rect: 37, 542, 120, 550 Destination: null Annotation: Subtype: Link Rect: 194, 478, 213, 486 Destination: 70 Annotation: Subtype: Link Rect: 235, 426, 255, 434 Destination: 100 Annotation: Subtype: Link Rect: 273, 426, 288, 434 Destination: null Annotation: Subtype: Link Rect: 37, 416, 108, 424 Destination: null Annotation: Subtype: Link Rect: 237, 289, 262, 297 Destination: 100 Annotation: Subtype: Link Rect: 379, 730, 405, 738 Destination: 100 Annotation: Subtype: Link Rect: 392, 689, 473, 696 Destination: null Annotation: Subtype: Link Rect: 395, 573, 478, 581 Destination: null Annotation: Subtype: Link Rect: 407, 521, 491, 529 Destination: null Annotation: Subtype: Link Rect: 316, 414, 397, 422 Destination: null Annotation: Subtype: Link Rect: 505, 373, 557, 381 Destination: null Annotation: Subtype: Link Rect: 306, 362, 332, 370 Destination: null Annotation: Subtype: Link Rect: 399, 289, 419, 297 Destination: 106 Annotation: Subtype: Link Rect: 438, 268, 459, 276 Destination: 106 Page: Label: 6 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 40, 285, 60, 293 Destination: 106 Annotation: Subtype: Link Rect: 104, 275, 123, 283 Destination: 106 Annotation: Subtype: Link Rect: 164, 202, 184, 210 Destination: 124 Annotation: Subtype: Link Rect: 485, 285, 493, 293 Destination: null Annotation: Subtype: Link Rect: 442, 264, 451, 272 Destination: null Annotation: Subtype: Link Rect: 484, 244, 493, 252 Destination: null Annotation: Subtype: Link Rect: 439, 223, 448, 231 Destination: null Annotation: Subtype: Link Rect: 506, 202, 515, 210 Destination: null Annotation: Subtype: Link Rect: 336, 108, 345, 116 Destination: null Annotation: Subtype: Link Rect: 347, 108, 356, 116 Destination: null Annotation: Subtype: Link Rect: 309, 55, 318, 63 Destination: null Annotation: Subtype: Link Rect: 322, 55, 331, 63 Destination: null Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 203, 486, 212, 494 Destination: null Annotation: Subtype: Link Rect: 98, 454, 107, 462 Destination: null Annotation: Subtype: Link Rect: 153, 402, 162, 410 Destination: null Annotation: Subtype: Link Rect: 40, 381, 49, 389 Destination: null Annotation: Subtype: Link Rect: 53, 381, 62, 389 Destination: null Annotation: Subtype: Link Rect: 142, 297, 151, 305 Destination: null Annotation: Subtype: Link Rect: 205, 224, 214, 232 Destination: null Annotation: Subtype: Link Rect: 116, 203, 125, 211 Destination: null Annotation: Subtype: Link Rect: 170, 161, 179, 169 Destination: null Annotation: Subtype: Link Rect: 129, 141, 138, 149 Destination: null Annotation: Subtype: Link Rect: 175, 109, 183, 117 Destination: null Annotation: Subtype: Link Rect: 325, 465, 334, 473 Destination: null Annotation: Subtype: Link Rect: 481, 423, 485, 431 Destination: 156 Annotation: Subtype: Link Rect: 367, 392, 376, 400 Destination: null Annotation: Subtype: Link Rect: 378, 392, 387, 400 Destination: null Annotation: Subtype: Link Rect: 532, 360, 541, 368 Destination: null Annotation: Subtype: Link Rect: 543, 360, 552, 368 Destination: null Annotation: Subtype: Link Rect: 397, 339, 406, 347 Destination: null Annotation: Subtype: Link Rect: 341, 318, 350, 326 Destination: null Annotation: Subtype: Link Rect: 352, 318, 361, 326 Destination: null Annotation: Subtype: Link Rect: 497, 235, 506, 243 Destination: null Annotation: Subtype: Link Rect: 501, 214, 510, 222 Destination: null Annotation: Subtype: Link Rect: 513, 214, 521, 222 Destination: null Annotation: Subtype: Link Rect: 380, 182, 389, 190 Destination: null Annotation: Subtype: Link Rect: 391, 182, 400, 190 Destination: null Annotation: Subtype: Link Rect: 485, 109, 489, 117 Destination: 156 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 271, 140, 288, 148 Annotation: Subtype: Link Rect: 37, 129, 184, 137 Annotation: Subtype: Link Rect: 53, 90, 256, 96 Annotation: Subtype: Link Rect: 53, 82, 209, 88 Annotation: Subtype: Link Rect: 212, 82, 223, 88 Annotation: Subtype: Link Rect: 53, 74, 281, 80 Annotation: Subtype: Link Rect: 53, 66, 245, 73 Annotation: Subtype: Link Rect: 53, 58, 286, 65 Annotation: Subtype: Link Rect: 53, 50, 286, 57 Annotation: Subtype: Link Rect: 322, 732, 528, 738 Annotation: Subtype: Link Rect: 322, 724, 472, 730 Annotation: Subtype: Link Rect: 322, 716, 555, 722 Annotation: Subtype: Link Rect: 322, 708, 555, 714 Annotation: Subtype: Link Rect: 322, 700, 552, 706 Annotation: Subtype: Link Rect: 322, 692, 354, 698 Annotation: Subtype: Link Rect: 358, 692, 368, 698 Annotation: Subtype: Link Rect: 322, 684, 539, 690 Annotation: Subtype: Link Rect: 322, 676, 550, 682 Annotation: Subtype: Link Rect: 322, 668, 333, 674 Annotation: Subtype: Link Rect: 336, 668, 347, 674 Annotation: Subtype: Link Rect: 322, 660, 550, 666 Annotation: Subtype: Link Rect: 322, 652, 442, 658 Annotation: Subtype: Link Rect: 445, 652, 456, 658 Annotation: Subtype: Link Rect: 322, 644, 553, 651 Annotation: Subtype: Link Rect: 322, 636, 364, 643 Annotation: Subtype: Link Rect: 367, 636, 378, 643 Annotation: Subtype: Link Rect: 322, 628, 525, 635 Annotation: Subtype: Link Rect: 322, 620, 552, 627 Annotation: Subtype: Link Rect: 322, 612, 555, 619 Annotation: Subtype: Link Rect: 322, 604, 391, 611 Annotation: Subtype: Link Rect: 322, 596, 525, 603 Annotation: Subtype: Link Rect: 322, 588, 540, 595 Annotation: Subtype: Link Rect: 322, 580, 555, 587 Annotation: Subtype: Link Rect: 322, 572, 506, 579 Annotation: Subtype: Link Rect: 323, 565, 544, 571 Annotation: Subtype: Link Rect: 323, 557, 516, 563 Annotation: Subtype: Link Rect: 519, 557, 530, 563 Annotation: Subtype: Link Rect: 323, 549, 555, 555 Annotation: Subtype: Link Rect: 323, 541, 553, 547 Annotation: Subtype: Link Rect: 323, 533, 365, 539 Annotation: Subtype: Link Rect: 368, 533, 379, 539 Annotation: Subtype: Link Rect: 323, 525, 555, 531 Annotation: Subtype: Link Rect: 323, 517, 544, 523 Annotation: Subtype: Link Rect: 323, 509, 344, 515 Annotation: Subtype: Link Rect: 323, 501, 555, 507 Annotation: Subtype: Link Rect: 323, 493, 555, 499 Annotation: Subtype: Link Rect: 323, 485, 337, 491 Annotation: Subtype: Link Rect: 340, 485, 354, 491 Annotation: Subtype: Link Rect: 323, 477, 528, 483 Annotation: Subtype: Link Rect: 323, 469, 546, 475 Annotation: Subtype: Link Rect: 323, 461, 518, 467 Annotation: Subtype: Link Rect: 522, 461, 536, 467 Annotation: Subtype: Link Rect: 323, 453, 555, 459 Annotation: Subtype: Link Rect: 323, 445, 542, 451 Annotation: Subtype: Link Rect: 323, 437, 555, 443 Annotation: Subtype: Link Rect: 323, 429, 382, 435 Annotation: Subtype: Link Rect: 385, 429, 399, 435 Annotation: Subtype: Link Rect: 323, 421, 536, 427 Annotation: Subtype: Link Rect: 323, 413, 532, 419 Annotation: Subtype: Link Rect: 323, 405, 494, 411 Annotation: Subtype: Link Rect: 497, 405, 512, 411 Annotation: Subtype: Link Rect: 323, 397, 527, 403 Annotation: Subtype: Link Rect: 323, 389, 555, 396 Annotation: Subtype: Link Rect: 323, 381, 481, 388 Annotation: Subtype: Link Rect: 485, 381, 511, 388 Annotation: Subtype: Link Rect: 323, 373, 555, 380 Annotation: Subtype: Link Rect: 323, 365, 555, 372 Annotation: Subtype: Link Rect: 323, 357, 456, 364 Annotation: Subtype: Link Rect: 459, 357, 470, 364 Annotation: Subtype: Link Rect: 323, 349, 543, 356 Annotation: Subtype: Link Rect: 323, 341, 529, 348 Annotation: Subtype: Link Rect: 323, 333, 476, 340 Annotation: Subtype: Link Rect: 323, 325, 546, 332 Annotation: Subtype: Link Rect: 323, 317, 550, 324 Annotation: Subtype: Link Rect: 323, 309, 522, 316 Annotation: Subtype: Link Rect: 323, 301, 537, 308 Annotation: Subtype: Link Rect: 323, 294, 555, 300 Annotation: Subtype: Link Rect: 323, 286, 538, 292 Annotation: Subtype: Link Rect: 323, 278, 333, 284 Annotation: Subtype: Link Rect: 337, 278, 347, 284 Annotation: Subtype: Link Rect: 323, 270, 555, 276 Annotation: Subtype: Link Rect: 323, 262, 555, 268 Annotation: Subtype: Link Rect: 323, 254, 540, 260 Annotation: Subtype: Link Rect: 323, 246, 449, 252 Annotation: Subtype: Link Rect: 452, 246, 467, 252 Annotation: Subtype: Link Rect: 323, 238, 539, 244 Annotation: Subtype: Link Rect: 323, 230, 555, 236 Annotation: Subtype: Link Rect: 323, 222, 457, 228 Annotation: Subtype: Link Rect: 323, 214, 540, 220 Annotation: Subtype: Link Rect: 323, 206, 547, 212 Annotation: Subtype: Link Rect: 323, 198, 355, 204 Annotation: Subtype: Link Rect: 358, 198, 369, 204 Annotation: Subtype: Link Rect: 323, 190, 555, 196 Annotation: Subtype: Link Rect: 323, 182, 546, 188 Annotation: Subtype: Link Rect: 323, 174, 550, 180 Annotation: Subtype: Link Rect: 323, 166, 529, 172 Annotation: Subtype: Link Rect: 532, 166, 547, 172 Annotation: Subtype: Link Rect: 323, 158, 555, 164 Annotation: Subtype: Link Rect: 323, 150, 551, 156 Annotation: Subtype: Link Rect: 323, 142, 448, 148 Annotation: Subtype: Link Rect: 451, 142, 462, 148 Annotation: Subtype: Link Rect: 323, 134, 536, 140 Annotation: Subtype: Link Rect: 323, 126, 555, 133 Annotation: Subtype: Link Rect: 323, 118, 547, 125 Annotation: Subtype: Link Rect: 323, 110, 410, 117 Annotation: Subtype: Link Rect: 413, 110, 424, 117 Annotation: Subtype: Link Rect: 323, 102, 536, 109 Annotation: Subtype: Link Rect: 323, 94, 555, 101 Annotation: Subtype: Link Rect: 323, 86, 509, 93 Annotation: Subtype: Link Rect: 512, 86, 523, 93 Annotation: Subtype: Link Rect: 323, 78, 552, 85 Annotation: Subtype: Link Rect: 323, 70, 554, 77 Annotation: Subtype: Link Rect: 323, 62, 375, 69 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 54, 732, 276, 738 Annotation: Subtype: Link Rect: 54, 724, 278, 730 Annotation: Subtype: Link Rect: 54, 716, 197, 722 Annotation: Subtype: Link Rect: 54, 708, 286, 714 Annotation: Subtype: Link Rect: 54, 700, 281, 706 Annotation: Subtype: Link Rect: 54, 692, 222, 698 Annotation: Subtype: Link Rect: 225, 692, 236, 698 Annotation: Subtype: Link Rect: 54, 684, 285, 690 Annotation: Subtype: Link Rect: 54, 676, 268, 682 Annotation: Subtype: Link Rect: 54, 668, 282, 674 Annotation: Subtype: Link Rect: 54, 660, 64, 666 Annotation: Subtype: Link Rect: 68, 660, 78, 666 Annotation: Subtype: Link Rect: 54, 652, 280, 658 Annotation: Subtype: Link Rect: 54, 644, 283, 651 Annotation: Subtype: Link Rect: 54, 636, 200, 643 Annotation: Subtype: Link Rect: 203, 636, 218, 643 Annotation: Subtype: Link Rect: 54, 628, 286, 635 Annotation: Subtype: Link Rect: 54, 620, 286, 627 Annotation: Subtype: Link Rect: 54, 612, 251, 619 Annotation: Subtype: Link Rect: 54, 604, 286, 611 Annotation: Subtype: Link Rect: 54, 596, 273, 603 Annotation: Subtype: Link Rect: 278, 596, 286, 603 Annotation: Subtype: Link Rect: 54, 588, 218, 595 Annotation: Subtype: Link Rect: 221, 588, 248, 595 Annotation: Subtype: Link Rect: 54, 580, 286, 587 Annotation: Subtype: Link Rect: 54, 572, 258, 579 Annotation: Subtype: Link Rect: 54, 565, 208, 571 Annotation: Subtype: Link Rect: 212, 565, 226, 571 Annotation: Subtype: Link Rect: 54, 557, 284, 563 Annotation: Subtype: Link Rect: 54, 549, 283, 555 Annotation: Subtype: Link Rect: 54, 541, 275, 547 Annotation: Subtype: Link Rect: 54, 533, 223, 539 Annotation: Subtype: Link Rect: 226, 533, 237, 539 Annotation: Subtype: Link Rect: 54, 525, 258, 531 Annotation: Subtype: Link Rect: 54, 517, 252, 523 Annotation: Subtype: Link Rect: 255, 517, 266, 523 Annotation: Subtype: Link Rect: 54, 509, 286, 515 Annotation: Subtype: Link Rect: 54, 501, 282, 507 Annotation: Subtype: Link Rect: 54, 493, 282, 499 Annotation: Subtype: Link Rect: 54, 485, 75, 491 Annotation: Subtype: Link Rect: 54, 477, 286, 483 Annotation: Subtype: Link Rect: 54, 469, 273, 475 Annotation: Subtype: Link Rect: 54, 461, 168, 467 Annotation: Subtype: Link Rect: 171, 461, 182, 467 Annotation: Subtype: Link Rect: 54, 453, 285, 459 Annotation: Subtype: Link Rect: 54, 445, 286, 451 Annotation: Subtype: Link Rect: 54, 437, 170, 443 Annotation: Subtype: Link Rect: 173, 437, 184, 443 Annotation: Subtype: Link Rect: 54, 429, 284, 435 Annotation: Subtype: Link Rect: 54, 421, 120, 427 Annotation: Subtype: Link Rect: 124, 421, 134, 427 Annotation: Subtype: Link Rect: 54, 413, 286, 419 Annotation: Subtype: Link Rect: 54, 405, 86, 411 Annotation: Subtype: Link Rect: 89, 405, 100, 411 Annotation: Subtype: Link Rect: 54, 397, 285, 403 Annotation: Subtype: Link Rect: 54, 389, 265, 396 Annotation: Subtype: Link Rect: 54, 381, 64, 388 Annotation: Subtype: Link Rect: 68, 381, 78, 388 Annotation: Subtype: Link Rect: 323, 732, 533, 738 Annotation: Subtype: Link Rect: 323, 724, 535, 730 Annotation: Subtype: Link Rect: 323, 716, 550, 722 Annotation: Subtype: Link Rect: 323, 708, 555, 714 Annotation: Subtype: Link Rect: 323, 700, 505, 706 Annotation: Subtype: Link Rect: 508, 700, 523, 706 Annotation: Subtype: Link Rect: 323, 692, 535, 698 Annotation: Subtype: Link Rect: 323, 684, 550, 690 Annotation: Subtype: Link Rect: 323, 676, 337, 682 Annotation: Subtype: Link Rect: 340, 676, 354, 682 Annotation: Subtype: Link Rect: 323, 668, 555, 674 Annotation: Subtype: Link Rect: 323, 660, 553, 666 Annotation: Subtype: Link Rect: 323, 652, 362, 658 Annotation: Subtype: Link Rect: 365, 652, 372, 658 Annotation: Subtype: Link Rect: 323, 644, 519, 651 Annotation: Subtype: Link Rect: 323, 636, 555, 643 Annotation: Subtype: Link Rect: 323, 628, 553, 635 Annotation: Subtype: Link Rect: 323, 620, 374, 627 Annotation: Subtype: Link Rect: 378, 620, 388, 627 Annotation: Subtype: Link Rect: 323, 612, 555, 619 Annotation: Subtype: Link Rect: 323, 604, 518, 611 Annotation: Subtype: Link Rect: 323, 596, 543, 603 Annotation: Subtype: Link Rect: 323, 588, 555, 595 Annotation: Subtype: Link Rect: 323, 580, 514, 587 Annotation: Subtype: Link Rect: 518, 580, 532, 587 Annotation: Subtype: Link Rect: 323, 572, 555, 579 Annotation: Subtype: Link Rect: 323, 565, 552, 571 Annotation: Subtype: Link Rect: 323, 557, 447, 563 Annotation: Subtype: Link Rect: 450, 557, 461, 563 Annotation: Subtype: Link Rect: 323, 549, 549, 555 Annotation: Subtype: Link Rect: 323, 541, 527, 547 Annotation: Subtype: Link Rect: 323, 533, 553, 539 Annotation: Subtype: Link Rect: 323, 525, 355, 531 Annotation: Subtype: Link Rect: 358, 525, 369, 531 Annotation: Subtype: Link Rect: 323, 517, 555, 523 Annotation: Subtype: Link Rect: 323, 509, 553, 515 Annotation: Subtype: Link Rect: 323, 501, 463, 507 Annotation: Subtype: Link Rect: 467, 501, 485, 507 Annotation: Subtype: Link Rect: 323, 493, 541, 499 Annotation: Subtype: Link Rect: 323, 485, 546, 491 Annotation: Subtype: Link Rect: 323, 477, 555, 483 Annotation: Subtype: Link Rect: 323, 469, 399, 475 Annotation: Subtype: Link Rect: 403, 469, 413, 475 Annotation: Subtype: Link Rect: 323, 461, 546, 467 Annotation: Subtype: Link Rect: 323, 453, 555, 459 Annotation: Subtype: Link Rect: 323, 445, 525, 451 Annotation: Subtype: Link Rect: 323, 437, 510, 443 Annotation: Subtype: Link Rect: 323, 429, 555, 435 Annotation: Subtype: Link Rect: 323, 421, 533, 427 Annotation: Subtype: Link Rect: 323, 413, 522, 419 Annotation: Subtype: Link Rect: 323, 405, 555, 411 Annotation: Subtype: Link Rect: 323, 397, 548, 403 Annotation: Subtype: Link Rect: 323, 389, 465, 396 Annotation: Subtype: Link Rect: 468, 389, 479, 396 Checksum: c14c1b32 Type: CRC32 Checksum: b12a9fe4160261d28f8738fb7f5f4e27 Type: MD5 Checksum: 03e72946c293e2c842faa7b1598b578718d82956 Type: SHA-1