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Objects: 761 FreeObjects: 1 IncrementalUpdates: 3 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Probiotic effects on immunity and microbiome in HIV-1 discordant patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Cohort description Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Treatment formulations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: T-cell and inflammation marker quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Faecal DNA extraction, library preparation and sequencing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Sequence filtering and quality control Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Taxonomy annotation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Gene function and pathway diversity analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Alpha and beta diversity metrics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Statistical testing Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Cohort description and follow-up Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Safety and adverse events Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Synbiotic formulation does not affect CD4+ and CD8+ counts but correlates with increased CD4/CD8 ratio and reduced inflammatio温㸾൥湤潢樍㜵㌠〠潢樼㰯偡牥湴‷㌴‰⁒⽎數琠㜵㈠〠刯䑥獴⣾＀猀㌀开㈩⽐牥瘠㜳㔠〠刯呩瑬攨Safety and adverse events Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Intervention doesn’t correlate with faecal microbiome changes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Synbiotic supplementation affects sulphate assimilation on the gut Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Presence of probiotic strains in faeces does not relate to changes in faecal microbiome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Detection of probiotic in faeces associates with decreased inflammation (CRP, IL-6) while non-detection associates with incre愀猀攀搀 䌀䐀㐀⼀䌀䐀㠀 爀愀琀椀漩㸾൥湤潢樍㜴㤠〠潢樼㰯偡牥湴‷㌴‰⁒⽎數琠㜴㠠〠刯䑥獴⣾＀猀㌀开㘩⽐牥瘠㜵〠〠刯呩瑬攨Presence of probiotic strains in faeces does not relate to changes in faecal microbiome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Probiotic presence in faeces is not coupled with lower abundances of ASR pathways Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Supplementary material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Info: Title: Probiotic effects on immunity and microbiome in HIV-1 discordant patients Author: Carlos Blázquez-Bondia Subject: Background: Some HIV-1 infected patients are unable to completely recover normal CD4+ T-cell (CD4+) counts after achieving HIV-1 suppression with combined Antiretroviral Therapy (cART), hence being classified as immuno-discordant Keywords: probiotics, prebiotics, synbiotics, HIV, immune reconstitution Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Thu Dec 08 03:08:41 CET 2022 ModDate: Thu Dec 08 04:03:13 CET 2022 ID: 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hence being classified as immuno-discordant Probiotic effects on immunity and microbiome in HIV-1 discordant patients Carlos Blázquez-Bondia Mariona Parera Francesc Català-Moll Maria Casadellà Aleix Elizalde-Torrent Meritxell Aguilo´ Jordi Espadaler-Mazo José Ramon Santos Roger Paredes Marc Noguera-Julian probiotics prebiotics synbiotics HIV immune reconstitution uuid:797a6971-132f-4825-a191-5f5b03c03c15 uuid:90944a3b-c067-4bb0-a82b-f7a0ab6eb616 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 686, 509, 707 Annotation: Subtype: Link Rect: 222, 661, 466, 682 Annotation: Subtype: Link Rect: 222, 636, 407, 657 Annotation: Subtype: Link Rect: 56, 39, 136, 46 Annotation: Subtype: Link Rect: 492, 39, 538, 46 Annotation: Subtype: Link Rect: 56, 691, 133, 706 Annotation: Subtype: Link Rect: 56, 530, 128, 537 Annotation: Subtype: Link Rect: 56, 340, 167, 347 Annotation: Subtype: Link Rect: 96, 272, 155, 279 Annotation: Subtype: Link Rect: 56, 263, 140, 270 Annotation: 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