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Item: Title: Systemic cellular viroimmunotherapy for canine high-­grade gliomas Children: Item: Title: Abstract Item: Title: Background Item: Title: Material and methods Children: Item: Title: Patient selection Item: Title: Clinical study design Item: Title: Cell culture and dCelyvir preparation Item: Title: MRI and RAVNO criteria Item: Title: Histopathology, diagnosis, and immunohistochemistry Item: Title: Cytokine analysis Item: Title: Antiviral-specific antibodies Item: Title: DNA extraction from blood and tissues and qPCR analysis Item: Title: Flow cytometry Item: Title: RNA extraction, gene expression, and tumor-infiltrating immune cell profile Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: Canine patient demographics and clinical status Item: Title: Safety and toxicity of dCelyvir Item: Title: Imaging findings Item: Title: Clinical outcome Item: Title: Virus and antiviral antibody detection Item: Title: Immune response in peripheral blood Item: 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