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Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 749 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis Children: Item: Title: Abstract Children: Item: Title: Background: Item: Title: Results: Item: Title: Conclusions: Item: Title: Background Item: Title: Results Children: Item: Title: Identifying functional genes in lipid-associated loci Item: Title: Effects of protein-altering lipid alleles with protective effects on CAD, T2D, and NAFLD Item: Title: Driver tissues for lipid levels Item: Title: Polygenic scores for lipid phenotypes and phenome-wide association scans Item: Title: Lipid loci show sex-specific effects Item: Title: Lipid-associated loci on the X chromosome Item: Title: Discussion Item: Title: Conclusions Item: Title: Methods Children: Item: Title: Meta-analysis Item: Title: Replication Item: Title: Gene prioritization methods Children: Item: Title: Closest gene Item: Title: Colocalization with GTEx eQTLs Item: Title: Transcriptome-wide association studies (TWAS) Item: Title: Genes with coding variants Item: Title: DEPICT Item: Title: PoPS Item: Title: Monogenic genes Item: Title: Mouse knockout lipid phenotype silver set genes Item: Title: Overlap between methods Item: Title: Text mining analysis Item: Title: Drug target mining analysis Item: Title: Driver tissues for lipid levels Item: Title: PheWAS analysis Children: Item: Title: Construction of lipid PGSs Item: Title: PheWAS of lipid PGSs and index lipid variants in the UK Biobank and MVP Item: Title: Meta-analysis of MVP and the UK Biobank PheWAS results Item: Title: Lipid index variants with CAD, T2D, and NAFLD datasets Children: Item: Title: GWAS and meta-analysis of NAFLD in the UK Biobank and Michigan Genomics Initiative (MGI) Item: Title: CADT2D colocalization analysis with lipid traits Item: Title: Acknowledgements Item: Title: References Info: Title: Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis Author: Stavroula Kanoni Subject: Genome Biology, https://doi.org/10.1186/s13059-022-02837-1 Keywords: Cholesterol;Lipids;Genetics;Genome-wide association study;GWAS Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Sat Dec 24 05:25:17 CET 2022 ModDate: Tue Dec 27 10:18:22 CET 2022 ID: 0x40691aefbdc8631e6ce7280a26a03433, 0xaad863e22636e7a5473cb3ad9ef25ed5 Filters: FilterPipeline: 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Graham Yuxuan Wang Ida Surakka Shweta Ramdas Xiang Zhu Shoa L. Clarke Konain Fatima Bhatti Sailaja Vedantam Thomas W. Winkler Adam E. Locke Eirini Marouli Greg J. M. Zajac Kuan-Han H. Wu Ioanna Ntalla Qin Hui Derek Klarin Austin T. Hilliard Zeyuan Wang Chao Xue Gudmar Thorleifsson Anna Helgadottir Daniel F. Gudbjartsson Hilma Holm Isleifur Olafsson Mi Yeong Hwang Sohee Han Masato Akiyama Saori Sakaue Chikashi Terao Masahiro Kanai Wei Zhou Ben M. Brumpton Humaira Rasheed Aki S. Havulinna Yogasudha Veturi Jennifer Allen Pacheco Elisabeth A. Rosenthal Todd Lingren QiPing Feng Iftikhar J. Kullo Akira Narita Jun Takayama Hilary C. Martin Karen A. Hunt Bhavi Trivedi Jeffrey Haessler Franco Giulianini Yuki Bradford Jason E. Miller Archie Campbell Kuang Lin Iona Y. Millwood Asif Rasheed George Hindy Jessica D. Faul Wei Zhao David R. Weir Constance Turman Hongyan Huang Mariaelisa Graff Ananyo Choudhury Dhriti Sengupta Anubha Mahajan Michael R. Brown Weihua Zhang Ketian Yu Ellen M. Schmidt Anita Pandit Stefan Gustafsson Xianyong Yin Jian’an Luan Jing-Hua Zhao Fumihiko Matsuda Hye-Mi Jang Kyungheon Yoon Carolina Medina-Gomez Achilleas Pitsillides Jouke Jan Hottenga Andrew R. Wood Yingji Ji Zishan Gao Simon Haworth Noha A. Yousri Ruth E. Mitchell Jin Fang Chai Mette Aadahl Anne A. Bjerregaard Jie Yao Ani Manichaikul Chii-Min Hwu Yi-Jen Hung Helen R. Warren Julia Ramirez Jette Bork-Jensen Line L. Kårhus Anuj Goel Maria Sabater-Lleal Raymond Noordam Pala Mauro Floris Matteo Aaron F. McDaid Pedro Marques-Vidal Matthias Wielscher Stella Trompet Naveed Sattar Line T. Møllehave Matthias Munz Lingyao Zeng Jianfeng Huang Bin Yang Alaitz Poveda Azra Kurbasic Claudia Lamina Lukas Forer Markus Scholz Tessel E. Galesloot Jonathan P. Bradfield Sanni E. Ruotsalainen EWarwick Daw Joseph M. Zmuda Jonathan S. Mitchell Christian Fuchsberger Henry Christensen Jennifer A. Brody Miguel Vazquez-Moreno Mary F. Feitosa Mary K. Wojczynski Zhe Wang Michael H. 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Willer Themistocles L. Assimes Gina M. Peloso 10.1186/s13059-022-02837-1 2010-04-23 true springer.com springerlink.com https://doi.org/10.1186/s13059-022-02837-1 10.1186/s13059-022-02837-1 1474-760X journal Genome Biology The Author(s) 2010-04-23 true 10.1186/s13059-022-02837-1 noindex springer.com springerlink.com uuid:ff32c557-3ead-4442-af48-42717df3ba0d uuid:ac95ce07-1c59-4ed8-b534-a40c9c280025 default 1 converted uuid:ff32c557-3ead-4442-af48-42717df3ba0d converted to PDF/A-2b pdfToolbox 2022-12-26T04:57:49Z 2 B Gina M. 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