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Title:          Copy-number intratumor heterogeneity increases the risk of relapse in chemotherapy-naive stage II colon cancer
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      Title: Copy-number intratumor heterogeneity increases the risk of relapse in chemotherapy-naive stage II colon cancer
      Destination: atl_PATH_5870_
      Children: 
       Item: 
        Title: Introduction
        Destination: HeadingPATH_5870path5870-sec-0001
       Item: 
        Title: Materials and methods
        Destination: HeadingPATH_5870path5870-sec-0002
        Children: 
         Item: 
          Title: Cohorts of patients and tumor samples
          Destination: HeadingPATH_5870path5870-sec-0003
         Item: 
          Title: SNP arrays and copy-number analysis
          Destination: HeadingPATH_5870path5870-sec-0004
         Item: 
          Title: Targeted next-generation sequencing
          Destination: HeadingPATH_5870path5870-sec-0005
         Item: 
          Title: Predictive modeling by machine learning analysis
          Destination: HeadingPATH_5870path5870-sec-0006
       Item: 
        Title: Results
        Destination: HeadingPATH_5870path5870-sec-0007
        Children: 
         Item: 
          Title: Clinicopathological characteristics and their prognostic value in the study population
          Destination: HeadingPATH_5870path5870-sec-0008
         Item: 
          Title: Specific chromosomal aberrations and high CNA load in recurrent tumors
          Destination: HeadingPATH_5870path5870-sec-0009
         Item: 
          Title: Recurrent tumors exhibit an increased number of subclonal copy-number alterations
          Destination: HeadingPATH_5870path5870-sec-0010
         Item: 
          Title: Subclonal SNV and indel counts are not associated with disease relapse
          Destination: HeadingPATH_5870path5870-sec-0011
         Item: 
          Title: Tumor aneuploidy and intratumor heterogeneity are associated with risk of disease relapse
          Destination: HeadingPATH_5870path5870-sec-0012
         Item: 
          Title: Genomic markers improve the prediction of disease recurrence compared with clinicopathological parameters alone
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       Item: 
        Title: Discussion
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       Item: 
        Title: Acknowledgements
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       Item: 
        Title: Author contributions statement
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        Children: 
         Item: 
          Title: Data availability statement
          Destination: HeadingPATH_5870path5870-sec-0018
       Item: 
        Title: References
        Destination: HeadingPATH_5870path5870-bibl-00011
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      Annotation: 
       Subtype: Link
       Rect: 433, 23, 538, 31
     Thumb: true
    Page: 
     Label: 81
     Sequence: 14
     Annotations: 
      Annotation: 
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       Rect: 267, 23, 323, 31
      Annotation: 
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     Thumb: true
  Checksum: c6ad9f0a
   Type: CRC32
  Checksum: 0112ea16547c8f83345134b9e18eb57b
   Type: MD5
  Checksum: f0bd68ddaf5f701b1186ee06e312b1ca9c2ca940
   Type: SHA-1
  Checksum: 9442c593958fe7032644e926a0004e6283385a9117dbc38262d44cf01083ea59
   Type: SHA-256