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Villarreal-Salazar Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Dec 7 17:51:21 2022 CET ModDate: Wed Dec 7 17:52:14 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 10006672 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FJGAGP+AdvOTad521943 Type 1C WinAnsi yes yes no 1045 0 FJGAHA+AdvP4C4E59 Type 1C WinAnsi yes yes no 1048 0 FJGAHB+AdvOT9d0303c0.B Type 1C WinAnsi yes yes no 1051 0 FJGAHC+AdvOT8e81dcaa Type 1C WinAnsi yes yes no 1053 0 FJGAHD+AdvOT8e81dcaa+fb Type 1C Custom yes yes yes 1058 0 FJGAHE+AdvP4C4E74 Type 1C Custom yes yes yes 1046 0 FJGAIF+AdvPSSym Type 1C Custom yes yes no 1069 0 FJGAIG+AdvOT8e81dcaa+20 Type 1C WinAnsi yes yes no 1063 0 FJGAIH+AdvOTa4800bed.I Type 1C WinAnsi yes yes no 1065 0 FJGAOI+AdvPS44A44B Type 1C WinAnsi yes yes no 744 0 FJGAOG+AdvPS3FDD77 Type 1C WinAnsi yes yes no 739 0 FJGAOH+AdvPS3F4C13 Type 1C WinAnsi yes yes no 746 0 FJGIAN+AdvOT1ae6bdaa.BI Type 1C WinAnsi yes yes no 752 0 FJGNMK+AdvPS7DED Type 1C WinAnsi yes yes no 758 0 FJGNML+AdvP4C4E51 Type 1C WinAnsi yes yes no 756 0 FJHCKO+AdvOT9d0303c0.B+fb Type 1C Custom yes yes yes 764 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-07 02:29:07 CEST RepresentationInformation: pmc_9758572.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-08-03 02:24:26 CEST Size: 10006672 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - 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Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: 1. Background Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: 2. Material and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: 2.1. Ethical approval Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: 2.2. Patients’ muscle biopsies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: 2.3. Studies in mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 2.4. Histochemistry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 2.5. Immunofluorescence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 2.6. Electron microscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: 2.7. Mitochondrial DNA copy number Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 2.8. Mitochondrial DNA deletion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 2.9. mRNA levels Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 2.10. Western blots Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: 2.11. Mitochondrial oxidative phosphorylation system Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: 2.12. Mass spectrometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 2.13. Peak oxygen uptake in patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 2.14. Statistical analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Children: Item: Title: 3.1. Structural damage, glycogen levels and mitochondrial content Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 3.2. Mitochondrial network Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 3.3. Cytoskeleton and mitochondrial network in McArdle mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 3.4. Mitochondrial fission/fusion proteins Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 3.5. Mitochondrial content and biogenesis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 3.6. OXPHOS-related proteins Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 3.7. Peak aerobic capacity in patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 3.8. Muscle cytoskeleton and mitochondrial network in two patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 5. Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Ethics approval Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Consent for publication Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Availability of data and material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Authors contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: flink11 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Conflict of interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Appendix A. Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Info: Title: Low aerobic capacity in McArdle disease: A role for mitochondrial network impairment? Author: M. 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M. Villarreal-Salazar A. Santalla A. Real-Martínez G. Nogales-Gadea P.L. Valenzuela C. Fiuza-Luces A.L. Andreu J.C. Rodríguez-Aguilera M.A. Martín J. Arenas J. Vissing A. Lucia T.O. Krag T. Pinós McArdle disease Skeletal muscle Glycogen Aerobic capacity Cytoskeleton and mitochondrial network Molecular Metabolism, 66 (2022) 101648. doi:10.1016/j.molmet.2022.101648 The Author(s) journal Molecular Metabolism © 2022 The Author(s). Published by Elsevier GmbH. 2212-8778 66 December 2022 101648 101648 10.1016/j.molmet.2022.101648 https://doi.org/10.1016/j.molmet.2022.101648 2010-04-23 true 10.1016/j.molmet.2022.101648 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.molmet.2022.101648 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2022-12-07T22:21:21+05:30 2022-12-07T22:22:14+05:30 2022-12-07T22:22:14+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:6179521c-43ef-4b7a-9022-7465d6a089c2 uuid:ff6adbd3-5dc9-457c-a64b-a381110d9d7d http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 121, 604, 121, 605 Annotation: Subtype: Link Rect: 122, 606, 126, 615 Destination: 962 Annotation: Subtype: Link Rect: 128, 606, 132, 615 Destination: 962 Annotation: Subtype: Link Rect: 134, 606, 141, 615 Destination: 962 Annotation: Subtype: Link Rect: 188, 604, 188, 605 Annotation: Subtype: Link Rect: 190, 606, 194, 615 Destination: 962 Annotation: Subtype: 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