7e718de75410a5f03b98518003ad1349 ijerph_a2023m2v20an2935.pdf e774196d9408c4212a385fdab229f4a3c8a8b37f ijerph_a2023m2v20an2935.pdf 013c79d64649aa412ae20c7716747738269b125ad811eb2c7ba192c99356f882 ijerph_a2023m2v20an2935.pdf Title: Central Sensitization and Chronic Pain Personality Profile: Is There New Evidence? A Case-Control Study Subject: Background: Personality traits are relevant for pain perception in persistent pain disorders, although they have not been studied in depth in sensitized and nonsensitized patients with knee osteoarthritis (OA). Objective: To explain and compare the personality profile of patients with OA, with and without central sensitization (CS), and fibromyalgia (FM). Setting: Participants were selected at the Rheumatology Department in two major hospitals in Spain. Participants: Case-control study where the sample consists of 15 patients with OA and CS (OA-CS), 31 OA without CS (OA-noCS), 47 FM, and 22 controls. We used a rigorous and systematic process that ensured the sample strictly fulfilled all the inclusion/exclusion criteria, so the sample is very well delimited. Primary outcome measures: Personality was assessed by the Temperament and Character Inventory of Cloninger. Results: The percentile in harm-avoidance dimension for the FM group is higher compared to OA groups and controls. The most frequent temperamental profiles in patients are cautious, methodical, and explosive. Patients with FM are more likely to report larger scores in harm-avoidance, with an increase in logistic regression adjusted odds ratio (ORadj) between 4.2% and 70.2%. Conclusions: Harm-avoidance seems to be the most important dimension in personality patients with chronic pain, as previously found. We found no differences between OA groups and between sensitized groups, but there are differences between FM and OA-noCS, so harm-avoidance might be the key to describe personality in patients with CS rather than the presence of prolonged pain, as found in the literature before. Keywords: osteoarthritis; fibromyalgia; central sensitization; personality Author: Marina Lopez-Ruiz, Andrea Doreste Soler, Jesus Pujol, Josep-Maria Losilla, Fabiola Ojeda, Laura Blanco-Hinojo, Gerard Martínez-Vilavella, Teresa Gutiérrez-Rosado, Jordi Monfort and Joan Deus Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Feb 8 07:11:35 2023 CET ModDate: Wed Feb 8 07:13:16 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1085238 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YSPQJI+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 GFKJOY+VnURWPalladioL Type 1 Custom yes yes no 15 0 NPVFKI+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 XWTDSU+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 GPULYR+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 LWQXII+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 49 0 IWRJUR+CMSY10 Type 1 Builtin yes yes no 77 0 AGNCLG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 88 0 AGNCMH+PalatinoLinotype TrueType WinAnsi yes yes no 91 0 AGNCMJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 94 0 AGNHJO+Calibri CID TrueType Identity-H yes yes yes 97 0 NMWFWU+URWPalladioL-BoldItal Type 1 Custom yes yes no 109 0 AGNCLG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 123 0 AGNCMG+PalatinoLinotype CID TrueType Identity-H yes yes yes 126 0 AGNCMH+PalatinoLinotype TrueType WinAnsi yes yes no 132 0 AGNCMJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 135 0 AGNKFA+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 148 0 AGNCLG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 151 0 AGNCMH+PalatinoLinotype TrueType WinAnsi yes yes no 154 0 AGNCMJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 157 0 JLZORU+EURM10 Type 1 Builtin yes yes no 164 0 AGNKFA+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 175 0 AGNCLG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 178 0 AGNCMG+PalatinoLinotype CID TrueType Identity-H yes yes yes 181 0 AGNCMH+PalatinoLinotype TrueType WinAnsi yes yes no 187 0 AGNCMJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 190 0 AGNHJO+Calibri CID TrueType Identity-H yes yes yes 193 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-24 02:33:37 CET RepresentationInformation: ijerph_a2023m2v20an2935.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-09 02:14:15 CET Size: 1085238 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 371 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Procedure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Assessment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Data Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Info: Title: Central Sensitization and Chronic Pain Personality Profile: Is There New Evidence? A Case-Control Study Author: Marina Lopez-Ruiz, Andrea Doreste Soler, Jesus Pujol, Josep-Maria Losilla, Fabiola Ojeda, Laura Blanco-Hinojo, Gerard Martínez-Vilavella, Teresa Gutiérrez-Rosado, Jordi Monfort and Joan Deus Subject: Background: Personality traits are relevant for pain perception in persistent pain disorders, although they have not been studied in depth in sensitized and nonsensitized patients with knee osteoarthritis (OA). Objective: To explain and compare the personality profile of patients with OA, with and without central sensitization (CS), and fibromyalgia (FM). Setting: Participants were selected at the Rheumatology Department in two major hospitals in Spain. Participants: Case-control study where the sample consists of 15 patients with OA and CS (OA-CS), 31 OA without CS (OA-noCS), 47 FM, and 22 controls. We used a rigorous and systematic process that ensured the sample strictly fulfilled all the inclusion/exclusion criteria, so the sample is very well delimited. Primary outcome measures: Personality was assessed by the Temperament and Character Inventory of Cloninger. Results: The percentile in harm-avoidance dimension for the FM group is higher compared to OA groups and controls. The most frequent temperamental profiles in patients are cautious, methodical, and explosive. Patients with FM are more likely to report larger scores in harm-avoidance, with an increase in logistic regression adjusted odds ratio (ORadj) between 4.2% and 70.2%. Conclusions: Harm-avoidance seems to be the most important dimension in personality patients with chronic pain, as previously found. We found no differences between OA groups and between sensitized groups, but there are differences between FM and OA-noCS, so harm-avoidance might be the key to describe personality in patients with CS rather than the presence of prolonged pain, as found in the literature before. 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