2eee95dd6a4247d26096cb4435dd3d99 s41408-023-00797-8.pdf ffbbcb595fd8e045a1b8d5d1e0c5f5d8becdaaae s41408-023-00797-8.pdf be1d03c9b0f0edae3c9d096004b244aaed4292607117692097bc72a785776911 s41408-023-00797-8.pdf Title: Isatuximab, carfilzomib, and dexamethasone in patients with relapsed multiple myeloma: updated results from IKEMA, a randomized Phase 3 study Subject: Blood Cancer Journal, doi:10.1038/s41408-023-00797-8 Keywords: Author: Thomas Martin Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Thu Sep 14 08:02:14 2023 CEST ModDate: Sat Nov 18 18:33:58 2023 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1522683 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FPCLOD+AdvTTab7e17fd Type 1C WinAnsi yes yes no 31 0 FPCLID+AdvTT6780a46b+01 Type 1C Custom yes yes yes 456 0 FPCLOE+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 32 0 FPCLNC+AdvOT46dcae81+20 Type 1C WinAnsi yes yes no 33 0 FPCLOC+AdvOT65f8a23b.I Type 1C WinAnsi yes yes no 34 0 FPCLOH+AdvOT46dcae81+22 Type 1C Custom yes yes yes 39 0 FPCLOI+AdvOTa20b42a7 Type 1C WinAnsi yes yes no 457 0 FPCLOF+AdvMyriad_I Type 1C WinAnsi yes yes no 458 0 FPCLOG+AdvMyriad_R Type 1C WinAnsi yes yes no 40 0 FPCKEE+AdvTT5afe5d37.B Type 1C WinAnsi yes yes no 459 0 FPCKJD+Arial-BoldMT Type 1C WinAnsi yes yes no 96 0 FPCKMD+AdvOT46dcae81 Type 1C Custom yes yes yes 41 0 FPCKME+AdvOT46dcae81+fb Type 1C Custom yes yes yes 42 0 FPCKMF+AdvTT6780a46b Type 1C Custom yes yes yes 43 0 FPCKOF+AdvTT2876772e+27 Type 1C Custom yes yes yes 460 0 FPCMNG+AdvTT6780a46b+fb Type 1C Custom yes yes yes 35 0 FPCMNH+AdvOT7d2ebc01 Type 1C WinAnsi yes yes no 36 0 FPCMEH+AdvTTab7e17fd+22 Type 1C Custom yes yes no 37 0 FPCMNF+AdvOT919a0533.B Type 1C WinAnsi yes yes no 38 0 FPCNHF+AdvOTd0125be5.BI Type 1C WinAnsi yes yes no 66 0 FPCNHG+AdvTT6780a46b+20 Type 1C WinAnsi yes yes no 67 0 FPCNGE+AdvOT3b30f6db.B+fb Type 1C Custom yes yes yes 68 0 FPCNIH+AdvTT6780a46b+22 Type 1C Custom yes yes yes 69 0 FPDCDL+AdvOT3b30f6db.B+22 Type 1C Custom yes yes yes 169 0 FPDCIK+AdvTT7b515deb Type 1C WinAnsi yes yes no 204 0 FPDCNK+AdvOT3b30f6db.B+20 Type 1C WinAnsi yes yes no 221 0 FPDCMJ+AdvOT46dcae81+01 Type 1C WinAnsi yes yes no 222 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-24 02:30:04 CET RepresentationInformation: s41408-023-00797-8.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-02-23 17:50:25 CET Size: 1522683 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 570 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Isatuximab, carfilzomib, and dexamethasone in patients with relapsed multiple myeloma: updated results from IKEMA, a randomized Phase 3 study Destination: title_link Children: Item: Title: Introduction Destination: A1 Item: Title: Methods Destination: A2 Children: Item: Title: Study design and patients Destination: B1 Item: Title: Treatment Destination: B2 Item: Title: Assessments and endpoints Destination: B3 Item: Title: Statistical analyses Destination: B4 Item: Title: Results Destination: A3 Children: Item: Title: Patients Destination: B5 Item: Title: Efficacy Destination: B6 Item: Title: Safety Destination: B7 Item: Title: Discussion Destination: A4 Item: Title: References Destination: A5 Item: Title: Acknowledgements Destination: A6 Item: Title: Author contributions Destination: A7 Item: Title: Funding Destination: A8 Item: Title: Competing interests Destination: A9 Item: Title: ADDITIONAL INFORMATION Destination: M1 Item: Title: Appendix: Lay summary Destination: A10 Info: Title: Isatuximab, carfilzomib, and dexamethasone in patients with relapsed multiple myeloma: updated results from IKEMA, a randomized Phase 3 study Author: Thomas Martin Subject: Blood Cancer Journal, doi:10.1038/s41408-023-00797-8 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Thu Sep 14 08:32:14 CEST 2023 ModDate: Sat Nov 18 18:33:58 CET 2023 ID: 0xcadbe81c9144469dda782fb21e0668ae, 0xebc532b24e98943ebe2fe408e7051493 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 261 ImageHeight: 596 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: FPCNHF+AdvOTd0125be5.BI FontSubset: true FirstChar: 110 LastChar: 110 FontDescriptor: FontName: FPCNHF+AdvOTd0125be5.BI Flags: Nonsymbolic FontBBox: -93, -250, 927, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPCNHG+AdvTT6780a46b+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: FPCNHG+AdvTT6780a46b+20 Flags: Nonsymbolic FontBBox: 0, -114, 1156, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPCNGE+AdvOT3b30f6db.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FPCNGE+AdvOT3b30f6db.B+fb Flags: Symbolic FontBBox: 0, 0, 833, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FPCNIH+AdvTT6780a46b+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FPCNIH+AdvTT6780a46b+22 Flags: Symbolic FontBBox: 0, -250, 875, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FPCLID+AdvTT6780a46b+01 FontSubset: true FirstChar: 2 LastChar: 138 FontDescriptor: FontName: FPCLID+AdvTT6780a46b+01 Flags: Symbolic FontBBox: 0, -239, 885, 864 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FPCLOI+AdvOTa20b42a7 FontSubset: true FirstChar: 48 LastChar: 121 FontDescriptor: FontName: FPCLOI+AdvOTa20b42a7 Flags: Nonsymbolic FontBBox: -72, -239, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPCLOF+AdvMyriad_I FontSubset: true FirstChar: 66 LastChar: 117 FontDescriptor: FontName: FPCLOF+AdvMyriad_I Flags: Nonsymbolic FontBBox: -104, -239, 1083, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPCKEE+AdvTT5afe5d37.B FontSubset: true FirstChar: 65 LastChar: 84 FontDescriptor: FontName: FPCKEE+AdvTT5afe5d37.B Flags: Nonsymbolic FontBBox: -31, -250, 895, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPCKOF+AdvTT2876772e+27 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FPCKOF+AdvTT2876772e+27 Flags: Symbolic FontBBox: 0, -197, 968, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FPDCIK+AdvTT7b515deb FontSubset: true FirstChar: 174 LastChar: 174 FontDescriptor: FontName: FPDCIK+AdvTT7b515deb Flags: Nonsymbolic FontBBox: -93, -187, 854, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPDCNK+AdvOT3b30f6db.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: FPDCNK+AdvOT3b30f6db.B+20 Flags: Nonsymbolic FontBBox: -10, -197, 1250, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPDCMJ+AdvOT46dcae81+01 FontSubset: true FirstChar: 138 LastChar: 138 FontDescriptor: FontName: FPDCMJ+AdvOT46dcae81+01 Flags: Nonsymbolic FontBBox: -41, -218, 854, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPCLOD+AdvTTab7e17fd FontSubset: true FirstChar: 43 LastChar: 61 FontDescriptor: FontName: FPCLOD+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPCLOE+AdvOT3b30f6db.B FontSubset: true FirstChar: 37 LastChar: 121 FontDescriptor: FontName: FPCLOE+AdvOT3b30f6db.B Flags: Nonsymbolic FontBBox: -31, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPCKJD+Arial-BoldMT FontSubset: true FirstChar: 65 LastChar: 80 FontDescriptor: FontName: FPCKJD+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPCLNC+AdvOT46dcae81+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: FPCLNC+AdvOT46dcae81+20 Flags: Nonsymbolic FontBBox: 0, -197, 1125, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPCLOC+AdvOT65f8a23b.I FontSubset: true FirstChar: 46 LastChar: 115 FontDescriptor: FontName: FPCLOC+AdvOT65f8a23b.I Flags: Nonsymbolic FontBBox: -104, -250, 885, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPCMNG+AdvTT6780a46b+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: FPCMNG+AdvTT6780a46b+fb Flags: Symbolic FontBBox: 9, 0, 875, 750 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FPCMNH+AdvOT7d2ebc01 FontSubset: true FirstChar: 50 LastChar: 57 FontDescriptor: FontName: FPCMNH+AdvOT7d2ebc01 Flags: Nonsymbolic FontBBox: -31, -208, 958, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPCMEH+AdvTTab7e17fd+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: FPCMEH+AdvTTab7e17fd+22 Flags: Nonsymbolic FontBBox: -156, -218, 937, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: FPCMNF+AdvOT919a0533.B FontSubset: true FirstChar: 46 LastChar: 108 FontDescriptor: FontName: FPCMNF+AdvOT919a0533.B Flags: Nonsymbolic FontBBox: -31, -250, 656, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPCLOH+AdvOT46dcae81+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FPCLOH+AdvOT46dcae81+22 Flags: Symbolic FontBBox: 0, -145, 687, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FPCLOG+AdvMyriad_R FontSubset: true FirstChar: 35 LastChar: 117 FontDescriptor: FontName: FPCLOG+AdvMyriad_R Flags: Nonsymbolic FontBBox: -41, -239, 1125, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: FPCKMD+AdvOT46dcae81 FontSubset: true FirstChar: 2 LastChar: 244 FontDescriptor: FontName: FPCKMD+AdvOT46dcae81 Flags: Symbolic FontBBox: -41, -250, 833, 875 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FPDCDL+AdvOT3b30f6db.B+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: FPDCDL+AdvOT3b30f6db.B+22 Flags: Symbolic FontBBox: -10, -156, 718, 833 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FPCKME+AdvOT46dcae81+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: FPCKME+AdvOT46dcae81+fb Flags: Symbolic FontBBox: 0, 0, 739, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: FPCKMF+AdvTT6780a46b FontSubset: true FirstChar: 2 LastChar: 233 FontDescriptor: FontName: FPCKMF+AdvTT6780a46b Flags: Symbolic FontBBox: -41, -250, 875, 843 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf doi:10.1038/s41408-023-00797-8 Isatuximab, carfilzomib, and dexamethasone in patients with relapsed multiple myeloma: updated results from IKEMA, a randomized Phase 3 study Thomas Martin Meletios-Athanasios Dimopoulos Joseph Mikhael Kwee Yong Marcelo Capra Thierry Facon Roman Hajek Ivan Špička Ross Baker Kihyun Kim Gracia Martinez Chang-Ki Min Ludek Pour Xavier Leleu Albert Oriol Youngil Koh Kenshi Suzuki France Casca Sandrine Macé Marie-Laure Risse Philippe Moreau Springer US Blood Cancer Journal, doi:10.1038/s41408-023-00797-8 Springer 2023-11-18T18:33:58+01:00 2023-09-14T11:32:14+05:30 2023-11-18T18:33:58+01:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) uuid:084f6417-5844-4ab5-9202-9bec4498cb16 uuid:74a3e64f-6ef9-483b-b88c-618cc8d433c1 default 1 converted uuid:05df250e-43b5-4a73-a837-1b59f3d11c14 converted to PDF/A-2b pdfToolbox 2023-09-14T11:33:07+05:30 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 478, 689, 480, 721 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 478, 695, 534, 727 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 534, 695, 549, 705 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 534, 695, 549, 705 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 94, 604, 95, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 94, 604, 95, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 104, 604, 106, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 97, 604, 104, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 104, 604, 104, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 256, 604, 257, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 256, 604, 257, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 265, 604, 268, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 258, 604, 265, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 265, 604, 266, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 334, 604, 335, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 334, 604, 335, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 344, 604, 347, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 337, 604, 344, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 344, 604, 345, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 396, 604, 397, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 396, 604, 397, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 406, 604, 409, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 399, 604, 406, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 406, 604, 407, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 87, 593, 88, 602 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 87, 593, 88, 602 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 97, 593, 99, 602 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 90, 593, 97, 602 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 97, 593, 97, 602 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 505, 593, 506, 602 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 505, 593, 506, 602 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 515, 593, 517, 602 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 507, 593, 515, 602 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 515, 593, 515, 602 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 81, 582, 82, 591 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 81, 582, 82, 591 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 91, 582, 93, 591 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 84, 582, 91, 591 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 91, 582, 91, 591 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 239, 361, 404, 370 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 211, 257, 216, 266 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 220, 257, 225, 266 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 235, 207, 240, 216 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 245, 207, 249, 216 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 254, 207, 263, 216 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 328, 276, 333, 285 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 337, 276, 346, 285 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 86, 80, 148, 87 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 476, 749, 549, 757 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 47, 713, 56, 722 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 61, 713, 70, 722 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 264, 613, 273, 622 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 150, 478, 158, 486 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 101, 451, 109, 459 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 198, 127, 206, 135 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 148, 56, 156, 64 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 331, 651, 339, 659 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 473, 388, 478, 397 Flags: Print AppearanceDictionary: true Destination: 3 Annotation: Subtype: Link Rect: 436, 328, 441, 337 Flags: Print AppearanceDictionary: true Destination: 52 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 204, 68, 213, 77 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 333, 487, 337, 496 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 389, 347, 393, 356 Flags: Print AppearanceDictionary: true Destination: 84 Annotation: Subtype: Link Rect: 359, 228, 364, 237 Flags: Print AppearanceDictionary: true Destination: 84 Annotation: Subtype: Link Rect: 373, 168, 378, 177 Flags: Print AppearanceDictionary: true Destination: 84 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 253, 197, 258, 206 Flags: Print AppearanceDictionary: true Destination: 111 Annotation: Subtype: Link Rect: 124, 98, 129, 107 Flags: Print AppearanceDictionary: true Destination: 111 Annotation: Subtype: Link Rect: 473, 98, 478, 107 Flags: Print AppearanceDictionary: true Destination: 111 Annotation: Subtype: Link Rect: 464, 88, 473, 97 Flags: Print AppearanceDictionary: true Destination: 178 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 118, 327, 127, 336 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 111, 138, 116, 147 Flags: Print AppearanceDictionary: true Destination: 143 Annotation: Subtype: Link Rect: 167, 88, 177, 97 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 343, 510, 352, 519 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 304, 317, 313, 326 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 332, 267, 341, 276 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 346, 267, 355, 276 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 415, 227, 424, 236 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 475, 198, 484, 206 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 476, 118, 486, 127 Flags: Print AppearanceDictionary: true Destination: 211 Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 233, 324, 242, 333 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 246, 324, 256, 333 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 401, 334, 411, 343 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 353, 314, 362, 323 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 495, 225, 504, 234 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 508, 225, 518, 234 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 382, 175, 391, 184 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 359, 155, 369, 164 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 423, 85, 432, 94 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 437, 85, 446, 94 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 450, 85, 460, 94 Flags: Print AppearanceDictionary: true Destination: 211 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 194, 494, 203, 503 Flags: Print AppearanceDictionary: true Destination: 211 Annotation: Subtype: Link Rect: 158, 454, 167, 463 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 175, 364, 184, 373 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 262, 65, 283, 72 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 35, 56, 77, 63 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 473, 246, 549, 253 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 313, 237, 369, 244 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 396, 219, 549, 226 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 313, 210, 469, 217 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 313, 192, 514, 199 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 313, 183, 399, 190 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 347, 598, 475, 605 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 488, 562, 559, 569 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 311, 553, 333, 560 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 265, 643, 283, 650 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 35, 634, 146, 641 Flags: Print AppearanceDictionary: true Thumb: true Checksum: b39a5b0d Type: CRC32 Checksum: 2eee95dd6a4247d26096cb4435dd3d99 Type: MD5 Checksum: ffbbcb595fd8e045a1b8d5d1e0c5f5d8becdaaae Type: SHA-1 Checksum: be1d03c9b0f0edae3c9d096004b244aaed4292607117692097bc72a785776911 Type: SHA-256