e612669a84cf6a87a618578f74532188 nihms-1893725.pdf b24b92fad6a798896240b92c2198e5254f11f106 nihms-1893725.pdf f4279f761b1004a2073a0b6a62f277aa4d973bf549782093d6d6b914d1c1823c nihms-1893725.pdf Title: Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs Author: Katherine L. Moon, Heather J. Huson, Kathleen Morrill, Ming-Shan Wang, Xue Li, Krishnamoorthy Srikanth, , Kerstin Lindblad-Toh, Gavin J. Svenson, Elinor K. Karlsson, Beth ShapiroZoonomia Consortium Creator: Antenna House Formatter V7.3 MR1 Linux : 7.3.2.60453 (2023-03-06T13:41+09) Producer: Antenna House PDF Output Library 7.3.1863 CreationDate: Mon May 15 21:06:34 2023 CEST ModDate: Mon May 15 21:06:34 2023 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 832408 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- Times-Roman Type 1 Custom no no yes 12 0 Helvetica Type 1 Standard no no no 14 0 Times-Bold Type 1 Custom no no yes 23 0 Helvetica-Bold Type 1 Custom no no yes 192 0 LDYCKO+Code2000 CID TrueType Identity-H yes yes yes 639 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-01-11 02:30:00 CET RepresentationInformation: nihms-1893725.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-01-08 09:56:33 CET Size: 832408 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 85 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Abstract Item: Title: One-Sentence Summary: Item: Title: Materials and Methods: Children: Item: Title: Assembly of comparative canid genetic variants Item: Title: Ancient DNA extraction, library preparation, and genome assembly Item: Title: Variant calling Item: Title: Phylogenetic analysis and neighbor-joining trees Item: Title: Global ancestry inference Item: Title: Homozygosity and inbreeding metrics Item: Title: Population representative sampling Item: Title: Dog-referenced mammalian evolutionary constraint Item: Title: Unique, rare, and potentially deleterious variants Item: Title: Derived, common, and potentially beneficial variants Item: Title: Prediction of Balto’s aesthetic phenotypes Item: Title: Balto’s physiological adaptations Item: Title: References Item: Title: Figure 1. Item: Title: Figure 2. 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Moon, Heather J. Huson, Kathleen Morrill, Ming-Shan Wang, Xue Li, Krishnamoorthy Srikanth, , Kerstin Lindblad-Toh, Gavin J. Svenson, Elinor K. 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