9bc9481d89bee95939e402f28c0b99ab pmc_9826217.pdf 3c1411edb682c3744e1d8e30208002d9c9600f10 pmc_9826217.pdf 9a6bf71cbd079187374ff1279e56026f00b01a2e42af08aa08cc53d5fd82672c pmc_9826217.pdf Title: Host‐associated variability of the cdtABC operon, coding for the cytolethal distending toxin, in Campylobacter jejuni Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Thu Nov 3 07:32:39 2022 CET ModDate: Thu Nov 3 07:32:46 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 8459123 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XFPTRD+Lato-Bold CID TrueType Identity-H yes yes yes 355 0 HCNWBJ+Lato-Regular CID TrueType Identity-H yes yes yes 356 0 HCNWBJ+Lato-Bold TrueType WinAnsi yes yes yes 357 0 RELELP+Lato-Regular TrueType WinAnsi yes yes yes 358 0 RELELP+Lato-Italic TrueType WinAnsi yes yes yes 359 0 CFYSJT+Lato-BoldItalic TrueType WinAnsi yes yes yes 372 0 RELELP+Lato-Regular TrueType WinAnsi yes yes yes 225 0 MFZBNZ+Lato-Regular-SC700 TrueType WinAnsi yes yes yes 222 0 RELELP+Lato-Regular TrueType WinAnsi yes yes yes 230 0 MFZBNZ+Lato-Regular-SC700 TrueType WinAnsi yes yes yes 231 0 CFYSJT+STIX-Regular Type 1C WinAnsi yes yes yes 234 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-22 02:39:49 CEST RepresentationInformation: pmc_9826217.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-20 02:26:31 CEST Size: 8459123 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 391 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseThumbs Language: en-US Outlines: Item: Title: Host-­associated variability of the cdtABC operon, coding for the cytolethal distending toxin, in Campylobacter jejuni Children: Item: Title: Abstract Item: Title: 1|INTRODUCTION Item: Title: 2|MATERIALS AND METHODS Children: Item: Title: 2.1|Bacterial strains and culture conditions Item: Title: 2.2|PCR amplification Item: Title: 2.3|Genome sequencing Item: Title: 2.4|Phylogenetic analysis Item: Title: 2.5|Ethics approval Item: Title: 3|RESULTS Children: Item: Title: 3.1|The prevalence of the cdtA, cdtB and cdtC genes is highly variable among Campylobacter jejuni isolates from wild birds Item: Title: 3.2|Different cdtB alleles detected among the wild bird isolates Item: Title: 3.3|Whole-­genome sequencing reveals a high diversity in the cdtABC locus among wild bird isolates Item: Title: 3.4|Several Campylobacter jejuni isolates from wild birds carry nonfunctional cdtABC operons Item: Title: 4|DISCUSSION Item: Title: AUTHOR CONTRIBUTIONS Item: Title: ACKNOWLEDGEMENTS Item: Title: FUNDING INFORMATION Item: Title: CONFLICT OF INTEREST Children: Item: Title: DATA AVAILABILITY STATEMENT Item: Title: REFERENCES Info: Title: Host‐associated variability of the cdtABC operon, coding for the cytolethal distending toxin, in Campylobacter jejuni Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Thu Nov 03 08:02:39 CET 2022 ModDate: Thu Nov 03 08:02:46 CET 2022 ID: 0x0c913fd0b9fdcf40a1e74579632af68d, 0xf942d807e1cd5008105182575413b01a Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1876 ImageHeight: 3294 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2997 ImageHeight: 852 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2525 ImageHeight: 3454 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2867 ImageHeight: 2284 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2224 ImageHeight: 1803 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: XFPTRD+Lato-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: HCNWBJ+Lato-Regular Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: CFYSJT+STIX-Regular FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: CFYSJT+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true TrueType: Font: BaseFont: CFYSJT+Lato-BoldItalic FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: CFYSJT+Lato-BoldItalic Flags: Nonsymbolic, Italic FontBBox: -520, -283, 1293, 1098 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: HCNWBJ+Lato-Bold FontSubset: true FirstChar: 49 LastChar: 124 FontDescriptor: FontName: HCNWBJ+Lato-Bold Flags: Nonsymbolic FontBBox: -603, -285, 1344, 1100 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: RELELP+Lato-Regular FontSubset: true FirstChar: 32 LastChar: 243 FontDescriptor: FontName: RELELP+Lato-Regular Flags: Nonsymbolic FontBBox: -546, -268, 1342, 1079 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: RELELP+Lato-Italic FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: RELELP+Lato-Italic Flags: Nonsymbolic, Italic FontBBox: -501, -268, 1290, 1077 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: HCNWBJ+Lato-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: HCNWBJ+Lato-Regular Flags: Symbolic FontBBox: -546, -268, 1342, 1079 FontFile2: true Font: BaseFont: XFPTRD+Lato-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: XFPTRD+Lato-Bold Flags: Symbolic FontBBox: -603, -285, 1344, 1100 FontFile2: true XMP: 2022-11-08T15:00:55+05:30 2022-11-08T15:00:55+05:30 2022-11-08T15:00:55+05:30 Acrobat Distiller 10.1.7 (Windows) 10.1111/zph.12994 10.1111/(ISSN)1863-2378 3 VoR 10.1111/zph.12994 application/pdf Host‐associated variability of the cdtABC operon, coding for the cytolethal distending toxin, in Campylobacter jejuni uuid:406147a1-963f-44d4-ad04-a5585895a3bc uuid:89f49aca-fec9-4699-a2f8-d1d1ad9d29aa Pages: Page: Label: 966 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 72, 34, 180, 25 Annotation: Subtype: Link Rect: 267, 159, 286, 149 ActionDest: 182 Annotation: Subtype: Link Rect: 108, 146, 127, 136 ActionDest: 182 Annotation: Subtype: Link Rect: 178, 107, 197, 97 ActionDest: 182 Annotation: Subtype: Link Rect: 460, 211, 479, 201 ActionDest: 182 Annotation: Subtype: Link Rect: 463, 172, 482, 162 ActionDest: 182 Annotation: Subtype: Link Rect: 122, 608, 127, 592 ActionDest: 294 Annotation: Subtype: Link Rect: 274, 608, 286, 592 ActionDest: 294 Annotation: Subtype: Link Rect: 379, 608, 384, 592 ActionDest: 294 Annotation: Subtype: Link Rect: 485, 608, 497, 592 ActionDest: 294 Annotation: Subtype: Link Rect: 497, 606, 510, 593 Annotation: Subtype: Link Rect: 201, 590, 206, 574 ActionDest: 294 Annotation: Subtype: Link Rect: 319, 590, 319, 574 Annotation: Subtype: Link Rect: 319, 590, 324, 574 ActionDest: 294 Annotation: Subtype: Link Rect: 324, 588, 336, 575 Annotation: Subtype: Link Rect: 437, 590, 437, 574 Annotation: Subtype: Link Rect: 437, 590, 442, 574 ActionDest: 294 Annotation: Subtype: Link Rect: 442, 588, 455, 575 Annotation: Subtype: Link Rect: 211, 74, 395, 65 Annotation: Subtype: Link Rect: 66, 351, 130, 342 Annotation: Subtype: Link Rect: 45, 341, 98, 332 Page: Label: 967 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 154, 731, 172, 721 ActionDest: 205 Annotation: Subtype: Link Rect: 146, 679, 165, 669 ActionDest: 182 Annotation: Subtype: Link Rect: 128, 627, 148, 617 ActionDest: 205 Annotation: Subtype: Link Rect: 66, 601, 85, 591 ActionDest: 182 Annotation: Subtype: Link Rect: 228, 575, 248, 565 ActionDest: 205 Annotation: Subtype: Link Rect: 254, 419, 273, 409 ActionDest: 182 Annotation: Subtype: Link Rect: 87, 406, 106, 396 ActionDest: 182 Annotation: Subtype: Link Rect: 189, 406, 208, 396 ActionDest: 182 Annotation: Subtype: Link Rect: 267, 406, 286, 396 ActionDest: 182 Annotation: Subtype: Link Rect: 94, 393, 112, 383 ActionDest: 205 Annotation: Subtype: Link Rect: 157, 393, 175, 383 ActionDest: 205 Annotation: Subtype: Link Rect: 226, 211, 244, 201 ActionDest: 182 Annotation: Subtype: Link Rect: 415, 393, 419, 383 ActionDest: 1 Annotation: Subtype: Link Rect: 395, 380, 414, 370 ActionDest: 205 Annotation: Subtype: Link Rect: 510, 198, 529, 188 ActionDest: 182 Page: Label: 968 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 66, 614, 85, 604 ActionDest: 205 Annotation: Subtype: Link Rect: 169, 614, 188, 604 ActionDest: 205 Annotation: Subtype: Link Rect: 94, 484, 112, 474 ActionDest: 182 Annotation: Subtype: Link Rect: 200, 471, 218, 461 ActionDest: 205 Annotation: Subtype: Link Rect: 97, 432, 117, 422 ActionDest: 205 Annotation: Subtype: Link Rect: 170, 120, 174, 110 ActionDest: 67 Annotation: Subtype: Link Rect: 73, 94, 78, 84 ActionDest: 67 Annotation: Subtype: Link Rect: 492, 705, 511, 695 ActionDest: 182 Annotation: Subtype: Link Rect: 331, 692, 350, 682 ActionDest: 205 Annotation: Subtype: Link Rect: 480, 432, 484, 422 ActionDest: 67 Annotation: Subtype: Link Rect: 536, 237, 545, 227 ActionDest: 76 Annotation: Subtype: Link Rect: 536, 172, 545, 162 ActionDest: 76 Annotation: Subtype: Link Rect: 421, 81, 429, 71 ActionDest: 76 Page: Label: 969 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 175, 81, 184, 71 ActionDest: 76 Page: Label: 970 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 72, 510, 81, 500 ActionDest: 205 Annotation: Subtype: Link Rect: 122, 510, 131, 500 ActionDest: 205 Annotation: Subtype: Link Rect: 279, 471, 284, 461 ActionDest: 67 Annotation: Subtype: Link Rect: 277, 406, 286, 396 ActionDest: 205 Annotation: Subtype: Link Rect: 82, 393, 90, 383 ActionDest: 205 Annotation: Subtype: Link Rect: 94, 367, 103, 357 ActionDest: 76 Annotation: Subtype: Link Rect: 275, 354, 284, 344 ActionDest: 76 Annotation: Subtype: Link Rect: 471, 510, 480, 500 ActionDest: 76 Annotation: Subtype: Link Rect: 333, 484, 342, 474 ActionDest: 76 Annotation: Subtype: Link Rect: 503, 445, 511, 435 ActionDest: 76 Annotation: Subtype: Link Rect: 341, 432, 350, 422 ActionDest: 115 Annotation: Subtype: Link Rect: 356, 367, 365, 357 ActionDest: 115 Annotation: Subtype: Link Rect: 434, 289, 444, 279 ActionDest: 115 Page: Label: 971 Sequence: 6 Page: Label: 972 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 239, 198, 248, 188 ActionDest: 148 Annotation: Subtype: Link Rect: 277, 198, 286, 188 ActionDest: 205 Annotation: Subtype: Link Rect: 82, 185, 90, 175 ActionDest: 205 Annotation: Subtype: Link Rect: 160, 94, 169, 84 ActionDest: 148 Annotation: Subtype: Link Rect: 499, 159, 504, 149 ActionDest: 154 Annotation: Subtype: Link Rect: 538, 159, 547, 149 ActionDest: 205 Annotation: Subtype: Link Rect: 306, 146, 315, 136 ActionDest: 205 Annotation: Subtype: Link Rect: 335, 146, 344, 136 ActionDest: 205 Annotation: Subtype: Link Rect: 387, 146, 396, 136 ActionDest: 205 Annotation: Subtype: Link Rect: 451, 81, 460, 71 ActionDest: 115 Annotation: Subtype: Link Rect: 499, 81, 503, 71 ActionDest: 154 Annotation: Subtype: Link Rect: 508, 68, 512, 58 ActionDest: 154 Annotation: Subtype: Link Rect: 434, 315, 443, 304 ActionDest: 76 Page: Label: 973 Sequence: 8 Page: Label: 974 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 470, 727, 479, 716 ActionDest: 76 Page: Label: 975 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 242, 263, 261, 253 ActionDest: 182 Annotation: Subtype: Link Rect: 163, 224, 182, 214 ActionDest: 182 Annotation: Subtype: Link Rect: 236, 224, 255, 214 ActionDest: 182 Annotation: Subtype: Link Rect: 334, 393, 353, 383 ActionDest: 205 Annotation: Subtype: Link Rect: 401, 172, 420, 162 ActionDest: 182 Annotation: Subtype: Link Rect: 473, 172, 492, 162 ActionDest: 182 Annotation: Subtype: Link Rect: 525, 146, 545, 136 ActionDest: 182 Annotation: Subtype: Link Rect: 396, 68, 416, 58 ActionDest: 205 Page: Label: 976 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 97, 161, 109, 149 Annotation: Subtype: Link Rect: 110, 159, 258, 149 Annotation: Subtype: Link Rect: 104, 148, 117, 136 Annotation: Subtype: Link Rect: 117, 146, 264, 136 Annotation: Subtype: Link Rect: 98, 135, 111, 123 Annotation: Subtype: Link Rect: 111, 133, 258, 123 Page: Label: 977 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 63, 643, 219, 633 Annotation: Subtype: Link Rect: 217, 580, 288, 570 Annotation: Subtype: Link Rect: 63, 570, 87, 560 Annotation: Subtype: Link Rect: 354, 449, 479, 438 Checksum: eed9ce79 Type: CRC32 Checksum: 9bc9481d89bee95939e402f28c0b99ab Type: MD5 Checksum: 3c1411edb682c3744e1d8e30208002d9c9600f10 Type: SHA-1