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ErrorMessage: Invalid indirect destination - referenced object 'aff4' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff19' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff13' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff9' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff5' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff22' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff29' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'fn2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff8' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff27' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff12' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff26' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'fn3' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff16' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff8' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff10' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff15' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn3' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff3' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff25' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'cor2' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'cor1' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: 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cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'cor3' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff4' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff26' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn2' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff12' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff29' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff22' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn1' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff27' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff18' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff13' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff5' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff21' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff23' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff28' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: 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object 'aff17' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff20' cannot be found ID: PDF-HUL-122 Offset: 29790494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff24' cannot be found ID: PDF-HUL-122 Offset: 29790494 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 2796 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Pan-cancer proteogenomics connects oncogenic drivers to functional states Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Results Destination: flink2 Children: Item: Title: A pan-cancer proteogenomic landscape of driver alterations and associated multi-omic clusters Destination: slink3 Item: Title: Proteogenomic analyses reveal the heterogeneity of cis-effects of cancer mutations Destination: slink4 Item: Title: Inference of altered protein-protein interactions through protein co-variation analysis Destination: slink5 Item: Title: trans-effects of somatic mutations in cancer genes across the CPTAC cohort Destination: slink6 Item: Title: Comparative analysis between tumor and normal-adjacent tissue identifies key protein changes for oncogenic pathways Destination: slink7 Item: Title: Impact of somatic mutations on immunogenic neoantigens and druggable kinases Destination: slink8 Item: Title: Integrative multi-genomic scoring provides evidence on how somatic alterations alter cancer hallmarks Destination: slink9 Item: Title: Discussion Destination: flink10 Children: Item: Title: Limitations of the study Destination: slink11 Item: Title: Consortia Destination: flink12 Item: Title: Supplemental information Destination: falink13 Item: Title: Acknowledgments Destination: acklink1 Item: Title: Author contributions Destination: acklink2 Item: Title: Declaration of interests Destination: acklink3 Item: Title: References Destination: blink1 Item: Title: STAR★Methods Destination: flink14 Children: Item: Title: Key resources table Destination: slink15 Item: Title: Resource availability Destination: slink16 Children: Item: Title: Lead contact Destination: tlink1 Item: Title: Materials availability Destination: tlink2 Item: Title: Data and code availability Destination: tlink3 Item: Title: Experimental model and subject details Destination: slink17 Children: Item: Title: Human subjects Destination: tlink4 Item: Title: Clinical data annotation Destination: tlink5 Item: Title: Method details Destination: slink18 Children: Item: Title: Harmonized genome alignment Destination: tlink6 Item: Title: Somatic mutation calling Destination: tlink7 Children: Item: Title: Somatic Mutation Calling (pipeline from Washington University in St Louis) Destination: ftlink1 Item: Title: Somatic mutation calling (pipeline from Broad Institute of MIT and Harvard) Destination: ftlink2 Item: Title: Somatic mutation callset harmonization (pipeline from Broad Institute of MIT and Harvard) Destination: ftlink3 Item: Title: Germline variant calling and pathogenicity classification Destination: tlink8 Item: Title: Copy number variant calling Destination: tlink9 Children: Item: Title: Genomic data post-processing and GISTIC (pipeline from Broad Institute of MIT and Harvard) Destination: ftlink4 Item: Title: WGS copy number variant calling (pipeline from Washington University in St Louis) Destination: ftlink5 Item: Title: DNA methylation microarray processing Destination: tlink10 Item: Title: RNA data processing and quantification Destination: tlink11 Item: Title: RNA fusion detection Destination: tlink12 Item: Title: Cell-type annotation on differentially expressed markers Destination: tlink13 Item: Title: Tumor microenvironment inference Destination: tlink14 Item: Title: Cell type enrichment deconvolution using gene expression Destination: tlink15 Item: Title: Survival analysis Destination: tlink16 Item: Title: Ancestry prediction using SNPs from 1000 genomes project Destination: tlink17 Item: Title: MSI prediction Destination: tlink18 Item: Title: HLA typing and neoantigen prediction Destination: tlink19 Item: Title: Oncogenicity annotation Destination: tlink20 Children: Item: Title: OncoKB oncogenicity annotation Destination: ftlink6 Item: Title: Annotating putative driver missense mutations Destination: ftlink7 Item: Title: Computational methods to predict driver missense mutations Destination: ftlink8 Item: Title: Annotating putative driver in-frame indels Destination: ftlink9 Item: Title: Annotating driver putative Loss-of-Function (pLOF) mutations Destination: ftlink10 Item: Title: Annotating driver copy number alterations Destination: ftlink11 Item: Title: Driver annotation of gene fusions Destination: ftlink12 Item: Title: Normalization of protein abundance by RNA expression Destination: tlink21 Item: Title: Calculation of relative solvent accessibility of amino acid residues Destination: tlink22 Item: Title: Protein-protein interaction databases Destination: tlink23 Item: Title: Driver mutation interaction term regression model for protein-protein interactions Destination: tlink24 Item: Title: Robustness and subsampling analysis of the interaction term regression model for protein-protein interactions Destination: tlink25 Item: Title: Copy number mediation analysis Destination: tlink26 Item: Title: Phosphorylation interaction term regression model for protein-protein interactions Destination: tlink27 Item: Title: Regression analysis of neoantigens and inferred immune infiltration Destination: tlink28 Item: Title: Analysis of RB1 oncogenic alterations Destination: tlink29 Item: Title: Drug connectivity Destination: tlink30 Item: Title: Gene Set Enrichment Analysis (GSEA) on signature gene coefficients Destination: tlink31 Item: Title: The Kinase Library enrichment analysis Destination: tlink32 Item: Title: Genetic driver alterations’ cis impact on RNA, proteome, and PTMs Destination: tlink33 Item: Title: Similarity of drivers through trans-effects on proteome and PTMs Destination: tlink34 Item: Title: Multi-omic signatures and clusterings Destination: tlink35 Item: Title: C3PO Destination: tlink36 Item: Title: Proteomics data processing Destination: tlink37 Item: Title: Quantification and statistical analysis Destination: slink19 Children: Item: Title: RNA and protein quantification Destination: tlink38 Item: Title: Gene expression, proteomic, and phosphoproteomic feature-associated markers Destination: tlink39 Item: Title: Statistical power analysis of driver gene discovery Destination: tlink40 Item: Title: Additional resources Destination: slink20 Info: Title: Pan-cancer proteogenomics connects oncogenic drivers to functional states Author: Yize Li Subject: Cell, 186 (2023) 3921-3969. doi:10.1016/j.cell.2023.07.014 Creator: 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FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 61 ImageHeight: 30 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 16 ImageHeight: 151 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 395 ImageHeight: 61 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 111 ImageHeight: 91 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1 ImageHeight: 300 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 272 ImageHeight: 4 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 18 ImageHeight: 338 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 702 ImageHeight: 417 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 19 ImageHeight: 97 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 12 ImageHeight: 110 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 300 ImageHeight: 1 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 281 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 63 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 63 ImageHeight: 63 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 63 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 217 ImageHeight: 231 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 63 ImageHeight: 63 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 63 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 63 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 63 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 63 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 63 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 63 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 63 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 63 ImageHeight: 63 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1929 ImageHeight: 500 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 360 ImageHeight: 410 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 121 ImageHeight: 119 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 28 ImageHeight: 274 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 27 ImageHeight: 262 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 300 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 620 ImageHeight: 31 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 302 ImageHeight: 9 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 32 ImageHeight: 323 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 18 ImageHeight: 354 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 198 ImageHeight: 101 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 198 ImageHeight: 102 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 200 ImageHeight: 103 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 200 ImageHeight: 103 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 42 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 84 ImageHeight: 57 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 84 ImageHeight: 57 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 13 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 84 ImageHeight: 57 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 13 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 84 ImageHeight: 57 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 84 ImageHeight: 57 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 40 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 2 ImageHeight: 2 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 12 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 4 ImageHeight: 4 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 84 ImageHeight: 57 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 85 ImageHeight: 57 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 85 ImageHeight: 57 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 29 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 7 ImageHeight: 5 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 7 ImageHeight: 5 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 3 ImageHeight: 2 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 7 ImageHeight: 5 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed 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FontFile3: true Encoding: MacRomanEncoding XMP: application/pdf doi:10.1016/j.cell.2023.07.014 Pan-cancer proteogenomics connects oncogenic drivers to functional states Yize Li Eduard Porta-Pardo Collin Tokheim Matthew H. Bailey Tomer M. Yaron Vasileios Stathias Yifat Geffen Kathleen J. Imbach Song Cao Shankara Anand Yo Akiyama Wenke Liu Matthew A. Wyczalkowski Yizhe Song Erik P. Storrs Michael C. Wendl Wubing Zhang Mustafa Sibai Victoria Ruiz-Serra Wen-Wei Liang Nadezhda V. Terekhanova Fernanda Martins Rodrigues Karl R. Clauser David I. Heiman Qing Zhang Francois Aguet Anna P. Calinawan Saravana M. Dhanasekaran Chet Birger Shankha Satpathy Daniel Cui Zhou Liang-Bo Wang Jessika Baral Jared L. Johnson Emily M. Huntsman Pietro Pugliese Antonio Colaprico Antonio Iavarone Milan G. Chheda Christopher J. Ricketts David Fenyö Samuel H. Payne Henry Rodriguez Ana I. Robles Michael A. Gillette Chandan Kumar-Sinha Alexander J. Lazar Lewis C. Cantley Gad Getz Li Ding Clinical Proteomic Tumor Analysis Consortium Eunkyung An Meenakshi Anurag Jasmin Bavarva Michael J. Birrer Anna Calinawan Michele Ceccarelli Daniel W. Chan Arul M. Chinnaiyan Hanbyul Cho Shrabanti Chowdhury Marcin P. Cieslik Felipe da Veiga Leprevost Corbin Day Marcin J. Domagalski Yongchao Dou Brian J. Druker Nathan Edwards Matthew J. Ellis Myvizhi Esai Selvan Steven M. Foltz Alicia Francis Tania J. Gonzalez Robles Sara J.C. Gosline Zeynep H. Gümüş Tara Hiltke Runyu Hong Galen Hostetter Yingwei Hu Chen Huang Emily Huntsman Eric J. Jaehnig Scott D. Jewel Jiayi Ji Wen Jiang Lizabeth Katsnelson Karen A. Ketchum Iga Kolodziejczak Jonathan T. Lei Yuxing Liao Caleb M. Lindgren Tao Liu Weiping Ma Wilson McKerrow Alexey I. Nesvizhskii Chelsea Newton Robert Oldroyd Gilbert S. Omenn Amanda G. Paulovich Francesca Petralia Boris Reva Karin D. Rodland Kelly V. Ruggles Dmitry Rykunov Sara R. Savage Eric E. Schadt Michael Schnaubelt Tobias Schraink Zhiao Shi Richard D. Smith Xiaoyu Song Jimin Tan Ratna R. Thangudu Nicole Tignor Joshua M. Wang Pei Wang Ying (Cindy) Wang Bo Wen Maciej Wiznerowicz Xinpei Yi Bing Zhang Hui Zhang Xu Zhang Zhen Zhang pan-cancer oncogenic driver therapeutic target proteomics proteogenomics phosphoproteomics protein complex cancer hallmark CPTAC Cell, 186 (2023) 3921-3969. doi:10.1016/j.cell.2023.07.014 The Authors journal Cell © 2023 The Authors. Published by Elsevier Inc. 0092-8674 186 18 31 August 2023 2023-08-31 3921-3944.e25 3921 3944.e25 10.1016/j.cell.2023.07.014 https://doi.org/10.1016/j.cell.2023.07.014 2010-04-23 true 10.1016/j.cell.2023.07.014 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.cell.2023.07.014 noindex true 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2023-08-25T20:48:03+05:30 2023-08-28T07:08:03+05:30 2023-08-28T07:08:03+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:f6e4456c-e8ee-42f1-9b0c-9cbeb20ea45c uuid:7dd202d9-a4b0-472c-9155-a377ceff5db0 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 3921 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 354, 517, 499, 527 Annotation: Subtype: Link Rect: 354, 505, 482, 515 Annotation: Subtype: Link Rect: 354, 493, 430, 503 Annotation: Subtype: Link Rect: 100, 48, 260, 56 Annotation: Subtype: Link Rect: 53, 58, 69, 74 Page: Label: 3922 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 82, 605, 88, 614 Destination: 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