7b13a6759b11acbd7119c992c43c2e98 CA_A_Cancer_J_Clinicians_-_2022.pdf 8dcff60c0bef347bbc41b6d7abcd1715ef761650 CA_A_Cancer_J_Clinicians_-_2022.pdf 42ba4f00e225b27c5da13d873ff9943a6422e4b1a36d8b5888429d396825fc66 CA_A_Cancer_J_Clinicians_-_2022.pdf Title: Cancer epigenetics in clinical practice Subject: CA A Cancer J Clinicians 2023.73:376-424 Creator: Arbortext Advanced Print Publisher 11.2.5182/W-x64 Producer: PDFlib+PDI 9.1.2p4 (C++/Win64); modified using iText 4.2.0 by 1T3XT CreationDate: Wed Jun 21 23:05:26 2023 CEST ModDate: Fri Feb 23 14:16:43 2024 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 49 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 3372119 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SRTLJS+Lato-Regular Type 1C Custom yes yes yes 155 0 NXPURK+STIX-Bold Type 1C Custom yes yes yes 2342 0 UYDLTC+Lato-Bold Type 1C Custom yes yes yes 156 0 VZXDYP+Lato-Regular CID TrueType Identity-H yes yes yes 157 0 AYHPRW+Lato-Italic Type 1C Custom yes yes yes 158 0 HKQCRA+STIX-Regular Type 1C Custom yes yes yes 2343 0 ESSTIX-Two Type 1 Builtin yes no yes 159 0 Times-Roman Type 1 WinAnsi no no no 5 0 TeX_CM_Maths_Symbols Type 1 Builtin yes no yes 214 0 YBBAAR+STIXGeneral Type 1C Custom yes yes yes 250 0 YKXTPZ+Lato-Bold CID TrueType Identity-H yes yes yes 251 0 IANVNR+Lato-Italic CID TrueType Identity-H yes yes yes 328 0 RSHCCP+ArialMT Type 1 Custom yes yes no 367 0 YIFKDO+Arial-BoldMT Type 1 Custom yes yes no 371 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-24 02:30:13 CET RepresentationInformation: CA_A_Cancer_J_Clinicians_-_2022.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-02-23 14:24:53 CET Size: 3372119 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Cancer epigenetics in clinical practice Destination: mk:title Children: Item: Title: INTRODUCTION Destination: mk:H1_1 Item: Title: EPIGENETIC BIOMARKER LANDSCAPE IN CANCER Destination: mk:H1_2 Children: Item: Title: Methods for analyzing DNA methylation Destination: mk:H2_1 Item: Title: Source material for DNA methylation analysis and liquid biopsy Destination: mk:H2_2 Item: Title: DNA methylation‐based assays of clinical utility in oncology Destination: mk:H2_3 Children: Item: Title: Colorectal cancer Destination: mk:H3_. Item: Title: Cervical cancer Destination: mk:H3_. Item: Title: Bladder cancer Destination: mk:H3_. Item: Title: Cancer of unknown primary Destination: mk:H3_. Item: Title: DNA methylation‐based cancer classifiers for CNS tumors and sarcomas Destination: mk:H3_. Item: Title: Other investigative and exploratory clinical trials involving DNA methylation biomarkers Destination: mk:H3_. Item: Title: Histone modifications as biomarkers in cancer Destination: mk:H2_16 Item: Title: EPIGENETIC DRUGS Destination: mk:H1_3 Children: Item: Title: DNA methyltransferase inhibitors Destination: mk:H2_17 Children: Item: Title: Azacitidine and decitabine for the treatment of hematologic malignancies: Myelodysplastic syndrome, acute myeloid leukemia, ... Destination: mk:H3_. Item: Title: Histone deacetylase inhibitors Destination: mk:H2_20 Children: Item: Title: Vorinostat and romidepsin for the treatment of cutaneous T‐cell lymphoma Destination: mk:H3_. Item: Title: Belinostat and tucidinostat for the treatment of peripheral T‐cell lymphoma and other tumors Destination: mk:H3_. Item: Title: Proteolysis‐targeting chimeras to degrade HDACs Destination: mk:H3_. Item: Title: Histone methyltransferase inhibitors Destination: mk:H2_26 Children: Item: Title: Combination trials with histone methyltransferase inhibitors for the treatment of hematologic and solid malignancies Destination: mk:H3_. Item: Title: Histone demethylase inhibitors Destination: mk:H2_30 Children: Item: Title: LSD1 inhibitors for the treatment of Ewing sarcoma and combination trials in other cancer types Destination: mk:H3_. Item: Title: Bromodomain and extraterminal domain protein inhibitors Destination: mk:H2_32 Children: Item: Title: Degraders to target BET proteins Destination: mk:H3_. Item: Title: Inhibitors targeting alterations that disrupt the epigenome Destination: mk:H2_35 Children: Item: Title: Treatment of IDH1/IDH2‐mutant tumors Destination: mk:H3_. 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