b162a71da537f4ab252a5501faf96951 fneur-14-1295934.pdf 4ea6e4ba556fbfa5f1685df7ad3e26b8cc186aab fneur-14-1295934.pdf e7746a7dc5cd45b09a98d77fc0d2b3e4a57273040d3b215e5372609571d8d8f2 fneur-14-1295934.pdf Title: Phenobarbital does not worsen outcomes of neonatal hypoxia on hippocampal LTP on rats Subject: Introduction: Neonatal hypoxia is a common cause of early-life seizures. Author: Irene Sanchez-Brualla; Anjik Ghosh; Viktoriya A. Gibatova; Sean Quinlan; Eric Witherspoon; Stefano Vicini; Patrick A. Forcelli Creator: Adobe InDesign 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Fri Nov 17 06:54:02 2023 CET ModDate: Fri Nov 17 06:54:18 2023 CET Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 12321073 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GBQPSW+MuseoSans-500 Type 1C Custom yes yes yes 8 0 EYRDQA+MuseoSans-300 Type 1C Custom yes yes yes 58 0 CVNROE+MuseoSans-700 Type 1C Custom yes yes yes 57 0 ASOFMI+MinionPro-Regular Type 1C Custom yes yes yes 9 0 XQANWO+MuseoSans-300Italic Type 1C WinAnsi yes yes yes 160 0 WMQHIQ+MinionPro-It Type 1C Custom yes yes yes 10 0 UJRVGU+STIX-Regular Type 1C WinAnsi yes yes yes 56 0 SGNJEY+STIXGeneral-Regular Type 1C Custom yes yes yes 73 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-28 03:26:35 CET RepresentationInformation: fneur-14-1295934.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-23 05:43:07 CEST Size: 12321073 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 1422 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-GB Outlines: Item: Title: Phenobarbital does not worsen outcomes of neonatal hypoxia on hippocampal LTP on rats Children: Item: Title: 1 Introduction Item: Title: 2 Materials and methods Children: Item: Title: 2.1 Experimental design Item: Title: 2.2 Animals Item: Title: 2.3 Graded global hypoxia Item: Title: 2.4 Drug treatment Item: Title: 2.5 Brain slice preparation Item: Title: 2.6 LTP recording Item: Title: 2.7 LTP analysis Item: Title: 2.8 EEG recording and analysis in neonatal animals Item: Title: 2.9 EEG recording and analysis in adult animals Item: Title: 2.10 Statistical analysis Item: Title: 3 Results Children: Item: Title: 3.1 Model validation Item: Title: 3.2 Neither hypoxia nor drug treatment modify hippocampal excitability Item: Title: 3.3 Treatments did not modify post-tetanic potentiation, independently of the induction protocol used Item: Title: 3.4 Under a theta burst stimulation protocol, the treatments modified hippocampal LTP in an age- and sex-dependent manner Item: Title: 3.5 Under a tetanization protocol, only hypoxia-exposed P29+ males showed an increase in hippocampal LTP Item: Title: 4 Discussion Item: Title: Data availability statement Item: Title: Ethics statement Item: Title: Author contributions Item: Title: References Info: Title: Phenobarbital does not worsen outcomes of neonatal hypoxia on hippocampal LTP on rats Author: Irene Sanchez-Brualla; Anjik Ghosh; Viktoriya A. Gibatova; Sean Quinlan; Eric Witherspoon; Stefano Vicini; Patrick A. Forcelli Subject: Introduction: Neonatal hypoxia is a common cause of early-life seizures. 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