2bed2b12fa49de8ef2efb8d172a2b4c8 EnvPol_a2023v329p121656.pdf 6b69c3ecaa701111df57846ec90dd31233290fec EnvPol_a2023v329p121656.pdf d0e93a306535c3fdbd293b1a8b405640593903e1e9e0fe6d0fd3112fd0df97f1 EnvPol_a2023v329p121656.pdf Title: The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics Subject: Environmental Pollution, 329 (2023) 121656. doi:10.1016/j.envpol.2023.121656 Keywords: Nanoplastics,Polystyrene,Digestion,Characterization,Cell uptake,Hazard effects Author: Lourdes Vela Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed May 17 05:18:48 2023 CEST ModDate: Wed May 17 13:31:14 2023 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 5759530 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XHLTYL+CharisSIL CID TrueType Identity-H yes yes yes 662 0 FVGVKS+CharisSIL-Bold CID TrueType Identity-H yes yes yes 667 0 GBNAGF+Univers Type 1C Builtin yes yes yes 672 0 NNLAUQ+TeX_CM_Roman Type 1C Builtin yes yes yes 676 0 LXULLT+CharisSIL-Italic CID TrueType Identity-H yes yes yes 680 0 UKNHXR+STIX-Regular Type 1C Custom yes yes yes 685 0 NOIOLI+CharisSIL CID TrueType Identity-H yes yes yes 653 0 TSNKIJ+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 271 0 JAOSPW+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 275 0 ECKGTB+CharisSIL-Italic CID TrueType Identity-H yes yes yes 264 0 NTMBZO+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 280 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 02:35:13 CEST RepresentationInformation: EnvPol_a2023v329p121656.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-05-26 16:52:16 CEST Size: 5759530 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 5722135 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 5722135 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 5722135 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 5722135 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 764 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: 2 Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: 2.1 Nanopolystyrene selection, in vitro digestion, and dispersion preparation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: 2.2 Characterization of digested/undigested PSNPLs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Children: Item: Title: 2.2.1 Transmission electron microscopy (TEM) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 2.2.2 Scanning electron microscopy (SEM) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 2.2.3 Dynamic light scattering (DLS) and zeta potential Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 2.2.4 Nanotracking analysis (NTA) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 2.2.5 Confocal Raman microspectroscopy (CRM) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 2.3 Cells used and culture conditions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 2.4 Cell internalization by flow cytometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 2.5 fPSNPL and dfPSNPL intracellular localization by confocal microscopy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 2.6 Cell viability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 2.7 Reactive oxygen species (ROS) quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: 2.8 Genotoxic and oxidative DNA damage induction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: 3 Results and discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Children: Item: Title: 3.1 Particle characterization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Children: Item: Title: 3.1.1 Morphology, dry state size distribution, and shape Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: 3.1.2 Aqueous solution size distribution and zeta potential Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: 3.1.3 Nanotracking analysis (NTA) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: 3.1.4 Visualization and characterization of proteins on the surface of PS particles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: 3.2 Cell internalization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: 3.3 Intracellular presence of fPSNPLs and dfPSNPLs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: 3.4 Cytotoxicity assessment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: 3.5 Production of intracellular ROS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: 3.6 Genotoxic and oxidative DNA damage Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: 4 Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Author contribution statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: Declaration of competing interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: Appendix A Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Info: Title: The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics Author: Lourdes Vela Subject: Environmental Pollution, 329 (2023) 121656. doi:10.1016/j.envpol.2023.121656 Keywords: Nanoplastics,Polystyrene,Digestion,Characterization,Cell uptake,Hazard effects Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed May 17 05:18:48 CEST 2023 ModDate: Wed May 17 13:31:14 CEST 2023 ID: 0x967d88f9d9fa98416afe85c8c3389ac0, 0xf9ff684edbda1d2db6cff87c0f836995 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: JAOSPW+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: XHLTYL+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: LXULLT+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: FVGVKS+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: GBNAGF+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: GBNAGF+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NNLAUQ+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: NNLAUQ+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NTMBZO+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: NTMBZO+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: UKNHXR+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 8 FontDescriptor: FontName: UKNHXR+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TSNKIJ+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: TSNKIJ+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: JAOSPW+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JAOSPW+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: XHLTYL+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: XHLTYL+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: LXULLT+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: LXULLT+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: FVGVKS+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: FVGVKS+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true XMP: application/pdf 10.1016/j.envpol.2023.121656 Elsevier Ltd Environmental Pollution, 329 (2023) 121656. doi:10.1016/j.envpol.2023.121656 Nanoplastics Polystyrene Digestion Characterization Cell uptake Hazard effects The potential effects of in vitro digestion on the physicochemical and biological characteristics of polystyrene nanoplastics Lourdes Vela Aliro Villacorta Tom Venus Irina Estrela-Lopis Susana Pastor Alba García-Rodriguez Laura Rubio Ricard Marcos Alba Hernández journal Environmental Pollution © 2023 The Authors. Published by Elsevier Ltd. 0269-7491 329 15 July 2023 2023-07-15 121656 121656 10.1016/j.envpol.2023.121656 https://doi.org/10.1016/j.envpol.2023.121656 2010-04-23 true 10.1016/j.envpol.2023.121656 elsevier.com sciencedirect.com http://creativecommons.org/licenses/by/4.0/ VoR 10.1016/j.envpol.2023.121656 noindex 2010-04-23 true 17th May 2023 sciencedirect.com elsevier.com Elsevier 2023-05-17T11:31:14 2023-05-17T03:18:48 2023-05-17T11:31:14 True 17th May 2023 Acrobat Distiller 8.1.0 (Windows) Nanoplastics,Polystyrene,Digestion,Characterization,Cell uptake,Hazard effects uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 100, 576, 106, 587 Flags: Print Destination: 638 Annotation: Subtype: Link Rect: 107, 571, 192, 582 Flags: Print Destination: 638 Annotation: Subtype: Link Rect: 192, 576, 198, 587 Flags: Print Destination: 638 Annotation: Subtype: Link Rect: 199, 571, 264, 582 Flags: Print Destination: 638 Annotation: Subtype: Link Rect: 264, 571, 440, 582 Flags: Print Destination: 638 Annotation: Subtype: Link Rect: 440, 571, 447, 582 Flags: Print Destination: 638 Annotation: Subtype: Link Rect: 145, 563, 221, 574 Flags: Print Destination: 638 Annotation: Subtype: Link Rect: 222, 558, 302, 569 Flags: Print Destination: 638 Annotation: Subtype: Link Rect: 302, 563, 308, 574 Flags: Print Destination: 638 Annotation: Subtype: Link Rect: 309, 566, 313, 571 Flags: Print Destination: 638 Annotation: Subtype: Link Rect: 309, 558, 396, 569 Flags: Print Destination: 638 Annotation: Subtype: Link Rect: 396, 558, 400, 569 Flags: Print Destination: 638 Annotation: Subtype: Link Rect: 73, 240, 180, 248 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 40, 198, 136, 206 Flags: Print Destination: 134 Annotation: Subtype: Link Rect: 142, 198, 185, 206 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 260, 177, 288, 185 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 37, 166, 81, 174 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 534, 281, 557, 289 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 306, 271, 365, 279 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 370, 271, 443, 279 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 527, 187, 557, 195 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 306, 177, 345, 185 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 98, 104, 171, 111 Flags: Print Annotation: Subtype: Link Rect: 321, 722, 369, 730 Flags: Print Annotation: Subtype: Link Rect: 274, 667, 397, 675 Flags: Print Annotation: Subtype: Link Rect: 37, 87, 188, 94 Flags: Print Annotation: Subtype: Link Rect: 297, 749, 300, 757 Flags: Print Annotation: Subtype: Link Rect: 226, 748, 368, 760 Annotation: Subtype: Link Rect: 499, 616, 528, 645 Annotation: Subtype: Link Rect: 406, 57, 552, 69 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 176, 720, 249, 728 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 228, 689, 283, 696 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 66, 626, 137, 634 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 128, 584, 202, 592 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 75, 490, 158, 498 Flags: Print Destination: 134 Annotation: Subtype: Link Rect: 124, 437, 192, 445 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 201, 375, 286, 383 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 37, 364, 134, 372 Flags: Print Destination: 134 Annotation: Subtype: Link Rect: 139, 364, 207, 372 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 211, 364, 278, 372 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 118, 123, 194, 131 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 508, 584, 557, 592 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 306, 573, 324, 581 Flags: Print Destination: 161 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 88, 561, 151, 569 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 246, 282, 288, 290 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 37, 272, 55, 280 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 220, 92, 283, 100 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 309, 689, 374, 696 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 531, 510, 557, 518 Flags: Print Destination: null Annotation: Subtype: Link Rect: 306, 500, 360, 508 Flags: Print Destination: null Annotation: Subtype: Link Rect: 546, 364, 557, 372 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 306, 353, 346, 361 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 481, 353, 541, 361 Flags: Print Destination: 134 Annotation: Subtype: Link Rect: 353, 311, 416, 319 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 309, 238, 379, 246 Flags: Print Destination: 134 Annotation: Subtype: Link Rect: 387, 196, 465, 204 Flags: Print Destination: null Annotation: Subtype: Link Rect: 403, 81, 458, 89 Flags: Print Destination: 161 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 68, 678, 88, 686 Flags: Print Destination: 40 Annotation: Subtype: Link Rect: 264, 542, 283, 550 Flags: Print Destination: 40 Annotation: Subtype: Link Rect: 60, 448, 120, 456 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 124, 448, 189, 456 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 193, 448, 252, 456 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 40, 427, 60, 435 Flags: Print Destination: 74 Annotation: Subtype: Link Rect: 71, 427, 90, 435 Flags: Print Destination: 74 Annotation: Subtype: Link Rect: 112, 333, 155, 341 Flags: Print Destination: 134 Annotation: Subtype: Link Rect: 159, 333, 224, 341 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 238, 312, 258, 320 Flags: Print Destination: 74 Annotation: Subtype: Link Rect: 355, 720, 420, 728 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 429, 720, 450, 728 Flags: Print Destination: 74 Annotation: Subtype: Link Rect: 408, 699, 478, 707 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 482, 699, 552, 707 Flags: Print Destination: 134 Annotation: Subtype: Link Rect: 355, 678, 429, 686 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 362, 668, 436, 676 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 517, 657, 557, 665 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 306, 647, 324, 655 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 328, 647, 400, 655 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 306, 573, 326, 581 Flags: Print Destination: 74 Annotation: Subtype: Link Rect: 386, 521, 408, 529 Flags: Print Destination: 74 Annotation: Subtype: Link Rect: 424, 511, 446, 519 Flags: Print Destination: 74 Annotation: Subtype: Link Rect: 309, 427, 329, 435 Flags: Print Destination: 74 Annotation: Subtype: Link Rect: 546, 406, 557, 414 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 306, 396, 346, 404 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 306, 320, 327, 328 Flags: Print Destination: 87 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 215, 73, 283, 81 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 382, 63, 461, 71 Flags: Print Destination: 134 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 67, 520, 135, 528 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 247, 449, 267, 457 Flags: Print Destination: 87 Annotation: Subtype: Link Rect: 536, 509, 557, 517 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 306, 499, 345, 507 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 480, 489, 543, 497 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 371, 468, 451, 476 Flags: Print Destination: 161 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 155, 668, 231, 676 Flags: Print Destination: null Annotation: Subtype: Link Rect: 77, 553, 181, 561 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 40, 532, 103, 540 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 153, 432, 173, 440 Flags: Print Destination: 104 Annotation: Subtype: Link Rect: 429, 647, 478, 655 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 400, 626, 466, 634 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 511, 615, 557, 623 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 306, 605, 324, 613 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 424, 594, 483, 602 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 368, 473, 417, 481 Flags: Print Destination: 123 Annotation: Subtype: Link Rect: 353, 463, 372, 471 Flags: Print Destination: 123 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 37, 349, 57, 357 Flags: Print Destination: 134 Annotation: Subtype: Link Rect: 40, 150, 166, 158 Flags: Print Destination: 161 Annotation: Subtype: Link Rect: 73, 119, 125, 127 Flags: Print Destination: 161 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 516, 285, 557, 292 Flags: Print Annotation: Subtype: Link Rect: 306, 274, 432, 282 Flags: Print Annotation: Subtype: Link Rect: 378, 218, 485, 224 Flags: Print Annotation: Subtype: Link Rect: 522, 194, 555, 200 Flags: Print Annotation: Subtype: Link Rect: 318, 186, 391, 192 Flags: Print Annotation: Subtype: Link Rect: 483, 170, 555, 176 Flags: Print Annotation: Subtype: Link Rect: 318, 162, 387, 168 Flags: Print Annotation: Subtype: Link Rect: 347, 138, 456, 144 Flags: Print Annotation: Subtype: Link Rect: 318, 106, 435, 112 Flags: Print Annotation: Subtype: Link Rect: 465, 90, 537, 96 Flags: Print Annotation: Subtype: Link Rect: 318, 82, 427, 88 Flags: Print Annotation: Subtype: Link Rect: 369, 58, 499, 65 Flags: Print Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 85, 716, 191, 722 Flags: Print Annotation: Subtype: Link Rect: 78, 684, 184, 690 Flags: Print Annotation: Subtype: Link Rect: 73, 652, 195, 658 Flags: Print Annotation: Subtype: Link Rect: 97, 628, 228, 635 Flags: Print Annotation: Subtype: Link Rect: 138, 612, 257, 619 Flags: Print Annotation: Subtype: Link Rect: 106, 580, 237, 587 Flags: Print Annotation: Subtype: Link Rect: 180, 557, 256, 563 Flags: Print Annotation: Subtype: Link Rect: 49, 549, 114, 555 Flags: Print Annotation: Subtype: Link Rect: 198, 525, 270, 531 Flags: Print Annotation: Subtype: Link Rect: 49, 517, 90, 523 Flags: Print Annotation: Subtype: Link Rect: 85, 493, 226, 499 Flags: Print Annotation: Subtype: Link Rect: 264, 469, 286, 475 Flags: Print Annotation: Subtype: Link Rect: 49, 461, 179, 467 Flags: Print Annotation: Subtype: Link Rect: 123, 437, 267, 443 Flags: Print Annotation: Subtype: Link Rect: 229, 421, 274, 427 Flags: Print Annotation: Subtype: Link Rect: 49, 413, 144, 419 Flags: Print Annotation: Subtype: Link Rect: 78, 397, 209, 403 Flags: Print Annotation: Subtype: Link Rect: 153, 373, 229, 380 Flags: Print Annotation: Subtype: Link Rect: 49, 365, 126, 372 Flags: Print Annotation: Subtype: Link Rect: 196, 341, 272, 348 Flags: Print Annotation: Subtype: Link Rect: 49, 333, 107, 340 Flags: Print Annotation: Subtype: Link Rect: 202, 309, 274, 316 Flags: Print Annotation: Subtype: Link Rect: 49, 301, 79, 308 Flags: Print Annotation: Subtype: Link Rect: 240, 270, 286, 276 Flags: Print Annotation: Subtype: Link Rect: 49, 262, 120, 268 Flags: Print Annotation: Subtype: Link Rect: 126, 238, 239, 244 Flags: Print Annotation: Subtype: Link Rect: 483, 724, 555, 730 Flags: Print Annotation: Subtype: Link Rect: 318, 716, 377, 722 Flags: Print Annotation: Subtype: Link Rect: 422, 716, 551, 722 Flags: Print Annotation: Subtype: Link Rect: 318, 708, 390, 714 Flags: Print Annotation: Subtype: Link Rect: 347, 700, 548, 706 Flags: Print Annotation: Subtype: Link Rect: 318, 692, 471, 698 Flags: Print Annotation: Subtype: Link Rect: 508, 676, 553, 682 Flags: Print Annotation: Subtype: Link Rect: 318, 668, 384, 674 Flags: Print Annotation: Subtype: Link Rect: 431, 644, 549, 651 Flags: Print Annotation: Subtype: Link Rect: 318, 636, 342, 643 Flags: Print Annotation: Subtype: Link Rect: 508, 612, 553, 619 Flags: Print Annotation: Subtype: Link Rect: 318, 604, 407, 611 Flags: Print Annotation: Subtype: Link Rect: 458, 572, 533, 579 Flags: Print Annotation: Subtype: Link Rect: 318, 565, 367, 571 Flags: Print Annotation: Subtype: Link Rect: 421, 533, 553, 539 Flags: Print Annotation: Subtype: Link Rect: 318, 509, 413, 515 Flags: Print Annotation: Subtype: Link Rect: 522, 485, 555, 491 Flags: Print Annotation: Subtype: Link Rect: 318, 477, 423, 483 Flags: Print Annotation: Subtype: Link Rect: 478, 461, 549, 467 Flags: Print Annotation: Subtype: Link Rect: 318, 453, 364, 459 Flags: Print Annotation: Subtype: Link Rect: 517, 437, 550, 443 Flags: Print Annotation: Subtype: Link Rect: 318, 429, 384, 435 Flags: Print Annotation: Subtype: Link Rect: 431, 405, 545, 411 Flags: Print Annotation: Subtype: Link Rect: 318, 397, 342, 403 Flags: Print Annotation: Subtype: Link Rect: 522, 373, 555, 380 Flags: Print Annotation: Subtype: Link Rect: 318, 365, 407, 372 Flags: Print Annotation: Subtype: Link Rect: 318, 325, 450, 332 Flags: Print Annotation: Subtype: Link Rect: 406, 309, 523, 316 Flags: Print Annotation: Subtype: Link Rect: 318, 286, 458, 292 Flags: Print Annotation: Subtype: Link Rect: 318, 262, 435, 268 Flags: Print Annotation: Subtype: Link Rect: 406, 238, 544, 244 Flags: Print Checksum: 62ba8f7c Type: CRC32 Checksum: 2bed2b12fa49de8ef2efb8d172a2b4c8 Type: MD5 Checksum: 6b69c3ecaa701111df57846ec90dd31233290fec Type: SHA-1