5dbd938f92092dc42996c5118f538f03 pmc_9976735.pdf a1d801e28843a8e285554fb508b27759ce2929cd pmc_9976735.pdf 36a581a2d3ccbc096c07a31ebdf0f52727a8833be334dc4f0a4262f9314c738d pmc_9976735.pdf Title: Ageing meets kidney disease Subject: AcademicSubjects/MED00280, DOI: 10.1093/ageing/afac157, Age and Ageing, 51, 00, 30 06 2022. Abstract: Chronic kidney disease (CKD) is defined as abnormalities of kidney structure or function, present for >3 months, with implications for health. The most used diagnostic criteria are a urinary albumin: creatinine ratio ≥30 mg/g or an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m. Either of these diagnostic thresholds is associated with adverse health outcomes. GFR decreases with age and the prevalence of CKD is highest in older adults; moreover, the presence of CKD is associated with an increased risk of all-cause and cardiovascular death related to accelerated ageing in all age ranges, and the absolute increase in risk is highest for those aged >75 years. Indeed, premature death is a more common outcome than CKD progression to kidney failure requiring kidney replacement therapy. The progressive ageing of the world population contributes to the projection that CKD will become the second most common cause of death before the end of the century in countries with long life expectancy. The current collection of selected studies on kidney disease and ageing published in Age&Ageing, NDT and CKJ provides an overview of key topics, including cognitive decline, sarcopaenia, wasting and cardiovascular and non-cardiovascular morbidity and mortality, the management of kidney failure and gender differences in CKD progression. 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referenced object 'myrefsref31' cannot be found Offset: 212468 MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 661 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Ageing meets kidney disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Cognitive decline Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Sarcopaenia, assessment of kidney function Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Cardiovascular diseases Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Management of kidney function Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 6 Funding: Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 7 Conflict of interest statement: Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Info: Title: Ageing meets kidney disease Author: Subject: AcademicSubjects/MED00280, DOI: 10.1093/ageing/afac157, Age and Ageing, 51, 00, 30 06 2022. Abstract: Chronic kidney disease (CKD) is defined as abnormalities of kidney structure or function, present for >3 months, with implications for health. The most used diagnostic criteria are a urinary albumin: creatinine ratio ≥30 mg/g or an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m. Either of these diagnostic thresholds is associated with adverse health outcomes. GFR decreases with age and the prevalence of CKD is highest in older adults; moreover, the presence of CKD is associated with an increased risk of all-cause and cardiovascular death related to accelerated ageing in all age ranges, and the absolute increase in risk is highest for those aged >75 years. Indeed, premature death is a more common outcome than CKD progression to kidney failure requiring kidney replacement therapy. The progressive ageing of the world population contributes to the projection that CKD will become the second most common cause of death before the end of the century in countries with long life expectancy. The current collection of selected studies on kidney disease and ageing published in Age&Ageing, NDT and CKJ provides an overview of key topics, including cognitive decline, sarcopaenia, wasting and cardiovascular and non-cardiovascular morbidity and mortality, the management of kidney failure and gender differences in CKD progression. Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 22.0 (Windows); modified using iTextSharp 4.1.6 by 1T3XT CreationDate: Tue Aug 09 11:29:41 CEST 2022 ModDate: Fri Jul 28 13:27:07 CEST 2023 ID: 0x5793aa13779adbc29c70451acf93ec9e, 0x8f38e96b4822d21415f17502b6d8c819 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 819 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: LDLAEP+AGaramondPro-Italic FontSubset: true FirstChar: 38 LastChar: 116 FontDescriptor: FontName: LDLAEP+AGaramondPro-Italic Flags: Serif, Symbolic, Italic FontBBox: -182, -338, 1668, 917 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LDLAAN+GillSansMTStd-Light FontSubset: true FirstChar: 2 LastChar: 83 FontDescriptor: FontName: LDLAAN+GillSansMTStd-Light Flags: Symbolic FontBBox: -215, -232, 1036, 937 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LDKPOM+GillSansStd-Light FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: LDKPOM+GillSansStd-Light Flags: Symbolic FontBBox: -215, -250, 1036, 897 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LDKPOL+GillSansStd-LightItalic FontSubset: true FirstChar: 65 LastChar: 110 FontDescriptor: FontName: LDKPOL+GillSansStd-LightItalic Flags: Symbolic, Italic FontBBox: -205, -250, 1051, 894 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LDLALN+GillSansStd-BoldItalic FontSubset: true FirstChar: 46 LastChar: 116 FontDescriptor: FontName: LDLALN+GillSansStd-BoldItalic Flags: Symbolic, Italic, ForceBold FontBBox: -190, -250, 1074, 915 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LDKPPN+AGaramondPro-Regular FontSubset: true FirstChar: 2 LastChar: 243 FontDescriptor: FontName: LDKPPN+AGaramondPro-Regular Flags: Serif, Symbolic FontBBox: -183, -354, 1356, 917 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LDLADO+MTSYN FontSubset: true FirstChar: 2 LastChar: 61 FontDescriptor: FontName: LDLADO+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LDLACO+MTMI FontSubset: true FirstChar: 2 LastChar: 62 FontDescriptor: FontName: LDLACO+MTMI Flags: Serif, Symbolic, Italic FontBBox: 0, -213, 987, 680 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LDLCGE+AGaramondPro-Bold FontSubset: true FirstChar: 46 LastChar: 148 FontDescriptor: FontName: LDLCGE+AGaramondPro-Bold Flags: Serif, Symbolic, ForceBold FontBBox: -158, -302, 1147, 899 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LDKPNL+GillSansStd-Bold FontSubset: true FirstChar: 44 LastChar: 122 FontDescriptor: FontName: LDKPNL+GillSansStd-Bold Flags: Symbolic, ForceBold FontBBox: -177, -250, 1167, 929 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true TrueType: Font: BaseFont: JJNYJI+ArialMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: JJNYJI+ArialMT Flags: Nonsymbolic FontBBox: -664, -324, 2000, 1039 FontFile2: true Encoding: WinAnsiEncoding XMP: application/pdf Ageing meets kidney disease Ortiz AlbertoMattace-Raso FrancescoSoler María JoséFouque Denis AcademicSubjects/MED00280, DOI: 10.1093/ageing/afac157, Age and Ageing, 51, 00, 30 06 2022. Abstract: Chronic kidney disease (CKD) is defined as abnormalities of kidney structure or function, present for >3 months, with implications for health. The most used diagnostic criteria are a urinary albumin: creatinine ratio ≥30 mg/g or an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m. Either of these diagnostic thresholds is associated with adverse health outcomes. GFR decreases with age and the prevalence of CKD is highest in older adults; moreover, the presence of CKD is associated with an increased risk of all-cause and cardiovascular death related to accelerated ageing in all age ranges, and the absolute increase in risk is highest for those aged >75 years. Indeed, premature death is a more common outcome than CKD progression to kidney failure requiring kidney replacement therapy. The progressive ageing of the world population contributes to the projection that CKD will become the second most common cause of death before the end of the century in countries with long life expectancy. The current collection of selected studies on kidney disease and ageing published in Age&Ageing, NDT and CKJ provides an overview of key topics, including cognitive decline, sarcopaenia, wasting and cardiovascular and non-cardiovascular morbidity and mortality, the management of kidney failure and gender differences in CKD progression. ageingchronic kidney diseasecognitive declinehaemodialysistransplantationsarcopaenia This article has been co-published with permission in Clinical Kidney Journal, Nephrology Dialysis Transplantation, and Age and Ageing. © The Author(s) 2022. Published by Oxford University Press on behalf of the ERA and the British Geriatrics Society. All rights reserved. The articles are identical except for minor stylistic and spelling differences in keeping with each journal's style. Either citation can be used when citing this article. 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