c33cbcb6866f22452799280da9031efe  289533.pdf
64cf7084dc1c0bb14b891c91788a21ee611d7115  289533.pdf
ad23643ffb5eb9e0264c0b37415e77f58a8e04682a2e7b98c10d64a041fad12e  289533.pdf

Producer:       Acrobat Distiller 10.0.0 (Windows)
CreationDate:   Mon Feb 26 10:54:29 2024 CET
ModDate:        Mon Feb 26 10:54:54 2024 CET
Tagged:         yes
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          16
Encrypted:      no
Page size:      594 x 783 pts
Page rot:       0
File size:      1093704 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
LKKLMF+HelveticaNeueLTStd-BdEx       Type 1C           Custom           yes yes yes   1382  0
LKKMMH+FuturaStd-CondensedBold       Type 1C           Custom           yes yes yes   1395  0
LKKLMG+dummy-space                   Type 1C           WinAnsi          yes yes no    1405  0
LKKMEE+AGaramond-Regular             Type 1C           MacRoman         yes yes no    1387  0
LKKMHD+HelveticaLTStd-Bold           Type 1C           Custom           yes yes yes   1372  0
LKKMHE+HelveticaLTStd-Roman          Type 1C           Custom           yes yes yes   1377  0
LKKMIF+AGaramond-Italic              Type 1C           WinAnsi          yes yes no    1369  0
LKKMLF+MTSY                          Type 1C           Custom           yes yes yes   1390  0
LKKMLG+FuturaStd-CondensedLight      Type 1C           Custom           yes yes yes   1364  0
LKKMMG+FuturaStd-Condensed           Type 1C           Custom           yes yes yes   1400  0
LKKMNI+AGaramond-Bold                Type 1C           WinAnsi          yes yes no     163  0
LKKMNJ+HelveticaLTStd-Obl            Type 1C           Custom           yes yes yes      3  0
LKKMNK+HelveticaLTStd-Light          Type 1C           Custom           yes yes yes      7  0
LKKNBJ+RMTMI                         Type 1C           Custom           yes yes yes    166  0
LKKNDK+AGaramond-BoldItalic          Type 1C           MacRoman         yes yes no     171  0
LKKNMH+HelveticaLTStd-BoldCond       Type 1C           Custom           yes yes yes    174  0
LKKNNI+MTSYB                         Type 1C           Custom           yes yes yes    179  0
LKLAAK+HelveticaLTStd-BoldCondObl    Type 1C           Custom           yes yes yes    190  0
LKLAJI+HelveticaLTStd-LightCond      Type 1C           Custom           yes yes yes    185  0
LKLCCO+LMMathSymbols5-Regular        Type 1C           Custom           yes yes yes    195  0
LKLIHG+HelveticaLTStd-LightCondObl   Type 1C           Custom           yes yes yes    138  0
LKMANA+RMTMIB                        Type 1C           Custom           yes yes yes    201  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-02-29 02:34:15 CET
 RepresentationInformation: 289533.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-02-28 11:13:02 CET
  Size: 1093704
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Invalid indirect destination - referenced object 'tb5fn1' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'tb3fn1' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'tb5fn2' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'tb4fn1' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'tb5fn3' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'tb5fn4' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'tb2fn1' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'tb4fn2' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb5fn1' cannot be found
   ID: PDF-HUL-122
   Offset: 971827
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb3fn1' cannot be found
   ID: PDF-HUL-122
   Offset: 971827
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb5fn2' cannot be found
   ID: PDF-HUL-122
   Offset: 971827
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb5fn3' cannot be found
   ID: PDF-HUL-122
   Offset: 971827
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb4fn1' cannot be found
   ID: PDF-HUL-122
   Offset: 971827
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb2fn1' cannot be found
   ID: PDF-HUL-122
   Offset: 971827
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb5fn4' cannot be found
   ID: PDF-HUL-122
   Offset: 971827
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb4fn2' cannot be found
   ID: PDF-HUL-122
   Offset: 971827
  MIMEtype: application/pdf
  Profile: Linearized PDF, Tagged PDF
  PDFMetadata: 
   Objects: 1431
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: true
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: English
    Outlines: 
     Item: 
      Title: Pomalidomide, Bortezomib, and Dexamethasone in Lenalidomide-Pretreated Multiple Myeloma: A Subanalysis of OPTIMISMM by Frailty and Bortezomib Dose Adjustment
      Destination: chapter..1
      Children: 
       Item: 
        Title: Introduction
        Destination: section..1
       Item: 
        Title: Patients and Methods
        Destination: section..2
        Children: 
         Item: 
          Title: Patients
          Destination: subsection..2.1
         Item: 
          Title: Treatment
          Destination: subsection..2.2
         Item: 
          Title: Frailty Analysis
          Destination: subsection..2.3
         Item: 
          Title: Dose Adjustment
          Destination: subsection..2.4
         Item: 
          Title: Endpoints and Assessments
          Destination: subsection..2.5
         Item: 
          Title: Statistical Considerations
          Destination: subsection..2.6
       Item: 
        Title: Results
        Destination: section..3
        Children: 
         Item: 
          Title: Patient Disposition and Characteristics
          Destination: subsection..3.1
         Item: 
          Title: Efficacy
          Destination: subsection..3.2
         Item: 
          Title: Safety
          Destination: subsection..3.3
       Item: 
        Title: Discussion
        Destination: section..4
       Item: 
        Title: Conclusion
        Destination: section..5
        Children: 
         Item: 
          Title: Clinical Practice Points
          Destination: subsection..5.1
       Item: 
        Title: Data Availability Statement
        Destination: section..6
       Item: 
        Title: Author Contributions
        Destination: section..7
       Item: 
        Title: Disclosure
        Destination: section..8
       Item: 
        Title: Acknowledgments
        Destination: section..9
       Item: 
        Title: References
        Destination: section..10
       Item: 
        Title: Supplementary material
        Destination: section..11
   Info: 
    Producer: Acrobat Distiller 10.0.0 (Windows)
    CreationDate: Mon Feb 26 11:24:29 CET 2024
    ModDate: Mon Feb 26 11:24:54 CET 2024
   ID: 0xfde1dd47099ef3d04f242b7c48283fcf, 0xdee9c03e483653ed4547425d9d93ffbc
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1750
      ImageHeight: 639
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1650
      ImageHeight: 727
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: LKKMHE+HelveticaLTStd-Roman
      FontSubset: true
      FirstChar: 37
      LastChar: 147
      FontDescriptor: 
       FontName: LKKMHE+HelveticaLTStd-Roman
       Flags: Symbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKKMNJ+HelveticaLTStd-Obl
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: LKKMNJ+HelveticaLTStd-Obl
       Flags: Symbolic, Italic
       FontBBox: -170, -225, 1116, 931
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKKMNI+AGaramond-Bold
      FontSubset: true
      FirstChar: 68
      LastChar: 121
      FontDescriptor: 
       FontName: LKKMNI+AGaramond-Bold
       Flags: Serif, Nonsymbolic, ForceBold
       FontBBox: -158, -269, 1147, 862
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LKLCCO+LMMathSymbols5-Regular
      FontSubset: true
      FirstChar: 128
      LastChar: 128
      FontDescriptor: 
       FontName: LKLCCO+LMMathSymbols5-Regular
       Flags: Symbolic, Italic
       FontBBox: 0, -944, 1448, 791
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKKLMF+HelveticaNeueLTStd-BdEx
      FontSubset: true
      FirstChar: 65
      LastChar: 121
      FontDescriptor: 
       FontName: LKKLMF+HelveticaNeueLTStd-BdEx
       Flags: Symbolic, ForceBold
       FontBBox: -145, -213, 1163, 984
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKKNBJ+RMTMI
      FontSubset: true
      FirstChar: 2
      LastChar: 62
      FontDescriptor: 
       FontName: LKKNBJ+RMTMI
       Flags: Symbolic, Italic
       FontBBox: 0, -213, 987, 680
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKKMNK+HelveticaLTStd-Light
      FontSubset: true
      FirstChar: 40
      LastChar: 169
      FontDescriptor: 
       FontName: LKKMNK+HelveticaLTStd-Light
       Flags: Symbolic
       FontBBox: -164, -250, 1000, 979
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKMANA+RMTMIB
      FontSubset: true
      FirstChar: 2
      LastChar: 2
      FontDescriptor: 
       FontName: LKMANA+RMTMIB
       Flags: Symbolic, Italic, ForceBold
       FontBBox: 0, -208, 994, 706
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKLIHG+HelveticaLTStd-LightCondObl
      FontSubset: true
      FirstChar: 76
      LastChar: 117
      FontDescriptor: 
       FontName: LKLIHG+HelveticaLTStd-LightCondObl
       Flags: Symbolic, Italic
       FontBBox: -170, -285, 1069, 986
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKKMEE+AGaramond-Regular
      FontSubset: true
      FirstChar: 37
      LastChar: 222
      FontDescriptor: 
       FontName: LKKMEE+AGaramond-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -183, -269, 1099, 851
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: LKKNDK+AGaramond-BoldItalic
      FontSubset: true
      FirstChar: 65
      LastChar: 222
      FontDescriptor: 
       FontName: LKKNDK+AGaramond-BoldItalic
       Flags: Serif, Nonsymbolic, Italic, ForceBold
       FontBBox: -183, -285, 1166, 862
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: LKKMLF+MTSY
      FontSubset: true
      FirstChar: 2
      LastChar: 61
      FontDescriptor: 
       FontName: LKKMLF+MTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKKNMH+HelveticaLTStd-BoldCond
      FontSubset: true
      FirstChar: 2
      LastChar: 122
      FontDescriptor: 
       FontName: LKKNMH+HelveticaLTStd-BoldCond
       Flags: Symbolic, ForceBold
       FontBBox: -169, -250, 1091, 991
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKKMMH+FuturaStd-CondensedBold
      FontSubset: true
      FirstChar: 46
      LastChar: 101
      FontDescriptor: 
       FontName: LKKMMH+FuturaStd-CondensedBold
       Flags: Symbolic, ForceBold
       FontBBox: -140, -261, 1195, 990
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKKNNI+MTSYB
      FontSubset: true
      FirstChar: 61
      LastChar: 61
      FontDescriptor: 
       FontName: LKKNNI+MTSYB
       Flags: Symbolic, ForceBold
       FontBBox: -16, -935, 1043, 896
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKKMLG+FuturaStd-CondensedLight
      FontSubset: true
      FirstChar: 36
      LastChar: 169
      FontDescriptor: 
       FontName: LKKMLG+FuturaStd-CondensedLight
       Flags: Symbolic
       FontBBox: -125, -221, 896, 961
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKKMMG+FuturaStd-Condensed
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: LKKMMG+FuturaStd-Condensed
       Flags: Symbolic
       FontBBox: -157, -216, 894, 969
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKKMIF+AGaramond-Italic
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: LKKMIF+AGaramond-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -182, -285, 1150, 851
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LKLAJI+HelveticaLTStd-LightCond
      FontSubset: true
      FirstChar: 37
      LastChar: 133
      FontDescriptor: 
       FontName: LKLAJI+HelveticaLTStd-LightCond
       Flags: Symbolic
       FontBBox: -170, -250, 1000, 986
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKKMHD+HelveticaLTStd-Bold
      FontSubset: true
      FirstChar: 37
      LastChar: 147
      FontDescriptor: 
       FontName: LKKMHD+HelveticaLTStd-Bold
       Flags: Symbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LKKLMG+dummy-space
      FontSubset: true
      FirstChar: 32
      LastChar: 32
      FontDescriptor: 
       FontName: LKKLMG+dummy-space
       Flags: Nonsymbolic
       FontBBox: 0, 0, 0, 0
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: LKLAAK+HelveticaLTStd-BoldCondObl
      FontSubset: true
      FirstChar: 80
      LastChar: 80
      FontDescriptor: 
       FontName: LKLAAK+HelveticaLTStd-BoldCondObl
       Flags: Symbolic, Italic, ForceBold
       FontBBox: -169, -288, 1142, 991
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.4-c005 78.147326, 2012/08/23-13:03:03        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/"
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
	    xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/"
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/"
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
            xmlns:crossmark="http://crossref.org/crossmark/1.0/"
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmp:CreateDate>2012-08-24T16:03:10+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:ModifyDate>2013-02-20T16:20:50+05:30</xmp:ModifyDate>
         <xmp:MetadataDate>2013-02-20T16:20:50+05:30</xmp:MetadataDate>
         <pdf:Producer>Acrobat Distiller 9.0.0 (Windows)</pdf:Producer>
         <pdf:Keywords>"Charlson Comorbidity Index"; "dose modifications"; "ECOG PS"; "immunomodulatory agent"; "relapsed/refractory multiple myeloma"</pdf:Keywords>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.clml.2023.10.009</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Pomalidomide, Bortezomib, and Dexamethasone in Lenalidomide-Pretreated Multiple Myeloma: A Subanalysis of OPTIMISMM by Frailty and Bortezomib Dose Adjustment</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
		<rdf:li>Albert Oriol</rdf:li>
<rdf:li>Meletios Dimopoulos</rdf:li>
<rdf:li>Fredrik Schjesvold</rdf:li>
<rdf:li>Meral Beksac</rdf:li>
<rdf:li>Thierry Facon</rdf:li>
<rdf:li>Sujith Dhanasiri</rdf:li>
<rdf:li>Shien Guo</rdf:li>
<rdf:li>Yutian Mu</rdf:li>
<rdf:li>Kevin Hong</rdf:li>
<rdf:li>Christian Gentili</rdf:li>
<rdf:li>Monica Galli</rdf:li>
<rdf:li>Munci Yagci</rdf:li>
<rdf:li>Alessandra Larocca</rdf:li>
<rdf:li>Paul Richardson</rdf:li>
<rdf:li>Katja Weisel</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Clinical Lymphoma, Myeloma and Leukemia, 24 (2024) 165-176.e4. doi:10.1016/j.clml.2023.10.009</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier Inc.</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Charlson Comorbidity Index</rdf:li>
<rdf:li>dose modifications</rdf:li>
<rdf:li>ECOG PS</rdf:li>
<rdf:li>immunomodulatory agent</rdf:li>
<rdf:li>relapsed/refractory multiple myeloma</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <xmpMM:DocumentID>uuid:fd8cfc10-4791-4a8b-8025-00abb91efa0c</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:d56e5e26-6274-4fa7-ad08-30fc2ecddb91</xmpMM:InstanceID>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:copyright>&#169; 2023 The Author(s). Published by Elsevier Inc.</prism:copyright>
         <prism:publicationName>Clinical Lymphoma, Myeloma and Leukemia</prism:publicationName>
         <prism:issn>2152-2650</prism:issn>
         <prism:volume>24</prism:volume>
	 <prism:number>3</prism:number>
	 
	 
         <prism:doi>10.1016/j.clml.2023.10.009</prism:doi>
         <prism:url>https://doi.org/10.1016/j.clml.2023.10.009</prism:url>
         <prism:startingPage>165</prism:startingPage>
         <prism:endingPage>176.e4</prism:endingPage>
         <prism:pageRange>165-176.e4</prism:pageRange>
         <prism:coverDisplayDate>March 2024</prism:coverDisplayDate>
         
         <pdfx:ElsevierWebPDFSpecifications>7.0</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <ali:license_ref><rdf:Bag><rdf:li rdf:parseType="Resource"><ali:uri>http://creativecommons.org/licenses/by/4.0/</ali:uri></rdf:li></rdf:Bag></ali:license_ref>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <pdfx:doi>10.1016/j.clml.2023.10.009</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:AuthoritativeDomain>
            <rdf:Bag>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Bag>
         </pdfx:AuthoritativeDomain>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:DOI>10.1016/j.clml.2023.10.009</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 165
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 53, 716, 133, 727
      Annotation: 
       Subtype: Link
       Rect: 157, 577, 165, 595
       Destination: 1332
      Annotation: 
       Subtype: Link
       Rect: 295, 577, 303, 595
       Destination: 1332
      Annotation: 
       Subtype: Link
       Rect: 413, 577, 421, 595
       Destination: 1332
      Annotation: 
       Subtype: Link
       Rect: 502, 577, 510, 595
       Destination: 1332
      Annotation: 
       Subtype: Link
       Rect: 165, 560, 173, 578
       Destination: 1332
      Annotation: 
       Subtype: Link
       Rect: 272, 560, 280, 578
       Destination: 1332
      Annotation: 
       Subtype: Link
       Rect: 347, 560, 354, 578
       Destination: 1332
      Annotation: 
       Subtype: Link
       Rect: 421, 560, 428, 578
       Destination: 1332
      Annotation: 
       Subtype: Link
       Rect: 504, 560, 512, 578
       Destination: 1332
      Annotation: 
       Subtype: Link
       Rect: 188, 543, 196, 561
       Destination: 1332
      Annotation: 
       Subtype: Link
       Rect: 276, 543, 289, 561
       Destination: 1332
      Annotation: 
       Subtype: Link
       Rect: 366, 543, 379, 561
       Destination: 1332
      Annotation: 
       Subtype: Link
       Rect: 493, 543, 506, 561
       Destination: 1332
      Annotation: 
       Subtype: Link
       Rect: 295, 526, 308, 544
       Destination: 1332
      Annotation: 
       Subtype: Link
       Rect: 381, 526, 394, 544
       Destination: 1332
      Annotation: 
       Subtype: Link
       Rect: 96, 72, 159, 81
      Annotation: 
       Subtype: Link
       Rect: 55, 37, 169, 47
      Annotation: 
       Subtype: Link
       Rect: 53, 27, 166, 37
    Page: 
     Label: 166
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 321, 603, 498, 614
      Annotation: 
       Subtype: Link
       Rect: 142, 525, 147, 536
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 147, 525, 153, 536
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 186, 477, 197, 488
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 244, 453, 250, 464
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 250, 453, 255, 464
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 160, 417, 165, 429
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 90, 393, 96, 405
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 96, 393, 101, 405
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 232, 357, 245, 369
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 156, 298, 162, 309
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 162, 298, 167, 309
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 167, 298, 173, 309
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 173, 298, 189, 309
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 143, 238, 159, 249
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 155, 178, 163, 189
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 102, 94, 111, 106
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 459, 550, 467, 561
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 501, 478, 506, 489
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 398, 310, 406, 321
       Destination: 106
    Page: 
     Label: 167
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 55, 591, 137, 602
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 140, 591, 149, 602
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 404, 390, 485, 401
       Destination: 134
      Annotation: 
       Subtype: Link
       Rect: 381, 342, 459, 353
       Destination: 147
      Annotation: 
       Subtype: Link
       Rect: 307, 115, 389, 126
       Destination: 157
      Annotation: 
       Subtype: Link
       Rect: 423, 67, 501, 78
       Destination: 151
    Page: 
     Label: 168
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 160, 247, 191, 258
       Destination: 40
      Annotation: 
       Subtype: Link
       Rect: 205, 163, 236, 174
       Destination: 52
      Annotation: 
       Subtype: Link
       Rect: 330, 295, 362, 306
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 387, 223, 420, 235
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 434, 223, 441, 235
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 390, 116, 422, 127
       Destination: 74
    Page: 
     Label: 169
     Sequence: 5
    Page: 
     Label: 170
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 55, 295, 85, 306
       Destination: 74
      Annotation: 
       Subtype: Link
       Rect: 282, 222, 290, 234
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 105, 198, 132, 210
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 508, 211, 536, 223
       Destination: 80
    Page: 
     Label: 171
     Sequence: 7
    Page: 
     Label: 172
     Sequence: 8
    Page: 
     Label: 173
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 282, 675, 288, 686
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 403, 675, 409, 686
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 524, 675, 530, 686
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 239, 424, 245, 435
       Destination: 101
      Annotation: 
       Subtype: Link
       Rect: 193, 221, 202, 232
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 128, 161, 136, 172
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 240, 125, 249, 136
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 249, 125, 265, 136
       Destination: 106
    Page: 
     Label: 174
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 110, 582, 118, 593
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 282, 438, 290, 450
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 282, 355, 290, 366
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 271, 104, 280, 115
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 365, 677, 374, 689
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 437, 594, 446, 605
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 336, 546, 345, 557
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 533, 474, 541, 486
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 467, 414, 475, 426
       Destination: 106
    Page: 
     Label: 175
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 337, 292, 361
      Annotation: 
       Subtype: Link
       Rect: 315, 114, 560, 134
      Annotation: 
       Subtype: Link
       Rect: 315, 98, 560, 118
    Page: 
     Label: 176
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 44, 694, 295, 714
      Annotation: 
       Subtype: Link
       Rect: 44, 678, 295, 698
      Annotation: 
       Subtype: Link
       Rect: 44, 647, 295, 682
      Annotation: 
       Subtype: Link
       Rect: 44, 623, 295, 650
      Annotation: 
       Subtype: Link
       Rect: 44, 591, 295, 626
      Annotation: 
       Subtype: Link
       Rect: 44, 567, 295, 594
      Annotation: 
       Subtype: Link
       Rect: 44, 535, 295, 570
      Annotation: 
       Subtype: Link
       Rect: 44, 512, 294, 532
      Annotation: 
       Subtype: Link
       Rect: 76, 497, 236, 504
      Annotation: 
       Subtype: Link
       Rect: 44, 455, 295, 491
      Annotation: 
       Subtype: Link
       Rect: 44, 439, 295, 459
      Annotation: 
       Subtype: Link
       Rect: 44, 407, 295, 443
      Annotation: 
       Subtype: Link
       Rect: 44, 65, 295, 411
      Annotation: 
       Subtype: Link
       Rect: 317, 718, 562, 738
      Annotation: 
       Subtype: Link
       Rect: 317, 704, 562, 723
      Annotation: 
       Subtype: Link
       Rect: 317, 678, 562, 706
      Annotation: 
       Subtype: Link
       Rect: 317, 655, 562, 682
      Annotation: 
       Subtype: Link
       Rect: 317, 631, 562, 658
      Annotation: 
       Subtype: Link
       Rect: 317, 599, 562, 634
      Annotation: 
       Subtype: Link
       Rect: 317, 575, 562, 602
      Annotation: 
       Subtype: Link
       Rect: 317, 551, 562, 578
      Annotation: 
       Subtype: Link
       Rect: 317, 527, 562, 554
      Annotation: 
       Subtype: Link
       Rect: 317, 503, 562, 530
      Annotation: 
       Subtype: Link
       Rect: 317, 471, 562, 507
      Annotation: 
       Subtype: Link
       Rect: 317, 447, 562, 475
      Annotation: 
       Subtype: Link
       Rect: 317, 423, 562, 451
    Page: 
     Label: 177
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 156, 634, 162, 645
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 226, 371, 233, 380
       Destination: 106
    Page: 
     Label: 178
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 102, 400, 107, 411
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 75, 292, 80, 303
       Destination: null
    Page: 
     Label: 179
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 112, 558, 117, 569
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 94, 462, 99, 473
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 112, 282, 116, 293
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 116, 282, 121, 293
       Destination: null
    Page: 
     Label: 180
     Sequence: 16
  Checksum: e7c5f207
   Type: CRC32
  Checksum: c33cbcb6866f22452799280da9031efe
   Type: MD5
  Checksum: 64cf7084dc1c0bb14b891c91788a21ee611d7115
   Type: SHA-1
  Checksum: ad23643ffb5eb9e0264c0b37415e77f58a8e04682a2e7b98c10d64a041fad12e
   Type: SHA-256