04dca5d50746caed23c4c1aef8debe77  BriJouPha_a2021iENG.pdf
23ec3501d7bed0ba7d7427415e0669f7b8b05a44  BriJouPha_a2021iENG.pdf
852759e98a23b6caabd71315b7cfd47e5bcd26611eba3349d64af21ef6bd9512  BriJouPha_a2021iENG.pdf

Title:          Remote local photoactivation of morphine produces analgesia without opioid‐related adverse effects
Subject:        British J Pharmacology 0.0
Producer:       iText 4.2.0 by 1T3XT
CreationDate:   Wed Nov  2 11:45:31 2022 CET
ModDate:        Wed Nov  2 11:45:31 2022 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          18
Encrypted:      no
Page size:      595.276 x 782.362 pts
Page rot:       0
File size:      5968497 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
GPBBFJ+AdvTT6071803a.B               Type 1C           WinAnsi          yes yes no      86  0
GPBBFK+AdvP4C4E59                    Type 1C           Custom           yes yes yes     87  0
GPBBNI+AdvTTa9c1b374                 Type 1C           WinAnsi          yes yes no      88  0
GPBBNJ+AdvTTeb5f0e55.I               Type 1C           WinAnsi          yes yes no      89  0
GPBEPH+AdvTTa9c1b374+20              Type 1C           WinAnsi          yes yes no      90  0
Times-Roman                          Type 1            WinAnsi          no  no  no       2  0
GPBFAI+AdvP4C4E74                    Type 1C           Custom           yes yes yes    129  0
GPBICF+AdvOT8608a8d1+03              Type 1C           Custom           yes yes yes    151  0
GPBIEG+AdvOT8b40f9c2.B+03            Type 1C           Custom           yes yes yes    152  0
GPBLIE+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no     171  0
GPBLHD+AdvP4C4E46                    Type 1C           Custom           yes yes yes    172  0
GPCGGC+AdvTTfac587ca.B               Type 1C           WinAnsi          yes yes no     206  0
GPFLGN+AdvTTa9c1b374+01              Type 1C           WinAnsi          yes yes no     341  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-05-27 03:20:55 CEST
 RepresentationInformation: BriJouPha_a2021iENG.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-03-31 11:59:24 CEST
  Size: 5968497
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 0
   FreeObjects: 2
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: Remote local photoactivation of morphine produces analgesia without opioid-related adverse effects
      Destination: 1
      Children: 
       Item: 
        Title: 1  INTRODUCTION
        Destination: 1
       Item: 
        Title:   What is already known
        Destination: 1
       Item: 
        Title:   What does this study add
        Destination: 1
       Item: 
        Title:   What is the clinical significance
        Destination: 1
       Item: 
        Title: 2  METHODS
        Destination: 1
        Children: 
         Item: 
          Title: 2.1  Drug synthesis
          Destination: 1
          Children: 
           Item: 
            Title: 2.1.1  Synthesis of 4-(bromomethyl)-7-(diethylamino)-2H-chromen-2-one
            Destination: 1
           Item: 
            Title: 2.1.2  Synthesis of 7-(diethylamino)-4-((((4R,7S,12bS)-7-hydroxy-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methanobenzofuro[...
            Destination: 1
         Item: 
          Title: 2.2  Photochemical characterization
          Destination: 1
         Item: 
          Title: 2.3  Cell culture
          Destination: 1
         Item: 
          Title: 2.4  Dorsal rood ganglion (DRG) isolation and primary culture
          Destination: 1
         Item: 
          Title: 2.5  Intracellular calcium determinations
          Destination: 1
         Item: 
          Title: 2.6  Electrophysiology
          Destination: 1
         Item: 
          Title: 2.7  Animals
          Destination: 1
         Item: 
          Title: 2.8  Epidural fibre-optic implantation
          Destination: 1
         Item: 
          Title: 2.9  Formalin test
          Destination: 1
         Item: 
          Title: 2.10  Gastrointestinal transit
          Destination: 1
         Item: 
          Title: 2.11  Opioid tolerance
          Destination: 1
         Item: 
          Title: 2.12  Morphine-induced conditioned place preference
          Destination: 1
         Item: 
          Title: 2.13  Naloxone-precipitated morphine withdrawal
          Destination: 1
         Item: 
          Title: 2.14  Data and statistical analysis
          Destination: 1
         Item: 
          Title: 2.15  Materials
          Destination: 1
         Item: 
          Title: 2.16  Nomenclature of targets and ligands
          Destination: 1
       Item: 
        Title: 3  RESULTS
        Destination: 1
        Children: 
         Item: 
          Title: 3.1  Design and synthesis of photocaged morphine
          Destination: 1
         Item: 
          Title: 3.2  Optical control of μ-opioid receptor in cultured cells and primary neurons
          Destination: 1
         Item: 
          Title: 3.3  Photocontrolling morphine-mediated antinociception
          Destination: 1
         Item: 
          Title: 3.4  Reduction of tolerance and opioid-related side effects upon photocaged-morphine treatment
          Destination: 1
       Item: 
        Title: 4  DISCUSSION
        Destination: 1
       Item: 
        Title: ACKNOWLEDGMENTS
        Destination: 1
       Item: 
        Title:   AUTHOR CONTRIBUTIONS
        Destination: 1
       Item: 
        Title:   CONFLICT OF INTEREST
        Destination: 1
       Item: 
        Title:   DECLARATION OF TRANSPARENCY AND SCIENTIFIC RIGOUR
        Destination: 1
        Children: 
         Item: 
          Title:   DATA AVAILABILITY STATEMENT
          Destination: 1
       Item: 
        Title: REFERENCES
        Destination: 1
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1237
      ImageHeight: 1631
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
     Name: Im1
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1157
      ImageHeight: 1017
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1890
      ImageHeight: 932
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1772
      ImageHeight: 1662
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2092
      ImageHeight: 881
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2092
      ImageHeight: 650
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2092
      ImageHeight: 884
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1654
      ImageHeight: 1030
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1654
      ImageHeight: 1500
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 83
      ImageHeight: 83
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 71
      ImageHeight: 68
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: GPBFAI+AdvP4C4E74
      FontSubset: true
      FirstChar: 1
      LastChar: 254
      FontDescriptor: 
       FontName: GPBFAI+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GPFLGN+AdvTTa9c1b374+01
      FontSubset: true
      FirstChar: 138
      LastChar: 138
      FontDescriptor: 
       FontName: GPFLGN+AdvTTa9c1b374+01
       Flags: Nonsymbolic
       FontBBox: -62, -187, 1333, 1052
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GPBBFJ+AdvTT6071803a.B
      FontSubset: true
      FirstChar: 40
      LastChar: 250
      FontDescriptor: 
       FontName: GPBBFJ+AdvTT6071803a.B
       Flags: Nonsymbolic
       FontBBox: -52, -177, 1041, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GPBBFK+AdvP4C4E59
      FontSubset: true
      FirstChar: 1
      LastChar: 61
      FontDescriptor: 
       FontName: GPBBFK+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GPBICF+AdvOT8608a8d1+03
      FontSubset: true
      FirstChar: 1
      LastChar: 6
      FontDescriptor: 
       FontName: GPBICF+AdvOT8608a8d1+03
       Flags: Symbolic
       FontBBox: -479, -364, 854, 927
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GPBBNI+AdvTTa9c1b374
      FontSubset: true
      FirstChar: 37
      LastChar: 252
      FontDescriptor: 
       FontName: GPBBNI+AdvTTa9c1b374
       Flags: Nonsymbolic
       FontBBox: -41, -177, 1010, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GPBIEG+AdvOT8b40f9c2.B+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: GPBIEG+AdvOT8b40f9c2.B+03
       Flags: Symbolic
       FontBBox: -500, -416, 916, 937
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GPBBNJ+AdvTTeb5f0e55.I
      FontSubset: true
      FirstChar: 38
      LastChar: 250
      FontDescriptor: 
       FontName: GPBBNJ+AdvTTeb5f0e55.I
       Flags: Nonsymbolic
       FontBBox: -83, -177, 989, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GPBEPH+AdvTTa9c1b374+20
      FontSubset: true
      FirstChar: 129
      LastChar: 150
      FontDescriptor: 
       FontName: GPBEPH+AdvTTa9c1b374+20
       Flags: Nonsymbolic
       FontBBox: -239, -218, 1166, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GPBLIE+AdvP4C4E51
      FontSubset: true
      FirstChar: 61
      LastChar: 61
      FontDescriptor: 
       FontName: GPBLIE+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GPBLHD+AdvP4C4E46
      FontSubset: true
      FirstChar: 1
      LastChar: 105
      FontDescriptor: 
       FontName: GPBLHD+AdvP4C4E46
       Flags: Symbolic
       FontBBox: 17, -1759, 560, 40
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GPCGGC+AdvTTfac587ca.B
      FontSubset: true
      FirstChar: 49
      LastChar: 85
      FontDescriptor: 
       FontName: GPCGGC+AdvTTfac587ca.B
       Flags: Nonsymbolic
       FontBBox: -72, -177, 1062, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.4-c005 78.147326, 2012/08/23-13:03:03 " xmlns:x="adobe:ns:meta/">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
<jav:journal_article_version>VoR</jav:journal_article_version>
<prism:doi>10.1111/bph.15645</prism:doi>
<pdfx:WPS-ARTICLEDOI>10.1111/bph.15645</pdfx:WPS-ARTICLEDOI>
<pdfx:WPS-JOURNALDOI>10.1111/(ISSN)1476-5381</pdfx:WPS-JOURNALDOI>
<pdfx:WPS-PROCLEVEL>3</pdfx:WPS-PROCLEVEL> 
<dc:title>
<rdf:Alt>
<rdf:li xml:lang="x-default">Remote local photoactivation of morphine produces analgesia without opioid‐related adverse effects</rdf:li>
</rdf:Alt>
</dc:title>
<pdf:Producer>iText 4.2.0 by 1T3XT</pdf:Producer><xmp:ModifyDate>2022-11-02T03:45:31-07:00</xmp:ModifyDate></rdf:Description>
</rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 0, 15, 595, 1680
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 241, 578, 250, 586
      Annotation: 
       Subtype: Link
       Rect: 393, 578, 402, 586
      Annotation: 
       Subtype: Link
       Rect: 447, 560, 455, 568
      Annotation: 
       Subtype: Link
       Rect: 65, 239, 114, 246
      Annotation: 
       Subtype: Link
       Rect: 118, 239, 178, 246
      Annotation: 
       Subtype: Link
       Rect: 65, 185, 152, 192
      Annotation: 
       Subtype: Link
       Rect: 45, 730, 124, 737
      Annotation: 
       Subtype: Link
       Rect: 205, 62, 350, 69
      Annotation: 
       Subtype: Link
       Rect: 411, 22, 518, 29
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 200, 357, 234, 365
      Annotation: 
       Subtype: Link
       Rect: 246, 357, 286, 365
      Annotation: 
       Subtype: Link
       Rect: 45, 344, 102, 352
      Annotation: 
       Subtype: Link
       Rect: 116, 344, 155, 352
      Annotation: 
       Subtype: Link
       Rect: 211, 344, 243, 352
      Annotation: 
       Subtype: Link
       Rect: 257, 344, 286, 352
      Annotation: 
       Subtype: Link
       Rect: 45, 331, 97, 339
      Annotation: 
       Subtype: Link
       Rect: 120, 331, 158, 339
      Annotation: 
       Subtype: Link
       Rect: 437, 188, 549, 196
      Annotation: 
       Subtype: Link
       Rect: 306, 175, 345, 183
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 366, 149, 428, 157
      Annotation: 
       Subtype: Link
       Rect: 524, 149, 549, 157
      Annotation: 
       Subtype: Link
       Rect: 306, 136, 340, 144
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 408, 656, 549, 664
      Annotation: 
       Subtype: Link
       Rect: 306, 642, 410, 650
      Annotation: 
       Subtype: Link
       Rect: 410, 643, 448, 651
      Annotation: 
       Subtype: Link
       Rect: 500, 642, 509, 650
      Annotation: 
       Subtype: Link
       Rect: 509, 643, 549, 651
      Annotation: 
       Subtype: Link
       Rect: 432, 71, 502, 79
     Thumb: true
    Page: 
     Sequence: 6
     Thumb: true
    Page: 
     Sequence: 7
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 268, 500, 288, 508
      Annotation: 
       Subtype: Link
       Rect: 45, 487, 91, 495
      Annotation: 
       Subtype: Link
       Rect: 380, 721, 512, 729
     Thumb: true
    Page: 
     Sequence: 9
     Thumb: true
    Page: 
     Sequence: 10
     Thumb: true
    Page: 
     Sequence: 11
     Thumb: true
    Page: 
     Sequence: 12
     Thumb: true
    Page: 
     Sequence: 13
     Thumb: true
    Page: 
     Sequence: 14
     Thumb: true
    Page: 
     Sequence: 15
     Thumb: true
    Page: 
     Sequence: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 201, 318, 272, 326
      Annotation: 
       Subtype: Link
       Rect: 45, 305, 130, 313
      Annotation: 
       Subtype: Link
       Rect: 90, 201, 99, 209
      Annotation: 
       Subtype: Link
       Rect: 101, 199, 244, 207
      Annotation: 
       Subtype: Link
       Rect: 102, 188, 110, 196
      Annotation: 
       Subtype: Link
       Rect: 112, 186, 255, 194
      Annotation: 
       Subtype: Link
       Rect: 103, 175, 112, 183
      Annotation: 
       Subtype: Link
       Rect: 114, 173, 257, 181
      Annotation: 
       Subtype: Link
       Rect: 58, 103, 224, 110
      Annotation: 
       Subtype: Link
       Rect: 319, 701, 463, 708
      Annotation: 
       Subtype: Link
       Rect: 445, 596, 549, 603
      Annotation: 
       Subtype: Link
       Rect: 319, 585, 334, 593
      Annotation: 
       Subtype: Link
       Rect: 340, 554, 484, 561
      Annotation: 
       Subtype: Link
       Rect: 319, 480, 437, 488
      Annotation: 
       Subtype: Link
       Rect: 413, 417, 549, 424
      Annotation: 
       Subtype: Link
       Rect: 319, 406, 348, 414
      Annotation: 
       Subtype: Link
       Rect: 319, 354, 441, 361
      Annotation: 
       Subtype: Link
       Rect: 463, 333, 549, 341
      Annotation: 
       Subtype: Link
       Rect: 319, 322, 379, 330
      Annotation: 
       Subtype: Link
       Rect: 433, 291, 549, 298
      Annotation: 
       Subtype: Link
       Rect: 319, 280, 361, 288
      Annotation: 
       Subtype: Link
       Rect: 430, 228, 549, 235
      Annotation: 
       Subtype: Link
       Rect: 319, 217, 360, 225
      Annotation: 
       Subtype: Link
       Rect: 455, 154, 549, 162
      Annotation: 
       Subtype: Link
       Rect: 319, 144, 379, 151
      Annotation: 
       Subtype: Link
       Rect: 453, 91, 549, 99
      Annotation: 
       Subtype: Link
       Rect: 319, 81, 360, 89
     Thumb: true
    Page: 
     Sequence: 17
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 170, 721, 288, 729
      Annotation: 
       Subtype: Link
       Rect: 58, 711, 103, 718
      Annotation: 
       Subtype: Link
       Rect: 58, 669, 221, 676
      Annotation: 
       Subtype: Link
       Rect: 206, 627, 288, 634
      Annotation: 
       Subtype: Link
       Rect: 58, 616, 94, 624
      Annotation: 
       Subtype: Link
       Rect: 206, 574, 288, 582
      Annotation: 
       Subtype: Link
       Rect: 58, 564, 179, 571
      Annotation: 
       Subtype: Link
       Rect: 83, 532, 242, 540
      Annotation: 
       Subtype: Link
       Rect: 226, 469, 288, 477
      Annotation: 
       Subtype: Link
       Rect: 58, 459, 116, 466
      Annotation: 
       Subtype: Link
       Rect: 206, 396, 288, 403
      Annotation: 
       Subtype: Link
       Rect: 58, 385, 96, 393
      Annotation: 
       Subtype: Link
       Rect: 150, 322, 268, 330
      Annotation: 
       Subtype: Link
       Rect: 167, 291, 288, 298
      Annotation: 
       Subtype: Link
       Rect: 58, 280, 121, 288
      Annotation: 
       Subtype: Link
       Rect: 143, 238, 288, 246
      Annotation: 
       Subtype: Link
       Rect: 58, 228, 75, 235
      Annotation: 
       Subtype: Link
       Rect: 151, 186, 288, 194
      Annotation: 
       Subtype: Link
       Rect: 58, 175, 84, 183
      Annotation: 
       Subtype: Link
       Rect: 101, 133, 261, 141
      Annotation: 
       Subtype: Link
       Rect: 226, 102, 288, 109
      Annotation: 
       Subtype: Link
       Rect: 58, 91, 100, 99
      Annotation: 
       Subtype: Link
       Rect: 512, 711, 549, 718
      Annotation: 
       Subtype: Link
       Rect: 319, 701, 431, 708
      Annotation: 
       Subtype: Link
       Rect: 353, 648, 518, 655
      Annotation: 
       Subtype: Link
       Rect: 467, 627, 549, 634
      Annotation: 
       Subtype: Link
       Rect: 319, 616, 347, 624
      Annotation: 
       Subtype: Link
       Rect: 404, 574, 549, 582
      Annotation: 
       Subtype: Link
       Rect: 319, 564, 382, 571
      Annotation: 
       Subtype: Link
       Rect: 467, 459, 549, 466
      Annotation: 
       Subtype: Link
       Rect: 319, 449, 390, 456
      Annotation: 
       Subtype: Link
       Rect: 319, 322, 471, 330
      Annotation: 
       Subtype: Link
       Rect: 487, 270, 549, 277
      Annotation: 
       Subtype: Link
       Rect: 319, 259, 380, 267
      Annotation: 
       Subtype: Link
       Rect: 391, 207, 501, 214
      Annotation: 
       Subtype: Link
       Rect: 378, 144, 495, 151
      Annotation: 
       Subtype: Link
       Rect: 467, 112, 549, 120
      Annotation: 
       Subtype: Link
       Rect: 319, 102, 376, 109
      Annotation: 
       Subtype: Link
       Rect: 453, 60, 549, 67
      Annotation: 
       Subtype: Link
       Rect: 319, 50, 349, 57
     Thumb: true
    Page: 
     Sequence: 18
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 262, 690, 288, 698
      Annotation: 
       Subtype: Link
       Rect: 58, 679, 185, 687
      Annotation: 
       Subtype: Link
       Rect: 392, 643, 517, 651
     Thumb: true
  Checksum: df894930
   Type: CRC32
  Checksum: 04dca5d50746caed23c4c1aef8debe77
   Type: MD5
  Checksum: 23ec3501d7bed0ba7d7427415e0669f7b8b05a44
   Type: SHA-1