7e36eac57be9537e3fa097b31227ada8 nihms-1910168.pdf 6a5c8ff559e8cad3cfa42de95cafcc4fa0098ed1 nihms-1910168.pdf e0345ccbfc7d5e6ebea16682017fff09ced49a382f09e322be9706867aa402d5 nihms-1910168.pdf Title: Analysis of the different subpeptidomes presented by the HLA class I molecules of the B7 supertype Keywords: HLA, antigen presentation, immunopeptidome, B7 supertype, peptide Author: Adrián Tirado-Herranz, Pablo Guasp, Alba Pastor-Moreno, María Area-Navarro, Iñaki Alvarez Creator: Antenna House Formatter V7.3 MR1 Linux : 7.3.2.60453 (2023-03-06T13:41+09) Producer: Antenna House PDF Output Library 7.3.1863 CreationDate: Wed Jul 12 19:59:11 2023 CEST ModDate: Wed Jul 12 19:59:11 2023 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 23 Encrypted: no Page size: 612 x 792 pts (letter) Page rot: 0 File size: 1304110 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- Helvetica-Bold Type 1 Custom no no yes 11 0 Helvetica Type 1 Custom no no yes 14 0 Times-Roman Type 1 Custom no no yes 30 0 Times-Bold Type 1 Custom no no yes 38 0 QLKGYC+Code2000 CID TrueType Identity-H yes yes yes 59 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-07 02:30:29 CET RepresentationInformation: nihms-1910168.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-02-06 14:14:03 CET Size: 1304110 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 668 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Abstract Item: Title: Introduction Item: Title: Materials and methods Children: Item: Title: HLA-B peptidomes Item: Title: Identification of the HLA-I anchor motifs Item: Title: MHC binding affinities of HLA-I ligands. Item: Title: Statistical analysis. Item: Title: Analysis of crystal structures Item: Title: Results Children: Item: Title: Features of the B7 supertype peptidomes Item: Title: Anchor motifs of the B7 supertype HLA molecules Item: Title: HLA-B*54:01 presents, as B*51:01 and B*51:08, two subpeptidomes with favored acid residues in P1, but with Glu1 preferred to Asp1 in the subpeptidome containing Ala2 Item: Title: HLA-B35 subtypes and HLA-B*53:01 show two subpeptidomes with polar and acidic residues favored at P1 in the subpeptidome containing Ala2 Item: Title: Other HLA-B molecules of the B7 supertype do not present apparent subpeptidomes Item: Title: Peptidomes containing different amino acids than Pro or Ala at P2 show similar features to the Ala2 subpeptidome Item: Title: The presence of Thr45 and Phe67 instead of Glu45 and Tyr67 is associated with the presence of subpeptidomes in the B7 supertype molecules Item: Title: Residue 116 defines different residue preferences at the peptide C-terminal position Item: Title: Theoretical binding affinity of ligands to HLA molecules of the B7 supertype Item: Title: Discussion Item: Title: References Item: Title: Figure 1. Item: Title: Figure 2. Item: Title: Figure 3. Item: Title: Figure 4. Item: Title: Figure 5: Item: Title: Figure 6. Item: Title: Table 1. Item: Title: Table 2. Item: Title: Table 3. Item: Title: Table 4. 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