e379a1c8c66ec455fcd615d016758b8e pmc_9817972.pdf 553b31d6118cb70fb7cf4825d8335c5fd07db22c pmc_9817972.pdf 2b43813b4eb05995b9a2546797e1713cfc8916ffdf6d425e856cdd8778c43b83 pmc_9817972.pdf Title: Immune Response and Effects of COVID-19 Vaccination in Patients with Lung Cancer—COVID Lung Vaccine Study Subject: Lung cancer patients represent a subgroup of special vulnerability in whom the SARS-CoV-2 infection could attain higher rates of morbidity and mortality. Therefore, those patients were recommended to receive SARS-CoV-2 vaccines once they were approved. However, little was known at that time regarding the degree of immunity developed after vaccination or vaccine-related adverse events, and more uncertainty involved the real need for a third dose. We sought to evaluate the immune response developed after vaccination, as well as the safety and efficacy of SARS-CoV-2 vaccines in a cohort of patients with lung cancer. Patients were identified through the Oncology/Hematology Outpatient Vaccination Program. Anti-Spike IgG was measured before any vaccine and at 3–6-, 6–9- and 12–15-month time points after the 2nd dose. Detailed clinical data were also collected. In total, 126 patients with lung cancer participated and received at least one dose of the SARS-CoV-2 vaccine. At 3–6 months after 2nd dose, 99.1% of baseline seronegative patients seroconverted and anti-Spike IgG titers went from a median value of 9.45 to 720 UI/mL. At the 6–9-month time point, titers raised to a median value of 924 UI/mL, and at 12–15 months, after the boost dose, they reached a median value of 3064 UI/mL. Adverse events to the vaccine were mild, and no SARS- CoV-2 infection-related deaths were recorded. In this lung cancer cohort, COVID-19 vaccines were safe and effective irrespective of the systemic anticancer therapy. Most of the patients developed anti-Spike IgG after the second dose, and these titers were maintained over time with low infection and reinfection rates with a mild clinical course. Keywords: SARS-CoV-2; lung cancer; vaccination immune response; anti-spike antibodies Author: Ainhoa Hernandez, Marc Boigues, Eudald Felip, Marc Cucurull, Lucia Notario, Anna Pous, Pere Torres, Marta Benitez, Marina Rodriguez, Bibiana Quirant, Margarita Romeo, Daniel Fuster and Teresa Moran Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Jan 5 01:49:45 2023 CET ModDate: Thu Jan 5 01:55:42 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1428997 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GXRZWQ+VnURWPalladioL Type 1 Custom yes yes no 10 0 LBDCCH+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 TGJDFM+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 AXVHWT+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 43 0 CNXSVA+CMSY10 Type 1 Builtin yes yes no 65 0 JOPOHO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 75 0 JOPOHP+PalatinoLinotype CID TrueType Identity-H yes yes yes 78 0 JOPOIA+PalatinoLinotype TrueType WinAnsi yes yes no 84 0 JOPOIC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 87 0 JOPPLL+Calibri,Italic CID TrueType Identity-H yes yes yes 90 0 RIJDHR+CMBSY10 Type 1 Builtin yes yes no 103 0 JOPOHO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 119 0 JOPOIA+PalatinoLinotype TrueType WinAnsi yes yes no 122 0 JOPOIC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 125 0 JOPOHO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 138 0 JOPOHP+PalatinoLinotype CID TrueType Identity-H yes yes yes 141 0 JOPOIA+PalatinoLinotype TrueType WinAnsi yes yes no 147 0 JOPOIC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 150 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-08 02:34:12 CET RepresentationInformation: pmc_9817972.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2023-08-02 02:20:41 CEST Size: 1428997 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 395 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Material and Methods Destination: section.2 Children: Item: Title: Serologies Destination: subsection.2.1 Item: Title: Statistical Considerations Destination: subsection.2.2 Item: Title: Results Destination: section.3 Children: Item: Title: Cohort Description Destination: subsection.3.1 Item: Title: Type of Vaccines Destination: subsection.3.2 Item: Title: Prior Serologic Status Destination: subsection.3.3 Item: Title: Seroconversion Destination: subsection.3.4 Item: Title: Adverse Events to Vaccines Destination: subsection.3.5 Item: Title: Protection Destination: subsection.3.6 Item: Title: Mortality Destination: subsection.3.7 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.5 Info: Title: Immune Response and Effects of COVID-19 Vaccination in Patients with Lung Cancer COVID Lung Vaccine Study Author: Ainhoa Hernandez, Marc Boigues, Eudald Felip, Marc Cucurull, Lucia Notario, Anna Pous, Pere Torres, Marta Benitez, Marina Rodriguez, Bibiana Quirant, Margarita Romeo, Daniel Fuster and Teresa Moran Subject: Lung cancer patients represent a subgroup of special vulnerability in whom the SARS-CoV-2 infection could attain higher rates of morbidity and mortality. Therefore, those patients were recommended to receive SARS-CoV-2 vaccines once they were approved. However, little was known at that time regarding the degree of immunity developed after vaccination or vaccine-related adverse events, and more uncertainty involved the real need for a third dose. We sought to evaluate the immune response developed after vaccination, as well as the safety and efficacy of SARS-CoV-2 vaccines in a cohort of patients with lung cancer. Patients were identified through the Oncology/Hematology Outpatient Vaccination Program. Anti-Spike IgG was measured before any vaccine and at 3 6-, 6 9- and 12 15-month time points after the 2nd dose. Detailed clinical data were also collected. In total, 126 patients with lung cancer participated and received at least one dose of the SARS-CoV-2 vaccine. At 3 6 months after 2nd dose, 99.1% of baseline seronegative patients seroconverted and anti-Spike IgG titers went from a median value of 9.45 to 720 UI/mL. At the 6 9-month time point, titers raised to a median value of 924 UI/mL, and at 12 15 months, after the boost dose, they reached a median value of 3064 UI/mL. Adverse events to the vaccine were mild, and no SARS- CoV-2 infection-related deaths were recorded. In this lung cancer cohort, COVID-19 vaccines were safe and effective irrespective of the systemic anticancer therapy. Most of the patients developed anti-Spike IgG after the second dose, and these titers were maintained over time with low infection and reinfection rates with a mild clinical course. 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