227c76abb17984969224a2a51fcdb7c3  GPRC5C.pdf
1165051a4aaa15b365c3398f6e06181c20f20b24  GPRC5C.pdf
a159cfb3b877dc6267f26da339c4fe33d9dfc706f8cf0170487ed731faecc938  GPRC5C.pdf

Title:          GPRC5C drives branched-chain amino acid metabolism in leukemogenesis
Subject:        BLOOD ADVANCES, 7 (2023) 7525-7538. doi:10.1182/bloodadvances.2023010460
Author:         Yu Wei Zhang
Creator:        Elsevier
Producer:       Acrobat Distiller 8.1.0 (Windows)
CreationDate:   Wed Dec 13 13:03:28 2023 CET
ModDate:        Wed Dec 13 13:05:42 2023 CET
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Pages:          14
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Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-02-22 02:32:41 CET
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     Item: 
      Title: GPRC5C drives branched-chain amino acid metabolism in leukemogenesis
      Destination: titlink1
      Children: 
       Item: 
        Title: Introduction
        Destination: flink1
       Item: 
        Title: Methods
        Destination: flink2
        Children: 
         Item: 
          Title: Human ethics
          Destination: slink1
         Item: 
          Title: Mouse models
          Destination: slink2
         Item: 
          Title: Generation of MLL-AF9 mice
          Destination: slink3
         Item: 
          Title: Isolation of mouse LSKs
          Destination: slink4
         Item: 
          Title: Cell cycle analysis (Ki-67)
          Destination: slink5
         Item: 
          Title: CellROX
          Destination: slink6
         Item: 
          Title: Annexin V staining
          Destination: slink7
         Item: 
          Title: Staining with pNF-κB
          Destination: slink8
         Item: 
          Title: Caspase-3 staining
          Destination: slink9
         Item: 
          Title: Single-cell division
          Destination: slink10
         Item: 
          Title: Quantitative reverse transcription PCRanalysis
          Destination: slink11
         Item: 
          Title: Virus production and primary cell infection
          Destination: slink12
         Item: 
          Title: Cell culture media
          Destination: slink13
         Item: 
          Title: Construction of lentiviral shRNAs targeting Slc7a5 and Slc43a1
          Destination: slink14
         Item: 
          Title: Preparation of liver/spleen sections
          Destination: slink15
         Item: 
          Title: Seahorse XF cell mito stress test
          Destination: slink16
         Item: 
          Title: Metabolomics
          Destination: slink17
         Item: 
          Title: Calculation of CDI
          Destination: slink18
         Item: 
          Title: Bulk RNA-seq
          Destination: slink19
         Item: 
          Title: Bulk RNA-seq analysis method: low-level processing
          Destination: slink20
         Item: 
          Title: Bulk RNA-seq analysis method: downstream analysis
          Destination: slink21
         Item: 
          Title: Statistics and reproducibility
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         Item: 
          Title: Kaplan-Meier curve based on GPRC5C expression
          Destination: slink23
       Item: 
        Title: Results
        Destination: flink3
        Children: 
         Item: 
          Title: Elevated GPRC5C expression correlates with poor survival
          Destination: slink24
         Item: 
          Title: Gprc5c overexpression drives progression of MLL-AF9 driven AML (alias KMT2A::MLLT3)
          Destination: slink25
         Item: 
          Title: Gprc5c KO delays disease development in MLL-AF9–driven AML
          Destination: slink26
         Item: 
          Title: Gprc5c modulates BCAA metabolism in AML
          Destination: slink27
         Item: 
          Title: BCAA transporters Slc43a1 and Slc7a5 are critical for leukemic viability
          Destination: slink28
         Item: 
          Title: GPRC5C enhances BCAA transporters expression through NF-κB signaling
          Destination: slink29
         Item: 
          Title: JPH203 treatment is an effective antileukemia treatment
          Destination: slink30
         Item: 
          Title: Combination treatment (JPH203 with venetoclax and azacitidine) rewires metabolism to diminish AML viability
          Destination: slink31
       Item: 
        Title: Discussion
        Destination: flink4
       Item: 
        Title: Authorship
        Destination: flink5
       Item: 
        Title: References
        Destination: blink1
   Info: 
    Title: GPRC5C drives branched-chain amino acid metabolism in leukemogenesis
    Author: Yu Wei Zhang
    Subject: BLOOD ADVANCES, 7 (2023) 7525-7538. doi:10.1182/bloodadvances.2023010460
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Wed Dec 13 13:33:28 CET 2023
    ModDate: Wed Dec 13 13:35:42 CET 2023
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   Type: CRC32
  Checksum: 227c76abb17984969224a2a51fcdb7c3
   Type: MD5
  Checksum: 1165051a4aaa15b365c3398f6e06181c20f20b24
   Type: SHA-1
  Checksum: a159cfb3b877dc6267f26da339c4fe33d9dfc706f8cf0170487ed731faecc938
   Type: SHA-256