cbd53241e672c86e44b6553776c7706f  pmc_9970954.pdf
9ac7ffabf224c1fa83d734d28d61b96a50a50a5a  pmc_9970954.pdf
4dd304733cd3d0076d6ceae266487b35b3992685793fa1db6abd5b75a19c1bc4  pmc_9970954.pdf

Title:          Neural correlates of digital measures shown by structural MRI: a post-hoc analysis of a smartphone-based remote assessment feasibility study in multiple sclerosis
Subject:        Journal of Neurology, https://doi.org/10.1007/s00415-022-11494-0
Keywords:       Multiple sclerosis; Smartphone sensor; MRI; Neural correlates; Digital health technology tools
Author:         Marco Ganzetti 
Creator:        Springer
Producer:       Acrobat Distiller 10.1.8 (Windows)
CreationDate:   Mon Dec 26 05:41:23 2022 CET
ModDate:        Sat Feb 18 17:31:17 2023 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          13
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      1144557 bytes
Optimized:      yes
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes    715  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes    713  0
MyriadPro-SemiboldSemiCn             Type 1C           Custom           yes no  yes    714  0
PYBYWN+MyriadPro-Bold                Type 1C           WinAnsi          yes yes yes    726  0
ULCHIK+STIX-Regular                  Type 1C           Custom           yes yes yes    727  0
STIX-Italic                          Type 1C           WinAnsi          yes no  yes    733  0
AXJLPS+Wingdings-Regular             Type 1C           WinAnsi          yes yes yes    739  0
PIPSFQ+MyriadPro-SemiCn2             Type 1C           WinAnsi          yes yes yes    778  0
Springnew-Regular                    Type 1C           WinAnsi          yes no  yes    749  0
MyriadPro-BoldSemiCn                 Type 1C           Custom           yes no  yes    329  0
TMTSUM+ArialMT                       Type 1C           WinAnsi          yes yes no     413  0
ArialMT2                             Type 1C           WinAnsi          yes no  no     412  0
TMTSUM+Arial-BoldMT                  Type 1C           WinAnsi          yes yes no     414  0
Arial-BoldMT2                        Type 1C           WinAnsi          yes no  no     420  0
ArialMT3                             Type 1C           WinAnsi          yes no  no     418  0
DVWGOS+STIX-Bold                     Type 1C           WinAnsi          yes yes yes    419  0
ArialMT4                             Type 1C           WinAnsi          yes no  no     448  0
Arial-BoldMT3                        Type 1C           WinAnsi          yes no  no     453  0
YQUSMC+Arial-ItalicMT                Type 1C           WinAnsi          yes yes no     457  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-06-22 02:32:08 CEST
 RepresentationInformation: pmc_9970954.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-03-09 02:13:23 CET
  Size: 1144557
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 842
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Neural correlates of digital measures shown by structural MRI: a post-hoc analysis of a smartphone-based remote assessment fea猀椀戀椀氀椀琀礀 猀琀甀搀礀 椀渀ꀀ洀甀氀琀椀瀀氀攀 猀挀氀攀爀漀猀椀猩㸾൥湤潢樍㜹㠠〠潢樍㰼⽄⠴ㄵ弲〲㉟ㄱ㐹㑟䅲瑩捬攮楮摤㩁湣桯爠ㄺㄳ㤩⽓⽇潔漾㸍敮摯扪ഷ㤹‰扪഼㰯䄠㠳㈠〠刯䍛〮〠〮〠〮そ⽃潵湴‴⽆‰⽆楲獴‸㌳‰⁒⽌慳琠㠳㐠〠刯乥硴‸ㄴ‰⁒⽐慲敮琠㜹㜠〠刯呩瑬攨Abstract
      Children: 
       Item: 
        Title: Abstract
        Children: 
         Item: 
          Title: Background 
         Item: 
          Title: Methods 
         Item: 
          Title: Results 
         Item: 
          Title: Conclusions 
       Item: 
        Title: Introduction
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Study design and participants
         Item: 
          Title: Floodlight PoC app
          Children: 
           Item: 
            Title: Smartphone sensor-based tests
           Item: 
            Title: Digital data processing
         Item: 
          Title: MRI acquisition and processing
          Children: 
           Item: 
            Title: Image acquisition
           Item: 
            Title: Image processing
         Item: 
          Title: Standard clinical measures
         Item: 
          Title: Statistical analysis
       Item: 
        Title: Results
       Item: 
        Title: Discussion
       Item: 
        Title: Conclusions
       Item: 
        Title: Acknowledgements 
       Item: 
        Title: References
   Info: 
    Title: Neural correlates of digital measures shown by structural MRI: a post-hoc analysis of a smartphone-based remote assessment feasibility study in multiple sclerosis
    Author: Marco Ganzetti 
    Subject: Journal of Neurology, https://doi.org/10.1007/s00415-022-11494-0
    Keywords: Multiple sclerosis; Smartphone sensor; MRI; Neural correlates; Digital health technology tools
    Creator: Springer
    Producer: Acrobat Distiller 10.1.8 (Windows)
    CreationDate: Mon Dec 26 06:11:23 CET 2022
    ModDate: Sat Feb 18 18:01:17 CET 2023
   ID: 0x731a07dc21b59b4a98ac3f7a4d34f5d8, 0x7c5d75563652464da84efcaacd46d898
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2032
      ImageHeight: 618
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1336
      ImageHeight: 33
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2436
      ImageHeight: 800
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 251
      ImageHeight: 25
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: ArialMT4
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: ArialMT4
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: ArialMT3
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: ArialMT3
       Flags: Nonsymbolic
       FontBBox: -222, -325, 1072, 1037
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: AXJLPS+Wingdings-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: AXJLPS+Wingdings-Regular
       Flags: Nonsymbolic
       FontBBox: 0, -103, 1359, 439
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: DVWGOS+STIX-Bold
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: DVWGOS+STIX-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -998, -552, 2000, 1055
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: Arial-BoldMT2
      FirstChar: 32
      LastChar: 119
      FontDescriptor: 
       FontName: Arial-BoldMT2
       Flags: Nonsymbolic
       FontBBox: -167, -376, 1075, 1048
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Arial-BoldMT3
      FirstChar: 32
      LastChar: 119
      FontDescriptor: 
       FontName: Arial-BoldMT3
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1056
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-BoldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-BoldSemiCn
       Flags: Nonsymbolic
       FontBBox: -133, -250, 1161, 894
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: YQUSMC+Arial-ItalicMT
      FontSubset: true
      FirstChar: 32
      LastChar: 82
      FontDescriptor: 
       FontName: YQUSMC+Arial-ItalicMT
       Flags: Nonsymbolic
       FontBBox: -517, -325, 1359, 998
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-SemiboldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldSemiCn
       Flags: Nonsymbolic
       FontBBox: -131, -250, 1115, 886
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiCn
       Flags: Nonsymbolic
       FontBBox: -128, -250, 1059, 876
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: PYBYWN+MyriadPro-Bold
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: PYBYWN+MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: ULCHIK+STIX-Regular
      FontSubset: true
      FirstChar: 22
      LastChar: 250
      FontDescriptor: 
       FontName: ULCHIK+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ArialMT2
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: ArialMT2
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: STIX-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIX-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: TMTSUM+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: TMTSUM+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: TMTSUM+Arial-BoldMT
      FontSubset: true
      FirstChar: 32
      LastChar: 146
      FontDescriptor: 
       FontName: TMTSUM+Arial-BoldMT
       Flags: Nonsymbolic
       FontBBox: -628, -376, 2000, 1056
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2019/10/10-02:41:22        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:crossmark="http://crossref.org/crossmark/1.0/"
            xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
            xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
            xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/"
            xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
            xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
            xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
            xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
            xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
            xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#">
         <xmp:CreateDate>2022-12-26T10:11:23+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2023-02-18T22:01:17+05:30</xmp:ModifyDate>
         <xmp:MetadataDate>2023-02-18T22:01:17+05:30</xmp:MetadataDate>
         <pdf:Producer>Acrobat Distiller 10.1.8 (Windows)</pdf:Producer>
         <pdf:Keywords>Multiple sclerosis; Smartphone sensor; MRI; Neural correlates; Digital health technology tools</pdf:Keywords>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1007/s00415-022-11494-0</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer Berlin Heidelberg</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Journal of Neurology, https://doi.org/10.1007/s00415-022-11494-0</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Multiple sclerosis</rdf:li>
               <rdf:li>Smartphone sensor</rdf:li>
               <rdf:li>MRI</rdf:li>
               <rdf:li>Neural correlates</rdf:li>
               <rdf:li>Digital health technology tools</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Neural correlates of digital measures shown by structural MRI: a post-hoc analysis of a smartphone-based remote assessment feasibility study in multiple sclerosis</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Marco Ganzetti </rdf:li>
               <rdf:li>Jennifer S. Graves </rdf:li>
               <rdf:li>Sven P. Holm </rdf:li>
               <rdf:li>Frank Dondelinger </rdf:li>
               <rdf:li>Luciana Midaglia </rdf:li>
               <rdf:li>Laura Gaetano </rdf:li>
               <rdf:li>Licinio Craveiro </rdf:li>
               <rdf:li>Florian Lipsmeier </rdf:li>
               <rdf:li>Corrado Bernasconi </rdf:li>
               <rdf:li>Xavier Montalban </rdf:li>
               <rdf:li>Stephen L. Hauser </rdf:li>
               <rdf:li>Michael Lindemann </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1007/s00415-022-11494-0</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1007/s00415-022-11494-0</prism:url>
         <prism:doi>10.1007/s00415-022-11494-0</prism:doi>
         <prism:issn>1432-1459</prism:issn>
         <prism:volume>270</prism:volume>
         <prism:number>3</prism:number>
         <prism:startingPage>1624</prism:startingPage>
         <prism:endingPage>1636</prism:endingPage>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Journal of Neurology</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1007/s00415-022-11494-0</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>CVoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:04af9a67-c880-4544-895b-06059e6ab2e3</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:0820ecdf-cfa2-4e24-a871-0ce44e22fb88</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:f18865d3-3f64-4d02-8ac2-b289dea6184c</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2023-02-18T22:00:23+05:30</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:d5c6eba2-5ede-4a04-a80c-b01666959f7b</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2023-02-18T22:01:17+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Marco Ganzetti</author:name>
                  <author:orcid>http://orcid.org/0000-0002-7049-171X</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Jennifer S. Graves</author:name>
                  <author:orcid>http://orcid.org/0000-0003-1539-1940</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Sven P. Holm</author:name>
                  <author:orcid>http://orcid.org/0000-0001-5947-3388</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Frank Dondelinger</author:name>
                  <author:orcid>http://orcid.org/0000-0003-1816-6300</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Luciana Midaglia</author:name>
                  <author:orcid>http://orcid.org/0000-0001-7981-2228</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Laura Gaetano</author:name>
                  <author:orcid>http://orcid.org/0000-0002-5214-2858</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Licinio Craveiro</author:name>
                  <author:orcid>http://orcid.org/0000-0002-8841-8035</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Florian Lipsmeier</author:name>
                  <author:orcid>http://orcid.org/0000-0002-8663-819X</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Corrado Bernasconi</author:name>
                  <author:orcid>http://orcid.org/0000-0002-1019-5468</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Xavier Montalban</author:name>
                  <author:orcid>http://orcid.org/0000-0002-0098-9918</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Stephen L. Hauser</author:name>
                  <author:orcid>http://orcid.org/0000-0002-4932-4001</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Michael Lindemann</author:name>
                  <author:orcid>http://orcid.org/0000-0003-1010-3890</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>An unordered array of references to resources that were incorporated, by inclusion or reference, into this document.</pdfaProperty:description>
                           <pdfaProperty:name>Ingredients</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A structure containing the characteristics of a font used in a document</pdfaProperty:description>
                           <pdfaProperty:name>Fonts</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag Font</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structure containing the characteristics of a font used in a document.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Font#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stFnt</pdfaType:prefix>
                           <pdfaType:type>Font</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1624
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 118, 616, 131, 604
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 213, 616, 226, 604
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 287, 616, 300, 604
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 393, 616, 405, 604
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 490, 616, 502, 604
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 116, 604, 128, 591
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 202, 604, 214, 591
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 295, 604, 307, 591
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 399, 604, 411, 591
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 500, 604, 512, 591
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 131, 591, 143, 579
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 235, 591, 247, 579
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 513, 726, 546, 694
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 1625
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 120, 696, 125, 681
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 105, 621, 111, 606
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 138, 571, 143, 556
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 148, 571, 153, 556
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 122, 559, 128, 544
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 212, 446, 217, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 161, 421, 166, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 171, 421, 182, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 115, 346, 125, 331
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 223, 146, 234, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 116, 121, 127, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 132, 121, 142, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 342, 685, 352, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 344, 673, 354, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 362, 567, 372, 552
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 378, 567, 388, 552
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 328, 454, 333, 439
       Flags: Print
       AppearanceDictionary: true
       Destination: 23
      Annotation: 
       Subtype: Link
       Rect: 454, 429, 459, 414
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
     Thumb: true
    Page: 
     Label: 1626
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 206, 474, 217, 459
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 427, 386, 437, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 442, 386, 452, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 331, 299, 342, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 347, 299, 358, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 387, 261, 397, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 402, 261, 412, 246
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 490, 149, 500, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 505, 149, 516, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 476, 136, 486, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 492, 136, 502, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 409, 124, 419, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 468, 124, 473, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
     Thumb: true
    Page: 
     Label: 1627
     Sequence: 4
     Thumb: true
    Page: 
     Label: 1628
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 157, 560, 162, 545
       Flags: Print
       AppearanceDictionary: true
       Destination: 42
      Annotation: 
       Subtype: Link
       Rect: 272, 460, 283, 445
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 97, 410, 107, 395
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 254, 373, 264, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 54, 85, 120, 70
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 520, 736, 544, 721
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 724, 369, 709
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 396, 549, 406, 534
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 430, 536, 435, 521
       Flags: Print
       AppearanceDictionary: true
       Destination: 64
      Annotation: 
       Subtype: Link
       Rect: 536, 311, 541, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 387, 249, 392, 234
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 517, 174, 522, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 528, 174, 533, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
     Thumb: true
    Page: 
     Label: 1629
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 448, 649, 453, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 458, 649, 463, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 391, 374, 396, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 402, 374, 408, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 330, 211, 335, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 341, 211, 346, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 515, 174, 520, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 525, 174, 530, 159
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 327, 124, 332, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
     Thumb: true
    Page: 
     Label: 1630
     Sequence: 7
     Thumb: true
    Page: 
     Label: 1631
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 510, 624, 515, 609
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
      Annotation: 
       Subtype: Link
       Rect: 327, 486, 332, 471
       Flags: Print
       AppearanceDictionary: true
       Destination: 105
     Thumb: true
    Page: 
     Label: 1632
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 382, 724, 393, 709
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 332, 699, 343, 684
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 339, 624, 349, 609
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 354, 624, 365, 609
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 309, 586, 320, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 325, 586, 335, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 309, 536, 320, 521
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 325, 536, 335, 521
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 405, 486, 415, 471
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 344, 324, 354, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 464, 299, 474, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 479, 299, 490, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 309, 186, 319, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 469, 149, 474, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 150
      Annotation: 
       Subtype: Link
       Rect: 479, 149, 489, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 479, 86, 489, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 494, 86, 503, 71
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
     Thumb: true
    Page: 
     Label: 1633
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 189, 624, 199, 609
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 204, 624, 214, 609
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 140, 224, 150, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 155, 224, 165, 209
       Flags: Print
       AppearanceDictionary: true
       Destination: 203
      Annotation: 
       Subtype: Link
       Rect: 514, 736, 524, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 283
      Annotation: 
       Subtype: Link
       Rect: 530, 736, 540, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 283
      Annotation: 
       Subtype: Link
       Rect: 391, 380, 542, 367
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 452, 160, 544, 147
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 150, 332, 137
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 1634
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 137, 239, 287, 226
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 164, 162, 289, 150
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 152, 80, 140
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 188, 122, 289, 110
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 112, 94, 100
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 377, 726, 526, 713
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 394, 696, 510, 683
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 394, 636, 510, 623
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 381, 606, 509, 593
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 520, 576, 544, 563
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 566, 449, 553
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 416, 536, 544, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 526, 346, 513
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 416, 486, 544, 473
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 476, 335, 463
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 381, 436, 534, 423
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 493, 406, 544, 393
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 396, 417, 383
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 413, 366, 544, 353
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 356, 353, 343
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 363, 306, 466, 293
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 429, 276, 544, 263
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 377, 246, 511, 233
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 456, 216, 544, 203
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 206, 381, 193
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 381, 166, 526, 153
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 126, 472, 113
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 362, 96, 544, 83
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 86, 368, 73
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 1635
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 227, 716, 289, 703
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 706, 152, 693
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 113, 666, 257, 653
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 205, 626, 289, 613
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 616, 106, 603
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 251, 586, 289, 573
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 576, 182, 563
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 186, 456, 289, 443
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 446, 133, 433
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 162, 406, 289, 393
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 396, 121, 383
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 109, 376, 253, 363
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 265, 346, 289, 333
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 336, 160, 323
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 286, 289, 273
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 276, 110, 263
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 252, 246, 289, 233
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 236, 179, 223
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 196, 216, 183
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 207, 156, 289, 143
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 146, 157, 133
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 264, 116, 289, 103
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 106, 197, 93
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 404, 726, 544, 713
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 420, 696, 544, 683
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 493, 666, 544, 653
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 656, 421, 643
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 420, 616, 544, 603
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 606, 348, 593
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 520, 566, 544, 553
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 556, 445, 543
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 482, 526, 544, 513
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 516, 413, 503
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 422, 476, 541, 463
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 395, 436, 544, 423
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 340, 406, 528, 393
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 463, 376, 544, 363
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 366, 426, 353
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 440, 336, 544, 323
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 326, 389, 313
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 379, 286, 526, 273
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 417, 246, 544, 233
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 236, 335, 223
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 419, 206, 544, 193
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 196, 370, 183
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 146, 439, 133
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 106, 472, 93
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 1636
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 205, 736, 289, 723
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 726, 126, 713
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 117, 686, 262, 673
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 388, 716, 537, 703
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: d35b2c04
   Type: CRC32
  Checksum: cbd53241e672c86e44b6553776c7706f
   Type: MD5
  Checksum: 9ac7ffabf224c1fa83d734d28d61b96a50a50a5a
   Type: SHA-1