52888b043f460b1f74e6dd39d6698e6d  pmc_9726274.pdf
751f7a922a2c0821aae54b40b021f17de5967a65  pmc_9726274.pdf
fbc2fec6ecfe0ce0350446bf2cfcb2f3bf9130298952dd1e141ecdde2fdbf8ec  pmc_9726274.pdf

Creator:        Adobe InDesign 15.1 (Windows)
Producer:       Adobe PDF Library 15.0
CreationDate:   Fri Dec  2 10:13:48 2022 CET
ModDate:        Fri Dec  2 10:13:50 2022 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          10
Encrypted:      no
Page size:      594 x 792 pts
Page rot:       0
File size:      861284 bytes
Optimized:      yes
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
HelveticaNeueLTStd-MdEx              Type 1C           WinAnsi          yes no  yes    212  0
HelveticaNeueLTStd-Md                Type 1C           WinAnsi          yes no  yes    213  0
HelveticaNeueLTStd-Hv                Type 1C           Custom           yes no  yes    214  0
HelveticaNeueLTStd-Lt                Type 1C           Custom           yes no  yes    215  0
HelveticaNeueLTStd-BdEx              Type 1C           WinAnsi          yes no  yes    227  0
HelveticaNeueLTStd-MdIt              Type 1C           Custom           yes no  yes    232  0
SabonLTStd-Roman                     Type 1C           Custom           yes no  yes    233  0
HelveticaNeueLTStd-LtIt              Type 1C           Custom           yes no  yes    234  0
GRWHSW+Avenir-Roman                  Type 1C           WinAnsi          yes yes no     267  0
GRWHSW+AkzidenzGroteskBE-Md          Type 1C           WinAnsi          yes yes no     270  0
HelveticaNeueLTStd-Bd                Type 1C           WinAnsi          yes no  yes    120  0
HFYHBU+GandhariUnicode-Roman         Type 1C           Custom           yes yes yes    128  0
SabonLTStd-BoldItalic                Type 1C           WinAnsi          yes no  yes    136  0
HelveticaNeueLTStd-BdCn              Type 1C           Custom           yes no  yes    137  0
HelveticaNeueLTStd-LtCn              Type 1C           Custom           yes no  yes    130  0
SabonLTStd-Italic                    Type 1C           WinAnsi          yes no  yes    143  0
PKUTJE+STIXGeneral-Regular           Type 1C           Custom           yes yes yes    142  0
STIXGeneral-Bold                     Type 1C           WinAnsi          yes no  yes    144  0
SabonLTStd-Bold                      Type 1C           WinAnsi          yes no  yes    156  0
STIXGeneral-BoldItalic               Type 1C           Custom           yes no  yes    151  0
STIXGeneral-Italic                   Type 1C           WinAnsi          yes no  yes    157  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-09-08 02:40:49 CEST
 RepresentationInformation: pmc_9726274.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-08-04 02:18:58 CEST
  Size: 861284
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF, ISO PDF/A-1, Level B
  PDFMetadata: 
   Objects: 317
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseNone
    Language: en-US
   Info: 
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0
    CreationDate: Fri Dec 02 10:43:48 CET 2022
    ModDate: Fri Dec 02 10:43:50 CET 2022
   ID: 0x045f09c7a7543f448d19873075160c3f, 0x18dc5a1a9a90f2489dbcdae619c995b1
   Filters: 
    FilterPipeline: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: HFYHBU+GandhariUnicode-Roman
      FontSubset: true
      FirstChar: 31
      LastChar: 149
      FontDescriptor: 
       FontName: HFYHBU+GandhariUnicode-Roman
       Flags: Serif, Nonsymbolic
       FontBBox: -752, -250, 1779, 944
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-LtCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-LtCn
       Flags: Nonsymbolic
       FontBBox: -167, -204, 1000, 927
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-BdEx
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-BdEx
       Flags: Nonsymbolic
       FontBBox: -145, -213, 1163, 984
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-MdIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-MdIt
       Flags: Nonsymbolic, Italic
       FontBBox: -165, -218, 1125, 947
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: SabonLTStd-BoldItalic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: SabonLTStd-BoldItalic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -147, -238, 1080, 955
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: SabonLTStd-Roman
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: SabonLTStd-Roman
       Flags: Serif, Nonsymbolic
       FontBBox: -165, -228, 1000, 944
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-BdCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-BdCn
       Flags: Nonsymbolic
       FontBBox: -164, -224, 1066, 961
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-LtIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-LtIt
       Flags: Nonsymbolic, Italic
       FontBBox: -165, -214, 1099, 951
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: PKUTJE+STIXGeneral-Regular
      FontSubset: true
      FirstChar: 29
      LastChar: 31
      FontDescriptor: 
       FontName: PKUTJE+STIXGeneral-Regular
       Flags: Serif, Symbolic
       FontBBox: -995, -455, 2000, 1055
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: SabonLTStd-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: SabonLTStd-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -146, -228, 1059, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: STIXGeneral-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIXGeneral-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -998, -455, 2000, 1055
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-MdEx
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-MdEx
       Flags: Nonsymbolic
       FontBBox: -172, -220, 1159, 978
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-Md
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-Md
       Flags: Nonsymbolic
       FontBBox: -165, -221, 1066, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-Hv
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-Hv
       Flags: Nonsymbolic
       FontBBox: -169, -234, 1096, 951
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-Lt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-Lt
       Flags: Nonsymbolic
       FontBBox: -166, -214, 1050, 967
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: STIXGeneral-BoldItalic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIXGeneral-BoldItalic
       Flags: Serif, Symbolic
       FontBBox: -1030, -455, 1430, 1055
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HelveticaNeueLTStd-Bd
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaNeueLTStd-Bd
       Flags: Nonsymbolic
       FontBBox: -166, -218, 1078, 975
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: SabonLTStd-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: SabonLTStd-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -163, -228, 1000, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: STIXGeneral-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIXGeneral-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 6.0-c002 79.164460, 2020/05/12-16:04:17        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <xmp:CreateDate>2022-12-02T14:43:48+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2022-12-02T14:43:50+05:30</xmp:MetadataDate>
         <xmp:ModifyDate>2022-12-02T14:43:50+05:30</xmp:ModifyDate>
         <xmp:CreatorTool>Adobe InDesign 15.1 (Windows)</xmp:CreatorTool>
         <xmpMM:InstanceID>uuid:2ae84999-52a5-4a05-be7e-15aec5b10954</xmpMM:InstanceID>
         <xmpMM:OriginalDocumentID>xmp.did:07801174072068118C149D4CFFA16D8F</xmpMM:OriginalDocumentID>
         <xmpMM:DocumentID>xmp.id:4a5fe625-c710-d249-ba2b-6c3bffb9c127</xmpMM:DocumentID>
         <xmpMM:RenditionClass>proof:pdf</xmpMM:RenditionClass>
         <xmpMM:DerivedFrom rdf:parseType="Resource">
            <stRef:instanceID>xmp.iid:328b0c7c-82c5-294d-95b3-c979139c9d18</stRef:instanceID>
            <stRef:documentID>xmp.did:328b0c7c-82c5-294d-95b3-c979139c9d18</stRef:documentID>
            <stRef:originalDocumentID>xmp.did:07801174072068118C149D4CFFA16D8F</stRef:originalDocumentID>
            <stRef:renditionClass>default</stRef:renditionClass>
         </xmpMM:DerivedFrom>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:parameters>from application/x-indesign to application/pdf</stEvt:parameters>
                  <stEvt:softwareAgent>Adobe InDesign 15.1 (Windows)</stEvt:softwareAgent>
                  <stEvt:changed>/</stEvt:changed>
                  <stEvt:when>2022-12-02T14:43:48+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <dc:format>application/pdf</dc:format>
         <pdf:Producer>Adobe PDF Library 15.0</pdf:Producer>
         <pdf:Trapped>False</pdf:Trapped>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 168, 637, 171, 625
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 173, 637, 176, 625
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 178, 637, 181, 625
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 183, 637, 186, 625
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 306, 637, 310, 625
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 412, 637, 415, 625
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 515, 637, 519, 625
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 519, 637, 522, 625
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 522, 638, 535, 625
      Annotation: 
       Subtype: Link
       Rect: 183, 625, 186, 613
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 260, 625, 263, 613
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 265, 625, 268, 613
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 428, 625, 431, 613
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 433, 625, 436, 613
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 438, 625, 441, 613
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 238, 613, 242, 601
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 243, 613, 246, 601
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 368, 613, 371, 601
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 373, 613, 374, 601
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 456, 613, 459, 601
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 461, 613, 462, 601
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 151, 601, 154, 589
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 156, 601, 157, 589
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 306, 601, 310, 589
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 311, 601, 312, 589
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 433, 601, 436, 589
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 438, 601, 439, 589
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 549, 601, 552, 589
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 175, 589, 176, 577
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 263, 589, 268, 577
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 400, 589, 404, 577
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 498, 589, 502, 577
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 504, 589, 507, 577
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 509, 589, 512, 577
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 208, 577, 211, 565
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 213, 577, 215, 565
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 216, 577, 219, 565
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 221, 577, 223, 565
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 323, 577, 326, 565
       ActionDest: 1
      Annotation: 
       Subtype: Link
       Rect: 454, 577, 457, 565
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 459, 577, 461, 565
       ActionDest: 168
      Annotation: 
       Subtype: Link
       Rect: 462, 577, 465, 565
       ActionDest: 1
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 247, 559, 250, 549
       ActionDest: 86
      Annotation: 
       Subtype: Link
       Rect: 252, 559, 255, 549
       ActionDest: 86
      Annotation: 
       Subtype: Link
       Rect: 236, 529, 239, 519
       ActionDest: 86
      Annotation: 
       Subtype: Link
       Rect: 77, 479, 80, 469
       ActionDest: 86
      Annotation: 
       Subtype: Link
       Rect: 272, 479, 275, 469
       ActionDest: 86
      Annotation: 
       Subtype: Link
       Rect: 277, 479, 280, 469
       ActionDest: 116
      Annotation: 
       Subtype: Link
       Rect: 183, 429, 186, 419
       ActionDest: 116
      Annotation: 
       Subtype: Link
       Rect: 217, 369, 220, 359
       ActionDest: 116
      Annotation: 
       Subtype: Link
       Rect: 222, 369, 228, 359
       ActionDest: 116
      Annotation: 
       Subtype: Link
       Rect: 175, 279, 181, 269
       ActionDest: 116
      Annotation: 
       Subtype: Link
       Rect: 96, 229, 102, 219
       ActionDest: 116
      Annotation: 
       Subtype: Link
       Rect: 168, 199, 174, 189
       ActionDest: 116
      Annotation: 
       Subtype: Link
       Rect: 488, 679, 494, 669
       ActionDest: 116
      Annotation: 
       Subtype: Link
       Rect: 306, 471, 335, 461
       ActionDest: 36
      Annotation: 
       Subtype: Link
       Rect: 461, 159, 524, 150
      Annotation: 
       Subtype: Link
       Rect: 297, 150, 393, 141
    Page: 
     Sequence: 3
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 432, 591, 437, 581
       ActionDest: 116
      Annotation: 
       Subtype: Link
       Rect: 319, 561, 325, 551
       ActionDest: 116
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 517, 680, 545, 670
       ActionDest: 52
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 561, 74, 551
       ActionDest: 57
      Annotation: 
       Subtype: Link
       Rect: 116, 293, 120, 283
       ActionDest: 57
      Annotation: 
       Subtype: Link
       Rect: 138, 284, 142, 274
       ActionDest: 57
      Annotation: 
       Subtype: Link
       Rect: 97, 275, 101, 263
       ActionDest: 57
      Annotation: 
       Subtype: Link
       Rect: 255, 192, 259, 180
       ActionDest: 57
      Annotation: 
       Subtype: Link
       Rect: 520, 192, 524, 180
       ActionDest: 57
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 239, 329, 297, 319
      Annotation: 
       Subtype: Link
       Rect: 51, 319, 90, 309
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 97, 367, 282, 357
      Annotation: 
       Subtype: Link
       Rect: 36, 357, 128, 347
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 269, 729, 297, 719
      Annotation: 
       Subtype: Link
       Rect: 51, 719, 297, 709
      Annotation: 
       Subtype: Link
       Rect: 51, 709, 294, 699
      Annotation: 
       Subtype: Link
       Rect: 258, 413, 261, 403
       ActionDest: 116
      Annotation: 
       Subtype: Link
       Rect: 262, 413, 268, 403
       ActionDest: 116
      Annotation: 
       Subtype: Link
       Rect: 69, 323, 75, 313
       ActionDest: 116
      Annotation: 
       Subtype: Link
       Rect: 77, 323, 82, 313
       ActionDest: 116
      Annotation: 
       Subtype: Link
       Rect: 92, 103, 98, 93
       ActionDest: 116
      Annotation: 
       Subtype: Link
       Rect: 476, 726, 558, 715
      Annotation: 
       Subtype: Link
       Rect: 312, 716, 348, 705
      Annotation: 
       Subtype: Link
       Rect: 446, 578, 558, 567
      Annotation: 
       Subtype: Link
       Rect: 312, 568, 470, 557
    Page: 
     Sequence: 10
  Checksum: 88194037
   Type: CRC32
  Checksum: 52888b043f460b1f74e6dd39d6698e6d
   Type: MD5
  Checksum: 751f7a922a2c0821aae54b40b021f17de5967a65
   Type: SHA-1