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Title:          Immune restoration with ibrutinib plus venetoclax in first-line chronic lymphocytic leukemia: the phase 2 CAPTIVATE study
Subject:        BLOOD ADVANCES, 7 (2023) 5294-5303. doi:10.1182/bloodadvances.2023010236
Author:         Carol Moreno∗
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      Title: Immune restoration with ibrutinib plus venetoclax in first-line chronic lymphocytic leukemia: the phase 2 CAPTIVATE study
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        Title: Introduction
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       Item: 
        Title: Materials and methods
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          Title: Study design and treatment
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         Item: 
          Title: Immunophenotyping
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         Item: 
          Title: BCL-2 sensitization
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          Title: Safety analysis
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         Item: 
          Title: Statistical analysis
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        Title: Results
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          Title: Baseline characteristics and patient disposition
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         Item: 
          Title: Ibrutinib treatment sensitizes CLL cells to venetoclax
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         Item: 
          Title: Addition of venetoclax to ibrutinib drives a rapid decrease of circulating CLL cells
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          Title: B-cell count recovery after cycle 16 varied based on the randomized treatment arm
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         Item: 
          Title: Abnormal counts of T cells normalized to healthy donor levels
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          Title: Ibrutinib plus venetoclax drives recovery of classical monocytes and DCs
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          Title: Analysis from GLOW confirms the changes in immune cell subsets observed in CAPTIVATE
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         Item: 
          Title: Treatment-emergent infections decrease over time regardless of randomized treatment
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        Title: Discussion
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        Title: Authorship
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        Title: References
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   Type: CRC32
  Checksum: 1506e0ce998dd39e5905174f2ac76dda
   Type: MD5
  Checksum: d696400afeb2e87aca96168c9368c1173249a8c6
   Type: SHA-1
  Checksum: 821f85e9d2418d6dfdd7df2e9e3587b2ad2ee5e3ab9dc81a2cd1452c1f149fa0
   Type: SHA-256