c114422f4fea274372e03db109abd653 pmc_9798322.pdf 2f22de9c097c0b2c7e027d6ec745a160f23a0279 pmc_9798322.pdf 20de56fff890c69959a30f1b10c3b3d55900fde7fe0923c3e354803c6b3e2733 pmc_9798322.pdf Title: Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment: Comparison between self-administration and experimenter-administration Subject: Intracranial electrical self-stimulation (ICSS) is a useful procedure in animal research. Keywords: intracranial self-stimulation, medial forebrain bundle (MFB), brain reward system, learning, memory Author: Laia Vila-Solés Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.16 CreationDate: Wed Dec 14 04:39:52 2022 CET ModDate: Wed Dec 14 05:35:59 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 21 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 7979775 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GLQLWF+MinionPro-Regular Type 1 Custom yes yes no 35 0 LZSCWM+MuseoSans-700 Type 1 Custom yes yes no 36 0 IOCWJM+MuseoSans-300 Type 1 Custom yes yes no 37 0 PIXMQJ+MuseoSans-300Italic Type 1 Custom yes yes no 42 0 OKMQQU+MuseoSans-500 Type 1 Custom yes yes no 43 0 PVERPS+MinionPro-Bold Type 1 Custom yes yes no 159 0 VQGHBK+MTSYN Type 1 Builtin yes yes no 263 0 TYIUKF+MinionPro-It Type 1 Custom yes yes no 397 0 CFTLTF+MTGU Type 1 Builtin yes yes no 398 0 XODHDR+RBLMI Type 1 Builtin yes yes no 634 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-01-20 02:29:58 CET RepresentationInformation: pmc_9798322.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-01-19 02:14:33 CET Size: 7979775 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1137 FreeObjects: 45 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment: Comparison between self-administration and experimenter-administration Children: Item: Title: Introduction Item: Title: Materials and equipment Children: Item: Title: Stimulation electrode and ground screw materials Item: Title: Surgery equipment Item: Title: Electrical brain stimulation equipment Children: Item: Title: Skinner box Item: Title: Stimulator Item: Title: Behavioral apparatus Item: Title: Methods Children: Item: Title: Stimulation electrode and ground screw preparation Item: Title: Stereotaxic surgery Item: Title: Behavior shaping and optimal intensity search (OIS) Item: Title: Morris Water Maze acquisition Item: Title: Intracranial electrical stimulation treatment Item: Title: Morris Water Maze retention Item: Title: Tissue collection and immunohistochemical study Item: Title: Results Children: Item: Title: Quantification and statistical analysis Item: Title: Optimal intensity of ICSS and responses rate evolution Item: Title: Learning and memory outcomes Children: Item: Title: Acquisition Item: Title: Retention Item: Title: Immunohistochemistry outcomes Item: Title: Advantages and limitations Item: Title: Troubleshooting Item: Title: Discussion Item: Title: Key resources table Item: Title: Data availability statement Item: Title: Ethics statement Item: Title: Author contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: Conflict of interest Item: Title: Publisher's note Item: Title: Supplementary material Item: Title: References Info: Title: Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment: Comparison between self-administration and experimenter-administration Author: Laia Vila-Solés Subject: Intracranial electrical self-stimulation (ICSS) is a useful procedure in animal research. Keywords: intracranial self-stimulation, medial forebrain bundle (MFB), brain reward system, learning, memory Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.16 CreationDate: Wed Dec 14 05:09:52 CET 2022 ModDate: Wed Dec 14 06:05:59 CET 2022 ID: 0x5525f8c6417fcfe00a582e76ba18331b, 0x150997baf4f3664ab13bde1f7f084af8 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: GLQLWF+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 250 FontDescriptor: FontName: GLQLWF+MinionPro-Regular Flags: Symbolic FontBBox: -289, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: LZSCWM+MuseoSans-700 FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: LZSCWM+MuseoSans-700 Flags: Symbolic FontBBox: -125, -210, 1126, 902 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: IOCWJM+MuseoSans-300 FontSubset: true FirstChar: 2 LastChar: 242 FontDescriptor: FontName: IOCWJM+MuseoSans-300 Flags: Symbolic FontBBox: -118, -210, 1088, 883 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VQGHBK+MTSYN FontSubset: true FirstChar: 2 LastChar: 48 FontDescriptor: FontName: VQGHBK+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: PIXMQJ+MuseoSans-300Italic FontSubset: true FirstChar: 46 LastChar: 118 FontDescriptor: FontName: PIXMQJ+MuseoSans-300Italic Flags: Symbolic FontBBox: -245, -210, 1030, 883 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: XODHDR+RBLMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: XODHDR+RBLMI Flags: Symbolic FontBBox: -11, -230, 987, 750 FontFile: true Font: BaseFont: OKMQQU+MuseoSans-500 FontSubset: true FirstChar: 2 LastChar: 237 FontDescriptor: FontName: OKMQQU+MuseoSans-500 Flags: Symbolic FontBBox: -121, -210, 1088, 892 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: TYIUKF+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: TYIUKF+MinionPro-It Flags: Symbolic FontBBox: -201, -360, 1684, 919 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CFTLTF+MTGU FontSubset: true FirstChar: 97 LastChar: 109 FontDescriptor: FontName: CFTLTF+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: PVERPS+MinionPro-Bold FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: PVERPS+MinionPro-Bold Flags: Symbolic FontBBox: -318, -360, 1684, 917 FontFile: true EncodingDictionary: Differences: true XMP: intracranial self-stimulation, medial forebrain bundle (MFB), brain reward system, learning, memory pdfTeX-1.40.16 1.5 application/pdf fnbeh-16-1046259.tex Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment: Comparison between self-administration and experimenter-administration Intracranial electrical self-stimulation (ICSS) is a useful procedure in animal research. Laia Vila-Solés Soleil García-Brito Laura Aldavert-Vera Elisabet Kádár Gemma Huguet Ignacio Morgado-Bernal Pilar Segura-Torres 2022-12-14T09:09:52+05:30 intracranial self-stimulation medial forebrain bundle (MFB) brain reward system learning memory 2022-12-14T09:09:52+05:30 2022-12-14T10:05:59+05:30 2022-12-14T10:05:59+05:30 LaTeX with hyperref package uuid:88dceaea-888d-4c46-ab18-826ce4182626 uuid:251e5ea4-4b6b-43dc-8412-e2a04af41e81 Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 55, 784, 291, 800 Annotation: Subtype: Link Rect: 428, 792, 481, 801 Annotation: Subtype: Link Rect: 428, 784, 532, 792 Annotation: Subtype: Link Rect: 428, 772, 544, 783 Annotation: Subtype: Link Rect: 56, 689, 133, 706 Annotation: Subtype: Link Rect: 69, 328, 166, 335 Annotation: Subtype: Link Rect: 55, 260, 83, 267 Annotation: Subtype: Link Rect: 83, 260, 119, 267 Annotation: Subtype: Link Rect: 119, 260, 155, 267 Annotation: Subtype: Link Rect: 155, 260, 181, 267 Annotation: 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Annotation: Subtype: Link Rect: 497, 595, 539, 604 Annotation: Subtype: Link Rect: 317, 589, 379, 596 Annotation: Subtype: Link Rect: 435, 567, 537, 575 Annotation: Subtype: Link Rect: 457, 538, 539, 547 Annotation: Subtype: Link Rect: 317, 531, 320, 538 Annotation: Subtype: Link Rect: 421, 509, 489, 518 Annotation: Subtype: Link Rect: 325, 474, 423, 482 Annotation: Subtype: Link Rect: 55, 39, 176, 48 Annotation: Subtype: Link Rect: 491, 39, 539, 48 Checksum: 7615788b Type: CRC32 Checksum: c114422f4fea274372e03db109abd653 Type: MD5 Checksum: 2f22de9c097c0b2c7e027d6ec745a160f23a0279 Type: SHA-1