7d71b4c2f9e6b429e288b0a4f607dc25 Imaging_and_Genetic_Tools.pdf 727c0a709fb36155d4d290582e4954b16d94aec4 Imaging_and_Genetic_Tools.pdf 00f7c1ad1b34e9ce60a61af9f1bc17da1e7ecc88a072aea303a752ec5d9dba02 Imaging_and_Genetic_Tools.pdf Title: Imaging and Genetic Tools for the Investigation of the Endocannabinoid System in the CNS Subject: As central nervous system (CNS)-related disorders present an increasing cause of global morbidity, mortality, and high pressure on our healthcare system, there is an urgent need for new insights and treatment options. The endocannabinoid system (ECS) is a critical network of endogenous compounds, receptors, and enzymes that contribute to CNS development and regulation. Given its multifaceted involvement in neurobiology and its significance in various CNS disorders, the ECS as a whole is considered a promising therapeutic target. Despite significant advances in our understanding of the ECS’s role in the CNS, its complex architecture and extensive crosstalk with other biological systems present challenges for research and clinical advancements. To bridge these knowledge gaps and unlock the full therapeutic potential of ECS interventions in CNS-related disorders, a plethora of molecular–genetic tools have been developed in recent years. Here, we review some of the most impactful tools for investigating the neurological aspects of the ECS. We first provide a brief introduction to the ECS components, including cannabinoid receptors, endocannabinoids, and metabolic enzymes, emphasizing their complexity. This is followed by an exploration of cutting-edge imaging tools and genetic models aimed at elucidating the roles of these principal ECS components. Special emphasis is placed on their relevance in the context of CNS and its associated disorders. Keywords: endocannabinoids; CB1R; genetic mouse models; imaging tools; CNS Author: Armin Kouchaeknejad, Maria Helena De Donato, Gunter Van Der Walt and Emma Puighermanal Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Nov 3 07:35:28 2023 CET ModDate: Fri Nov 3 07:39:06 2023 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 49 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2926608 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UWTEUK+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 LHYLAS+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 CLINYV+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 37 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 40 0 QWAZIM+EURM10 Type 1 Builtin yes yes no 62 0 MPUDFL+PazoMath Type 1 Builtin yes yes no 66 0 OEADLJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 79 0 OEADLK+PalatinoLinotype CID TrueType Identity-H yes yes yes 82 0 OEADLL+PalatinoLinotype TrueType WinAnsi yes yes no 88 0 OEADLN+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 91 0 OEAEIJ+PalatinoLinotype TrueType MacRoman yes yes no 94 0 OEADLJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 108 0 OEADLK+PalatinoLinotype CID TrueType Identity-H yes yes yes 111 0 OEADLL+PalatinoLinotype TrueType WinAnsi yes yes no 117 0 OEADLN+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 120 0 OEAEIJ+PalatinoLinotype TrueType MacRoman yes yes no 123 0 FKUIVJ+CMSY10 Type 1 Builtin yes yes no 130 0 AXECYR+VnURWPalladioL Type 1 Custom yes yes no 140 0 OEADLJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 173 0 OEADLK+PalatinoLinotype CID TrueType Identity-H yes yes yes 176 0 OEADLL+PalatinoLinotype TrueType WinAnsi yes yes no 182 0 OEADLN+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 185 0 OEAEIJ+PalatinoLinotype TrueType MacRoman yes yes no 188 0 OEAKFI+PalatinoLinotype,Italic TrueType MacRoman yes yes no 191 0 PUFJGH+URWPalladioL-BoldItal Type 1 Custom yes yes no 204 0 IHGURL+EURM7 Type 1 Builtin yes yes no 224 0 DUJUUF+PazoMath-Italic Type 1 Builtin yes yes no 296 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-03-22 02:45:25 CET RepresentationInformation: Imaging_and_Genetic_Tools.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-03-21 19:23:46 CET Size: 2926608 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1363 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: The Endocannabinoid System (ECS) Destination: section.1 Children: Item: Title: Cannabinoid Receptors Destination: subsection.1.1 Item: Title: Endocannabinoids: Endogenous CBR Ligands Destination: subsection.1.2 Item: Title: The Enzymes Destination: subsection.1.3 Item: Title: Imaging the ECS Destination: section.2 Children: Item: Title: The Most Used Tools in ECS Imaging Destination: subsection.2.1 Item: Title: CB1R Imaging Destination: subsection.2.2 Item: Title: CB2R Destination: subsection.2.3 Item: Title: Imaging the Endocannabinoids Destination: subsection.2.4 Item: Title: Imaging eCB Metabolic Enzymes Destination: subsection.2.5 Item: Title: The Best Genetic Models to Investigate the ECS Destination: section.3 Children: Item: Title: C. elegans as a Model Destination: subsection.3.1 Children: Item: Title: The Endocannabinoid System in C. elegans Destination: subsubsection.3.1.1 Item: Title: Genetic Approaches Destination: subsubsection.3.1.2 Item: Title: Zebrafish as a Model for ECS Studies Destination: subsection.3.2 Children: Item: Title: The Endocannabinoid System in Zebrafish Destination: subsubsection.3.2.1 Item: Title: Genetic Approaches for ECS Manipulation in Zebrafish Destination: subsubsection.3.2.2 Item: Title: CB1R Models in Zebrafish Destination: subsubsection.3.2.3 Item: Title: CB2R Models in Zebrafish Destination: subsubsection.3.2.4 Item: Title: Mouse Models Destination: subsection.3.3 Children: Item: Title: CB1R Mouse Models Destination: subsubsection.3.3.1 Item: Title: Conditional CB1R Deletions Destination: subsubsection.3.3.2 Item: Title: MtCB1R Models Destination: subsubsection.3.3.3 Item: Title: CB2R Mouse Models Destination: subsubsection.3.3.4 Item: Title: CB1R B2R Genetic Models Destination: subsubsection.3.3.5 Item: Title: Genetic Mouse Models of eCB Metabolic Enzymes Destination: subsubsection.3.3.6 Item: Title: 2-AG Biosynthesis and Catabolism Destination: subsubsection.3.3.7 Item: Title: AEA Synthesis and Catabolism Destination: subsubsection.3.3.8 Item: Title: Concluding Remarks Destination: section.4 Item: Title: References Destination: section.5 Info: Title: Imaging and Genetic Tools for the Investigation of the Endocannabinoid System in the CNS Author: Armin Kouchaeknejad, Maria Helena De Donato, Gunter Van Der Walt and Emma Puighermanal Subject: As central nervous system (CNS)-related disorders present an increasing cause of global morbidity, mortality, and high pressure on our healthcare system, there is an urgent need for new insights and treatment options. The endocannabinoid system (ECS) is a critical network of endogenous compounds, receptors, and enzymes that contribute to CNS development and regulation. Given its multifaceted involvement in neurobiology and its significance in various CNS disorders, the ECS as a whole is considered a promising therapeutic target. Despite significant advances in our understanding of the ECS’s role in the CNS, its complex architecture and extensive crosstalk with other biological systems present challenges for research and clinical advancements. To bridge these knowledge gaps and unlock the full therapeutic potential of ECS interventions in CNS-related disorders, a plethora of molecular genetic tools have been developed in recent years. Here, we review some of the most impactful tools for investigating the neurological aspects of the ECS. We first provide a brief introduction to the ECS components, including cannabinoid receptors, endocannabinoids, and metabolic enzymes, emphasizing their complexity. This is followed by an exploration of cutting-edge imaging tools and genetic models aimed at elucidating the roles of these principal ECS components. Special emphasis is placed on their relevance in the context of CNS and its associated disorders. Keywords: endocannabinoids; CB1R; genetic mouse models; imaging tools; CNS Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Nov 03 07:35:28 CET 2023 ModDate: Fri Nov 03 07:39:06 CET 2023 ID: 0xcdacbc68b8c49942c90e701e0c3577c5, 0xcdacbc68b8c49942c90e701e0c3577c5 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: IHGURL+EURM7 FontSubset: true FirstChar: 11 LastChar: 11 FontDescriptor: FontName: IHGURL+EURM7 Flags: Symbolic FontBBox: -5, -243, 1229, 720 FontFile: true Font: BaseFont: MPUDFL+PazoMath FontSubset: true FirstChar: 68 LastChar: 68 FontDescriptor: FontName: MPUDFL+PazoMath Flags: Symbolic FontBBox: -40, -283, 878, 946 FontFile: true Font: BaseFont: FKUIVJ+CMSY10 FontSubset: true FirstChar: 0 LastChar: 48 FontDescriptor: FontName: FKUIVJ+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: CLINYV+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 150 FontDescriptor: FontName: CLINYV+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: DUJUUF+PazoMath-Italic FontSubset: true FirstChar: 97 LastChar: 98 FontDescriptor: FontName: DUJUUF+PazoMath-Italic Flags: Symbolic FontBBox: -70, -277, 902, 733 FontFile: true Font: BaseFont: UWTEUK+URWPalladioL-Bold FontSubset: true FirstChar: 2 LastChar: 134 FontDescriptor: FontName: UWTEUK+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: AXECYR+VnURWPalladioL FontSubset: true FirstChar: 129 LastChar: 243 FontDescriptor: FontName: AXECYR+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: PUFJGH+URWPalladioL-BoldItal FontSubset: true FirstChar: 49 LastChar: 114 FontDescriptor: FontName: PUFJGH+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: QWAZIM+EURM10 FontSubset: true FirstChar: 11 LastChar: 34 FontDescriptor: FontName: QWAZIM+EURM10 Flags: Symbolic FontBBox: -32, -243, 1060, 720 FontFile: true Font: BaseFont: LHYLAS+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: LHYLAS+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 34, 303, 152, 312 Annotation: Subtype: Link Rect: 34, 291, 80, 300 Annotation: Subtype: Link Rect: 34, 164, 96, 186 Annotation: Subtype: Link Rect: 126, 90, 154, 99 Annotation: Subtype: Link Rect: 34, 78, 147, 87 Annotation: Subtype: Link Rect: 34, 756, 180, 792 Annotation: Subtype: Link Rect: 515, 756, 560, 792 Annotation: Subtype: Link Rect: 145, 660, 156, 674 Annotation: Subtype: Link Rect: 261, 660, 272, 674 Annotation: Subtype: Link Rect: 514, 660, 525, 674 Annotation: Subtype: Link Rect: 473, 277, 480, 286 ActionDest: 259 Annotation: Subtype: Link Rect: 481, 277, 488, 286 ActionDest: 259 Annotation: Subtype: Link Rect: 200, 201, 207, 210 ActionDest: 259 Annotation: Subtype: Link Rect: 210, 201, 217, 210 ActionDest: 259 Annotation: Subtype: Link Rect: 250, 161, 257, 173 ActionDest: 59 Annotation: Subtype: Link Rect: 499, 151, 506, 160 ActionDest: 259 Annotation: Subtype: Link Rect: 211, 88, 218, 97 ActionDest: 259 Annotation: Subtype: Link Rect: 219, 88, 225, 97 ActionDest: 259 Annotation: Subtype: Link Rect: 143, 17, 286, 28 Annotation: Subtype: Link Rect: 422, 17, 560, 28 Annotation: Subtype: Link Rect: 34, 388, 87, 407 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 501, 531, 508, 543 ActionDest: 59 Annotation: Subtype: Link Rect: 549, 508, 556, 517 ActionDest: 259 Annotation: Subtype: Link Rect: 495, 471, 502, 479 ActionDest: 259 Annotation: Subtype: Link Rect: 376, 445, 388, 454 ActionDest: 259 Annotation: Subtype: Link Rect: 333, 408, 345, 417 ActionDest: 259 Annotation: Subtype: Link Rect: 544, 383, 556, 392 ActionDest: 259 Annotation: Subtype: Link Rect: 230, 332, 237, 341 ActionDest: 259 Annotation: Subtype: Link Rect: 238, 332, 250, 341 ActionDest: 259 Annotation: Subtype: Link Rect: 250, 332, 262, 341 ActionDest: 259 Annotation: Subtype: Link Rect: 355, 295, 367, 304 ActionDest: 262 Annotation: Subtype: Link Rect: 279, 119, 291, 128 ActionDest: 262 Annotation: Subtype: Link Rect: 291, 119, 303, 128 ActionDest: 262 Annotation: Subtype: Link Rect: 463, 94, 475, 103 ActionDest: 262 Annotation: Subtype: Link Rect: 231, 69, 238, 78 ActionDest: 259 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 472, 723, 484, 732 ActionDest: 262 Annotation: Subtype: Link Rect: 484, 723, 496, 732 ActionDest: 262 Annotation: Subtype: Link Rect: 197, 698, 209, 707 ActionDest: 262 Annotation: Subtype: Link Rect: 445, 635, 457, 644 ActionDest: 262 Annotation: Subtype: Link Rect: 417, 560, 429, 568 ActionDest: 259 Annotation: Subtype: Link Rect: 430, 559, 442, 568 ActionDest: 262 Annotation: Subtype: Link Rect: 507, 534, 519, 543 ActionDest: 259 Annotation: Subtype: Link Rect: 246, 497, 258, 506 ActionDest: 262 Annotation: Subtype: Link Rect: 262, 421, 274, 430 ActionDest: 262 Annotation: Subtype: Link Rect: 249, 396, 261, 405 ActionDest: 262 Annotation: Subtype: Link Rect: 267, 371, 279, 380 ActionDest: 262 Annotation: Subtype: Link Rect: 530, 270, 542, 279 ActionDest: 262 Annotation: Subtype: Link Rect: 542, 270, 554, 279 ActionDest: 262 Annotation: Subtype: Link Rect: 475, 233, 487, 242 ActionDest: 262 Annotation: Subtype: Link Rect: 488, 233, 500, 242 ActionDest: 262 Annotation: Subtype: Link Rect: 311, 170, 323, 179 ActionDest: 262 Annotation: Subtype: Link Rect: 190, 69, 197, 79 ActionDest: 259 Annotation: Subtype: Link Rect: 197, 69, 209, 79 ActionDest: 262 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 480, 735, 492, 744 ActionDest: 259 Annotation: Subtype: Link Rect: 346, 695, 353, 707 ActionDest: 59 Annotation: Subtype: Link Rect: 389, 695, 397, 707 ActionDest: 73 Annotation: Subtype: Link Rect: 404, 698, 416, 707 ActionDest: 262 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 369, 723, 381, 732 ActionDest: 262 Annotation: Subtype: Link Rect: 384, 723, 396, 732 ActionDest: 262 Annotation: Subtype: Link Rect: 309, 698, 321, 707 ActionDest: 262 Annotation: Subtype: Link Rect: 316, 647, 328, 657 ActionDest: 262 Annotation: Subtype: Link Rect: 331, 647, 343, 657 ActionDest: 265 Annotation: Subtype: Link Rect: 335, 597, 347, 606 ActionDest: 265 Annotation: Subtype: Link Rect: 356, 585, 368, 594 ActionDest: 262 Annotation: Subtype: Link Rect: 453, 469, 460, 481 ActionDest: 102 Annotation: Subtype: Link Rect: 415, 409, 427, 418 ActionDest: 259 Annotation: Subtype: Link Rect: 382, 346, 394, 355 ActionDest: 265 Annotation: Subtype: Link Rect: 549, 259, 556, 267 ActionDest: 259 Annotation: Subtype: Link Rect: 498, 183, 510, 192 ActionDest: 265 Annotation: Subtype: Link Rect: 549, 180, 556, 192 ActionDest: 102 Annotation: Subtype: Link Rect: 340, 145, 352, 154 ActionDest: 262 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 442, 723, 449, 732 ActionDest: 259 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 200, 708, 207, 720 ActionDest: 102 Annotation: Subtype: Link Rect: 544, 698, 556, 707 ActionDest: 262 Annotation: Subtype: Link Rect: 355, 673, 367, 682 ActionDest: 265 Annotation: Subtype: Link Rect: 368, 673, 380, 682 ActionDest: 265 Annotation: Subtype: Link Rect: 430, 610, 442, 619 ActionDest: 265 Annotation: Subtype: Link Rect: 348, 585, 360, 594 ActionDest: 265 Annotation: Subtype: Link Rect: 442, 434, 453, 443 ActionDest: 262 Annotation: Subtype: Link Rect: 361, 421, 373, 430 ActionDest: 265 Annotation: Subtype: Link Rect: 376, 421, 388, 430 ActionDest: 265 Annotation: Subtype: Link Rect: 393, 293, 400, 305 ActionDest: 127 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 193, 176, 200, 188 ActionDest: 127 Annotation: Subtype: Link Rect: 412, 141, 424, 150 ActionDest: 265 Annotation: Subtype: Link Rect: 425, 141, 437, 150 ActionDest: 265 Annotation: Subtype: Link Rect: 299, 116, 306, 125 ActionDest: 259 Annotation: Subtype: Link Rect: 306, 116, 318, 125 ActionDest: 265 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 286, 723, 298, 732 ActionDest: 265 Annotation: Subtype: Link Rect: 265, 622, 277, 631 ActionDest: 265 Annotation: Subtype: Link Rect: 284, 547, 291, 556 ActionDest: 259 Annotation: Subtype: Link Rect: 292, 547, 304, 556 ActionDest: 265 Annotation: Subtype: Link Rect: 308, 396, 320, 405 ActionDest: 265 Annotation: Subtype: Link Rect: 355, 394, 362, 407 ActionDest: 145 Annotation: Subtype: Link Rect: 531, 358, 543, 368 ActionDest: 265 Annotation: Subtype: Link Rect: 544, 358, 556, 368 ActionDest: 265 Annotation: Subtype: Link Rect: 492, 296, 504, 305 ActionDest: 265 Annotation: Subtype: Link Rect: 505, 296, 517, 305 ActionDest: 265 Annotation: Subtype: Link Rect: 314, 195, 326, 204 ActionDest: 265 Annotation: Subtype: Link Rect: 210, 170, 222, 179 ActionDest: 265 Annotation: Subtype: Link Rect: 350, 158, 362, 167 ActionDest: 265 Annotation: Subtype: Link Rect: 528, 145, 540, 154 ActionDest: 265 Annotation: Subtype: Link Rect: 544, 120, 556, 129 ActionDest: 262 Annotation: Subtype: Link Rect: 346, 95, 358, 104 ActionDest: 265 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 212, 622, 224, 631 ActionDest: 265 Annotation: Subtype: Link Rect: 245, 597, 257, 606 ActionDest: 265 Annotation: Subtype: Link Rect: 280, 535, 292, 544 ActionDest: 265 Annotation: Subtype: Link Rect: 396, 509, 408, 519 ActionDest: 268 Annotation: Subtype: Link Rect: 391, 484, 403, 493 ActionDest: 268 Annotation: Subtype: Link Rect: 406, 484, 418, 493 ActionDest: 268 Annotation: Subtype: Link Rect: 544, 459, 556, 468 ActionDest: 268 Annotation: Subtype: Link Rect: 423, 409, 435, 418 ActionDest: 259 Annotation: Subtype: Link Rect: 320, 384, 332, 393 ActionDest: 268 Annotation: Subtype: Link Rect: 514, 334, 526, 343 ActionDest: 268 Annotation: Subtype: Link Rect: 195, 283, 207, 293 ActionDest: 268 Annotation: Subtype: Link Rect: 208, 284, 220, 293 ActionDest: 268 Annotation: Subtype: Link Rect: 517, 154, 528, 163 ActionDest: 265 Annotation: Subtype: Link Rect: 530, 154, 541, 163 ActionDest: 265 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 518, 637, 529, 645 ActionDest: 265 Annotation: Subtype: Link Rect: 529, 637, 540, 645 ActionDest: 268 Annotation: Subtype: Link Rect: 518, 512, 529, 520 ActionDest: 265 Annotation: Subtype: Link Rect: 529, 512, 540, 520 ActionDest: 265 Annotation: Subtype: Link Rect: 524, 420, 535, 428 ActionDest: 265 Annotation: Subtype: Link Rect: 518, 356, 529, 364 ActionDest: 265 Annotation: Subtype: Link Rect: 529, 356, 540, 364 ActionDest: 268 Annotation: Subtype: Link Rect: 511, 282, 522, 290 ActionDest: 259 Annotation: Subtype: Link Rect: 523, 281, 534, 290 ActionDest: 268 Annotation: Subtype: Link Rect: 536, 281, 547, 290 ActionDest: 268 Annotation: Subtype: Link Rect: 517, 207, 528, 215 ActionDest: 268 Annotation: Subtype: Link Rect: 530, 207, 541, 215 ActionDest: 268 Annotation: Subtype: Link Rect: 371, 107, 378, 119 ActionDest: 155 Annotation: Subtype: Link Rect: 544, 97, 556, 106 ActionDest: 268 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 444, 685, 456, 694 ActionDest: 268 Annotation: Subtype: Link Rect: 256, 635, 268, 644 ActionDest: 268 Annotation: Subtype: Link Rect: 313, 522, 325, 531 ActionDest: 268 Annotation: Subtype: Link Rect: 325, 522, 337, 531 ActionDest: 268 Annotation: Subtype: Link Rect: 302, 447, 314, 456 ActionDest: 268 Annotation: Subtype: Link Rect: 454, 434, 466, 443 ActionDest: 268 Annotation: Subtype: Link Rect: 222, 371, 234, 380 ActionDest: 268 Annotation: Subtype: Link Rect: 234, 371, 246, 380 ActionDest: 268 Annotation: Subtype: Link Rect: 376, 334, 388, 343 ActionDest: 268 Annotation: Subtype: Link Rect: 240, 283, 251, 293 ActionDest: 268 Annotation: Subtype: Link Rect: 252, 283, 264, 293 ActionDest: 268 Annotation: Subtype: Link Rect: 332, 208, 343, 217 ActionDest: 268 Annotation: Subtype: Link Rect: 429, 196, 441, 205 ActionDest: 265 Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 518, 630, 529, 638 ActionDest: 268 Annotation: Subtype: Link Rect: 529, 630, 540, 638 ActionDest: 268 Annotation: Subtype: Link Rect: 518, 511, 529, 519 ActionDest: 268 Annotation: Subtype: Link Rect: 529, 511, 540, 519 ActionDest: 268 Annotation: Subtype: Link Rect: 517, 419, 528, 427 ActionDest: 268 Annotation: Subtype: Link Rect: 530, 419, 541, 427 ActionDest: 268 Annotation: Subtype: Link Rect: 518, 354, 529, 362 ActionDest: 265 Annotation: Subtype: Link Rect: 529, 354, 540, 362 ActionDest: 268 Annotation: Subtype: Link Rect: 517, 278, 528, 286 ActionDest: 268 Annotation: Subtype: Link Rect: 530, 278, 541, 286 ActionDest: 268 Annotation: Subtype: Link Rect: 460, 165, 472, 174 ActionDest: 262 Annotation: Subtype: Link Rect: 473, 165, 485, 174 ActionDest: 265 Annotation: Subtype: Link Rect: 529, 90, 541, 99 ActionDest: 268 Annotation: Subtype: Link Rect: 544, 90, 556, 99 ActionDest: 271 Page: Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 544, 710, 556, 719 ActionDest: 271 Annotation: Subtype: Link Rect: 194, 696, 201, 707 ActionDest: 158 Annotation: Subtype: Link Rect: 524, 601, 535, 610 ActionDest: 271 Annotation: Subtype: Link Rect: 524, 559, 535, 567 ActionDest: 271 Annotation: Subtype: Link Rect: 241, 474, 253, 483 ActionDest: 271 Annotation: Subtype: Link Rect: 412, 449, 419, 458 ActionDest: 259 Annotation: Subtype: Link Rect: 544, 386, 556, 395 ActionDest: 271 Annotation: Subtype: Link Rect: 549, 260, 556, 270 ActionDest: 161 Annotation: Subtype: Link Rect: 280, 210, 292, 219 ActionDest: 271 Annotation: Subtype: Link Rect: 304, 160, 316, 169 ActionDest: 271 Annotation: Subtype: Link Rect: 397, 110, 409, 119 ActionDest: 271 Annotation: Subtype: Link Rect: 382, 97, 394, 106 ActionDest: 271 Annotation: Subtype: Link Rect: 397, 97, 409, 106 ActionDest: 271 Annotation: Subtype: Link Rect: 544, 85, 556, 94 ActionDest: 271 Annotation: Subtype: Link Rect: 461, 59, 473, 69 ActionDest: 271 Page: Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 357, 723, 369, 732 ActionDest: 271 Annotation: Subtype: Link Rect: 526, 673, 538, 682 ActionDest: 271 Annotation: Subtype: Link Rect: 539, 673, 556, 682 ActionDest: 271 Annotation: Subtype: Link Rect: 215, 635, 232, 644 ActionDest: 271 Annotation: Subtype: Link Rect: 271, 585, 288, 594 ActionDest: 271 Annotation: Subtype: Link Rect: 292, 560, 309, 569 ActionDest: 271 Annotation: Subtype: Link Rect: 517, 429, 528, 437 ActionDest: 271 Annotation: Subtype: Link Rect: 530, 429, 541, 437 ActionDest: 271 Annotation: Subtype: Link Rect: 516, 309, 527, 317 ActionDest: 271 Annotation: Subtype: Link Rect: 527, 309, 542, 317 ActionDest: 271 Annotation: Subtype: Link Rect: 517, 216, 528, 225 ActionDest: 271 Annotation: Subtype: Link Rect: 530, 216, 541, 225 ActionDest: 271 Annotation: Subtype: Link Rect: 514, 135, 529, 144 ActionDest: 271 Annotation: Subtype: Link Rect: 529, 135, 545, 144 ActionDest: 271 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 292, 582, 309, 591 ActionDest: 271 Annotation: Subtype: Link Rect: 312, 582, 329, 591 ActionDest: 271 Annotation: Subtype: Link Rect: 221, 481, 238, 490 ActionDest: 271 Annotation: Subtype: Link Rect: 539, 443, 556, 452 ActionDest: 271 Annotation: Subtype: Link Rect: 378, 380, 395, 389 ActionDest: 271 Annotation: Subtype: Link Rect: 429, 292, 446, 302 ActionDest: 274 Annotation: Subtype: Link Rect: 449, 293, 466, 302 ActionDest: 274 Annotation: Subtype: Link Rect: 313, 255, 330, 264 ActionDest: 274 Annotation: Subtype: Link Rect: 467, 217, 484, 226 ActionDest: 274 Annotation: Subtype: Link Rect: 256, 192, 273, 201 ActionDest: 274 Annotation: Subtype: Link Rect: 311, 189, 318, 201 ActionDest: 167 Annotation: Subtype: Link Rect: 315, 142, 332, 151 ActionDest: 274 Annotation: Subtype: Link Rect: 223, 117, 240, 126 ActionDest: 274 Annotation: Subtype: Link Rect: 241, 117, 258, 126 ActionDest: 274 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 216, 723, 233, 732 ActionDest: 274 Annotation: Subtype: Link Rect: 236, 723, 253, 732 ActionDest: 274 Annotation: Subtype: Link Rect: 413, 155, 512, 166 Annotation: Subtype: Link Rect: 539, 72, 556, 81 ActionDest: 274 Page: Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 283, 560, 300, 568 ActionDest: 274 Annotation: Subtype: Link Rect: 300, 560, 317, 568 ActionDest: 274 Annotation: Subtype: Link Rect: 303, 509, 320, 518 ActionDest: 274 Annotation: Subtype: Link Rect: 320, 509, 337, 518 ActionDest: 274 Annotation: Subtype: Link Rect: 376, 506, 383, 518 ActionDest: 167 Annotation: Subtype: Link Rect: 479, 484, 495, 493 ActionDest: 271 Annotation: Subtype: Link Rect: 496, 484, 513, 493 ActionDest: 274 Annotation: Subtype: Link Rect: 514, 484, 530, 493 ActionDest: 274 Annotation: Subtype: Link Rect: 363, 446, 380, 455 ActionDest: 274 Annotation: Subtype: Link Rect: 361, 408, 378, 417 ActionDest: 274 Annotation: Subtype: Link Rect: 382, 333, 399, 342 ActionDest: 274 Annotation: Subtype: Link Rect: 389, 257, 405, 267 ActionDest: 274 Annotation: Subtype: Link Rect: 238, 195, 255, 204 ActionDest: 274 Annotation: Subtype: Link Rect: 256, 195, 273, 204 ActionDest: 274 Annotation: Subtype: Link Rect: 444, 157, 461, 166 ActionDest: 274 Annotation: Subtype: Link Rect: 505, 117, 512, 129 ActionDest: 198 Page: Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 524, 698, 539, 706 ActionDest: 274 Annotation: Subtype: Link Rect: 524, 676, 539, 685 ActionDest: 274 Annotation: Subtype: Link Rect: 524, 650, 539, 658 ActionDest: 274 Annotation: Subtype: Link Rect: 524, 623, 539, 631 ActionDest: 274 Annotation: Subtype: Link Rect: 524, 601, 539, 609 ActionDest: 274 Annotation: Subtype: Link Rect: 524, 585, 539, 593 ActionDest: 274 Annotation: Subtype: Link Rect: 524, 569, 539, 577 ActionDest: 274 Annotation: Subtype: Link Rect: 524, 547, 539, 556 ActionDest: 274 Annotation: Subtype: Link Rect: 524, 521, 539, 529 ActionDest: 278 Annotation: Subtype: Link Rect: 524, 494, 539, 502 ActionDest: 278 Annotation: Subtype: Link Rect: 524, 467, 539, 476 ActionDest: 278 Annotation: Subtype: Link Rect: 553, 375, 560, 387 ActionDest: 201 Annotation: Subtype: Link Rect: 509, 340, 526, 349 ActionDest: 274 Annotation: Subtype: Link Rect: 265, 277, 282, 286 ActionDest: 278 Annotation: Subtype: Link Rect: 491, 252, 508, 261 ActionDest: 274 Annotation: Subtype: Link Rect: 191, 227, 208, 236 ActionDest: 278 Annotation: Subtype: Link Rect: 209, 227, 226, 236 ActionDest: 278 Annotation: Subtype: Link Rect: 257, 176, 274, 186 ActionDest: 278 Annotation: Subtype: Link Rect: 195, 139, 212, 148 ActionDest: 274 Annotation: Subtype: Link Rect: 366, 89, 383, 98 ActionDest: 278 Page: Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 285, 723, 302, 732 ActionDest: 274 Annotation: Subtype: Link Rect: 208, 673, 225, 682 ActionDest: 278 Annotation: Subtype: Link Rect: 318, 622, 335, 631 ActionDest: 278 Annotation: Subtype: Link Rect: 539, 572, 556, 581 ActionDest: 278 Annotation: Subtype: Link Rect: 514, 487, 530, 495 ActionDest: 274 Annotation: Subtype: Link Rect: 507, 471, 522, 479 ActionDest: 274 Annotation: Subtype: Link Rect: 522, 471, 538, 479 ActionDest: 278 Annotation: Subtype: Link Rect: 514, 455, 530, 464 ActionDest: 274 Annotation: Subtype: Link Rect: 514, 440, 530, 448 ActionDest: 274 Annotation: Subtype: Link Rect: 507, 424, 522, 432 ActionDest: 274 Annotation: Subtype: Link Rect: 522, 424, 538, 432 ActionDest: 278 Annotation: Subtype: Link Rect: 514, 408, 530, 416 ActionDest: 278 Annotation: Subtype: Link Rect: 514, 392, 530, 401 ActionDest: 274 Annotation: Subtype: Link Rect: 514, 371, 530, 379 ActionDest: 278 Annotation: Subtype: Link Rect: 192, 308, 199, 320 ActionDest: 208 Annotation: Subtype: Link Rect: 268, 295, 275, 307 ActionDest: 198 Annotation: Subtype: Link Rect: 396, 260, 413, 269 ActionDest: 278 Annotation: Subtype: Link Rect: 348, 185, 365, 194 ActionDest: 274 Annotation: Subtype: Link Rect: 193, 147, 210, 156 ActionDest: 278 Annotation: Subtype: Link Rect: 210, 147, 227, 156 ActionDest: 278 Annotation: Subtype: Link Rect: 424, 110, 441, 119 ActionDest: 274 Annotation: Subtype: Link Rect: 207, 72, 224, 81 ActionDest: 278 Page: Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 343, 710, 359, 719 ActionDest: 274 Annotation: Subtype: Link Rect: 539, 698, 556, 707 ActionDest: 274 Annotation: Subtype: Link Rect: 447, 660, 464, 669 ActionDest: 278 Annotation: Subtype: Link Rect: 505, 622, 522, 631 ActionDest: 278 Annotation: Subtype: Link Rect: 522, 536, 537, 544 ActionDest: 274 Annotation: Subtype: Link Rect: 522, 520, 537, 528 ActionDest: 278 Annotation: Subtype: Link Rect: 514, 504, 529, 513 ActionDest: 274 Annotation: Subtype: Link Rect: 529, 504, 545, 513 ActionDest: 278 Annotation: Subtype: Link Rect: 522, 488, 537, 497 ActionDest: 278 Annotation: Subtype: Link Rect: 316, 420, 333, 429 ActionDest: 271 Annotation: Subtype: Link Rect: 333, 420, 350, 429 ActionDest: 278 Annotation: Subtype: Link Rect: 351, 420, 368, 429 ActionDest: 278 Annotation: Subtype: Link Rect: 232, 279, 244, 291 ActionDest: 212 Annotation: Subtype: Link Rect: 225, 269, 242, 278 ActionDest: 278 Annotation: Subtype: Link Rect: 419, 206, 436, 215 ActionDest: 278 Annotation: Subtype: Link Rect: 436, 206, 453, 215 ActionDest: 278 Annotation: Subtype: Link Rect: 454, 206, 471, 215 ActionDest: 278 Annotation: Subtype: Link Rect: 474, 206, 491, 215 ActionDest: 278 Annotation: Subtype: Link Rect: 522, 193, 538, 202 ActionDest: 278 Annotation: Subtype: Link Rect: 539, 193, 556, 202 ActionDest: 278 Annotation: Subtype: Link Rect: 268, 143, 285, 152 ActionDest: 278 Annotation: Subtype: Link Rect: 288, 143, 305, 152 ActionDest: 281 Annotation: Subtype: Link Rect: 437, 131, 454, 140 ActionDest: 281 Annotation: Subtype: Link Rect: 224, 93, 241, 102 ActionDest: 281 Annotation: Subtype: Link Rect: 244, 93, 261, 102 ActionDest: 281 Annotation: Subtype: Link Rect: 482, 80, 499, 89 ActionDest: 281 Page: Sequence: 22 Annotations: Annotation: Subtype: Link Rect: 234, 698, 251, 707 ActionDest: 281 Annotation: Subtype: Link Rect: 480, 685, 497, 694 ActionDest: 281 Annotation: Subtype: Link Rect: 497, 685, 514, 694 ActionDest: 281 Annotation: Subtype: Link Rect: 226, 647, 243, 657 ActionDest: 271 Annotation: Subtype: Link Rect: 477, 632, 489, 644 ActionDest: 212 Annotation: Subtype: Link Rect: 481, 623, 498, 631 ActionDest: 278 Annotation: Subtype: Link Rect: 499, 622, 516, 631 ActionDest: 281 Annotation: Subtype: Link Rect: 240, 610, 257, 619 ActionDest: 278 Annotation: Subtype: Link Rect: 257, 610, 274, 619 ActionDest: 278 Annotation: Subtype: Link Rect: 408, 610, 424, 619 ActionDest: 278 Annotation: Subtype: Link Rect: 425, 610, 442, 619 ActionDest: 281 Annotation: Subtype: Link Rect: 193, 597, 210, 606 ActionDest: 278 Annotation: Subtype: Link Rect: 213, 597, 229, 606 ActionDest: 281 Annotation: Subtype: Link Rect: 440, 597, 456, 606 ActionDest: 281 Annotation: Subtype: Link Rect: 457, 597, 474, 606 ActionDest: 281 Annotation: Subtype: Link Rect: 475, 597, 491, 606 ActionDest: 281 Annotation: Subtype: Link Rect: 285, 560, 302, 569 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 469, 526, 478 ActionDest: 278 Annotation: Subtype: Link Rect: 511, 443, 526, 451 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 416, 526, 424 ActionDest: 278 Annotation: Subtype: Link Rect: 511, 383, 526, 392 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 357, 526, 365 ActionDest: 278 Annotation: Subtype: Link Rect: 511, 330, 526, 338 ActionDest: 278 Annotation: Subtype: Link Rect: 511, 303, 526, 312 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 276, 526, 285 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 250, 526, 258 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 228, 526, 237 ActionDest: 278 Annotation: Subtype: Link Rect: 511, 207, 526, 216 ActionDest: 278 Annotation: Subtype: Link Rect: 511, 180, 526, 189 ActionDest: 281 Page: Sequence: 23 Annotations: Annotation: Subtype: Link Rect: 495, 676, 510, 685 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 650, 526, 658 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 618, 526, 626 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 580, 526, 588 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 547, 526, 556 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 521, 526, 529 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 489, 526, 497 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 456, 526, 465 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 418, 526, 427 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 375, 526, 384 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 322, 526, 330 ActionDest: 278 Annotation: Subtype: Link Rect: 511, 295, 526, 303 ActionDest: 278 Annotation: Subtype: Link Rect: 511, 274, 526, 282 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 247, 526, 255 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 215, 526, 223 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 183, 526, 191 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 156, 526, 164 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 135, 526, 143 ActionDest: 278 Page: Sequence: 24 Annotations: Annotation: Subtype: Link Rect: 511, 676, 526, 685 ActionDest: 278 Annotation: Subtype: Link Rect: 511, 644, 526, 652 ActionDest: 278 Annotation: Subtype: Link Rect: 511, 612, 526, 620 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 580, 526, 588 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 547, 526, 556 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 515, 526, 524 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 472, 526, 481 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 434, 526, 443 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 408, 526, 416 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 381, 526, 389 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 349, 526, 357 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 316, 526, 325 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 284, 526, 292 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 252, 526, 260 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 231, 526, 239 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 209, 526, 218 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 156, 526, 164 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 124, 526, 132 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 102, 526, 111 ActionDest: 284 Page: Sequence: 25 Annotations: Annotation: Subtype: Link Rect: 511, 682, 526, 690 ActionDest: 278 Annotation: Subtype: Link Rect: 511, 655, 526, 663 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 623, 526, 631 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 596, 526, 605 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 575, 526, 583 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 554, 526, 562 ActionDest: 284 Annotation: Subtype: Link Rect: 511, 521, 526, 530 ActionDest: 278 Annotation: Subtype: Link Rect: 511, 484, 526, 492 ActionDest: 278 Annotation: Subtype: Link Rect: 511, 446, 526, 454 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 408, 526, 417 ActionDest: 281 Annotation: Subtype: Link Rect: 511, 376, 526, 385 ActionDest: 281 Annotation: Subtype: Link Rect: 284, 293, 301, 302 ActionDest: 284 Annotation: Subtype: Link Rect: 304, 293, 321, 302 ActionDest: 284 Annotation: Subtype: Link Rect: 194, 265, 206, 277 ActionDest: 228 Annotation: Subtype: Link Rect: 264, 142, 281, 151 ActionDest: 281 Annotation: Subtype: Link Rect: 195, 117, 211, 126 ActionDest: 281 Annotation: Subtype: Link Rect: 351, 104, 368, 113 ActionDest: 281 Annotation: Subtype: Link Rect: 368, 104, 385, 113 ActionDest: 284 Annotation: Subtype: Link Rect: 386, 105, 403, 113 ActionDest: 287 Annotation: Subtype: Link Rect: 466, 92, 483, 101 ActionDest: 284 Page: Sequence: 26 Annotations: Annotation: Subtype: Link Rect: 229, 723, 246, 732 ActionDest: 284 Annotation: Subtype: Link Rect: 364, 597, 376, 606 ActionDest: 262 Annotation: Subtype: Link Rect: 376, 597, 393, 606 ActionDest: 281 Annotation: Subtype: Link Rect: 394, 597, 411, 606 ActionDest: 284 Annotation: Subtype: Link Rect: 411, 597, 428, 606 ActionDest: 287 Annotation: Subtype: Link Rect: 429, 597, 446, 606 ActionDest: 287 Annotation: Subtype: Link Rect: 202, 572, 214, 582 ActionDest: 228 Annotation: Subtype: Link Rect: 485, 495, 496, 503 ActionDest: 262 Annotation: Subtype: Link Rect: 497, 495, 512, 503 ActionDest: 281 Annotation: Subtype: Link Rect: 507, 468, 522, 476 ActionDest: 287 Annotation: Subtype: Link Rect: 507, 446, 522, 455 ActionDest: 284 Annotation: Subtype: Link Rect: 507, 425, 522, 433 ActionDest: 287 Annotation: Subtype: Link Rect: 507, 398, 522, 406 ActionDest: 287 Annotation: Subtype: Link Rect: 507, 371, 522, 380 ActionDest: 278 Annotation: Subtype: Link Rect: 507, 345, 522, 353 ActionDest: 287 Annotation: Subtype: Link Rect: 509, 312, 520, 321 ActionDest: 262 Annotation: Subtype: Link Rect: 507, 280, 522, 288 ActionDest: 287 Annotation: Subtype: Link Rect: 507, 259, 522, 267 ActionDest: 274 Annotation: Subtype: Link Rect: 499, 237, 515, 246 ActionDest: 287 Annotation: Subtype: Link Rect: 515, 237, 530, 246 ActionDest: 287 Annotation: Subtype: Link Rect: 507, 211, 522, 219 ActionDest: 287 Annotation: Subtype: Link Rect: 507, 184, 522, 192 ActionDest: 278 Annotation: Subtype: Link Rect: 507, 163, 522, 171 ActionDest: 287 Annotation: Subtype: Link Rect: 509, 136, 520, 144 ActionDest: 262 Annotation: Subtype: Link Rect: 507, 103, 522, 111 ActionDest: 287 Annotation: Subtype: Link Rect: 507, 76, 522, 85 ActionDest: 274 Page: Sequence: 27 Annotations: Annotation: Subtype: Link Rect: 507, 687, 523, 695 ActionDest: 284 Annotation: Subtype: Link Rect: 507, 665, 523, 674 ActionDest: 287 Annotation: Subtype: Link Rect: 507, 639, 523, 647 ActionDest: 287 Annotation: Subtype: Link Rect: 507, 612, 523, 620 ActionDest: 287 Annotation: Subtype: Link Rect: 507, 585, 523, 594 ActionDest: 287 Annotation: Subtype: Link Rect: 507, 553, 523, 561 ActionDest: 281 Annotation: Subtype: Link Rect: 509, 521, 520, 529 ActionDest: 262 Annotation: Subtype: Link Rect: 509, 494, 520, 502 ActionDest: 262 Annotation: Subtype: Link Rect: 507, 461, 523, 470 ActionDest: 287 Annotation: Subtype: Link Rect: 507, 429, 523, 438 ActionDest: 281 Annotation: Subtype: Link Rect: 459, 336, 471, 345 ActionDest: 259 Annotation: Subtype: Link Rect: 472, 336, 484, 345 ActionDest: 262 Annotation: Subtype: Link Rect: 481, 321, 493, 333 ActionDest: 234 Annotation: Subtype: Link Rect: 281, 286, 293, 295 ActionDest: 262 Annotation: Subtype: Link Rect: 258, 223, 270, 232 ActionDest: 262 Annotation: Subtype: Link Rect: 305, 173, 317, 182 ActionDest: 262 Annotation: Subtype: Link Rect: 420, 160, 432, 170 ActionDest: 262 Page: Sequence: 28 Annotations: Annotation: Subtype: Link Rect: 516, 692, 527, 700 ActionDest: 262 Annotation: Subtype: Link Rect: 516, 665, 527, 674 ActionDest: 262 Annotation: Subtype: Link Rect: 516, 633, 527, 642 ActionDest: 262 Annotation: Subtype: Link Rect: 516, 590, 527, 598 ActionDest: 262 Annotation: Subtype: Link Rect: 222, 417, 239, 426 ActionDest: 271 Annotation: Subtype: Link Rect: 240, 417, 257, 426 ActionDest: 287 Annotation: Subtype: Link Rect: 540, 392, 557, 401 ActionDest: 271 Annotation: Subtype: Link Rect: 194, 378, 206, 389 ActionDest: 234 Annotation: Subtype: Link Rect: 325, 329, 342, 338 ActionDest: 287 Annotation: Subtype: Link Rect: 486, 317, 503, 326 ActionDest: 287 Annotation: Subtype: Link Rect: 202, 254, 219, 263 ActionDest: 287 Annotation: Subtype: Link Rect: 521, 170, 537, 178 ActionDest: 287 Annotation: Subtype: Link Rect: 521, 143, 537, 152 ActionDest: 287 Annotation: Subtype: Link Rect: 521, 122, 537, 130 ActionDest: 287 Annotation: Subtype: Link Rect: 521, 106, 537, 115 ActionDest: 287 Annotation: Subtype: Link Rect: 521, 91, 537, 99 ActionDest: 287 Annotation: Subtype: Link Rect: 521, 75, 537, 83 ActionDest: 287 Page: Sequence: 29 Annotations: Annotation: Subtype: Link Rect: 522, 682, 537, 690 ActionDest: 290 Annotation: Subtype: Link Rect: 522, 666, 537, 674 ActionDest: 290 Annotation: Subtype: Link Rect: 522, 618, 537, 626 ActionDest: 287 Annotation: Subtype: Link Rect: 522, 591, 537, 600 ActionDest: 290 Annotation: Subtype: Link Rect: 522, 564, 537, 573 ActionDest: 290 Annotation: Subtype: Link Rect: 522, 528, 537, 536 ActionDest: 290 Annotation: Subtype: Link Rect: 522, 506, 537, 515 ActionDest: 290 Annotation: Subtype: Link Rect: 522, 479, 537, 488 ActionDest: 290 Annotation: Subtype: Link Rect: 522, 453, 537, 461 ActionDest: 290 Annotation: Subtype: Link Rect: 522, 426, 537, 434 ActionDest: 290 Annotation: Subtype: Link Rect: 522, 378, 537, 386 ActionDest: 290 Annotation: Subtype: Link Rect: 522, 346, 537, 354 ActionDest: 290 Annotation: Subtype: Link Rect: 522, 319, 537, 328 ActionDest: 290 Annotation: Subtype: Link Rect: 522, 271, 537, 279 ActionDest: 290 Annotation: Subtype: Link Rect: 423, 127, 440, 136 ActionDest: 271 Annotation: Subtype: Link Rect: 440, 127, 457, 136 ActionDest: 290 Annotation: Subtype: Link Rect: 366, 102, 378, 111 ActionDest: 265 Annotation: Subtype: Link Rect: 218, 64, 235, 74 ActionDest: 290 Page: Sequence: 30 Annotations: Annotation: Subtype: Link Rect: 496, 707, 508, 716 ActionDest: 262 Annotation: Subtype: Link Rect: 509, 707, 521, 716 ActionDest: 262 Annotation: Subtype: Link Rect: 521, 707, 538, 716 ActionDest: 290 Annotation: Subtype: Link Rect: 539, 707, 556, 716 ActionDest: 290 Annotation: Subtype: Link Rect: 462, 645, 474, 654 ActionDest: 265 Annotation: Subtype: Link Rect: 474, 644, 491, 654 ActionDest: 290 Annotation: Subtype: Link Rect: 492, 619, 504, 629 ActionDest: 268 Annotation: Subtype: Link Rect: 505, 619, 522, 629 ActionDest: 290 Annotation: Subtype: Link Rect: 364, 594, 381, 603 ActionDest: 271 Annotation: Subtype: Link Rect: 382, 594, 399, 603 ActionDest: 290 Annotation: Subtype: Link Rect: 399, 594, 416, 603 ActionDest: 290 Annotation: Subtype: Link Rect: 405, 529, 418, 541 ActionDest: 243 Annotation: Subtype: Link Rect: 200, 494, 212, 503 ActionDest: 262 Annotation: Subtype: Link Rect: 295, 431, 312, 440 ActionDest: 290 Annotation: Subtype: Link Rect: 355, 368, 372, 377 ActionDest: 290 Annotation: Subtype: Link Rect: 198, 330, 215, 339 ActionDest: 293 Annotation: Subtype: Link Rect: 537, 268, 554, 277 ActionDest: 293 Annotation: Subtype: Link Rect: 254, 217, 271, 227 ActionDest: 293 Annotation: Subtype: Link Rect: 338, 205, 355, 214 ActionDest: 293 Annotation: Subtype: Link Rect: 390, 130, 407, 139 ActionDest: 293 Annotation: Subtype: Link Rect: 240, 92, 257, 101 ActionDest: 293 Page: Sequence: 31 Annotations: Annotation: Subtype: Link Rect: 521, 697, 537, 706 ActionDest: 290 Annotation: Subtype: Link Rect: 521, 681, 537, 690 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 665, 537, 673 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 644, 537, 652 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 622, 537, 631 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 601, 537, 609 ActionDest: 290 Annotation: Subtype: Link Rect: 521, 574, 537, 583 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 547, 537, 556 ActionDest: 293 Annotation: Subtype: Link Rect: 524, 520, 535, 529 ActionDest: 262 Annotation: Subtype: Link Rect: 521, 494, 537, 502 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 467, 537, 475 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 440, 537, 449 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 413, 537, 422 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 386, 537, 395 ActionDest: 290 Annotation: Subtype: Link Rect: 521, 360, 537, 368 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 333, 537, 341 ActionDest: 290 Annotation: Subtype: Link Rect: 521, 306, 537, 315 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 274, 537, 282 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 242, 537, 250 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 221, 537, 229 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 199, 537, 208 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 172, 537, 181 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 146, 537, 154 ActionDest: 293 Page: Sequence: 32 Annotations: Annotation: Subtype: Link Rect: 522, 692, 537, 700 ActionDest: 293 Annotation: Subtype: Link Rect: 522, 665, 537, 674 ActionDest: 293 Annotation: Subtype: Link Rect: 522, 639, 537, 647 ActionDest: 293 Annotation: Subtype: Link Rect: 522, 612, 537, 620 ActionDest: 293 Annotation: Subtype: Link Rect: 522, 585, 537, 593 ActionDest: 293 Annotation: Subtype: Link Rect: 524, 553, 535, 561 ActionDest: 265 Annotation: Subtype: Link Rect: 524, 515, 535, 523 ActionDest: 262 Annotation: Subtype: Link Rect: 524, 477, 535, 486 ActionDest: 265 Annotation: Subtype: Link Rect: 524, 445, 535, 453 ActionDest: 268 Annotation: Subtype: Link Rect: 522, 418, 537, 426 ActionDest: 293 Annotation: Subtype: Link Rect: 522, 391, 537, 400 ActionDest: 293 Annotation: Subtype: Link Rect: 522, 364, 537, 373 ActionDest: 300 Annotation: Subtype: Link Rect: 364, 283, 376, 295 ActionDest: 243 Annotation: Subtype: Link Rect: 403, 273, 420, 282 ActionDest: 290 Annotation: Subtype: Link Rect: 420, 273, 437, 282 ActionDest: 300 Annotation: Subtype: Link Rect: 321, 235, 333, 244 ActionDest: 262 Annotation: Subtype: Link Rect: 333, 235, 345, 244 ActionDest: 268 Annotation: Subtype: Link Rect: 295, 185, 312, 194 ActionDest: 293 Annotation: Subtype: Link Rect: 307, 172, 324, 181 ActionDest: 293 Annotation: Subtype: Link Rect: 229, 135, 246, 144 ActionDest: 293 Annotation: Subtype: Link Rect: 290, 59, 307, 69 ActionDest: 293 Page: Sequence: 33 Annotations: Annotation: Subtype: Link Rect: 342, 735, 354, 744 ActionDest: 265 Annotation: Subtype: Link Rect: 301, 673, 318, 682 ActionDest: 300 Annotation: Subtype: Link Rect: 358, 622, 375, 631 ActionDest: 300 Annotation: Subtype: Link Rect: 273, 535, 285, 544 ActionDest: 262 Annotation: Subtype: Link Rect: 312, 459, 324, 468 ActionDest: 265 Annotation: Subtype: Link Rect: 194, 431, 206, 443 ActionDest: 253 Annotation: Subtype: Link Rect: 515, 434, 532, 443 ActionDest: 271 Annotation: Subtype: Link Rect: 186, 396, 203, 405 ActionDest: 300 Annotation: Subtype: Link Rect: 381, 384, 398, 393 ActionDest: 300 Annotation: Subtype: Link Rect: 539, 358, 556, 368 ActionDest: 290 Annotation: Subtype: Link Rect: 443, 333, 460, 342 ActionDest: 300 Annotation: Subtype: Link Rect: 352, 245, 369, 255 ActionDest: 300 Annotation: Subtype: Link Rect: 539, 233, 556, 242 ActionDest: 300 Annotation: Subtype: Link Rect: 387, 170, 404, 179 ActionDest: 300 Annotation: Subtype: Link Rect: 404, 170, 421, 179 ActionDest: 300 Page: Sequence: 34 Annotations: Annotation: Subtype: Link Rect: 526, 695, 540, 703 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 676, 540, 684 ActionDest: 293 Annotation: Subtype: Link Rect: 526, 657, 540, 665 ActionDest: 300 Annotation: Subtype: Link Rect: 528, 633, 538, 641 ActionDest: 262 Annotation: Subtype: Link Rect: 526, 609, 540, 617 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 586, 540, 593 ActionDest: 290 Annotation: Subtype: Link Rect: 526, 562, 540, 570 ActionDest: 290 Annotation: Subtype: Link Rect: 526, 538, 540, 546 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 515, 540, 522 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 486, 540, 494 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 458, 540, 465 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 439, 540, 446 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 424, 540, 432 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 405, 540, 413 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 386, 540, 394 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 372, 540, 380 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 358, 540, 366 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 344, 540, 351 ActionDest: 284 Annotation: Subtype: Link Rect: 526, 329, 540, 337 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 310, 540, 318 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 291, 540, 299 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 272, 540, 280 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 253, 540, 261 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 239, 540, 247 ActionDest: 300 Annotation: Subtype: Link Rect: 526, 225, 540, 232 ActionDest: 303 Annotation: Subtype: Link Rect: 528, 206, 538, 213 ActionDest: 268 Annotation: Subtype: Link Rect: 526, 182, 540, 190 ActionDest: 303 Annotation: Subtype: Link Rect: 256, 85, 273, 94 ActionDest: 300 Annotation: Subtype: Link Rect: 544, 69, 556, 81 ActionDest: 253 Page: Sequence: 35 Annotations: Annotation: Subtype: Link Rect: 376, 735, 393, 744 ActionDest: 303 Annotation: Subtype: Link Rect: 300, 698, 317, 707 ActionDest: 303 Annotation: Subtype: Link Rect: 365, 673, 382, 682 ActionDest: 303 Annotation: Subtype: Link Rect: 190, 647, 202, 657 ActionDest: 256 Annotation: Subtype: Link Rect: 521, 581, 537, 589 ActionDest: 303 Annotation: Subtype: Link Rect: 521, 560, 537, 568 ActionDest: 300 Annotation: Subtype: Link Rect: 524, 538, 535, 546 ActionDest: 262 Annotation: Subtype: Link Rect: 521, 511, 537, 520 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 490, 537, 498 ActionDest: 303 Annotation: Subtype: Link Rect: 521, 473, 537, 482 ActionDest: 303 Annotation: Subtype: Link Rect: 521, 457, 537, 465 ActionDest: 303 Annotation: Subtype: Link Rect: 521, 435, 537, 444 ActionDest: 300 Annotation: Subtype: Link Rect: 521, 414, 537, 422 ActionDest: 303 Annotation: Subtype: Link Rect: 521, 398, 537, 406 ActionDest: 303 Annotation: Subtype: Link Rect: 524, 376, 535, 384 ActionDest: 262 Annotation: Subtype: Link Rect: 521, 344, 537, 352 ActionDest: 303 Annotation: Subtype: Link Rect: 521, 316, 537, 325 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 300, 537, 308 ActionDest: 303 Annotation: Subtype: Link Rect: 521, 284, 537, 292 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 267, 537, 276 ActionDest: 293 Annotation: Subtype: Link Rect: 521, 251, 537, 259 ActionDest: 303 Annotation: Subtype: Link Rect: 521, 234, 537, 243 ActionDest: 303 Annotation: Subtype: Link Rect: 521, 218, 537, 226 ActionDest: 303 Annotation: Subtype: Link Rect: 521, 202, 537, 210 ActionDest: 303 Annotation: Subtype: Link Rect: 521, 180, 537, 189 ActionDest: 303 Annotation: Subtype: Link Rect: 521, 153, 537, 162 ActionDest: 303 Page: Sequence: 36 Annotations: Annotation: Subtype: Link Rect: 342, 455, 348, 466 ActionDest: 167 Annotation: Subtype: Link Rect: 487, 383, 524, 394 Annotation: Subtype: Link Rect: 59, 349, 96, 359 Annotation: Subtype: Link Rect: 166, 326, 203, 336 Annotation: Subtype: Link Rect: 91, 303, 128, 313 Annotation: Subtype: Link Rect: 386, 279, 423, 290 Annotation: Subtype: Link Rect: 59, 257, 96, 267 Annotation: Subtype: Link Rect: 59, 234, 96, 244 Annotation: Subtype: Link Rect: 248, 211, 286, 221 Annotation: Subtype: Link Rect: 122, 188, 159, 198 Annotation: Subtype: Link Rect: 351, 164, 388, 175 Annotation: Subtype: Link Rect: 86, 142, 124, 152 Annotation: Subtype: Link Rect: 130, 142, 166, 152 Annotation: Subtype: Link Rect: 520, 118, 557, 129 Annotation: Subtype: Link Rect: 59, 107, 95, 117 Annotation: Subtype: Link Rect: 519, 95, 557, 106 Annotation: Subtype: Link Rect: 59, 84, 95, 94 Annotation: Subtype: Link Rect: 206, 60, 244, 71 Page: Sequence: 37 Annotations: Annotation: Subtype: Link Rect: 131, 711, 168, 721 Annotation: Subtype: Link Rect: 293, 676, 331, 687 Annotation: Subtype: Link Rect: 520, 664, 557, 675 Annotation: Subtype: Link Rect: 207, 641, 244, 652 Annotation: Subtype: Link Rect: 77, 619, 115, 629 Annotation: Subtype: Link Rect: 449, 595, 487, 606 Annotation: Subtype: Link Rect: 174, 573, 212, 583 Annotation: Subtype: Link Rect: 218, 573, 254, 583 Annotation: Subtype: Link Rect: 406, 549, 444, 560 Annotation: Subtype: Link Rect: 450, 549, 486, 560 Annotation: Subtype: Link Rect: 210, 527, 247, 537 Annotation: Subtype: Link Rect: 254, 527, 290, 537 Annotation: Subtype: Link Rect: 519, 503, 557, 514 Annotation: Subtype: Link Rect: 59, 492, 95, 502 Annotation: Subtype: Link Rect: 163, 458, 201, 468 Annotation: Subtype: Link Rect: 115, 423, 152, 433 Annotation: Subtype: Link Rect: 520, 399, 557, 410 Annotation: Subtype: Link Rect: 329, 376, 367, 389 Annotation: Subtype: Link Rect: 108, 343, 146, 353 Annotation: Subtype: Link Rect: 179, 319, 216, 330 Annotation: Subtype: Link Rect: 59, 297, 96, 307 Annotation: Subtype: Link Rect: 135, 262, 173, 272 Annotation: Subtype: Link Rect: 179, 262, 215, 272 Annotation: Subtype: Link Rect: 59, 228, 96, 238 Annotation: Subtype: Link Rect: 102, 228, 138, 238 Annotation: Subtype: Link Rect: 59, 193, 96, 203 Annotation: Subtype: Link Rect: 223, 169, 261, 180 Annotation: Subtype: Link Rect: 144, 136, 182, 146 Annotation: Subtype: Link Rect: 260, 100, 297, 111 Annotation: Subtype: Link Rect: 59, 67, 96, 77 Page: Sequence: 38 Annotations: Annotation: Subtype: Link Rect: 509, 722, 547, 733 Annotation: Subtype: Link Rect: 59, 688, 96, 698 Annotation: Subtype: Link Rect: 152, 665, 189, 675 Annotation: Subtype: Link Rect: 90, 642, 128, 652 Annotation: Subtype: Link Rect: 298, 606, 335, 617 Annotation: Subtype: Link Rect: 203, 573, 240, 583 Annotation: Subtype: Link Rect: 135, 550, 173, 560 Annotation: Subtype: Link Rect: 305, 526, 342, 537 Annotation: Subtype: Link Rect: 171, 492, 208, 502 Annotation: Subtype: Link Rect: 215, 492, 251, 502 Annotation: Subtype: Link Rect: 306, 457, 343, 468 Annotation: Subtype: Link Rect: 59, 423, 96, 433 Annotation: Subtype: Link Rect: 102, 423, 138, 433 Annotation: Subtype: Link Rect: 520, 411, 557, 422 Annotation: Subtype: Link Rect: 59, 400, 95, 410 Annotation: Subtype: Link Rect: 131, 366, 168, 376 Annotation: Subtype: Link Rect: 175, 366, 211, 376 Annotation: Subtype: Link Rect: 218, 330, 256, 341 Annotation: Subtype: Link Rect: 285, 307, 323, 318 Annotation: Subtype: Link Rect: 285, 273, 322, 284 Annotation: Subtype: Link Rect: 329, 273, 365, 284 Annotation: Subtype: Link Rect: 219, 238, 257, 249 Annotation: Subtype: Link Rect: 263, 238, 299, 249 Annotation: Subtype: Link Rect: 458, 204, 495, 215 Annotation: Subtype: Link Rect: 502, 204, 538, 215 Annotation: Subtype: Link Rect: 104, 170, 142, 180 Annotation: Subtype: Link Rect: 306, 146, 343, 157 Annotation: Subtype: Link Rect: 246, 123, 283, 134 Annotation: Subtype: Link Rect: 475, 100, 512, 111 Annotation: Subtype: Link Rect: 519, 89, 557, 100 Annotation: Subtype: Link Rect: 223, 67, 261, 77 Annotation: Subtype: Link Rect: 267, 67, 303, 77 Page: Sequence: 39 Annotations: Annotation: Subtype: Link Rect: 242, 710, 279, 721 Annotation: Subtype: Link Rect: 285, 710, 322, 721 Annotation: Subtype: Link Rect: 345, 676, 382, 687 Annotation: Subtype: Link Rect: 388, 676, 424, 687 Annotation: Subtype: Link Rect: 131, 653, 168, 664 Annotation: Subtype: Link Rect: 175, 653, 211, 664 Annotation: Subtype: Link Rect: 359, 629, 397, 640 Annotation: Subtype: Link Rect: 403, 629, 439, 640 Annotation: Subtype: Link Rect: 444, 606, 482, 617 Annotation: Subtype: Link Rect: 59, 584, 96, 594 Annotation: Subtype: Link Rect: 86, 550, 124, 560 Annotation: Subtype: Link Rect: 429, 526, 466, 537 Annotation: Subtype: Link Rect: 202, 504, 239, 514 Annotation: Subtype: Link Rect: 313, 446, 350, 456 Annotation: Subtype: Link Rect: 357, 446, 393, 456 Annotation: Subtype: Link Rect: 190, 411, 228, 422 Annotation: Subtype: Link Rect: 234, 411, 270, 422 Annotation: Subtype: Link Rect: 317, 377, 354, 387 Annotation: Subtype: Link Rect: 361, 377, 397, 387 Annotation: Subtype: Link Rect: 247, 353, 285, 364 Annotation: Subtype: Link Rect: 291, 353, 327, 364 Annotation: Subtype: Link Rect: 95, 320, 133, 330 Annotation: Subtype: Link Rect: 157, 297, 194, 307 Annotation: Subtype: Link Rect: 278, 273, 316, 284 Annotation: Subtype: Link Rect: 472, 250, 510, 261 Annotation: Subtype: Link Rect: 303, 227, 341, 238 Annotation: Subtype: Link Rect: 95, 193, 132, 203 Annotation: Subtype: Link Rect: 320, 159, 357, 169 Annotation: Subtype: Link Rect: 364, 159, 400, 169 Annotation: Subtype: Link Rect: 418, 135, 456, 146 Annotation: Subtype: Link Rect: 462, 135, 498, 146 Annotation: Subtype: Link Rect: 251, 101, 289, 111 Annotation: Subtype: Link Rect: 295, 101, 331, 111 Annotation: Subtype: Link Rect: 86, 67, 123, 77 Annotation: Subtype: Link Rect: 129, 67, 165, 77 Page: Sequence: 40 Annotations: Annotation: Subtype: Link Rect: 520, 722, 557, 733 Annotation: Subtype: Link Rect: 136, 687, 174, 698 Annotation: Subtype: Link Rect: 503, 664, 540, 675 Annotation: Subtype: Link Rect: 140, 630, 177, 640 Annotation: Subtype: Link Rect: 208, 596, 246, 606 Annotation: Subtype: Link Rect: 419, 572, 457, 583 Annotation: Subtype: Link Rect: 243, 550, 281, 560 Annotation: Subtype: Link Rect: 185, 515, 223, 525 Annotation: Subtype: Link Rect: 157, 481, 194, 491 Annotation: Subtype: Link Rect: 200, 481, 236, 491 Annotation: Subtype: Link Rect: 400, 457, 438, 468 Annotation: Subtype: Link Rect: 519, 434, 557, 445 Annotation: Subtype: Link Rect: 59, 423, 95, 433 Annotation: Subtype: Link Rect: 59, 389, 96, 399 Annotation: Subtype: Link Rect: 205, 354, 242, 364 Annotation: Subtype: Link Rect: 363, 319, 400, 330 Annotation: Subtype: Link Rect: 332, 285, 370, 295 Annotation: Subtype: Link Rect: 168, 251, 206, 261 Annotation: Subtype: Link Rect: 186, 216, 223, 226 Annotation: Subtype: Link Rect: 300, 192, 337, 203 Annotation: Subtype: Link Rect: 519, 181, 557, 192 Annotation: Subtype: Link Rect: 59, 170, 95, 180 Annotation: Subtype: Link Rect: 236, 146, 274, 157 Annotation: Subtype: Link Rect: 280, 146, 316, 157 Annotation: Subtype: Link Rect: 339, 112, 376, 123 Annotation: Subtype: Link Rect: 360, 89, 398, 100 Annotation: Subtype: Link Rect: 404, 89, 440, 100 Annotation: Subtype: Link Rect: 345, 66, 383, 77 Annotation: Subtype: Link Rect: 389, 66, 425, 77 Page: Sequence: 41 Annotations: Annotation: Subtype: Link Rect: 59, 722, 96, 733 Annotation: Subtype: Link Rect: 462, 699, 500, 710 Annotation: Subtype: Link Rect: 326, 676, 363, 687 Annotation: Subtype: Link Rect: 348, 653, 385, 664 Annotation: Subtype: Link Rect: 316, 630, 354, 640 Annotation: Subtype: Link Rect: 113, 596, 151, 606 Annotation: Subtype: Link Rect: 157, 596, 193, 606 Annotation: Subtype: Link Rect: 519, 572, 557, 583 Annotation: Subtype: Link Rect: 286, 549, 324, 560 Annotation: Subtype: Link Rect: 330, 549, 366, 560 Annotation: Subtype: Link Rect: 369, 526, 407, 537 Annotation: Subtype: Link Rect: 479, 503, 515, 514 Annotation: Subtype: Link Rect: 521, 503, 557, 514 Annotation: Subtype: Link Rect: 467, 491, 505, 502 Annotation: Subtype: Link Rect: 284, 469, 322, 479 Annotation: Subtype: Link Rect: 305, 446, 342, 456 Annotation: Subtype: Link Rect: 367, 422, 405, 433 Annotation: Subtype: Link Rect: 478, 411, 516, 422 Annotation: Subtype: Link Rect: 286, 376, 323, 387 Annotation: Subtype: Link Rect: 329, 376, 365, 387 Annotation: Subtype: Link Rect: 192, 354, 230, 364 Annotation: Subtype: Link Rect: 236, 354, 272, 364 Annotation: Subtype: Link Rect: 300, 330, 337, 341 Annotation: Subtype: Link Rect: 343, 330, 379, 341 Annotation: Subtype: Link Rect: 463, 307, 501, 318 Annotation: Subtype: Link Rect: 131, 285, 168, 295 Annotation: Subtype: Link Rect: 175, 285, 211, 295 Annotation: Subtype: Link Rect: 135, 262, 173, 272 Annotation: Subtype: Link Rect: 179, 262, 215, 272 Annotation: Subtype: Link Rect: 519, 238, 557, 249 Annotation: Subtype: Link Rect: 59, 228, 95, 238 Annotation: Subtype: Link Rect: 205, 193, 242, 203 Annotation: Subtype: Link Rect: 272, 169, 310, 180 Annotation: Subtype: Link Rect: 131, 136, 168, 146 Annotation: Subtype: Link Rect: 219, 100, 257, 111 Annotation: Subtype: Link Rect: 104, 67, 142, 77 Annotation: Subtype: Link Rect: 148, 67, 184, 77 Page: Sequence: 42 Annotations: Annotation: Subtype: Link Rect: 358, 722, 396, 733 Annotation: Subtype: Link Rect: 91, 688, 128, 698 Annotation: Subtype: Link Rect: 134, 688, 170, 698 Annotation: Subtype: Link Rect: 59, 653, 96, 664 Annotation: Subtype: Link Rect: 102, 653, 138, 664 Annotation: Subtype: Link Rect: 258, 641, 560, 652 Annotation: Subtype: Link Rect: 56, 629, 509, 640 Annotation: Subtype: Link Rect: 519, 606, 557, 617 Annotation: Subtype: Link Rect: 59, 596, 95, 606 Annotation: Subtype: Link Rect: 412, 572, 449, 583 Annotation: Subtype: Link Rect: 206, 549, 244, 560 Annotation: Subtype: Link Rect: 203, 514, 241, 525 Annotation: Subtype: Link Rect: 495, 491, 533, 502 Annotation: Subtype: Link Rect: 279, 468, 317, 479 Annotation: Subtype: Link Rect: 277, 457, 560, 468 Annotation: Subtype: Link Rect: 56, 445, 545, 456 Annotation: Subtype: Link Rect: 178, 412, 216, 422 Annotation: Subtype: Link Rect: 222, 412, 258, 422 Annotation: Subtype: Link Rect: 472, 388, 509, 399 Annotation: Subtype: Link Rect: 515, 388, 551, 399 Annotation: Subtype: Link Rect: 117, 366, 155, 376 Annotation: Subtype: Link Rect: 161, 366, 197, 376 Annotation: Subtype: Link Rect: 444, 342, 482, 353 Annotation: Subtype: Link Rect: 508, 319, 546, 330 Annotation: Subtype: Link Rect: 318, 296, 355, 307 Annotation: Subtype: Link Rect: 95, 262, 133, 272 Annotation: Subtype: Link Rect: 409, 238, 446, 249 Annotation: Subtype: Link Rect: 254, 204, 292, 215 Annotation: Subtype: Link Rect: 435, 181, 472, 192 Annotation: Subtype: Link Rect: 393, 158, 430, 169 Annotation: Subtype: Link Rect: 437, 158, 473, 169 Annotation: Subtype: Link Rect: 59, 136, 96, 146 Annotation: Subtype: Link Rect: 102, 136, 138, 146 Annotation: Subtype: Link Rect: 282, 112, 320, 123 Annotation: Subtype: Link Rect: 326, 112, 362, 123 Annotation: Subtype: Link Rect: 59, 78, 96, 88 Page: Sequence: 43 Annotations: Annotation: Subtype: Link Rect: 200, 722, 238, 733 Annotation: Subtype: Link Rect: 59, 688, 96, 698 Annotation: Subtype: Link Rect: 59, 653, 96, 664 Annotation: Subtype: Link Rect: 409, 629, 447, 640 Annotation: Subtype: Link Rect: 404, 606, 442, 617 Annotation: Subtype: Link Rect: 350, 584, 388, 594 Annotation: Subtype: Link Rect: 351, 549, 389, 560 Annotation: Subtype: Link Rect: 395, 549, 431, 560 Annotation: Subtype: Link Rect: 194, 515, 231, 525 Annotation: Subtype: Link Rect: 238, 515, 274, 525 Annotation: Subtype: Link Rect: 445, 491, 483, 502 Annotation: Subtype: Link Rect: 489, 491, 525, 502 Annotation: Subtype: Link Rect: 371, 468, 408, 479 Annotation: Subtype: Link Rect: 104, 435, 141, 445 Annotation: Subtype: Link Rect: 506, 411, 543, 422 Annotation: Subtype: Link Rect: 416, 388, 454, 399 Annotation: Subtype: Link Rect: 256, 365, 294, 376 Annotation: Subtype: Link Rect: 248, 330, 285, 341 Annotation: Subtype: Link Rect: 104, 308, 142, 318 Annotation: Subtype: Link Rect: 474, 284, 512, 295 Annotation: Subtype: Link Rect: 518, 284, 554, 295 Annotation: Subtype: Link Rect: 352, 261, 389, 272 Annotation: Subtype: Link Rect: 395, 261, 431, 272 Annotation: Subtype: Link Rect: 59, 228, 96, 238 Annotation: Subtype: Link Rect: 479, 204, 516, 215 Annotation: Subtype: Link Rect: 521, 204, 557, 215 Annotation: Subtype: Link Rect: 279, 181, 317, 192 Annotation: Subtype: Link Rect: 347, 158, 384, 169 Annotation: Subtype: Link Rect: 445, 135, 483, 146 Annotation: Subtype: Link Rect: 382, 112, 419, 123 Annotation: Subtype: Link Rect: 95, 78, 133, 88 Page: Sequence: 44 Annotations: Annotation: Subtype: Link Rect: 469, 722, 506, 733 Annotation: Subtype: Link Rect: 479, 699, 515, 710 Annotation: Subtype: Link Rect: 521, 699, 557, 710 Annotation: Subtype: Link Rect: 520, 676, 557, 687 Annotation: Subtype: Link Rect: 131, 642, 168, 652 Annotation: Subtype: Link Rect: 175, 642, 211, 652 Annotation: Subtype: Link Rect: 433, 618, 470, 629 Annotation: Subtype: Link Rect: 411, 595, 448, 606 Annotation: Subtype: Link Rect: 455, 595, 491, 606 Annotation: Subtype: Link Rect: 257, 572, 294, 583 Annotation: Subtype: Link Rect: 59, 538, 96, 548 Annotation: Subtype: Link Rect: 489, 514, 526, 525 Annotation: Subtype: Link Rect: 113, 481, 151, 491 Annotation: Subtype: Link Rect: 59, 446, 96, 456 Annotation: Subtype: Link Rect: 203, 422, 241, 433 Annotation: Subtype: Link Rect: 104, 389, 141, 399 Annotation: Subtype: Link Rect: 147, 389, 183, 399 Annotation: Subtype: Link Rect: 449, 365, 487, 376 Annotation: Subtype: Link Rect: 478, 342, 515, 353 Annotation: Subtype: Link Rect: 521, 342, 557, 353 Annotation: Subtype: Link Rect: 248, 319, 286, 330 Annotation: Subtype: Link Rect: 246, 285, 283, 295 Annotation: Subtype: Link Rect: 370, 261, 407, 272 Annotation: Subtype: Link Rect: 420, 238, 458, 249 Annotation: Subtype: Link Rect: 203, 215, 241, 226 Annotation: Subtype: Link Rect: 176, 193, 213, 203 Annotation: Subtype: Link Rect: 287, 169, 325, 180 Annotation: Subtype: Link Rect: 331, 169, 367, 180 Annotation: Subtype: Link Rect: 404, 146, 442, 157 Annotation: Subtype: Link Rect: 448, 146, 484, 157 Annotation: Subtype: Link Rect: 245, 124, 282, 134 Annotation: Subtype: Link Rect: 288, 124, 324, 134 Annotation: Subtype: Link Rect: 477, 112, 514, 123 Annotation: Subtype: Link Rect: 95, 90, 133, 100 Annotation: Subtype: Link Rect: 512, 66, 550, 77 Page: Sequence: 45 Annotations: Annotation: Subtype: Link Rect: 95, 711, 133, 721 Annotation: Subtype: Link Rect: 461, 687, 499, 698 Annotation: Subtype: Link Rect: 113, 653, 150, 664 Annotation: Subtype: Link Rect: 497, 629, 534, 640 Annotation: Subtype: Link Rect: 59, 596, 96, 606 Annotation: Subtype: Link Rect: 102, 596, 138, 606 Annotation: Subtype: Link Rect: 519, 572, 557, 583 Annotation: Subtype: Link Rect: 59, 561, 95, 571 Annotation: Subtype: Link Rect: 135, 527, 173, 537 Annotation: Subtype: Link Rect: 179, 527, 215, 537 Annotation: Subtype: Link Rect: 448, 503, 486, 514 Annotation: Subtype: Link Rect: 492, 503, 528, 514 Annotation: Subtype: Link Rect: 419, 480, 456, 491 Annotation: Subtype: Link Rect: 176, 446, 213, 456 Annotation: Subtype: Link Rect: 257, 411, 295, 422 Annotation: Subtype: Link Rect: 415, 388, 452, 399 Annotation: Subtype: Link Rect: 104, 354, 142, 364 Annotation: Subtype: Link Rect: 499, 330, 537, 341 Annotation: Subtype: Link Rect: 404, 307, 441, 318 Annotation: Subtype: Link Rect: 447, 307, 483, 318 Annotation: Subtype: Link Rect: 412, 284, 449, 295 Annotation: Subtype: Link Rect: 455, 284, 492, 295 Annotation: Subtype: Link Rect: 113, 251, 151, 261 Annotation: Subtype: Link Rect: 157, 251, 193, 261 Annotation: Subtype: Link Rect: 497, 227, 535, 238 Annotation: Subtype: Link Rect: 358, 192, 396, 203 Annotation: Subtype: Link Rect: 284, 158, 322, 169 Annotation: Subtype: Link Rect: 59, 124, 96, 134 Annotation: Subtype: Link Rect: 192, 90, 229, 100 Annotation: Subtype: Link Rect: 350, 66, 388, 77 Page: Sequence: 46 Annotations: Annotation: Subtype: Link Rect: 289, 710, 327, 721 Annotation: Subtype: Link Rect: 167, 687, 205, 698 Annotation: Subtype: Link Rect: 211, 687, 247, 698 Annotation: Subtype: Link Rect: 193, 653, 231, 664 Annotation: Subtype: Link Rect: 237, 653, 273, 664 Annotation: Subtype: Link Rect: 286, 618, 323, 629 Annotation: Subtype: Link Rect: 510, 595, 547, 606 Annotation: Subtype: Link Rect: 131, 561, 168, 571 Annotation: Subtype: Link Rect: 175, 561, 211, 571 Annotation: Subtype: Link Rect: 95, 527, 133, 537 Annotation: Subtype: Link Rect: 494, 503, 532, 514 Annotation: Subtype: Link Rect: 239, 468, 277, 479 Annotation: Subtype: Link Rect: 479, 445, 516, 456 Annotation: Subtype: Link Rect: 248, 411, 285, 422 Annotation: Subtype: Link Rect: 108, 377, 146, 387 Annotation: Subtype: Link Rect: 265, 353, 303, 364 Annotation: Subtype: Link Rect: 309, 353, 345, 364 Annotation: Subtype: Link Rect: 335, 330, 372, 341 Annotation: Subtype: Link Rect: 379, 330, 415, 341 Annotation: Subtype: Link Rect: 279, 307, 317, 318 Annotation: Subtype: Link Rect: 117, 262, 155, 272 Annotation: Subtype: Link Rect: 161, 262, 197, 272 Annotation: Subtype: Link Rect: 219, 238, 256, 249 Annotation: Subtype: Link Rect: 452, 227, 489, 238 Annotation: Subtype: Link Rect: 495, 227, 531, 238 Annotation: Subtype: Link Rect: 59, 193, 96, 203 Annotation: Subtype: Link Rect: 268, 169, 306, 180 Annotation: Subtype: Link Rect: 505, 158, 542, 169 Annotation: Subtype: Link Rect: 316, 123, 354, 134 Annotation: Subtype: Link Rect: 360, 123, 396, 134 Annotation: Subtype: Link Rect: 185, 89, 222, 100 Annotation: Subtype: Link Rect: 229, 89, 265, 100 Page: Sequence: 47 Annotations: Annotation: Subtype: Link Rect: 213, 710, 251, 721 Annotation: Subtype: Link Rect: 347, 687, 385, 698 Annotation: Subtype: Link Rect: 391, 687, 427, 698 Annotation: Subtype: Link Rect: 223, 653, 261, 664 Annotation: Subtype: Link Rect: 489, 629, 527, 640 Annotation: Subtype: Link Rect: 59, 596, 96, 606 Annotation: Subtype: Link Rect: 486, 572, 523, 583 Annotation: Subtype: Link Rect: 185, 538, 222, 548 Annotation: Subtype: Link Rect: 248, 503, 285, 514 Annotation: Subtype: Link Rect: 193, 469, 231, 479 Annotation: Subtype: Link Rect: 215, 435, 252, 445 Annotation: Subtype: Link Rect: 118, 400, 155, 410 Annotation: Subtype: Link Rect: 161, 400, 197, 410 Annotation: Subtype: Link Rect: 140, 366, 177, 376 Annotation: Subtype: Link Rect: 184, 366, 220, 376 Annotation: Subtype: Link Rect: 468, 342, 506, 353 Annotation: Subtype: Link Rect: 494, 319, 532, 330 Annotation: Subtype: Link Rect: 179, 285, 216, 295 Annotation: Subtype: Link Rect: 222, 285, 258, 295 Annotation: Subtype: Link Rect: 179, 251, 217, 261 Annotation: Subtype: Link Rect: 411, 215, 448, 226 Annotation: Subtype: Link Rect: 189, 181, 227, 192 Annotation: Subtype: Link Rect: 256, 147, 294, 157 Annotation: Subtype: Link Rect: 313, 123, 351, 134 Annotation: Subtype: Link Rect: 95, 90, 133, 100 Annotation: Subtype: Link Rect: 139, 90, 175, 100 Page: Sequence: 48 Annotations: Annotation: Subtype: Link Rect: 113, 711, 150, 721 Annotation: Subtype: Link Rect: 157, 711, 193, 721 Annotation: Subtype: Link Rect: 284, 687, 322, 698 Annotation: Subtype: Link Rect: 100, 653, 137, 664 Annotation: Subtype: Link Rect: 448, 629, 485, 640 Annotation: Subtype: Link Rect: 491, 629, 527, 640 Annotation: Subtype: Link Rect: 444, 606, 482, 617 Annotation: Subtype: Link Rect: 496, 583, 533, 594 Annotation: Subtype: Link Rect: 59, 550, 96, 560 Annotation: Subtype: Link Rect: 257, 526, 294, 537 Annotation: Subtype: Link Rect: 59, 492, 96, 502 Annotation: Subtype: Link Rect: 102, 492, 138, 502 Annotation: Subtype: Link Rect: 370, 457, 407, 468 Annotation: Subtype: Link Rect: 413, 457, 449, 468 Annotation: Subtype: Link Rect: 221, 423, 258, 433 Annotation: Subtype: Link Rect: 422, 388, 459, 399 Annotation: Subtype: Link Rect: 465, 388, 501, 399 Annotation: Subtype: Link Rect: 104, 354, 142, 364 Annotation: Subtype: Link Rect: 400, 330, 437, 341 Annotation: Subtype: Link Rect: 189, 296, 227, 307 Annotation: Subtype: Link Rect: 294, 273, 332, 284 Annotation: Subtype: Link Rect: 448, 250, 486, 261 Annotation: Subtype: Link Rect: 211, 215, 249, 226 Annotation: Subtype: Link Rect: 426, 192, 463, 203 Annotation: Subtype: Link Rect: 470, 192, 506, 203 Annotation: Subtype: Link Rect: 301, 169, 338, 180 Annotation: Subtype: Link Rect: 345, 169, 381, 180 Annotation: Subtype: Link Rect: 346, 146, 383, 157 Annotation: Subtype: Link Rect: 389, 146, 425, 157 Annotation: Subtype: Link Rect: 222, 123, 259, 134 Annotation: Subtype: Link Rect: 319, 100, 357, 111 Annotation: Subtype: Link Rect: 355, 77, 392, 88 Page: Sequence: 49 Annotations: Annotation: Subtype: Link Rect: 428, 722, 465, 733 Annotation: Subtype: Link Rect: 459, 699, 497, 710 Annotation: Subtype: Link Rect: 477, 676, 514, 687 Annotation: Subtype: Link Rect: 519, 652, 557, 664 Annotation: Subtype: Link Rect: 59, 642, 95, 652 Annotation: Subtype: Link Rect: 340, 618, 377, 629 Annotation: Subtype: Link Rect: 383, 618, 419, 629 Annotation: Subtype: Link Rect: 409, 595, 447, 606 Annotation: Subtype: Link Rect: 506, 572, 543, 583 Annotation: Subtype: Link Rect: 59, 538, 96, 548 Annotation: Subtype: Link Rect: 102, 538, 138, 548 Annotation: Subtype: Link Rect: 118, 504, 155, 514 Annotation: Subtype: Link Rect: 161, 504, 197, 514 Annotation: Subtype: Link Rect: 509, 481, 546, 491 Annotation: Subtype: Link Rect: 131, 446, 168, 456 Annotation: Subtype: Link Rect: 471, 422, 508, 433 Annotation: Subtype: Link Rect: 400, 399, 438, 410 Annotation: Subtype: Link Rect: 204, 365, 242, 376 Annotation: Subtype: Link Rect: 248, 365, 284, 376 Annotation: Subtype: Link Rect: 465, 330, 502, 341 Annotation: Subtype: Link Rect: 509, 330, 545, 341 Annotation: Subtype: Link Rect: 441, 307, 478, 318 Annotation: Subtype: Link Rect: 484, 307, 520, 318 Checksum: 53a1d7b1 Type: CRC32 Checksum: 7d71b4c2f9e6b429e288b0a4f607dc25 Type: MD5 Checksum: 727c0a709fb36155d4d290582e4954b16d94aec4 Type: SHA-1 Checksum: 00f7c1ad1b34e9ce60a61af9f1bc17da1e7ecc88a072aea303a752ec5d9dba02 Type: SHA-256