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Title:          Adipose tissue coregulates cognitive function
Subject:        Sci. Adv. 2023.9:eadg4017
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Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-08-31 02:29:17 CEST
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      Title: INTRODUCTION
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     Item: 
      Title: RESULTS
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       Item: 
        Title: Adipose tissue gene expression is linked to several cognitive domains
        Destination: 1
       Item: 
        Title: Adipose tissue gene expression was associated with several cognitive functions later in life
        Destination: 1
       Item: 
        Title: Adipose tissue genes linked to cognitive function are involved in neuronal system and synaptic formation
        Destination: 1
       Item: 
        Title: Morbid obesity modulates the direction of the associations between adipose tissue genes and cognition
        Destination: 1
       Item: 
        Title: Blood expression levels of key genes linked to cognitive performance
        Destination: 1
       Item: 
        Title: Down-regulation of candidate genes in the fat body of Drosophila melanogaster improves cognition
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       Item: 
        Title: Neurotransmitter release cycle associated genes SLC18A2 and RIMS1 modulate cognition in mice adipose tissue or Drosophila fat body
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     Item: 
      Title: DISCUSSION
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     Item: 
      Title: MATERIALS AND METHODS
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      Children: 
       Item: 
        Title: Clinical cohorts
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       Item: 
        Title: Neuropsychological assessment
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        Children: 
         Item: 
          Title: Digit span tests
          Destination: 1
         Item: 
          Title: Trail making test
          Destination: 1
         Item: 
          Title: California verbal learning test-II
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         Item: 
          Title: STROOP test (Golden’s version)
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         Item: 
          Title: Memory binding test
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         Item: 
          Title: Symbol digit test
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          Title: General cognition
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        Title: Adipose tissue collection and handling
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        Title: VAT- and SAT-stranded RNA-seq (discovery IRONMET; validation cohort 1 INTESTINE)
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        Title: Circulating gene expression analysis (validation cohort 2, Aging Imageomics)
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       Item: 
        Title: VAT expression of candidate genes by RT-PCR (validation cohort 3 ADIPOBRAIN)
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       Item: 
        Title: Plasma HPLC-ESI-MS/MS metabolomics (discovery IRONMET)
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       Item: 
        Title: Plasma 1H NMR metabolomics (discovery IRONMET)
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       Item: 
        Title: Plasma cytokines and neurotoxic proteins
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        Title: D. melanogaster experiments
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          Title: D. melanogaster stocks and maintenance
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         Item: 
          Title: Drosophila courtship conditioning
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         Item: 
          Title: mRNA extraction and cDNA synthesis
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         Item: 
          Title: Quantitative real-time polymerase chain reaction
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       Item: 
        Title: mRNA sequencing of fat body and fly heads
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       Item: 
        Title: Mice experiment
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         Item: 
          Title: Animals
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          Title: Experimental procedure
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         Item: 
          Title: Novel object recognition test (V-MAZE)
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         Item: 
          Title: Locomotion
          Destination: 1
       Item: 
        Title: Statistical analysis
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         Item: 
          Title: RNA expression
          Destination: 1
         Item: 
          Title: Protein analysis
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         Item: 
          Title: Statistical analysis
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     Item: 
      Title: Supplementary Materials
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       Item: 
        Title: This PDF file includes:
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       Item: 
        Title: Other Supplementary Material for this manuscript includes the following:
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     Item: 
      Title: REFERENCES AND NOTES
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     Item: 
      Title: Acknowledgments
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