d56cd70ba8d1bffe18b89df41442e8ef BioBio_a2023v120n9p2672.pdf 814a0731a5e86276f25e65db0add259dc253dd93 BioBio_a2023v120n9p2672.pdf b7c2eb3e071b8f54499f3820182dd9d517218e5fa8bf917b4c73b3739bf5c6d1 BioBio_a2023v120n9p2672.pdf Title: Downstream process design for Gag HIV‐1 based virus‐like particles Subject: Biotech & Bioengineering 2023.120:2672-2684 Keywords: Creator: John Wiley & Sons Producer: iText 4.2.0 by 1T3XT CreationDate: Thu Aug 10 11:05:23 2023 CEST ModDate: Tue Oct 3 17:52:21 2023 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1225453 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GGIFKJ+AdvTTa9c1b374 Type 1C WinAnsi yes yes no 53 0 GGIFLK+AdvTT6071803a.B Type 1C WinAnsi yes yes no 54 0 GGIFLL+AdvTT6071803a.B+20 Type 1C Custom yes yes yes 110 0 GGIFNL+AdvTTa9c1b374+20 Type 1C Custom yes yes yes 55 0 GGIFOM+AdvTTeb5f0e55.I Type 1C WinAnsi yes yes no 226 0 GGIGDM+AdvTTa9c1b374+21 Type 1C WinAnsi yes yes no 51 0 GGIGDN+AdvTTa9c1b374+03 Type 1C Custom yes yes yes 52 0 GGIGDL+AdvTTa9c1b374+22 Type 1C Custom yes yes no 56 0 Times-Roman Type 1 WinAnsi no no no 5 0 GGIHEI+AdvTTfac587ca.B Type 1C WinAnsi yes yes no 109 0 GGJEOF+AdvTT6071803a.B+03 Type 1C Custom yes yes yes 225 0 GGJJJJ+AdvTTa9c1b374+01 Type 1C WinAnsi yes yes no 284 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-04 02:30:40 CEST RepresentationInformation: BioBio_a2023v120n9p2672.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-10-03 17:56:28 CEST Size: 1225453 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0001' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0001' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0001' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0001' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0001' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0002' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0001' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0001' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0001' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0002' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0001' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0001' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0002' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0001' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0001' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0002' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0001' cannot be found Offset: 1110865 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bit28419-suppl-0001' cannot be found Offset: 1110865 MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Downstream process design for Gag HIV-1 based virus-like particles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: 1 INTRODUCTION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 2 MATERIALS AND METHODS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Children: Item: Title: 2.1 Cell culture conditions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 2.2 Plasmid Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 2.3 VLP production by transient transfection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 2.4 Filtration equipment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Children: Item: Title: 2.4.1 Clarification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 2.4.2 TFF Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 2.5 Preparative chromatography Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Children: Item: Title: 2.5.1 Chromatographic system Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: 2.5.2 Chromatography media and mobile phases Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: 2.5.3 Intermediate purification, capture, and polishing of GagVLPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: 2.6 Western blot and SDS-PAGE Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: 2.7 Nanoparticle tracking analysis (NTA) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: 2.8 Fluorescence intensity measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: 2.9 Total protein and dsDNA quantification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: 2.10 Flow virometry analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: 2.11 Dynamic light scattering Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: 3 RESULTS AND DISCUSSION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Children: Item: Title: 3.1 Gag VLPs production and clarification step Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: 3.2 Intermediate step Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: 3.3 Capture step Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: 3.4 Polishing step Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: 3.5 Evaluation of the optimized purification process Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: 4 CONCLUSIONS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: ACKNOWLEDGMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: DATA AVAILABILITY STATEMENT Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: ORCID Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Item: Title: REFERENCES Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468 Item: Title: SUPPORTING INFORMATION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 327 ImageHeight: 85 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 327 ImageHeight: 85 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 327 ImageHeight: 85 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 327 ImageHeight: 85 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 327 ImageHeight: 85 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 327 ImageHeight: 85 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 327 ImageHeight: 85 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1789 ImageHeight: 591 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1800 ImageHeight: 622 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1800 ImageHeight: 608 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 327 ImageHeight: 85 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1800 ImageHeight: 543 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1802 ImageHeight: 621 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 327 ImageHeight: 85 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 327 ImageHeight: 85 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2000 ImageHeight: 769 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 327 ImageHeight: 85 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 327 ImageHeight: 85 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 327 ImageHeight: 85 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: GGJEOF+AdvTT6071803a.B+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: GGJEOF+AdvTT6071803a.B+03 Flags: Symbolic FontBBox: -519, -272, 1079, 979 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GGIFOM+AdvTTeb5f0e55.I FontSubset: true FirstChar: 38 LastChar: 122 FontDescriptor: FontName: GGIFOM+AdvTTeb5f0e55.I Flags: Nonsymbolic FontBBox: -88, -181, 991, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GGIGDM+AdvTTa9c1b374+21 FontSubset: true FirstChar: 153 LastChar: 153 FontDescriptor: FontName: GGIGDM+AdvTTa9c1b374+21 Flags: Nonsymbolic FontBBox: 1, -170, 1105, 774 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GGIGDN+AdvTTa9c1b374+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: GGIGDN+AdvTTa9c1b374+03 Flags: Symbolic FontBBox: -500, -268, 1045, 948 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GGIFKJ+AdvTTa9c1b374 FontSubset: true FirstChar: 35 LastChar: 246 FontDescriptor: FontName: GGIFKJ+AdvTTa9c1b374 Flags: Nonsymbolic FontBBox: -41, -182, 1020, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GGIFLK+AdvTT6071803a.B FontSubset: true FirstChar: 37 LastChar: 242 FontDescriptor: FontName: GGIFLK+AdvTT6071803a.B Flags: Nonsymbolic FontBBox: -60, -180, 1042, 949 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GGIFNL+AdvTTa9c1b374+20 FontSubset: true FirstChar: 1 LastChar: 133 FontDescriptor: FontName: GGIFNL+AdvTTa9c1b374+20 Flags: Symbolic FontBBox: -245, -218, 1168, 943 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: GGIGDL+AdvTTa9c1b374+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: GGIGDL+AdvTTa9c1b374+22 Flags: Nonsymbolic FontBBox: -6, -174, 682, 856 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GGJJJJ+AdvTTa9c1b374+01 FontSubset: true FirstChar: 138 LastChar: 138 FontDescriptor: FontName: GGJJJJ+AdvTTa9c1b374+01 Flags: Nonsymbolic FontBBox: -68, -197, 1342, 1061 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GGIHEI+AdvTTfac587ca.B FontSubset: true FirstChar: 49 LastChar: 85 FontDescriptor: FontName: GGIHEI+AdvTTfac587ca.B Flags: Nonsymbolic FontBBox: -77, -178, 1063, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: GGIFLL+AdvTT6071803a.B+20 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: GGIFLL+AdvTT6071803a.B+20 Flags: Symbolic FontBBox: -256, -229, 1223, 947 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdfdoi:10.1002/bit.28419 10.1002/bit.28419https://doi.org/10.1002/bit.28419 2023-05-06trueonlinelibrary.wiley.com10.1002/bit.28419 onlinelibrary.wiley.comtrue10.1002/bit.284192023-05-06 VoR Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 134, 594, 146, 606 Annotation: Subtype: Link Rect: 66, 464, 139, 471 Annotation: Subtype: Link Rect: 196, 97, 214, 105 Destination: 281 Annotation: Subtype: Link Rect: 267, 97, 284, 105 Destination: 322 Annotation: Subtype: Link Rect: 401, 149, 419, 157 Destination: 322 Annotation: Subtype: Link Rect: 478, 149, 497, 157 Destination: 322 Annotation: Subtype: Link Rect: 85, 25, 190, 32 Annotation: Subtype: Link Rect: 519, 782, 595, 767 Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 66, 708, 85, 716 Destination: 322 Annotation: Subtype: Link Rect: 139, 682, 158, 690 Destination: 281 Annotation: Subtype: Link Rect: 202, 643, 221, 651 Destination: 281 Annotation: Subtype: Link Rect: 182, 617, 200, 625 Destination: 281 Annotation: Subtype: Link Rect: 265, 578, 284, 586 Destination: 281 Annotation: Subtype: Link Rect: 227, 513, 246, 521 Destination: 281 Annotation: Subtype: Link Rect: 122, 500, 140, 508 Destination: 281 Annotation: Subtype: Link Rect: 224, 500, 242, 508 Destination: 322 Annotation: Subtype: Link Rect: 111, 383, 130, 391 Destination: 322 Annotation: Subtype: Link Rect: 267, 344, 286, 352 Destination: 281 Annotation: Subtype: Link Rect: 152, 331, 171, 339 Destination: 281 Annotation: Subtype: Link Rect: 226, 240, 245, 248 Destination: 281 Annotation: Subtype: Link Rect: 67, 227, 86, 235 Destination: 322 Annotation: Subtype: Link Rect: 167, 227, 185, 235 Destination: 322 Annotation: Subtype: Link Rect: 249, 188, 267, 196 Destination: 322 Annotation: Subtype: Link Rect: 200, 136, 219, 144 Destination: 281 Annotation: Subtype: Link Rect: 267, 136, 286, 144 Destination: 322 Annotation: Subtype: Link Rect: 102, 123, 121, 131 Destination: 322 Annotation: Subtype: Link Rect: 267, 45, 286, 53 Destination: 322 Annotation: Subtype: Link Rect: 392, 721, 410, 729 Destination: 322 Annotation: Subtype: Link Rect: 478, 721, 497, 729 Destination: 322 Annotation: Subtype: Link Rect: 367, 669, 386, 677 Destination: 322 Annotation: Subtype: Link Rect: 498, 643, 516, 651 Destination: 281 Annotation: Subtype: Link Rect: 329, 630, 348, 638 Destination: 322 Annotation: Subtype: Link Rect: 396, 630, 415, 638 Destination: 322 Annotation: Subtype: Link Rect: 529, 617, 547, 625 Destination: 322 Annotation: Subtype: Link Rect: 352, 604, 371, 612 Destination: 322 Annotation: Subtype: Link Rect: 452, 565, 470, 573 Destination: 322 Annotation: Subtype: Link Rect: 529, 565, 547, 573 Destination: 322 Annotation: Subtype: Link Rect: 358, 552, 377, 560 Destination: 322 Annotation: Subtype: Link Rect: 367, 227, 386, 235 Destination: 322 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 265, 695, 284, 703 Destination: 281 Annotation: Subtype: Link Rect: 202, 487, 221, 495 Destination: 281 Annotation: Subtype: Link Rect: 381, 305, 386, 313 Destination: 106 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 166, 383, 170, 391 Destination: 117 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 173, 492, 181, 495 Destination: 117 Annotation: Subtype: Link Rect: 192, 176, 200, 194 Destination: 281 Annotation: Subtype: Link Rect: 203, 106, 210, 123 Destination: 322 Annotation: Subtype: Link Rect: 219, 185, 226, 203 Destination: 322 Annotation: Subtype: Link Rect: 229, 114, 237, 132 Destination: 322 Annotation: Subtype: Link Rect: 246, 180, 253, 198 Destination: 281 Annotation: Subtype: Link Rect: 256, 156, 264, 174 Destination: 281 Annotation: Subtype: Link Rect: 273, 184, 280, 201 Destination: 322 Annotation: Subtype: Link Rect: 299, 169, 307, 186 Destination: 322 Annotation: Subtype: Link Rect: 326, 189, 334, 206 Destination: 322 Annotation: Subtype: Link Rect: 337, 106, 344, 123 Destination: 322 Annotation: Subtype: Link Rect: 353, 162, 361, 179 Destination: 322 Annotation: Subtype: Link Rect: 380, 163, 387, 181 Destination: 281 Annotation: Subtype: Link Rect: 396, 197, 404, 214 Destination: 281 Annotation: Subtype: Link Rect: 407, 156, 414, 174 Destination: 281 Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 215, 708, 234, 716 Destination: 281 Annotation: Subtype: Link Rect: 439, 565, 458, 573 Destination: 281 Annotation: Subtype: Link Rect: 515, 461, 524, 469 Destination: null Annotation: Subtype: Link Rect: 476, 409, 484, 417 Destination: 157 Annotation: Subtype: Link Rect: 383, 331, 392, 339 Destination: 157 Annotation: Subtype: Link Rect: 327, 240, 346, 248 Destination: 281 Annotation: Subtype: Link Rect: 395, 162, 414, 170 Destination: 281 Annotation: Subtype: Link Rect: 518, 162, 537, 170 Destination: 281 Annotation: Subtype: Link Rect: 392, 84, 410, 92 Destination: 281 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 277, 617, 286, 625 Destination: null Annotation: Subtype: Link Rect: 71, 604, 79, 612 Destination: 157 Annotation: Subtype: Link Rect: 88, 565, 97, 573 Destination: 157 Annotation: Subtype: Link Rect: 380, 591, 398, 599 Destination: 281 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 155, 708, 174, 716 Destination: 281 Annotation: Subtype: Link Rect: 160, 591, 178, 599 Destination: 322 Annotation: Subtype: Link Rect: 234, 591, 253, 599 Destination: 322 Annotation: Subtype: Link Rect: 67, 539, 76, 547 Destination: null Annotation: Subtype: Link Rect: 171, 500, 179, 508 Destination: 171 Annotation: Subtype: Link Rect: 223, 448, 231, 456 Destination: 203 Annotation: Subtype: Link Rect: 228, 409, 237, 417 Destination: 171 Annotation: Subtype: Link Rect: 72, 344, 90, 352 Destination: 322 Annotation: Subtype: Link Rect: 190, 344, 209, 352 Destination: 322 Annotation: Subtype: Link Rect: 201, 305, 220, 313 Destination: 322 Annotation: Subtype: Link Rect: 67, 292, 86, 300 Destination: 322 Annotation: Subtype: Link Rect: 401, 682, 410, 690 Destination: null Annotation: Subtype: Link Rect: 435, 643, 454, 651 Destination: 322 Annotation: Subtype: Link Rect: 402, 630, 410, 638 Destination: 171 Annotation: Subtype: Link Rect: 333, 591, 342, 599 Destination: 171 Annotation: Subtype: Link Rect: 455, 565, 475, 573 Destination: 281 Annotation: Subtype: Link Rect: 408, 552, 428, 560 Destination: 281 Annotation: Subtype: Link Rect: 369, 539, 388, 547 Destination: 281 Annotation: Subtype: Link Rect: 356, 513, 376, 521 Destination: 322 Annotation: Subtype: Link Rect: 506, 474, 525, 482 Destination: 281 Annotation: Subtype: Link Rect: 330, 461, 349, 469 Destination: 281 Annotation: Subtype: Link Rect: 403, 461, 422, 469 Destination: 322 Annotation: Subtype: Link Rect: 331, 305, 341, 313 Destination: null Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 259, 630, 268, 638 Destination: null Annotation: Subtype: Link Rect: 93, 591, 112, 599 Destination: 322 Annotation: Subtype: Link Rect: 170, 591, 188, 599 Destination: 322 Annotation: Subtype: Link Rect: 212, 552, 221, 560 Destination: null Annotation: Subtype: Link Rect: 493, 682, 511, 690 Destination: 322 Annotation: Subtype: Link Rect: 328, 669, 347, 677 Destination: 322 Annotation: Subtype: Link Rect: 413, 643, 422, 651 Destination: null Annotation: Subtype: Link Rect: 383, 617, 402, 625 Destination: 281 Annotation: Subtype: Link Rect: 516, 617, 535, 625 Destination: 281 Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 420, 656, 429, 664 Destination: null Annotation: Subtype: Link Rect: 429, 630, 448, 638 Destination: 322 Annotation: Subtype: Link Rect: 377, 513, 390, 521 Destination: null Annotation: Subtype: Link Rect: 430, 513, 439, 521 Destination: null Annotation: Subtype: Link Rect: 407, 487, 426, 495 Destination: 322 Annotation: Subtype: Link Rect: 536, 448, 545, 456 Destination: null Annotation: Subtype: Link Rect: 453, 422, 471, 430 Destination: 281 Annotation: Subtype: Link Rect: 403, 318, 422, 326 Destination: 322 Annotation: Subtype: Link Rect: 505, 305, 524, 313 Destination: 322 Annotation: Subtype: Link Rect: 480, 240, 489, 248 Destination: null Annotation: Subtype: Link Rect: 458, 214, 471, 222 Destination: null Annotation: Subtype: Link Rect: 489, 214, 503, 222 Destination: null Annotation: Subtype: Link Rect: 459, 162, 468, 170 Destination: 203 Annotation: Subtype: Link Rect: 493, 136, 502, 144 Destination: 203 Annotation: Subtype: Link Rect: 76, 264, 83, 267 Destination: 222 Annotation: Subtype: Link Rect: 76, 453, 83, 456 Destination: 222 Annotation: Subtype: Link Rect: 76, 574, 83, 577 Destination: 222 Annotation: Subtype: Link Rect: 151, 245, 158, 248 Destination: 222 Annotation: Subtype: Link Rect: 167, 75, 175, 77 Destination: 222 Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 70, 552, 79, 560 Destination: null Annotation: Subtype: Link Rect: 157, 539, 171, 547 Destination: null Annotation: Subtype: Link Rect: 189, 539, 203, 547 Destination: null Annotation: Subtype: Link Rect: 194, 513, 203, 521 Destination: 203 Annotation: Subtype: Link Rect: 148, 461, 167, 469 Destination: 281 Annotation: Subtype: Link Rect: 67, 409, 86, 417 Destination: 322 Annotation: Subtype: Link Rect: 156, 409, 174, 417 Destination: 322 Annotation: Subtype: Link Rect: 441, 578, 445, 586 Destination: 222 Annotation: Subtype: Link Rect: 340, 500, 359, 508 Destination: 281 Annotation: Subtype: Link Rect: 488, 500, 507, 508 Destination: 281 Annotation: Subtype: Link Rect: 329, 487, 349, 495 Destination: 322 Annotation: Subtype: Link Rect: 353, 487, 372, 495 Destination: 322 Annotation: Subtype: Link Rect: 417, 474, 422, 482 Destination: 255 Annotation: Subtype: Link Rect: 537, 448, 545, 456 Destination: 255 Annotation: Subtype: Link Rect: 391, 357, 401, 365 Destination: 255 Annotation: Subtype: Link Rect: 407, 318, 416, 326 Destination: 255 Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 213, 448, 231, 456 Destination: 281 Annotation: Subtype: Link Rect: 66, 435, 85, 443 Destination: 322 Annotation: Subtype: Link Rect: 134, 435, 152, 443 Destination: 322 Annotation: Subtype: Link Rect: 100, 136, 253, 144 Annotation: Subtype: Link Rect: 188, 66, 288, 73 Annotation: Subtype: Link Rect: 63, 55, 95, 63 Annotation: Subtype: Link Rect: 487, 690, 549, 697 Annotation: Subtype: Link Rect: 324, 679, 430, 687 Annotation: Subtype: Link Rect: 392, 637, 532, 644 Annotation: Subtype: Link Rect: 523, 594, 549, 601 Annotation: Subtype: Link Rect: 324, 583, 436, 591 Annotation: Subtype: Link Rect: 365, 531, 509, 538 Annotation: Subtype: Link Rect: 466, 478, 549, 486 Annotation: Subtype: Link Rect: 324, 468, 392, 475 Annotation: Subtype: Link Rect: 368, 426, 483, 433 Annotation: Subtype: Link Rect: 384, 374, 537, 381 Annotation: Subtype: Link Rect: 511, 352, 549, 359 Annotation: Subtype: Link Rect: 324, 341, 429, 349 Annotation: Subtype: Link Rect: 367, 299, 509, 306 Annotation: Subtype: Link Rect: 466, 266, 549, 274 Annotation: Subtype: Link Rect: 324, 256, 377, 263 Annotation: Subtype: Link Rect: 466, 214, 549, 222 Annotation: Subtype: Link Rect: 324, 203, 411, 211 Annotation: Subtype: Link Rect: 363, 151, 522, 158 Annotation: Subtype: Link Rect: 487, 97, 549, 105 Annotation: Subtype: Link Rect: 324, 87, 424, 94 Annotation: Subtype: Link Rect: 368, 55, 524, 63 Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 107, 700, 262, 707 Annotation: Subtype: Link Rect: 128, 658, 242, 665 Annotation: Subtype: Link Rect: 157, 605, 288, 613 Annotation: Subtype: Link Rect: 63, 595, 124, 602 Annotation: Subtype: Link Rect: 63, 553, 233, 560 Annotation: Subtype: Link Rect: 250, 511, 288, 518 Annotation: Subtype: Link Rect: 63, 500, 181, 508 Annotation: Subtype: Link Rect: 98, 458, 254, 466 Annotation: Subtype: Link Rect: 250, 427, 288, 435 Annotation: Subtype: Link Rect: 63, 416, 179, 424 Annotation: Subtype: Link Rect: 115, 364, 273, 371 Annotation: Subtype: Link Rect: 107, 311, 262, 319 Annotation: Subtype: Link Rect: 201, 269, 288, 277 Annotation: Subtype: Link Rect: 63, 259, 132, 266 Annotation: Subtype: Link Rect: 205, 217, 288, 224 Annotation: Subtype: Link Rect: 63, 206, 116, 214 Annotation: Subtype: Link Rect: 368, 700, 538, 707 Annotation: Subtype: Link Rect: 511, 668, 549, 676 Annotation: Subtype: Link Rect: 324, 658, 452, 665 Annotation: Subtype: Link Rect: 462, 605, 549, 613 Annotation: Subtype: Link Rect: 324, 595, 393, 602 Annotation: Subtype: Link Rect: 452, 543, 549, 550 Annotation: Subtype: Link Rect: 324, 532, 364, 540 Annotation: Subtype: Link Rect: 487, 479, 549, 487 Annotation: Subtype: Link Rect: 324, 469, 418, 476 Annotation: Subtype: Link Rect: 523, 438, 549, 445 Annotation: Subtype: Link Rect: 324, 427, 438, 435 Annotation: Subtype: Link Rect: 462, 385, 549, 392 Annotation: Subtype: Link Rect: 324, 374, 396, 382 Annotation: Subtype: Link Rect: 368, 332, 524, 340 Annotation: Subtype: Link Rect: 384, 198, 507, 206 Thumb: true Checksum: 42950a94 Type: CRC32 Checksum: d56cd70ba8d1bffe18b89df41442e8ef Type: MD5 Checksum: 814a0731a5e86276f25e65db0add259dc253dd93 Type: SHA-1