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Title:          Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
Subject:        Cancer Cell, 41 (2023) 1567-1592. doi:10.1016/j.ccell.2023.07.013
Author:         Wen-Wei Liang
Creator:        Elsevier
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     Item: 
      Title: Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell ...
      Destination: titlink1
      Children: 
       Item: 
        Title: Introduction
        Destination: flink1
       Item: 
        Title: Results
        Destination: flink2
        Children: 
         Item: 
          Title: Pan-Cancer landscape of DNA methylation and associated functional changes
          Destination: slink1
         Item: 
          Title: cis-Acting aberrant DNA methylation as a possible driver event
          Destination: slink2
         Item: 
          Title: Hypomethylated RTKs are newly identified driver events
          Destination: slink3
         Item: 
          Title: Hypermethylation of STAT5A is associated with pervasive changes in STAT5A regulon activity
          Destination: slink4
         Item: 
          Title: Hypermethylated STAT5A is associated with immune cell depletion in squamous tumors
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         Item: 
          Title: Aberrant methylation associated with therapeutic vulnerabilities
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       Item: 
        Title: Discussion
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       Item: 
        Title: Supplemental information
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       Item: 
        Title: Consortia
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       Item: 
        Title: Acknowledgments
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       Item: 
        Title: Author contributions
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       Item: 
        Title: Declaration of interests
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       Item: 
        Title: Inclusion and diversity
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       Item: 
        Title: Declaration of generative AI and AI-assisted technologies in the writing process
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       Item: 
        Title: References
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       Item: 
        Title: STAR★Methods
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        Children: 
         Item: 
          Title: Key resources table
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         Item: 
          Title: Resource availability
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           Item: 
            Title: Materials availability
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           Item: 
            Title: Data and code availability
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         Item: 
          Title: Experimental model and study participant details
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          Children: 
           Item: 
            Title: Human participants
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           Item: 
            Title: Clinical data annotation
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          Title: Methods details
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           Item: 
            Title: CPTAC datasets description
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           Item: 
            Title: DNA methylation data preprocessing
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           Item: 
            Title: Batch correction of DNA methylation value
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           Item: 
            Title: Multi-omic data correlation analysis
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           Item: 
            Title: Defining aberrant DNA methylation using RESET
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           Item: 
            Title: Validation in TCGA cohorts
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           Item: 
            Title: DEG analysis using scRNA-seq dataset
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           Item: 
            Title: Defining cancer-associated genes
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           Item: 
            Title: TFBS enrichment analysis
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           Item: 
            Title: Profiling genetic alterations at driver genes
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            Title: Histone acetylation analysis
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           Item: 
            Title: Frequency of gene hyper- or hypomethylation
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           Item: 
            Title: Regulon association analysis
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           Item: 
            Title: Cell type enrichment deconvolution
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           Item: 
            Title: Immunohistochemistry analysis
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           Item: 
            Title: Methylation-driven subtyping
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           Item: 
            Title: Pathway over-representation analysis
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           Item: 
            Title: Identification of significantly mutated genes
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           Item: 
            Title: RNA expression-based subtypes
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           Item: 
            Title: Druggable genes with aberrant methylation
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           Item: 
            Title: Statistical analysis
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  Checksum: eb61ae44
   Type: CRC32
  Checksum: 4831d1866395f064e9db297ceb379c39
   Type: MD5
  Checksum: cb9e8b5772dd03868c3bcec10cb788ee9a920acb
   Type: SHA-1
  Checksum: 66a71e92d80adc3cf3001789d689328d40e7c9b9dbf1a31de2489016502a00c8
   Type: SHA-256