c644ba05c8e5d2b250860350a17a5c67 pmc_9831655.pdf a1aa7e48be6a96e830c9dd4cbdbe7f509b01a2d1 pmc_9831655.pdf ab54b6232fa8b179f5b3cdec06b76aa8395c69e4a5e4d20c9f48557bc2025fd1 pmc_9831655.pdf Title: Case report: Challenges in immune reconstitution following hematopoietic stem cell transplantation for CTLA-4 insufficiency-like primary immune regulatory disorders Subject: Cytotoxic T-lymphocyte antigen-4 (CTLA-4) haploinsufficiency is a T-cell hyperactivation disorder that can manifest with both immunodeficiency and immune dysregulation Keywords: "CTLA-4, primary immunodeficiency, hematopoietic stem cell transplantation, abatacept, immune reconstitution, chimerism" Author: Adriana Margarit-Soler; Àngela Deyà-Martı´nez; Juan Torres Canizales; Alexandru Vlagea; Ana Garcı´a-Garcı´a; Ju´ lia Marsal; Maria Trabazo Del Castillo; Sı´lviaPlanas; Sı´lvia Simo; Ana Esteve-Sole; Marı´a Sua´rez-Lledo´ Grande; Isabel Badell; Montserrat Rovira Tarrats; Francesc Fernández-Avilés; Laia Alsina Creator: Arbortext Advanced Print Publisher 10.0.1306/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Mon Dec 26 23:50:28 2022 CET ModDate: Mon Dec 26 23:59:54 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.389 x 841.663 pts Page rot: 0 File size: 1057530 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IDMHCN+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 648 0 IDMHCO+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 649 0 IDMHDP+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 650 0 IDMHEA+AdvPSA18C Type 1C WinAnsi yes yes no 651 0 IDMHEB+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 652 0 IDMHEC+AdvPSA323 Type 1C Custom yes yes no 660 0 IDMHED+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 661 0 IDMHEE+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 662 0 IDMHEF+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 663 0 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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B51' cannot be found Offset: 1028905 MIMEtype: application/pdf PDFMetadata: Objects: 728 FreeObjects: 1 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Clinical description Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Case 1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Case 2 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Patient perspective and informed consent Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Supplementary material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Info: Title: Case report: Challenges in immune reconstitution 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Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2022-12-27T06:59:54+08:00 application/pdf Case report: Challenges in immune reconstitution following hematopoietic stem cell transplantation for CTLA-4 insufficiency-like primary immune regulatory disorders Adriana Margarit-Soler; Àngela Deyà-Martı´nez; Juan Torres Canizales; Alexandru Vlagea; Ana Garcı´a-Garcı´a; Ju´ lia Marsal; Maria Trabazo Del Castillo; Sı´lviaPlanas; Sı´lvia Simo; Ana Esteve-Sole; Marı´a Sua´rez-Lledo´ Grande; Isabel Badell; Montserrat Rovira Tarrats; Francesc Fernández-Avilés; Laia Alsina Cytotoxic T-lymphocyte antigen-4 (CTLA-4) haploinsufficiency is a T-cell hyperactivation disorder that can manifest with both immunodeficiency and immune dysregulation CTLA-4, primary immunodeficiency, hematopoietic stem cell transplantation, abatacept, immune reconstitution, chimerism uuid:14a27d46-2e6c-4d5b-bbee-ddb9e098c846 uuid:7227d52c-7dfa-4bc3-9adc-75c33dfecc94 Pages: Page: Label: 1 Annotations: Annotation: Subtype: 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