8376ed79ddd0f6809c342a118409e6c8 antibiotics-12-00742-v2.pdf 5f2f532ea59b7485c7bd7e6e8848a5f7bf130878 antibiotics-12-00742-v2.pdf 27c634dff4951a950789a3e4102747c81d4c859861adc6f01a1d2571cceeb792 antibiotics-12-00742-v2.pdf Title: New Antibiotics for Staphylococcus aureus Infection: An Update from the World Association of Infectious Diseases and Immunological Disorders (WAidid) and the Italian Society of Anti-Infective Therapy (SITA) Subject: Staphylococcus aureus is an extremely virulent pathogen that is capable of quickly evolving and developing antibiotic resistance. To overcome this problem, new antibiotics have been developed. Some of these have been licenced for use in clinical practice, mainly for the treatment of adults with acute skin and soft tissue infections, in addition to both community-acquired pneumonia (CAP) and nosocomial pneumonia (hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia). In this paper, the main characteristics and clinical use of new licenced anti-staphylococcal drugs have been discussed. In vitro studies have demonstrated that some new anti-staphylococcal antibiotics have better antimicrobial activity and, at least in certain cases, more favourable pharmacokinetic properties and higher safety and tolerability than the presently available anti-staphylococcal drugs. This suggests that they may have a potential use in reducing the risk of failure of S. aureus therapy. However, an in-depth analysis of microbiological and clinical studies carried out with these new drugs seems to indicate that further studies need to be conducted before the problem of resistance of S. aureus to the antibiotics available today can be completely solved. Considering the overall available research, the drugs that are active against S. aureus appear to present a great therapeutic opportunity for overcoming resistance to traditional therapy. There are advantages in the pharmacokinetic characteristics of some of these drugs and they have the potential to reduce hospital stays and economic costs associated with their use. Keywords: antibiotics; anti-infective therapy; antimicrobial resistance; MRSA; MSSA; Staphylococcus aureus Author: Susanna Esposito, Francesco Blasi, Nigel Curtis, Sheldon Kaplan, Tiziana Lazzarotto, Marianna Meschiari, Cristina Mussini, Maddalena Peghin, Carlos Rodrigo, Antonio Vena, Nicola Principi and Matteo Bassetti Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Apr 12 15:50:44 2023 CEST ModDate: Thu Apr 20 08:21:19 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 376637 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GQOEVW+VnURWPalladioL Type 1 Custom yes yes no 10 0 XXXXHS+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 UKNYEI+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 NRITYU+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 SJLJLN+URWPalladioL-BoldItal Type 1 Custom yes yes no 28 0 YYFPCJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 47 0 KOSUXD+CMSY10 Type 1 Builtin yes yes no 69 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 88 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-01-31 02:31:30 CET RepresentationInformation: antibiotics-12-00742-v2.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-01-30 09:43:42 CET Size: 376637 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 486 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Cephalosporins Destination: section.2 Children: Item: Title: Ceftobiprole Destination: subsection.2.1 Item: Title: Ceftaroline Destination: subsection.2.2 Item: Title: Glycopeptides Destination: section.3 Item: Title: Oxazolidinones Destination: section.4 Item: Title: Tetracyclines Destination: section.5 Item: Title: Quinolones Destination: section.6 Item: Title: Conclusions Destination: section.7 Item: Title: References Destination: section.8 Info: Title: New Antibiotics for Staphylococcus aureus Infection: An Update from the World Association of Infectious Diseases and Immunological Disorders (WAidid) and the Italian Society of Anti-Infective Therapy (SITA) Author: Susanna Esposito, Francesco Blasi, Nigel Curtis, Sheldon Kaplan, Tiziana Lazzarotto, Marianna Meschiari, Cristina Mussini, Maddalena Peghin, Carlos Rodrigo, Antonio Vena, Nicola Principi and Matteo Bassetti Subject: Staphylococcus aureus is an extremely virulent pathogen that is capable of quickly evolving and developing antibiotic resistance. To overcome this problem, new antibiotics have been developed. Some of these have been licenced for use in clinical practice, mainly for the treatment of adults with acute skin and soft tissue infections, in addition to both community-acquired pneumonia (CAP) and nosocomial pneumonia (hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia). In this paper, the main characteristics and clinical use of new licenced anti-staphylococcal drugs have been discussed. In vitro studies have demonstrated that some new anti-staphylococcal antibiotics have better antimicrobial activity and, at least in certain cases, more favourable pharmacokinetic properties and higher safety and tolerability than the presently available anti-staphylococcal drugs. This suggests that they may have a potential use in reducing the risk of failure of S. aureus therapy. However, an in-depth analysis of microbiological and clinical studies carried out with these new drugs seems to indicate that further studies need to be conducted before the problem of resistance of S. aureus to the antibiotics available today can be completely solved. Considering the overall available research, the drugs that are active against S. aureus appear to present a great therapeutic opportunity for overcoming resistance to traditional therapy. There are advantages in the pharmacokinetic characteristics of some of these drugs and they have the potential to reduce hospital stays and economic costs associated with their use. 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Subtype: Link Rect: 439, 250, 560, 261 Annotation: Subtype: Link Rect: 56, 238, 342, 249 Annotation: Subtype: Link Rect: 280, 227, 560, 238 Annotation: Subtype: Link Rect: 56, 215, 172, 226 Annotation: Subtype: Link Rect: 189, 181, 226, 192 Annotation: Subtype: Link Rect: 232, 181, 268, 192 Annotation: Subtype: Link Rect: 296, 146, 334, 157 Annotation: Subtype: Link Rect: 234, 112, 272, 123 Annotation: Subtype: Link Rect: 201, 77, 238, 88 Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 427, 722, 464, 733 Annotation: Subtype: Link Rect: 466, 664, 502, 675 Annotation: Subtype: Link Rect: 507, 664, 542, 675 Annotation: Subtype: Link Rect: 467, 641, 503, 652 Annotation: Subtype: Link Rect: 508, 641, 543, 652 Annotation: Subtype: Link Rect: 436, 629, 474, 640 Annotation: Subtype: Link Rect: 480, 629, 516, 640 Annotation: Subtype: Link Rect: 414, 618, 452, 629 Annotation: Subtype: Link Rect: 458, 618, 494, 629 Annotation: Subtype: Link Rect: 322, 596, 360, 606 Annotation: Subtype: Link Rect: 330, 560, 367, 571 Annotation: Subtype: Link Rect: 421, 549, 560, 560 Annotation: Subtype: Link Rect: 56, 537, 346, 548 Annotation: Subtype: Link Rect: 486, 526, 560, 537 Annotation: Subtype: Link Rect: 56, 514, 314, 525 Annotation: Subtype: Link Rect: 452, 491, 488, 502 Annotation: Subtype: Link Rect: 449, 422, 487, 433 Annotation: Subtype: Link Rect: 420, 399, 457, 410 Annotation: Subtype: Link Rect: 376, 388, 414, 399 Annotation: Subtype: Link Rect: 127, 366, 164, 376 Annotation: Subtype: Link Rect: 170, 366, 206, 376 Annotation: Subtype: Link Rect: 441, 342, 478, 353 Annotation: Subtype: Link Rect: 485, 342, 521, 353 Annotation: Subtype: Link Rect: 420, 330, 560, 341 Annotation: Subtype: Link Rect: 56, 319, 294, 330 Annotation: Subtype: Link Rect: 280, 307, 560, 318 Annotation: Subtype: Link Rect: 56, 296, 172, 307 Annotation: Subtype: Link Rect: 405, 261, 443, 272 Annotation: Subtype: Link Rect: 449, 261, 485, 272 Annotation: Subtype: Link Rect: 276, 215, 314, 226 Annotation: Subtype: Link Rect: 320, 215, 356, 226 Annotation: Subtype: Link Rect: 386, 181, 422, 192 Annotation: Subtype: Link Rect: 428, 181, 462, 192 Annotation: Subtype: Link Rect: 59, 159, 98, 169 Annotation: Subtype: Link Rect: 105, 159, 142, 169 Annotation: Subtype: Link Rect: 365, 136, 403, 146 Page: Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 195, 722, 233, 733 Annotation: Subtype: Link Rect: 257, 699, 294, 710 Checksum: f78413a0 Type: CRC32 Checksum: 8376ed79ddd0f6809c342a118409e6c8 Type: MD5 Checksum: 5f2f532ea59b7485c7bd7e6e8848a5f7bf130878 Type: SHA-1 Checksum: 27c634dff4951a950789a3e4102747c81d4c859861adc6f01a1d2571cceeb792 Type: SHA-256