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Title:          MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer
Subject:        Cell Reports Medicine, 4 (2023) 101006. doi:10.1016/j.xcrm.2023.101006
Author:         Juan J. Alburquerque-Bejar
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      Title: MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer
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        Title: Introduction
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       Item: 
        Title: Results
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         Item: 
          Title: Deficiencies in the cell-intrinsic response to IFNγ among LC cells
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         Item: 
          Title: IFNγ-mediated signaling impaired by genetic inactivation of IFNγ receptor 1 in LC
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         Item: 
          Title: Low basal levels of IγSGs occur in a subset of LC cells, associated in SCLCs with neuroendocrine characteristics
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         Item: 
          Title: Histone 3 acetylation at lysine 27 (H3K27ac) in IγSG promoters is decreased among SCLCs with neuroendocrine characteristics
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         Item: 
          Title: Cell-intrinsic transactivation and recruitment of IRF1 to the DNA by IFNγ is broadly deficient in part-R and non-R cells
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         Item: 
          Title: Genetic activation of MYC represses the constitutive expression of JAK2 and impairs the response to IFNγ
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         Item: 
          Title: MYC amplification is associated with a worse response to ICB
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        Title: Discussion
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         Item: 
          Title: Limitations of the study
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        Title: Supplemental information
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             Item: 
              Title: Cancer cell lines
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          Title: Method details
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           Item: 
            Title: Antibodies, western blots and immunostainings
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           Item: 
            Title: Construction of expression vectors and infections
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           Item: 
            Title: Sanger sequencing of the IFNGR1 gene
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            Title: Quantitative real-time PCRs and RNA sequencing
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           Item: 
            Title: Chromatin immunoprecipitation (ChIP)-sequencing of IRF1
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            Title: Global methylation microarray analysis
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          Title: Quantification and statistical analysis
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           Item: 
            Title: RNA sequencing data analysis
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           Item: 
            Title: Chromatin immunoprecipitation (ChIP)-sequencing data analysis
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