9c6efe4f059ef9baa7d8a400f3e88666 289384.pdf 8a373ea368490a77d5f0c7e8b8beafd05bc07478 289384.pdf ba0411ae92ebd764521cc21026900b3301264c1656390fafb588eb65503d8381 289384.pdf Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Thu Mar 23 03:19:32 2023 CET ModDate: Fri Feb 23 09:19:58 2024 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 501609 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OQIWLM+BookAntiqua-Bold CID TrueType Identity-H yes yes yes 296 0 NZRLXO+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 297 0 EREEBG+ArialMT CID TrueType Identity-H yes yes yes 298 0 AGNWCO+HelveticaNeueLTStd-BdCn Type 1C Custom yes yes yes 299 0 OSJBLM+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes yes 300 0 RFUJBG+HelveticaNeueLTStd-Roman Type 1C Custom yes yes yes 301 0 FNQPPE+HelveticaLTStd-BoldCond Type 1C WinAnsi yes yes yes 302 0 BKCCQM+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 303 0 AGNWCO+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 304 0 ALBGXO+NewBaskerville-Roman Type 1C WinAnsi yes yes yes 328 0 CWDSZK+Symbol Type 1C Custom yes yes yes 329 0 Helvetica Type 1 WinAnsi no no no 395 0 BKCCQM+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 378 0 AGNWCO+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 380 0 AGNWCO+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 382 0 VORCFY+SymbolMT CID TrueType Identity-H yes yes yes 216 0 CWDSZK+NewBaskerville-Italic Type 1C WinAnsi yes yes yes 204 0 BKCCQM+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 202 0 AGNWCO+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 198 0 AGNWCO+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 215 0 NXQGXO+ArialMT Type 1C WinAnsi yes yes no 219 0 NXQGXO+Arial-BoldMT Type 1C WinAnsi yes yes no 222 0 BKCCQM+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 73 0 AGNWCO+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 75 0 AGNWCO+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 77 0 NXQGXO+ZapfDingbats Type 1C Custom yes yes yes 224 0 BKCCQM+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 234 0 AGNWCO+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 232 0 AGNWCO+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 231 0 NXQGXO+HelveticaNeueLTStd-It Type 1C Custom yes yes yes 238 0 NXQGXO+ArialMT Type 1C Custom yes yes no 239 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-24 02:29:57 CET RepresentationInformation: 289384.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-02-23 09:48:29 CET Size: 501609 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 454 FreeObjects: 22 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: The Pyruvate Kinase Deficiency Global Longitudinal (Peak) Registry: rationale and study design Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Methods and analysis Children: Item: Title: Study design and objectives Item: Title: Registry governance Item: Title: Site selection and patient enrolment Item: Title: Peak Registry population Item: Title: Data collection Item: Title: Data quality and management Item: Title: Integration of NHS and Peak Registry data Item: Title: Data analysis Item: Title: Data sharing Item: Title: Ethics and dissemination Item: Title: Patient and public involvement Item: Title: Current status Item: Title: Discussion Item: Title: References Info: Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Thu Mar 23 03:49:32 CET 2023 ModDate: Fri Feb 23 01:19:58 CET 2024 ID: 0x5fc9b3e04d7295468a29e42ca4b1e9bc, 0x53067c4cd21db2110a00410810000000 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1240 ImageHeight: 737 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1197 ImageHeight: 690 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Fonts: Type0: Font: BaseFont: OQIWLM+BookAntiqua-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: VORCFY+SymbolMT Encoding: Identity-H ToUnicode: true Font: BaseFont: NZRLXO+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: EREEBG+ArialMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: NXQGXO+ZapfDingbats FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: NXQGXO+ZapfDingbats Flags: Symbolic FontBBox: -1, -143, 981, 820 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ALBGXO+NewBaskerville-Roman FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: ALBGXO+NewBaskerville-Roman Flags: Serif, Nonsymbolic FontBBox: -205, -272, 1207, 906 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: CWDSZK+Symbol FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: CWDSZK+Symbol Flags: Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: Helvetica Encoding: WinAnsiEncoding Font: BaseFont: AGNWCO+HelveticaNeueLTStd-BdCn FontSubset: true FirstChar: 31 LastChar: 121 FontDescriptor: FontName: AGNWCO+HelveticaNeueLTStd-BdCn Flags: Nonsymbolic FontBBox: -164, -224, 1066, 961 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: OSJBLM+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 32 LastChar: 167 FontDescriptor: FontName: OSJBLM+HelveticaNeueLTStd-Bd Flags: Nonsymbolic FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: CWDSZK+NewBaskerville-Italic FontSubset: true FirstChar: 75 LastChar: 82 FontDescriptor: FontName: CWDSZK+NewBaskerville-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -138, -274, 1347, 906 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: RFUJBG+HelveticaNeueLTStd-Roman FontSubset: true FirstChar: 29 LastChar: 248 FontDescriptor: FontName: RFUJBG+HelveticaNeueLTStd-Roman Flags: Nonsymbolic FontBBox: -166, -214, 1076, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FNQPPE+HelveticaLTStd-BoldCond FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: FNQPPE+HelveticaLTStd-BoldCond Flags: Nonsymbolic FontBBox: -169, -250, 1091, 991 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: NXQGXO+HelveticaNeueLTStd-It FontSubset: true FirstChar: 31 LastChar: 146 FontDescriptor: FontName: NXQGXO+HelveticaNeueLTStd-It Flags: Nonsymbolic, Italic FontBBox: -166, -214, 1106, 957 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: BKCCQM+HelveticaNeueLTStd-Cn FontSubset: true FirstChar: 29 LastChar: 169 FontDescriptor: FontName: BKCCQM+HelveticaNeueLTStd-Cn Flags: Nonsymbolic FontBBox: -164, -212, 1000, 932 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NXQGXO+ArialMT FontSubset: true FirstChar: 31 LastChar: 150 FontDescriptor: FontName: NXQGXO+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: AGNWCO+HelveticaNeueLTStd-CnO FontSubset: true FirstChar: 31 LastChar: 116 FontDescriptor: FontName: AGNWCO+HelveticaNeueLTStd-CnO Flags: Nonsymbolic, Italic FontBBox: -171, -272, 1068, 932 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NXQGXO+ArialMT FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: NXQGXO+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NXQGXO+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: NXQGXO+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: NZRLXO+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: NZRLXO+TimesNewRomanPSMT Flags: Serif, Symbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Font: BaseFont: EREEBG+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: EREEBG+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1006 FontFile2: true Font: BaseFont: OQIWLM+BookAntiqua-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: OQIWLM+BookAntiqua-Bold Flags: Serif, Symbolic FontBBox: -134, -337, 1193, 1021 FontFile2: true Font: BaseFont: VORCFY+SymbolMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: VORCFY+SymbolMT Flags: Symbolic FontBBox: 0, -220, 1113, 1005 FontFile2: true XMP: doi:bmjopen-2022-063605 application/pdf 2023-03-23T07:49:32+05:30 2024-02-23T00:19:58-08:00 2024-02-23T00:19:58-08:00 Adobe InDesign 15.1 (Windows) uuid:4c7c079a-1dd2-11b2-0a00-9000f8a087ff xmp.did:B2C59A163194E611BD009A7CB80B8EC7 xmp.id:97029d20-9814-fa45-b5db-62049c736511 proof:pdf xmp.iid:45afae91-5191-b644-ad6a-f67844f03c1b xmp.did:808f2f59-b71f-7943-a319-469b273911b1 xmp.did:B2C59A163194E611BD009A7CB80B8EC7 default converted from application/x-indesign to application/pdf Adobe InDesign 15.1 (Windows) / 2023-03-23T07:49:32+05:30 2cc38cb0-ead2-450d-96ae-f375bcec4635 Adobe PDF Library 15.0 False Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 38, 34, 63, 18 Annotation: Subtype: Link Rect: 42, 426, 119, 416 Annotation: Subtype: Link Rect: 40, 416, 110, 406 Annotation: Subtype: Link Rect: 38, 207, 134, 184 Annotation: Subtype: Link Rect: 239, 69, 288, 58 Annotation: Subtype: Link Rect: 375, 171, 385, 159 ActionDest: 135 Annotation: Subtype: Link Rect: 492, 99, 496, 87 ActionDest: 135 Annotation: Subtype: Link Rect: 576, 260, 587, 358 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 183, 699, 192, 687 ActionDest: 135 Annotation: Subtype: Link Rect: 233, 675, 237, 663 ActionDest: 135 Annotation: Subtype: Link Rect: 73, 651, 77, 639 ActionDest: 135 Annotation: Subtype: Link Rect: 238, 615, 247, 603 ActionDest: 135 Annotation: Subtype: Link Rect: 248, 579, 266, 567 ActionDest: 135 Annotation: Subtype: Link Rect: 73, 555, 82, 543 ActionDest: 135 Annotation: Subtype: Link Rect: 186, 507, 190, 495 ActionDest: 135 Annotation: Subtype: Link Rect: 140, 447, 144, 435 ActionDest: 135 Annotation: Subtype: Link Rect: 189, 423, 206, 411 ActionDest: 135 Annotation: Subtype: Link Rect: 86, 375, 98, 363 ActionDest: 135 Annotation: Subtype: Link Rect: 104, 363, 108, 351 ActionDest: 135 Annotation: Subtype: Link Rect: 92, 291, 95, 279 ActionDest: 135 Annotation: Subtype: Link Rect: 254, 279, 270, 267 ActionDest: 135 Annotation: Subtype: Link Rect: 218, 231, 225, 219 ActionDest: 135 Annotation: Subtype: Link Rect: 207, 195, 216, 183 ActionDest: 135 Annotation: Subtype: Link Rect: 408, 663, 415, 651 ActionDest: 135 Annotation: Subtype: Link Rect: 534, 615, 541, 603 ActionDest: 135 Annotation: Subtype: Link Rect: 534, 555, 541, 543 ActionDest: 135 Annotation: Subtype: Link Rect: 491, 495, 498, 483 ActionDest: 135 Annotation: Subtype: Link Rect: 342, 459, 357, 447 ActionDest: 135 Annotation: Subtype: Link Rect: 433, 387, 444, 375 ActionDest: 135 Annotation: Subtype: Link Rect: 535, 339, 542, 327 ActionDest: 135 Annotation: Subtype: Link Rect: 388, 291, 395, 279 ActionDest: 135 Annotation: Subtype: Link Rect: 422, 279, 428, 267 ActionDest: 135 Annotation: Subtype: Link Rect: 376, 195, 388, 183 ActionDest: 135 Annotation: Subtype: Link Rect: 335, 159, 348, 147 ActionDest: 135 Annotation: Subtype: Link Rect: 338, 135, 365, 123 ActionDest: 135 Annotation: Subtype: Link Rect: 449, 135, 467, 123 ActionDest: 135 Annotation: Subtype: Link Rect: 547, 135, 554, 123 ActionDest: 135 Annotation: Subtype: Link Rect: 479, 63, 486, 51 ActionDest: 135 Annotation: Subtype: Link Rect: 576, 260, 587, 358 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 139, 327, 174, 315 ActionDest: 64 Annotation: Subtype: Link Rect: 576, 260, 587, 358 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 576, 260, 587, 358 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 223, 561, 260, 549 ActionDest: 64 Annotation: Subtype: Link Rect: 89, 255, 150, 243 ActionDest: 82 Annotation: Subtype: Link Rect: 503, 255, 537, 243 ActionDest: 95 Annotation: Subtype: Link Rect: 576, 260, 587, 358 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 576, 260, 587, 358 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 576, 260, 587, 358 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 148, 195, 258, 183 Annotation: Subtype: Link Rect: 347, 723, 469, 711 Annotation: Subtype: Link Rect: 363, 374, 398, 362 ActionDest: 100 Annotation: Subtype: Link Rect: 576, 260, 587, 358 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 69, 663, 76, 651 ActionDest: 135 Annotation: Subtype: Link Rect: 110, 615, 117, 603 ActionDest: 135 Annotation: Subtype: Link Rect: 69, 519, 76, 507 ActionDest: 135 Annotation: Subtype: Link Rect: 243, 483, 250, 471 ActionDest: 135 Annotation: Subtype: Link Rect: 226, 363, 233, 351 ActionDest: 135 Annotation: Subtype: Link Rect: 205, 339, 220, 327 ActionDest: 135 Annotation: Subtype: Link Rect: 261, 303, 268, 291 ActionDest: 135 Annotation: Subtype: Link Rect: 343, 490, 434, 478 Annotation: Subtype: Link Rect: 518, 490, 554, 478 Annotation: Subtype: Link Rect: 306, 477, 380, 466 Annotation: Subtype: Link Rect: 576, 260, 587, 358 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 114, 290, 255, 281 Annotation: Subtype: Link Rect: 128, 194, 147, 185 Annotation: Subtype: Link Rect: 56, 160, 106, 151 Annotation: Subtype: Link Rect: 219, 143, 270, 134 Annotation: Subtype: Link Rect: 481, 747, 528, 738 Annotation: Subtype: Link Rect: 360, 713, 407, 704 Annotation: Subtype: Link Rect: 426, 696, 473, 687 Annotation: Subtype: Link Rect: 370, 670, 421, 661 Annotation: Subtype: Link Rect: 431, 653, 478, 644 Annotation: Subtype: Link Rect: 394, 628, 445, 619 Annotation: Subtype: Link Rect: 360, 602, 395, 593 Annotation: Subtype: Link Rect: 442, 568, 485, 559 Annotation: Subtype: Link Rect: 360, 543, 410, 534 Annotation: Subtype: Link Rect: 322, 508, 540, 500 Annotation: Subtype: Link Rect: 322, 500, 541, 491 Annotation: Subtype: Link Rect: 419, 474, 546, 466 Annotation: Subtype: Link Rect: 322, 466, 441, 457 Annotation: Subtype: Link Rect: 479, 449, 524, 440 Annotation: Subtype: Link Rect: 367, 407, 424, 398 Annotation: Subtype: Link Rect: 500, 390, 543, 381 Annotation: Subtype: Link Rect: 322, 381, 337, 372 Annotation: Subtype: Link Rect: 515, 339, 531, 330 Annotation: Subtype: Link Rect: 369, 305, 389, 296 Annotation: Subtype: Link Rect: 510, 288, 529, 279 Annotation: Subtype: Link Rect: 322, 279, 354, 270 Annotation: Subtype: Link Rect: 353, 262, 425, 253 Annotation: Subtype: Link Rect: 498, 245, 545, 236 Annotation: Subtype: Link Rect: 322, 203, 390, 194 Annotation: Subtype: Link Rect: 461, 177, 528, 168 Annotation: Subtype: Link Rect: 425, 126, 506, 117 Annotation: Subtype: Link Rect: 576, 260, 587, 358 Checksum: d66730b0 Type: CRC32 Checksum: 9c6efe4f059ef9baa7d8a400f3e88666 Type: MD5 Checksum: 8a373ea368490a77d5f0c7e8b8beafd05bc07478 Type: SHA-1 Checksum: ba0411ae92ebd764521cc21026900b3301264c1656390fafb588eb65503d8381 Type: SHA-256