7f2814be7bd89c94e0b070afd3f04eec  NLRP3_inflammasome.pdf
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1c95a7506d340f005d334b73bc92a07ce578d0b49332d455278003e56bcaea94  NLRP3_inflammasome.pdf

Title:          NLRP3 inflammasome activation and symptom burden in KRAS-mutated CMML patients is reverted by IL-1 blocking therapy
Subject:        Cell Reports Medicine, 4 (2023) 101329. doi:10.1016/j.xcrm.2023.101329
Author:         Laura Hurtado-Navarro
Creator:        Elsevier
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      Title: NLRP3 inflammasome activation and symptom burden in KRAS-mutated CMML patients is reverted by IL-1 blocking therapy
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        Title: Introduction
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       Item: 
        Title: Results
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         Item: 
          Title: The index patient
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         Item: 
          Title: Blockade of IL-1R with anakinra as a bridge therapy to allogeneic HSCT
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         Item: 
          Title: Anakinra treatment attenuates NLRP3 inflammasome activity
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         Item: 
          Title: Clinical-biological characteristics of the cohort of CMML and MDS/MPN KRASmut patients
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         Item: 
          Title: NLRP3 inflammasome is activated in CMML KRASmut patients
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         Item: 
          Title: Circulating levels of inflammatory cytokines in CMML KRASmut patients
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       Item: 
        Title: Discussion
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          Title: Limitations of the study
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            Title: Cells and treatments
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            Title: Evaluation of monocytes with ASC by flow cytometry
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            Title: Lactate dehydrogenase assay
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            Title: Cytokine evaluation
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            Title: Sequencing analysis
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            Title: Whole exome sequencing
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          Title: Quantification and statistical analysis
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    Title: NLRP3 inflammasome activation and symptom burden in KRAS-mutated CMML patients is reverted by IL-1 blocking therapy
    Author: Laura Hurtado-Navarro
    Subject: Cell Reports Medicine, 4 (2023) 101329. doi:10.1016/j.xcrm.2023.101329
    Creator: Elsevier
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