1d147c0af74a73a9831d2100b94d08b6  pmc_9803977.pdf
704c6bf1332763a2ea2e508b4754e2c45daf8e65  pmc_9803977.pdf
b764c959c6053bf9266f03b075b3f6cf2fa16e98cfb2ef84bb2d8abbda58784d  pmc_9803977.pdf

Title:          ICLAS LAQ Network for the Promotion of Animal Quality in Research
Subject:        AcademicSubjects/SCI01290, DOI: 10.1093/ilar/ilac003, ILAR Journal, 62, 3, 24 03 2022. Abstract: ICLAS Laboratory Animal Quality Network (LAQN) programs currently consist of the Performance Evaluation Program (PEP), which focuses on microbial monitoring by and for laboratory animal diagnostic laboratories, and the Genetic Reference Monitoring Program (GENRef), which provides assay-ready reference DNA for genetic testing of mouse strains. Since 2008, PEP has grown to become a truly international program with participating laboratories in 5 continents. Launched in 2016, GENRef currently distributes DNA from 12 common inbred mouse strains for use in genetic monitoring of locally inbred colonies as well as for genetic testing of stocks, particularly genetically engineered stocks, of uncertain origins. GENRef has the capacity to include additional strains as well as additional species. PEP and GENRef provide the reagents at cost, as a resource to the international scientific community, in the interest of improving research quality in an environment of growing concern for research quality, rigor, and reproducibility. 
Keywords:       
Author:         
Creator:        LaTeX with hyperref package
Producer:       Acrobat Distiller 22.0 (Windows)
CreationDate:   Mon Dec 26 10:31:10 2022 CET
ModDate:        Mon Dec 26 10:31:10 2022 CET
Tagged:         yes
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          6
Encrypted:      no
Page size:      612.616 x 792.466 pts
Page rot:       0
File size:      690676 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
ADHBDK+CaeciliaLTStd-Bold            Type 1C           Custom           yes yes yes    614  0
ADHBDL+CaeciliaLTStd-Roman           Type 1C           Custom           yes yes yes    615  0
ADHBGL+CaeciliaLTStd-Italic          Type 1C           Custom           yes yes yes    616  0
ADHBLK+MTSYN                         Type 1C           Custom           yes yes yes    617  0
ADHCBJ+CaeciliaLTStd-Heavy           Type 1C           Custom           yes yes yes    618  0
ADHDIB+Wingdings-Regular             Type 1C           Custom           yes yes no       8  0
ADHDJC+TimesNewRomanPSMT             Type 1C           WinAnsi          yes yes no       9  0
ADHDJD+TimesNewRomanPS-BoldMT        Type 1C           WinAnsi          yes yes no      10  0
ADHIEI+CaeciliaLTStd-BoldItalic      Type 1C           Custom           yes yes yes     32  0
ADHIBI+MTMI                          Type 1C           Custom           yes yes yes     33  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-02-02 02:36:47 CET
 RepresentationInformation: pmc_9803977.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-01-19 02:14:16 CET
  Size: 690676
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF, Tagged PDF
  PDFMetadata: 
   Objects: 654
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: true
     CenterWindow: false
     DisplayDocTitle: true
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title:  ICLAS LAQ Network for the Promotion of Animal Quality in Research
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
      Children: 
       Item: 
        Title: BACKGROUND  
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
       Item: 
        Title: LABORATORY ANIMAL QUALITY NETWORK
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
       Item: 
        Title: PERFORMANCE EVALUATION PROGRAM
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
       Item: 
        Title: IMPLEMENTATION OF PEP
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
       Item: 
        Title: PEP PARTICIPANTS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
       Item: 
        Title: PEP PROCEDURE
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
       Item: 
        Title: PEP SELF-ASSESSMENT
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
       Item: 
        Title: FUTURE CHALLENGES FOR PEP
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
       Item: 
        Title: GENETIC REFERENCE MONITORING PROGRAM
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
       Item: 
        Title: IMPLEMENTATION OF THE GENREF PROGRAM
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
       Item: 
        Title: GENREF SPECIMEN PRODUCTION  
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
       Item: 
        Title: FUTURE CHALLENGES FOR GENREF
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
       Item: 
        Title: CONCLUSION
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
   Info: 
    Title: ICLAS LAQ Network for the Promotion of Animal Quality in Research
    Author: 
    Subject: AcademicSubjects/SCI01290, DOI: 10.1093/ilar/ilac003, ILAR Journal, 62, 3, 24 03 2022. Abstract: ICLAS Laboratory Animal Quality Network (LAQN) programs currently consist of the Performance Evaluation Program (PEP), which focuses on microbial monitoring by and for laboratory animal diagnostic laboratories, and the Genetic Reference Monitoring Program (GENRef), which provides assay-ready reference DNA for genetic testing of mouse strains. Since 2008, PEP has grown to become a truly international program with participating laboratories in 5 continents. Launched in 2016, GENRef currently distributes DNA from 12 common inbred mouse strains for use in genetic monitoring of locally inbred colonies as well as for genetic testing of stocks, particularly genetically engineered stocks, of uncertain origins. GENRef has the capacity to include additional strains as well as additional species. PEP and GENRef provide the reagents at cost, as a resource to the international scientific community, in the interest of improving research quality in an environment of growing concern for research quality, rigor, and reproducibility. 
    Keywords: 
    Creator: LaTeX with hyperref package
    Producer: Acrobat Distiller 22.0 (Windows)
    CreationDate: Mon Dec 26 11:01:10 CET 2022
    ModDate: Mon Dec 26 11:01:10 CET 2022
   ID: 0x0a7a2286ccf734eac91505ceb03490c2, 0x586f7c41b48bc78909e7a2b5a458eb58
   Filters: 
    FilterPipeline: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: ADHIEI+CaeciliaLTStd-BoldItalic
      FontSubset: true
      FirstChar: 46
      LastChar: 116
      FontDescriptor: 
       FontName: ADHIEI+CaeciliaLTStd-BoldItalic
       Flags: Serif, Symbolic, Italic, ForceBold
       FontBBox: -169, -273, 1082, 932
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ADHIBI+MTMI
      FontSubset: true
      FirstChar: 181
      LastChar: 181
      FontDescriptor: 
       FontName: ADHIBI+MTMI
       Flags: Serif, Symbolic, Italic
       FontBBox: 0, -213, 987, 680
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ADHBDK+CaeciliaLTStd-Bold
      FontSubset: true
      FirstChar: 46
      LastChar: 122
      FontDescriptor: 
       FontName: ADHBDK+CaeciliaLTStd-Bold
       Flags: Serif, Symbolic, ForceBold
       FontBBox: -166, -273, 1141, 938
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ADHBDL+CaeciliaLTStd-Roman
      FontSubset: true
      FirstChar: 35
      LastChar: 169
      FontDescriptor: 
       FontName: ADHBDL+CaeciliaLTStd-Roman
       Flags: Serif, Symbolic
       FontBBox: -167, -270, 1136, 926
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ADHBGL+CaeciliaLTStd-Italic
      FontSubset: true
      FirstChar: 44
      LastChar: 120
      FontDescriptor: 
       FontName: ADHBGL+CaeciliaLTStd-Italic
       Flags: Serif, Symbolic, Italic
       FontBBox: -166, -270, 1053, 915
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ADHDIB+Wingdings-Regular
      FontSubset: true
      FirstChar: 2
      LastChar: 5
      FontDescriptor: 
       FontName: ADHDIB+Wingdings-Regular
       Flags: Symbolic
       FontBBox: 0, -211, 1359, 899
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: ADHBLK+MTSYN
      FontSubset: true
      FirstChar: 2
      LastChar: 138
      FontDescriptor: 
       FontName: ADHBLK+MTSYN
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 900
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ADHDJC+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: ADHDJC+TimesNewRomanPSMT
       Flags: Nonsymbolic
       FontBBox: -13, -216, 869, 695
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ADHCBJ+CaeciliaLTStd-Heavy
      FontSubset: true
      FirstChar: 45
      LastChar: 116
      FontDescriptor: 
       FontName: ADHCBJ+CaeciliaLTStd-Heavy
       Flags: Serif, Symbolic, ForceBold
       FontBBox: -170, -277, 1146, 970
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ADHDJD+TimesNewRomanPS-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: ADHDJD+TimesNewRomanPS-BoldMT
       Flags: Nonsymbolic
       FontBBox: -558, -328, 2000, 1056
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
<rdf:RDF xmlns:rdf = "http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:xap = "http://ns.adobe.com/xap/1.0/" xmlns:xapRights = "http://ns.adobe.com/xap/1.0/rights/" xmlns:dc = "http://purl.org/dc/elements/1.1/">
<rdf:Description rdf:about="">
<dc:format>application/pdf</dc:format>
<dc:title>ICLAS LAQ Network for the Promotion of Animal Quality in Research</dc:title>
<dc:creator><rdf:Seq><rdf:li>Vergara Patri</rdf:li><rdf:li>Ballard Gregory</rdf:li><rdf:li>Besch-Williford Cynthia</rdf:li><rdf:li>Hayashimoto Nobuhito</rdf:li><rdf:li>Pekow Cynthia</rdf:li><rdf:li>Perez Ana</rdf:li><rdf:li>Schmidt Katja</rdf:li><rdf:li>Shek William</rdf:li><rdf:li>Toft Martin</rdf:li><rdf:li>Yoshiki Atsushi</rdf:li></rdf:Seq></dc:creator>
<dc:description>AcademicSubjects/SCI01290, DOI: 10.1093/ilar/ilac003, ILAR Journal, 62, 3, 24 03 2022. Abstract: ICLAS Laboratory Animal Quality Network (LAQN) programs currently consist of the Performance Evaluation Program (PEP), which focuses on microbial monitoring by and for laboratory animal diagnostic laboratories, and the Genetic Reference Monitoring Program (GENRef), which provides assay-ready reference DNA for genetic testing of mouse strains. Since 2008, PEP has grown to become a truly international program with participating laboratories in 5 continents. Launched in 2016, GENRef currently distributes DNA from 12 common inbred mouse strains for use in genetic monitoring of locally inbred colonies as well as for genetic testing of stocks, particularly genetically engineered stocks, of uncertain origins. GENRef has the capacity to include additional strains as well as additional species. PEP and GENRef provide the reagents at cost, as a resource to the international scientific community, in the interest of improving research quality in an environment of growing concern for research quality, rigor, and reproducibility. </dc:description>
<dc:subject><rdf:Bag><rdf:li>animal models</rdf:li><rdf:li>diagnostic testing</rdf:li><rdf:li>genetic testing</rdf:li><rdf:li>mice</rdf:li><rdf:li>rats</rdf:li><rdf:li>reproducibility of results</rdf:li><rdf:li>quality control</rdf:li><rdf:li>virus</rdf:li></rdf:Bag></dc:subject>
<dc:rights>&#x00A9; The Author(s) 2021. Published by Oxford University Press on behalf of the National Academies of Sciences, Engineering, and Medicine. All rights reserved. For permissions, please email: journals.permissions@oup.com</dc:rights>
<xapRights:Marked>True</xapRights:Marked>
</rdf:Description>
</rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 337
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 452, 75, 502, 84
      Annotation: 
       Subtype: Link
       Rect: 61, 66, 169, 74
      Annotation: 
       Subtype: Link
       Rect: 61, 692, 127, 746
      Annotation: 
       Subtype: Link
       Rect: 312, 714, 425, 723
      Annotation: 
       Subtype: Link
       Rect: 487, 181, 490, 187
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 396, 170, 399, 176
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 400, 170, 404, 176
       Destination: 28
    Page: 
     Label: 338
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 200, 442, 203, 448
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 477, 467, 480, 473
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 494, 234, 520, 240
       Destination: 4
      Annotation: 
       Subtype: Link
       Rect: 346, 143, 372, 149
       Destination: 20
    Page: 
     Label: 339
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 313, 122, 339, 128
       Destination: 20
    Page: 
     Label: 340
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 240, 277, 265, 283
       Destination: 20
      Annotation: 
       Subtype: Link
       Rect: 149, 233, 178, 241
       Destination: 23
    Page: 
     Label: 341
     Sequence: 5
    Page: 
     Label: 342
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 294, 714, 298, 720
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 100, 693, 103, 699
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 451, 725, 454, 731
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 456, 725, 459, 731
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 315, 468, 368, 477
      Annotation: 
       Subtype: Link
       Rect: 316, 402, 322, 407
       Destination: 594
      Annotation: 
       Subtype: Link
       Rect: 316, 360, 322, 365
       Destination: 594
      Annotation: 
       Subtype: Link
       Rect: 316, 318, 322, 324
       Destination: 594
      Annotation: 
       Subtype: Link
       Rect: 316, 287, 322, 292
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 316, 245, 322, 250
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 316, 193, 322, 198
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 316, 161, 322, 167
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 316, 130, 322, 135
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 316, 99, 322, 104
       Destination: 28
  Checksum: 6a774d41
   Type: CRC32
  Checksum: 1d147c0af74a73a9831d2100b94d08b6
   Type: MD5
  Checksum: 704c6bf1332763a2ea2e508b4754e2c45daf8e65
   Type: SHA-1