f3eb4b52b46aa69be75bcf430264e70f pmc_9865329.pdf 6ff33c3eb209c62b8be6df6c50818cf6a341d80c pmc_9865329.pdf 0a4cd8457d3d2a3fac459fb04702211d0d27b11c1c51a7b6975c0f43903ef8b2 pmc_9865329.pdf Title: Mouse Models for Mycobacterium tuberculosis Pathogenesis: Show and Do Not Tell Subject: Science has been taking profit from animal models since the first translational experiments back in ancient Greece. From there, and across all history, several remarkable findings have been obtained using animal models. One of the most popular models, especially for research in infectious diseases, is the mouse. Regarding research in tuberculosis, the mouse has provided useful information about host and bacterial traits related to susceptibility to the infection. The effect of aging, sexual dimorphisms, the route of infection, genetic differences between mice lineages and unbalanced immunity scenarios upon Mycobacterium tuberculosis infection and tuberculosis development has helped, helps and will help biomedical researchers in the design of new tools for diagnosis, treatment and prevention of tuberculosis, despite various discrepancies and the lack of deep study in some areas of these traits. Keywords: tuberculosis; mouse; C3HeB/FeJ; vaccines; immunopathology; chemotherapy; tolerance; resistance; history Author: Pablo Soldevilla, Cristina Vilaplana and Pere-Joan Cardona Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Dec 28 11:37:23 2022 CET ModDate: Wed Dec 28 11:41:48 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 33 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1699176 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UCQIXI+VnURWPalladioL Type 1 Custom yes yes no 10 0 ROPRQN+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 YJRHUI+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 WNZYOX+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 VSDRPX+URWPalladioL-BoldItal Type 1 Custom yes yes no 28 0 UXHOAG+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 47 0 TMWBXL+EURM10 Type 1 Builtin yes yes no 72 0 FXXUVH+CMSY10 Type 1 Builtin yes yes no 80 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 88 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 92 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 96 0 BCDHEE+PalatinoLinotype-BoldItalic TrueType WinAnsi yes yes no 100 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 104 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 124 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 128 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 132 0 BCDHEE+PalatinoLinotype-BoldItalic TrueType WinAnsi yes yes no 136 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 140 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 182 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 186 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 190 0 BCDIEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 194 0 BLQQCU+EURM7 Type 1 Builtin yes yes no 215 0 IOLAWT+PazoMath-Italic Type 1 Builtin yes yes no 260 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-04 02:30:30 CEST RepresentationInformation: pmc_9865329.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-01-26 02:11:37 CET Size: 1699176 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 997 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Tuberculosis: Knowing the Enemy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: M. tuberculosis Infectious Pathway Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Role of Mice in the Study of Tuberculosis Development Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Children: Item: Title: Age Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Sex Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Route of Infection, Quantity and Virulence of Administered Bacteria Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Genetic Background (Lineages of Mice) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Immune Imbalance Scenarios Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Info: Title: Mouse Models for Mycobacterium tuberculosis Pathogenesis: Show and Do Not Tell Author: Pablo Soldevilla, Cristina Vilaplana and Pere-Joan Cardona Subject: Science has been taking profit from animal models since the first translational experiments back in ancient Greece. From there, and across all history, several remarkable findings have been obtained using animal models. One of the most popular models, especially for research in infectious diseases, is the mouse. Regarding research in tuberculosis, the mouse has provided useful information about host and bacterial traits related to susceptibility to the infection. The effect of aging, sexual dimorphisms, the route of infection, genetic differences between mice lineages and unbalanced immunity scenarios upon Mycobacterium tuberculosis infection and tuberculosis development has helped, helps and will help biomedical researchers in the design of new tools for diagnosis, treatment and prevention of tuberculosis, despite various discrepancies and the lack of deep study in some areas of these traits. 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