02ecba81f102af671b80683ab42acf47 pmc_9772550.pdf c34fb084de31fa7069c9557f533e17df563e8b28 pmc_9772550.pdf b2a6bbb7a8b4ad0096dafac4c8da3c7e81c23cb0400c1beddb03cb45609d3d5d pmc_9772550.pdf Title: Functional consequences of Genetics variant in TMC1 and TMC2 within a United Arab Emirates family with Pre-lingual hearing loss Subject: Saudi Journal of Biological Sciences, 30 (2023) 103520. doi:10.1016/j.sjbs.2022.103520 Author: Abdullah Al Mutery Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Wed Dec 14 07:27:33 2022 CET ModDate: Wed Dec 14 07:27:58 2022 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2890499 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PBOOHD+AdvGulliv-R Type 1C MacRoman yes yes no 548 0 PBOOHE+AdvGulliv-I Type 1C Custom yes yes no 549 0 PBOOJE+AdvCORRESAST Type 1C Custom yes yes yes 550 0 PBOOJF+AdvGulliv-F Type 1C WinAnsi yes yes no 551 0 PBOOKG+AdvPSSym Type 1C Custom yes yes no 552 0 PBOOKH+AdvGulliv-B Type 1C WinAnsi yes yes no 553 0 PBOONH+Helvetica-Bold Type 1C WinAnsi yes yes no 568 0 PBOPAH+AdvPSUnv Type 1C WinAnsi yes yes no 569 0 PBPFFB+AdvP4C4E74 Type 1C Custom yes yes no 273 0 PBPFFC+AdvPSMP13 Type 1C WinAnsi yes yes no 274 0 PBPIBC+AdvGulli-BI Type 1C WinAnsi yes yes no 281 0 PCBBOE+AdvSPSASORT Type 1C Custom yes yes no 283 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-03-22 02:45:56 CET RepresentationInformation: pmc_9772550.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-10-12 02:19:58 CEST Size: 2890499 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'web64para6' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para77' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para20' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para58' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para59' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para39' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para68' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para30' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para11' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para49' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para5' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para69' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para31' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para48' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para76' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para21' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64sec2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para10' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para41' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para79' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para38' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para32' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para60' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para13' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para46' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para66' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para47' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para80' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para18' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para75' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para61' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para3' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para12' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64table1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64Fig' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para40' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para33' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para19' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para81' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para26' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para67' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para4' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para74' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para44' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para16' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para72' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para25' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para63' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para53' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para54' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para73' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para35' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para82' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para24' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64title' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para45' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para83' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para14' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para27' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para52' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para34' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para55' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para9' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para62' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para17' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para56' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para51' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para65' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64sec1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para28' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para70' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para8' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para23' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para37' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para42' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para29' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para64' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para57' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para15' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para78' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para71' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para22' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para50' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para43' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para36' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para57' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para76' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para29' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para38' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para47' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para19' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para28' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para66' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para9' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para20' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para68' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para30' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para75' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para37' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para27' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64Fig' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para10' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para8' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para48' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para1' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para58' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para65' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para17' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para12' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para45' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para31' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para6' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para59' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para26' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para54' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para73' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para40' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec2' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para25' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para60' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para32' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para11' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para81' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para18' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para39' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para74' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para67' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para53' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para46' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para52' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para4' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para61' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para80' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para24' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64table1' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para43' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para62' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para42' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para33' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para14' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para71' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para72' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para5' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para44' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64title' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para51' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para13' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para23' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para82' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para79' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para41' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para34' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para69' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para64' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para36' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para55' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para2' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para50' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para35' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para21' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para16' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para83' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para78' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para49' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para77' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para63' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para56' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para22' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para70' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para3' cannot be found ID: PDF-HUL-122 Offset: 2865185 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para15' cannot be found ID: PDF-HUL-122 Offset: 2865185 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 637 FreeObjects: 27 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Functional consequences of Genetics variant in TMC1 and TMC2 within a United Arab Emirates family with Pre-lingual hearing lossTMC1 and TMC2 within a United Arab Emirates family with Pre-lingual hearing loss -- Destination: 1 Children: Item: Title: 1 Introduction Destination: 1 Item: Title: 2 Materials and methods Destination: 1 Children: Item: Title: 2.1 Patients and samples Destination: 1 Item: Title: 2.2 Whole exome sequencing and Bioinformatics analysis Destination: 1 Item: Title: 2.3 TMC1 exon 11 amplification Destination: 1 Item: Title: 2.4 Sanger sequencing Destination: 1 Item: Title: 2.5 In silico analysis of the c.596 A > T mutation Destination: 1 Item: Title: 2.6 Computational methodologies for predicting mutation impact Destination: 1 Item: Title: 3 Results Destination: 1 Children: Item: Title: 3.1 Clinical description: Hearing loss is an autosomal recessive trait Destination: 1 Item: Title: 3.2 Clinical description: Hearing loss is an autosomal recessivetrait Destination: 1 Item: Title: 3.3 Molecular analysis: Hearing loss trait is linked to c.596A > T mutation in TMC1 Destination: 1 Item: Title: 3.4 Missense mutation c.596 A > T led to Drastic structural changes in TMC1 Destination: 1 Item: Title: 3.5 Two coding genotypic variabilities within MET genes Destination: 1 Item: Title: 3.6 Structure validation Destination: 1 Item: Title: 3.7 Structure comparison Destination: 1 Item: Title: 3.8 TMC2-3D structural development Destination: 1 Item: Title: 3.9 p. Arg123Lys and p. Gln205Arg led to conformational alterations in TMC2 3D structure Destination: 1 Item: Title: 3.10 R123K and Q205R variations in TMC2 disrupted binding between TMC1N199I and TMC2 proteins Destination: 1 Item: Title: 4 Discussion Destination: 1 Item: Title: 5 Conclusions Destination: 1 Item: Title: Disclosure of funding Destination: 1 Item: Title: Declaration of Competing Interest Destination: 1 Item: Title: Appendix A Supplementary material Destination: 1 Item: Title: References Destination: 1 Item: Title: Further Reading Destination: 1 Info: Title: Functional consequences of Genetics variant in TMC1 and TMC2 within a United Arab Emirates family with Pre-lingual hearing loss Author: Abdullah Al Mutery Subject: Saudi Journal of Biological Sciences, 30 (2023) 103520. doi:10.1016/j.sjbs.2022.103520 Creator: Elsevier Producer: Acrobat Distiller 8.0.0 (Windows) CreationDate: Wed Dec 14 07:57:33 CET 2022 ModDate: Wed Dec 14 07:57:58 CET 2022 ID: 0x3daa07e9139a061007ef7b1f96306a47, 0x11ee03304773364489081e9bba2af69a Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 206 ImageHeight: 225 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 237 ImageHeight: 297 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2067 ImageHeight: 1045 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2067 ImageHeight: 1055 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1417 ImageHeight: 848 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1942 ImageHeight: 2003 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1963 ImageHeight: 1262 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1836 ImageHeight: 1411 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: PBPFFB+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: PBPFFB+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: PBPFFC+AdvPSMP13 FontSubset: true FirstChar: 97 LastChar: 97 FontDescriptor: FontName: PBPFFC+AdvPSMP13 Flags: Nonsymbolic FontBBox: 0, -302, 958, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PBOOHD+AdvGulliv-R FontSubset: true FirstChar: 37 LastChar: 245 FontDescriptor: FontName: PBOOHD+AdvGulliv-R Flags: Serif, Nonsymbolic FontBBox: -104, -250, 1041, 979 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: PBOOHE+AdvGulliv-I FontSubset: true FirstChar: 30 LastChar: 242 FontDescriptor: FontName: PBOOHE+AdvGulliv-I Flags: Serif, Nonsymbolic FontBBox: -135, -229, 1052, 968 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: PBOOJE+AdvCORRESAST FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: PBOOJE+AdvCORRESAST Flags: Symbolic FontBBox: 0, -947, 1041, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PBOOJF+AdvGulliv-F FontSubset: true FirstChar: 97 LastChar: 116 FontDescriptor: FontName: PBOOJF+AdvGulliv-F Flags: Serif, Nonsymbolic FontBBox: -104, -250, 1406, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PBOONH+Helvetica-Bold FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: PBOONH+Helvetica-Bold Flags: Nonsymbolic, ForceBold FontBBox: -170, -228, 1003, 962 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PBOOKG+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: PBOOKG+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: PBOOKH+AdvGulliv-B FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: PBOOKH+AdvGulliv-B Flags: Serif, Nonsymbolic FontBBox: -145, -239, 1125, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PBOPAH+AdvPSUnv FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: PBOPAH+AdvPSUnv Flags: Nonsymbolic FontBBox: -156, -229, 1000, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PBPIBC+AdvGulli-BI FontSubset: true FirstChar: 50 LastChar: 84 FontDescriptor: FontName: PBPIBC+AdvGulli-BI Flags: Nonsymbolic FontBBox: -166, -239, 1135, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PCBBOE+AdvSPSASORT FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: PCBBOE+AdvSPSASORT Flags: Symbolic FontBBox: -281, -437, 1343, 989 FontFile3: true EncodingDictionary: Differences: true XMP: application/pdf doi:10.1016/j.sjbs.2022.103520 Functional consequences of Genetics variant in TMC1 and TMC2 within a United Arab Emirates family with Pre-lingual hearing loss Abdullah Al Mutery Walaa Kamal Eldin Mohamed Mona Mahfood Jihen Chouchen Abdelaziz Tlili Non-syndromic Hearing Loss Whole-exome sequencing TMC1 c.596A > T mutation Phenotypic variability Protein docking Saudi Journal of Biological Sciences, 30 (2023) 103520. doi:10.1016/j.sjbs.2022.103520 The Authors journal Saudi Journal of Biological Sciences © 2022 The Authors. Published by Elsevier B.V. on behalf of King Saud University. 1319-562X 30 2 February 2023 103520 103520 10.1016/j.sjbs.2022.103520 https://doi.org/10.1016/j.sjbs.2022.103520 2010-04-23 true 10.1016/j.sjbs.2022.103520 elsevier.com sciencedirect.com VoR 10.1016/j.sjbs.2022.103520 noindex 2010-04-23 true 6.5 elsevier.com sciencedirect.com sciencedirect.com elsevier.com Elsevier 2022-12-14T11:57:58+05:30 2022-12-14T11:57:33+05:30 2022-12-14T11:57:58+05:30 True Acrobat Distiller 8.0.0 (Windows) False uuid:af730eaa-3380-43c8-9c2e-acf7be39899d uuid:c79356a2-d45f-439f-b193-4957bea1c391 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 103520 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 37, 624, 37, 633 Destination: null Annotation: Subtype: Link Rect: 37, 601, 37, 614 Destination: null Annotation: Subtype: Link Rect: 528, 587, 556, 615 Annotation: Subtype: Link Rect: 37, 562, 37, 572 Destination: null Annotation: Subtype: Link Rect: 136, 566, 140, 577 Destination: 464 Annotation: Subtype: Link Rect: 142, 566, 146, 577 Destination: 464 Annotation: Subtype: Link Rect: 148, 566, 152, 577 Destination: 464 Annotation: Subtype: Link Rect: 154, 566, 159, 579 Destination: 464 Annotation: Subtype: Link Rect: 313, 566, 317, 577 Destination: 464 Annotation: Subtype: Link Rect: 319, 566, 324, 577 Destination: 464 Annotation: Subtype: Link Rect: 406, 566, 410, 577 Destination: 464 Annotation: Subtype: Link Rect: 495, 566, 499, 577 Destination: 464 Annotation: Subtype: Link Rect: 108, 553, 112, 564 Destination: 464 Annotation: Subtype: Link Rect: 114, 553, 118, 564 Destination: 464 Annotation: Subtype: Link Rect: 120, 553, 125, 564 Destination: 464 Annotation: Subtype: Link Rect: 37, 535, 37, 541 Destination: null Annotation: Subtype: Link Rect: 37, 526, 37, 533 Destination: null Annotation: Subtype: Link Rect: 37, 518, 37, 524 Destination: null Annotation: Subtype: Link Rect: 37, 509, 37, 515 Destination: null Annotation: Subtype: Link Rect: 37, 475, 37, 484 Destination: null Annotation: Subtype: Link Rect: 142, 422, 142, 429 Destination: null Annotation: Subtype: Link Rect: 202, 475, 202, 484 Destination: null Annotation: Subtype: Link Rect: 381, 312, 553, 319 Annotation: Subtype: Link Rect: 37, 265, 37, 273 Destination: null Annotation: Subtype: Link Rect: 49, 244, 49, 252 Destination: null Annotation: Subtype: Link Rect: 454, 265, 542, 273 Annotation: Subtype: Link Rect: 546, 265, 557, 273 Annotation: Subtype: Link Rect: 306, 254, 342, 262 Annotation: Subtype: Link Rect: 533, 244, 557, 252 Destination: 186 Annotation: Subtype: Link Rect: 306, 234, 501, 241 Destination: 186 Annotation: Subtype: Link Rect: 309, 213, 528, 221 Destination: 186 Annotation: Subtype: Link Rect: 388, 179, 459, 187 Annotation: Subtype: Link Rect: 463, 179, 523, 187 Annotation: Subtype: Link Rect: 489, 117, 552, 125 Destination: 186 Annotation: Subtype: Link Rect: 318, 106, 318, 114 Destination: null Annotation: Subtype: Link Rect: 369, 85, 440, 93 Destination: 186 Annotation: Subtype: Link Rect: 37, 55, 166, 61 Annotation: Subtype: Link Rect: 222, 38, 374, 44 Annotation: Subtype: Link Rect: 103, 147, 178, 153 Annotation: Subtype: Link Rect: 232, 147, 288, 153 Annotation: Subtype: Link Rect: 37, 138, 93, 144 Annotation: Subtype: Link Rect: 194, 138, 252, 144 Annotation: Subtype: Link Rect: 257, 138, 288, 144 Annotation: Subtype: Link Rect: 37, 129, 82, 136 Annotation: Subtype: Link Rect: 215, 739, 379, 745 Annotation: Subtype: Link Rect: 323, 711, 374, 719 Annotation: Subtype: Link Rect: 290, 656, 403, 663 Page: Label: 103521 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 269, 696, 288, 704 Destination: 186 Annotation: Subtype: Link Rect: 37, 686, 288, 694 Destination: 186 Annotation: Subtype: Link Rect: 37, 676, 122, 684 Destination: 186 Annotation: Subtype: Link Rect: 225, 665, 283, 673 Destination: 186 Annotation: Subtype: Link Rect: 73, 634, 149, 642 Destination: 186 Annotation: Subtype: Link Rect: 212, 613, 267, 621 Destination: 186 Annotation: Subtype: Link Rect: 85, 581, 176, 589 Destination: 186 Annotation: Subtype: Link Rect: 137, 540, 198, 548 Destination: 186 Annotation: Subtype: Link Rect: 247, 456, 288, 464 Annotation: Subtype: Link Rect: 37, 445, 117, 453 Annotation: Subtype: Link Rect: 49, 435, 49, 443 Destination: null Annotation: Subtype: Link Rect: 49, 400, 49, 408 Destination: null Annotation: Subtype: Link Rect: 37, 322, 37, 330 Destination: null Annotation: Subtype: Link Rect: 37, 301, 37, 309 Destination: null Annotation: Subtype: Link Rect: 49, 281, 49, 289 Destination: null Annotation: Subtype: Link Rect: 37, 173, 37, 181 Destination: null Annotation: Subtype: Link Rect: 49, 153, 49, 161 Destination: null Annotation: Subtype: Link Rect: 220, 79, 288, 87 Destination: 186 Annotation: Subtype: Link Rect: 37, 69, 56, 77 Destination: 186 Annotation: Subtype: Link Rect: 162, 48, 239, 56 Destination: 186 Annotation: Subtype: Link Rect: 318, 717, 318, 725 Destination: null Annotation: Subtype: Link Rect: 404, 665, 532, 673 Annotation: Subtype: Link Rect: 306, 601, 306, 609 Destination: null Annotation: Subtype: Link Rect: 318, 580, 318, 588 Destination: null Annotation: Subtype: Link Rect: 318, 559, 318, 567 Destination: null Annotation: Subtype: Link Rect: 306, 442, 306, 450 Destination: null Annotation: Subtype: Link Rect: 318, 421, 318, 429 Destination: null Annotation: Subtype: Link Rect: 306, 304, 306, 312 Destination: null Annotation: Subtype: Link Rect: 318, 283, 318, 291 Destination: null Annotation: Subtype: Link Rect: 393, 273, 455, 281 Annotation: Subtype: Link Rect: 463, 273, 507, 281 Annotation: Subtype: Link Rect: 309, 263, 438, 271 Annotation: Subtype: Link Rect: 517, 263, 557, 271 Annotation: Subtype: Link Rect: 306, 252, 322, 260 Annotation: Subtype: Link Rect: 324, 252, 425, 260 Annotation: Subtype: Link Rect: 306, 230, 306, 237 Destination: null Annotation: Subtype: Link Rect: 318, 209, 318, 217 Destination: null Annotation: Subtype: Link Rect: 470, 125, 557, 133 Annotation: Subtype: Link Rect: 306, 114, 380, 122 Annotation: Subtype: Link Rect: 318, 102, 318, 110 Destination: null Annotation: Subtype: Link Rect: 376, 102, 534, 110 Annotation: Subtype: Link Rect: 309, 37, 411, 45 Page: Label: 103522 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 49, 717, 49, 725 Destination: null Annotation: Subtype: Link Rect: 260, 705, 288, 713 Annotation: Subtype: Link Rect: 37, 693, 167, 701 Annotation: Subtype: Link Rect: 221, 607, 288, 615 Annotation: Subtype: Link Rect: 37, 595, 72, 603 Annotation: Subtype: Link Rect: 49, 584, 49, 592 Destination: null Annotation: Subtype: Link Rect: 158, 574, 288, 582 Destination: 186 Annotation: Subtype: Link Rect: 37, 563, 126, 571 Destination: 186 Annotation: Subtype: Link Rect: 49, 543, 49, 551 Destination: null Annotation: Subtype: Link Rect: 40, 501, 104, 509 Destination: 186 Annotation: Subtype: Link Rect: 165, 490, 236, 498 Destination: 186 Annotation: Subtype: Link Rect: 40, 469, 152, 477 Destination: 186 Annotation: Subtype: Link Rect: 49, 459, 49, 467 Destination: null Annotation: Subtype: Link Rect: 151, 438, 222, 446 Destination: 186 Annotation: Subtype: Link Rect: 196, 427, 216, 435 Destination: 186 Annotation: Subtype: Link Rect: 196, 427, 282, 435 Destination: 186 Annotation: Subtype: Link Rect: 218, 375, 283, 383 Destination: 186 Annotation: Subtype: Link Rect: 68, 323, 127, 331 Destination: 186 Annotation: Subtype: Link Rect: 306, 717, 306, 725 Destination: null Annotation: Subtype: Link Rect: 306, 696, 306, 704 Destination: null Annotation: Subtype: Link Rect: 318, 675, 318, 683 Destination: null Annotation: Subtype: Link Rect: 503, 654, 524, 662 Destination: 46 Annotation: Subtype: Link Rect: 365, 643, 386, 651 Destination: 46 Annotation: Subtype: Link Rect: 306, 576, 306, 584 Destination: null Annotation: Subtype: Link Rect: 318, 555, 318, 563 Destination: null Annotation: Subtype: Link Rect: 503, 534, 524, 542 Destination: 46 Annotation: Subtype: Link Rect: 365, 524, 386, 532 Destination: 46 Annotation: Subtype: Link Rect: 306, 446, 306, 454 Destination: null Annotation: Subtype: Link Rect: 318, 415, 318, 423 Destination: null Annotation: Subtype: Link Rect: 344, 320, 374, 328 Destination: 81 Annotation: Subtype: Link Rect: 37, 43, 37, 55 Destination: null Page: Label: 103523 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 37, 409, 37, 417 Destination: null Annotation: Subtype: Link Rect: 49, 377, 49, 385 Destination: null Annotation: Subtype: Link Rect: 49, 262, 49, 270 Destination: null Annotation: Subtype: Link Rect: 149, 239, 288, 247 Annotation: Subtype: Link Rect: 37, 227, 59, 235 Annotation: Subtype: Link Rect: 49, 154, 49, 162 Destination: null Annotation: Subtype: Link Rect: 37, 69, 37, 77 Destination: null Annotation: Subtype: Link Rect: 49, 48, 49, 56 Destination: null Annotation: Subtype: Link Rect: 306, 367, 306, 375 Destination: null Annotation: Subtype: Link Rect: 318, 346, 318, 354 Destination: null Annotation: Subtype: Link Rect: 306, 238, 306, 246 Destination: null Annotation: Subtype: Link Rect: 318, 217, 318, 225 Destination: null Annotation: Subtype: Link Rect: 521, 217, 557, 225 Destination: 186 Annotation: Subtype: Link Rect: 306, 207, 325, 215 Destination: 186 Annotation: Subtype: Link Rect: 381, 184, 482, 192 Annotation: Subtype: Link Rect: 480, 90, 510, 98 Destination: 102 Annotation: Subtype: Link Rect: 318, 58, 318, 66 Destination: null Annotation: Subtype: Link Rect: 37, 719, 37, 725 Destination: null Page: Label: 103524 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 343, 717, 370, 725 Destination: 102 Annotation: Subtype: Link Rect: 405, 696, 425, 704 Destination: 121 Annotation: Subtype: Link Rect: 430, 665, 514, 673 Destination: 186 Annotation: Subtype: Link Rect: 359, 655, 443, 663 Destination: 186 Annotation: Subtype: Link Rect: 434, 634, 454, 642 Destination: 121 Annotation: Subtype: Link Rect: 306, 613, 306, 621 Destination: null Annotation: Subtype: Link Rect: 318, 592, 318, 600 Destination: null Annotation: Subtype: Link Rect: 535, 477, 555, 485 Destination: 121 Annotation: Subtype: Link Rect: 306, 456, 306, 464 Destination: null Annotation: Subtype: Link Rect: 318, 425, 318, 432 Destination: null Annotation: Subtype: Link Rect: 368, 299, 389, 307 Destination: 133 Annotation: Subtype: Link Rect: 318, 289, 318, 297 Destination: null Annotation: Subtype: Link Rect: 318, 205, 318, 213 Destination: null Annotation: Subtype: Link Rect: 306, 132, 306, 140 Destination: null Annotation: Subtype: Link Rect: 318, 100, 318, 108 Destination: null Annotation: Subtype: Link Rect: 37, 39, 43, 39 Destination: null Page: Label: 103525 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 80, 141, 100, 149 Destination: 142 Annotation: Subtype: Link Rect: 49, 99, 49, 107 Destination: null Annotation: Subtype: Link Rect: 309, 130, 330, 138 Destination: 142 Annotation: Subtype: Link Rect: 318, 89, 318, 97 Destination: null Annotation: Subtype: Link Rect: 407, 68, 429, 76 Destination: 142 Annotation: Subtype: Link Rect: 37, 205, 37, 217 Destination: null Annotation: Subtype: Link Rect: 37, 460, 37, 472 Destination: null Page: Label: 103526 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 170, 96, 191, 104 Destination: 142 Annotation: Subtype: Link Rect: 49, 65, 49, 73 Destination: null Annotation: Subtype: Link Rect: 318, 159, 318, 167 Destination: null Annotation: Subtype: Link Rect: 352, 75, 437, 83 Destination: 186 Annotation: Subtype: Link Rect: 37, 232, 37, 244 Destination: null Page: Label: 103527 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 80, 344, 202, 352 Annotation: Subtype: Link Rect: 178, 301, 288, 309 Annotation: Subtype: Link Rect: 37, 288, 49, 296 Annotation: Subtype: Link Rect: 49, 278, 49, 286 Destination: null Annotation: Subtype: Link Rect: 263, 225, 283, 233 Destination: 169 Annotation: Subtype: Link Rect: 37, 184, 37, 192 Destination: null Annotation: Subtype: Link Rect: 49, 163, 49, 171 Destination: null Annotation: Subtype: Link Rect: 187, 132, 288, 140 Destination: 186 Annotation: Subtype: Link Rect: 37, 121, 83, 129 Destination: 186 Annotation: Subtype: Link Rect: 318, 336, 318, 344 Destination: null Annotation: Subtype: Link Rect: 358, 294, 557, 302 Destination: 186 Annotation: Subtype: Link Rect: 306, 283, 391, 291 Destination: 186 Annotation: Subtype: Link Rect: 531, 252, 557, 260 Destination: 186 Annotation: Subtype: Link Rect: 306, 242, 349, 250 Destination: 186 Annotation: Subtype: Link Rect: 334, 221, 557, 229 Destination: 186 Annotation: Subtype: Link Rect: 306, 210, 325, 218 Destination: 186 Annotation: Subtype: Link Rect: 429, 189, 512, 197 Destination: 186 Annotation: Subtype: Link Rect: 339, 168, 431, 176 Destination: 186 Annotation: Subtype: Link Rect: 529, 135, 557, 143 Annotation: Subtype: Link Rect: 306, 123, 400, 131 Annotation: Subtype: Link Rect: 318, 91, 318, 99 Destination: null Annotation: Subtype: Link Rect: 381, 39, 536, 47 Destination: 186 Annotation: Subtype: Link Rect: 37, 410, 37, 422 Destination: null Page: Label: 103528 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 49, 268, 49, 276 Destination: null Annotation: Subtype: Link Rect: 37, 69, 37, 77 Destination: null Annotation: Subtype: Link Rect: 49, 48, 49, 56 Destination: null Annotation: Subtype: Link Rect: 306, 245, 306, 253 Destination: null Annotation: Subtype: Link Rect: 318, 224, 318, 232 Destination: null Annotation: Subtype: Link Rect: 306, 139, 306, 147 Destination: null Annotation: Subtype: Link Rect: 306, 118, 306, 126 Destination: null Annotation: Subtype: Link Rect: 306, 107, 467, 115 Annotation: Subtype: Link Rect: 306, 79, 306, 87 Destination: null Annotation: Subtype: Link Rect: 306, 62, 306, 68 Destination: null Annotation: Subtype: Link Rect: 485, 46, 557, 52 Annotation: Subtype: Link Rect: 318, 38, 375, 44 Annotation: Subtype: Link Rect: 37, 375, 37, 387 Destination: null Page: Label: 103529 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 37, 719, 37, 725 Destination: null Annotation: Subtype: Link Rect: 37, 719, 288, 725 Annotation: Subtype: Link Rect: 49, 711, 288, 717 Annotation: Subtype: Link Rect: 49, 703, 152, 709 Annotation: Subtype: Link Rect: 37, 695, 37, 701 Destination: null Annotation: Subtype: Link Rect: 215, 671, 288, 678 Annotation: Subtype: Link Rect: 49, 663, 115, 670 Annotation: Subtype: Link Rect: 37, 655, 37, 662 Destination: null Annotation: Subtype: Link Rect: 37, 655, 288, 662 Annotation: Subtype: Link Rect: 49, 647, 288, 654 Annotation: Subtype: Link Rect: 49, 639, 225, 646 Annotation: Subtype: Link Rect: 37, 631, 37, 638 Destination: null Annotation: Subtype: Link Rect: 115, 623, 288, 630 Annotation: Subtype: Link Rect: 49, 615, 275, 622 Annotation: Subtype: Link Rect: 37, 599, 37, 606 Destination: null Annotation: Subtype: Link Rect: 37, 599, 288, 606 Annotation: Subtype: Link Rect: 49, 591, 263, 598 Annotation: Subtype: Link Rect: 37, 583, 37, 590 Destination: null Annotation: Subtype: Link Rect: 194, 560, 288, 566 Annotation: Subtype: Link Rect: 49, 552, 107, 558 Annotation: Subtype: Link Rect: 37, 544, 37, 550 Destination: null Annotation: Subtype: Link Rect: 254, 544, 288, 550 Annotation: Subtype: Link Rect: 49, 536, 118, 542 Annotation: Subtype: Link Rect: 37, 528, 37, 534 Destination: null Annotation: Subtype: Link Rect: 49, 496, 167, 502 Annotation: Subtype: Link Rect: 37, 488, 37, 494 Destination: null Annotation: Subtype: Link Rect: 198, 472, 288, 478 Annotation: Subtype: Link Rect: 49, 464, 98, 470 Annotation: Subtype: Link Rect: 37, 456, 37, 462 Destination: null Annotation: Subtype: Link Rect: 216, 432, 288, 438 Annotation: Subtype: Link Rect: 49, 424, 84, 430 Annotation: Subtype: Link Rect: 37, 416, 37, 422 Destination: null Annotation: Subtype: Link Rect: 123, 392, 222, 399 Annotation: Subtype: Link Rect: 37, 384, 37, 391 Destination: null Annotation: Subtype: Link Rect: 194, 360, 288, 367 Annotation: Subtype: Link Rect: 49, 352, 107, 359 Annotation: Subtype: Link Rect: 37, 344, 37, 351 Destination: null Annotation: Subtype: Link Rect: 154, 320, 245, 327 Annotation: Subtype: Link Rect: 37, 313, 37, 319 Destination: null Annotation: Subtype: Link Rect: 100, 297, 227, 303 Annotation: Subtype: Link Rect: 37, 281, 37, 287 Destination: null Annotation: Subtype: Link Rect: 242, 265, 288, 271 Annotation: Subtype: Link Rect: 49, 257, 151, 263 Annotation: Subtype: Link Rect: 37, 249, 37, 255 Destination: null Annotation: Subtype: Link Rect: 523, 711, 557, 717 Annotation: Subtype: Link Rect: 318, 703, 400, 709 Annotation: Subtype: Link Rect: 306, 687, 306, 693 Destination: null Annotation: Subtype: Link Rect: 440, 671, 554, 678 Annotation: Subtype: Link Rect: 306, 663, 306, 670 Destination: null Annotation: Subtype: Link Rect: 306, 647, 306, 654 Destination: null Annotation: Subtype: Link Rect: 399, 631, 506, 638 Annotation: Subtype: Link Rect: 306, 623, 306, 630 Destination: null Annotation: Subtype: Link Rect: 306, 623, 557, 630 Annotation: Subtype: Link Rect: 318, 615, 557, 622 Annotation: Subtype: Link Rect: 318, 607, 395, 614 Annotation: Subtype: Link Rect: 306, 599, 306, 606 Destination: null Annotation: Subtype: Link Rect: 414, 568, 545, 574 Annotation: Subtype: Link Rect: 306, 560, 306, 566 Destination: null Annotation: Subtype: Link Rect: 318, 528, 431, 534 Annotation: Subtype: Link Rect: 306, 520, 306, 526 Destination: null Annotation: Subtype: Link Rect: 306, 520, 557, 526 Annotation: Subtype: Link Rect: 318, 512, 557, 518 Annotation: Subtype: Link Rect: 318, 504, 553, 510 Annotation: Subtype: Link Rect: 306, 496, 306, 502 Destination: null Annotation: Subtype: Link Rect: 484, 472, 557, 478 Annotation: Subtype: Link Rect: 318, 464, 352, 470 Annotation: Subtype: Link Rect: 306, 456, 306, 462 Destination: null Annotation: Subtype: Link Rect: 306, 410, 306, 416 Destination: null Annotation: Subtype: Link Rect: 535, 386, 557, 392 Annotation: Subtype: Link Rect: 318, 378, 417, 384 Annotation: Subtype: Link Rect: 306, 370, 306, 376 Destination: null Annotation: Subtype: Link Rect: 306, 370, 557, 376 Annotation: Subtype: Link Rect: 318, 362, 518, 368 Annotation: Subtype: Link Rect: 306, 354, 306, 360 Destination: null Annotation: Subtype: Link Rect: 511, 338, 557, 344 Annotation: Subtype: Link Rect: 318, 330, 407, 336 Annotation: Subtype: Link Rect: 306, 322, 306, 328 Destination: null Annotation: Subtype: Link Rect: 481, 290, 557, 296 Annotation: Subtype: Link Rect: 318, 282, 373, 288 Annotation: Subtype: Link Rect: 306, 274, 306, 281 Destination: null Annotation: Subtype: Link Rect: 425, 258, 547, 265 Checksum: a857655e Type: CRC32 Checksum: 02ecba81f102af671b80683ab42acf47 Type: MD5 Checksum: c34fb084de31fa7069c9557f533e17df563e8b28 Type: SHA-1 Checksum: b2a6bbb7a8b4ad0096dafac4c8da3c7e81c23cb0400c1beddb03cb45609d3d5d Type: SHA-256