21ce719250b383ff34633647d73e8727 pmc_9736680.pdf 890f614b2a72cb17338a5f9cccc073c1f39c290a pmc_9736680.pdf 1d6d512779d5ca4e513f748eaf83f535949aa62fa9abfcf0b1084bc81d93205f pmc_9736680.pdf Title: Protein Supplementation with Short Peptides Prevents Early Muscle Mass Loss after Roux-en-Y-Gastric Bypass Subject: Introduction: A significant reduction in fat-free mass (FFM) following bariatric surgery (BS) has been reported, and adequate protein intake is recommended for FFM preservation. Current guidelines of nutritional management after BS recommend complex protein (CP) compounds. However, Roux-en-Y-gastric bypass (RYGB) has a negative impact on CP digestion, leading to protein malabsorption. At present, there is no data regarding the impact of early supplementation with short peptide-based (SPB) or hydroxy methylbutyrate (HMB)-enriched formulas on the evolution of the FFM after the BS. Aim: The aim of this study is to evaluate the effect of nutritional products based on CP, HBM-enriched, or SPB formulas on the FFM of patients that undergo RYGB. Material and methods: This is a prospective interventional study, including three groups of patients (according to the type of protein product) as candidates for BS, recruited between December 2021 and April 2022, matched by age, gender, and BMI. All patients underwent evaluations at baseline and one month post-BS, including: medical history, physical and anthropometric evaluation, bioimpedance, and biochemical analysis. Results: A total of 60 patients were recruited: 63% women, mean age 43.13 9.4 years, and BMI 43.57 4.1 kg/m2. The % of FFM loss from total weight loss (TWL) was significantly lower in the SPB group than CP and HMB groups despite the major %TWL in this group (40.60 17.27 in CP, 34.57 13.15 in HMB, and 19.14 9.38 in SPB, p < 0.001). TWL% was 9.98 1.82 vs. 9.83 2.71 vs. 13.56 4.30, p < 0.001, respectively. Conclusion: In our study, the SPB supplementation prevented almost 50% FFM lost from the TWL than the CP- or HMB-enriched compounds at one month post-BS. These results are significant in the setting of muscle mass preservation after the BS, and have the potential to change the current guidelines for the management of nutritional supplementation after BS. Keywords: protein; nutrition supplementation; fat-free mass; bariatric surgery; short peptides; complex protein; HMB-enriched formulas Author: Marta Comas Martínez, Enzamaria Fidilio Meli, Fiorella Palmas Candia, Efrain Cordero, Irene Hernández, Ramon Vilallonga, Rosa Burgos, Anna Vila, Rafael Simó and Andreea Ciudin Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Dec 1 05:31:06 2022 CET ModDate: Thu Dec 1 05:34:58 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 307632 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LXPTTH+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 PDWHAF+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 TIFZHX+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 UWJUYN+CMSY10 Type 1 Builtin yes yes no 23 0 PRJKGQ+VnURWPalladioL-Bold Type 1 Custom yes yes no 27 0 HGMNRX+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 LWLIVD+EURM10 Type 1 Builtin yes yes no 68 0 SPXLNH+PazoMath Type 1 Builtin yes yes no 78 0 URYLRZ+URWPalladioL-BoldItal Type 1 Custom yes yes no 85 0 DUFXDP+VnURWPalladioL Type 1 Custom yes yes no 98 0 NJWNDJ+VnURWPalladioL-Italic Type 1 Custom yes yes no 102 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-07 02:29:28 CEST RepresentationInformation: pmc_9736680.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-08-03 02:25:16 CEST Size: 307632 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 239 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Info: Title: Protein Supplementation with Short Peptides Prevents Early Muscle Mass Loss after Roux-en-Y-Gastric Bypass Author: Marta Comas Martínez, Enzamaria Fidilio Meli, Fiorella Palmas Candia, Efrain Cordero, Irene Hernández, Ramon Vilallonga, Rosa Burgos, Anna Vila, Rafael Simó and Andreea Ciudin Subject: Introduction: A significant reduction in fat-free mass (FFM) following bariatric surgery (BS) has been reported, and adequate protein intake is recommended for FFM preservation. Current guidelines of nutritional management after BS recommend complex protein (CP) compounds. However, Roux-en-Y-gastric bypass (RYGB) has a negative impact on CP digestion, leading to protein malabsorption. At present, there is no data regarding the impact of early supplementation with short peptide-based (SPB) or hydroxy methylbutyrate (HMB)-enriched formulas on the evolution of the FFM after the BS. Aim: The aim of this study is to evaluate the effect of nutritional products based on CP, HBM-enriched, or SPB formulas on the FFM of patients that undergo RYGB. Material and methods: This is a prospective interventional study, including three groups of patients (according to the type of protein product) as candidates for BS, recruited between December 2021 and April 2022, matched by age, gender, and BMI. All patients underwent evaluations at baseline and one month post-BS, including: medical history, physical and anthropometric evaluation, bioimpedance, and biochemical analysis. Results: A total of 60 patients were recruited: 63% women, mean age 43.13 9.4 years, and BMI 43.57 4.1 kg/m2. The % of FFM loss from total weight loss (TWL) was significantly lower in the SPB group than CP and HMB groups despite the major %TWL in this group (40.60 17.27 in CP, 34.57 13.15 in HMB, and 19.14 9.38 in SPB, p < 0.001). TWL% was 9.98 1.82 vs. 9.83 2.71 vs. 13.56 4.30, p < 0.001, respectively. Conclusion: In our study, the SPB supplementation prevented almost 50% FFM lost from the TWL than the CP- or HMB-enriched compounds at one month post-BS. These results are significant in the setting of muscle mass preservation after the BS, and have the potential to change the current guidelines for the management of nutritional supplementation after BS. 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