995f855617dd3a5f982102511b0817ba  289534.pdf
01c3d466c2f8d236ce0e82cada92976fdcdde2b5  289534.pdf
e8bdaba15a566aeae2aec4547b806b82fa7b2319551ac48c42837efebaca3454  289534.pdf

Title:          Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin
Subject:        CellReports, 42 (2023) 112472. doi:10.1016/j.celrep.2023.112472
Author:         Claudia Garcia-Diaz
Creator:        Elsevier
Producer:       Acrobat Distiller 8.1.0 (Windows)
CreationDate:   Tue May 23 11:28:58 2023 CEST
ModDate:        Tue May 23 13:59:54 2023 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          28
Encrypted:      no
Page size:      602.986 x 782.986 pts
Page rot:       0
File size:      9099500 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MPNEIL+AdvPSHN-H                     Type 1C           MacRoman         yes yes no    1401  0
MPNEJL+AdvPSHN-M                     Type 1C           WinAnsi          yes yes no    1405  0
MPNEJM+AdvPSMPi6                     Type 1C           WinAnsi          yes yes no    1407  0
MPNGJB+AdvPSHN-MI                    Type 1C           WinAnsi          yes yes no    1410  0
MPNGJC+AdvPSSym                      Type 1C           WinAnsi          yes yes no    1412  0
MPNGJD+Helvetica-Bold                Type 1C           WinAnsi          yes yes no    1415  0
MPNEIL+AdvPSHN-H                     Type 1C           WinAnsi          yes yes no    1219  0
MPBEHI+AdvPSA189                     Type 1C           MacRoman         yes yes no    1181  0
MPNEJL+AdvPSHN-M                     Type 1C           Custom           yes yes no    1192  0
MPBEHK+AdvPSA183                     Type 1C           MacRoman         yes yes no    1223  0
MPBEJK+Advhelvneue-italic            Type 1C           MacRoman         yes yes no    1224  0
MPNGJC+AdvPSSym                      Type 1C           WinAnsi          yes yes no    1215  0
MPNGJD+Helvetica-Bold                Type 1C           WinAnsi          yes yes no    1183  0
MPCCGI+AdvPS3F4C13                   Type 1C           WinAnsi          yes yes no    1231  0
MPCHAN+AdvTT2876772e+20              Type 1C           Custom           yes yes yes   1252  0
MPCHAO+AdvHelN-L                     Type 1C           WinAnsi          yes yes no    1245  0
MPCIGH+AdvP4C4E74                    Type 1C           Custom           yes yes yes   1259  0
MPCPBO+AdvPS480274                   Type 1C           WinAnsi          yes yes no    1287  0
MPNEJM+AdvPSMPi6                     Type 1C           WinAnsi          yes yes no    1285  0
MPCPGO+AdvP4C4E59                    Type 1C           WinAnsi          yes yes no    1293  0
MPDAAM+AdvPSHN-HI                    Type 1C           WinAnsi          yes yes no    1306  0
MPDAFL+AdvP7DED                      Type 1C           WinAnsi          yes yes no    1313  0
MPDBCH+AdvPS4721B4                   Type 1C           WinAnsi          yes yes no    1328  0
MPDBCI+AdvP4C4E46                    Type 1C           WinAnsi          yes yes no    1329  0
MPDBDJ+AdvPS4BD310                   Type 1C           WinAnsi          yes yes no    1334  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2024-03-01 02:35:37 CET
 RepresentationInformation: 289534.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2024-02-29 10:36:48 CET
  Size: 9099500
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 1504
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin
      Destination: titlink1
      Children: 
       Item: 
        Title: Introduction
        Destination: flink1
       Item: 
        Title: Results
        Destination: flink2
        Children: 
         Item: 
          Title: Development of somatic GBM mouse models
          Destination: slink3
         Item: 
          Title: Tumor cell states differ between bulk and margin and are imposed by the microenvironment
          Destination: slink4
         Item: 
          Title: Bulk iNPC-like cells comprise a large proportion of dormant tumor cells
          Destination: slink5
         Item: 
          Title: Dormant iNPC-like tumor cells are induced by interferon in T cell niches
          Destination: slink6
         Item: 
          Title: Margin GSCs are biased toward astrocyte-like differentiation
          Destination: slink7
         Item: 
          Title: Bulk and margin cells are functionally distinct subpopulations
          Destination: slink8
       Item: 
        Title: Discussion
        Destination: flink9
        Children: 
         Item: 
          Title: Limitations of the study
          Destination: slink10
       Item: 
        Title: Supplemental information
        Destination: falink11
       Item: 
        Title: Acknowledgments
        Destination: acklink1
       Item: 
        Title: Author contributions
        Destination: acklink2
       Item: 
        Title: Declaration of interests
        Destination: acklink3
       Item: 
        Title: Acknowledgments
        Destination: acklink4
       Item: 
        Title: References
        Destination: blink1
       Item: 
        Title: STAR★Methods
        Destination: flink12
        Children: 
         Item: 
          Title: Key resources table
          Destination: slink13
         Item: 
          Title: Resource availability
          Destination: slink14
          Children: 
           Item: 
            Title: Lead contact
            Destination: tlink1
           Item: 
            Title: Materials availability
            Destination: tlink2
           Item: 
            Title: Data and code availability
            Destination: tlink3
         Item: 
          Title: Experimental model and study participant details
          Destination: slink15
         Item: 
          Title: Method details
          Destination: slink16
          Children: 
           Item: 
            Title: In vivo electroporation
            Destination: tlink4
           Item: 
            Title: Orthotopic injections
            Destination: tlink5
           Item: 
            Title: Tissue preparation and immunohistochemistry
            Destination: tlink6
           Item: 
            Title: Derivation and culture of cell lines
            Destination: tlink7
           Item: 
            Title: Regional injection of tumor-derived cells into organotypic tumor slices
            Destination: tlink8
           Item: 
            Title: T cell isolation from spleen and glioma-T cell co-culture
            Destination: tlink9
           Item: 
            Title: Interferon treatment and cell proliferation assay
            Destination: tlink10
           Item: 
            Title: Cell migration assay
            Destination: tlink11
           Item: 
            Title: Clonogenicity assay
            Destination: tlink12
           Item: 
            Title: Western blot
            Destination: tlink13
           Item: 
            Title: Plasmid generation
            Destination: tlink14
           Item: 
            Title: PiggyBases
            Destination: tlink15
           Item: 
            Title: PiggyBac plasmids
            Destination: tlink16
           Item: 
            Title: Flow cytometry analysis
            Destination: tlink17
           Item: 
            Title: Fluorescence-activated cell sorting for collection of single cells for RNA-sequencing
            Destination: tlink18
           Item: 
            Title: Single cell RNA library preparation (Smart-seq2)
            Destination: tlink19
           Item: 
            Title: Single cell RNA library preparation (10x)
            Destination: tlink20
           Item: 
            Title: Single cell RNA-seq data analysis (Smart-seq2)
            Destination: tlink21
            Children: 
             Item: 
              Title: Data pre-processing
              Destination: ftlink1
           Item: 
            Title: Clustering
            Destination: tlink22
           Item: 
            Title: Data integration
            Destination: tlink23
           Item: 
            Title: Differential expression and GO analysis
            Destination: tlink24
           Item: 
            Title: Single-cell RNA-seq (10x) data pre-processing and analysis
            Destination: tlink25
           Item: 
            Title: Analysis of publicly available human datasets
            Destination: tlink26
           Item: 
            Title: Digital pathology
            Destination: tlink27
            Children: 
             Item: 
              Title: Cell detection and validation
              Destination: ftlink2
           Item: 
            Title: Spatial metrics for co-localization of T cells and H2B-GFP LRC
            Destination: tlink28
           Item: 
            Title: Assessment of colocalization between T cells and GFP subpopulations
            Destination: tlink29
         Item: 
          Title: Quantification and statistical analysis
          Destination: slink17
   Info: 
    Title: Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin
    Author: Claudia Garcia-Diaz
    Subject: CellReports, 42 (2023) 112472. doi:10.1016/j.celrep.2023.112472
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Tue May 23 11:58:58 CEST 2023
    ModDate: Tue May 23 14:29:54 CEST 2023
   ID: 0x93cabb165fda7216f1f2e716f9af7279, 0xaf8081bedab7e542a834b492016edbd0
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1191
      ImageHeight: 1191
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 68
      ImageHeight: 68
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 68
      ImageHeight: 68
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 6
      ImageHeight: 11
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 8
      ImageHeight: 11
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1928
      ImageHeight: 1884
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 195
      ImageHeight: 195
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 199
      ImageHeight: 199
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 198
      ImageHeight: 198
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 198
      ImageHeight: 198
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 199
      ImageHeight: 199
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 198
      ImageHeight: 199
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 199
      ImageHeight: 199
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 199
      ImageHeight: 199
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 198
      ImageHeight: 199
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 199
      ImageHeight: 199
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 199
      ImageHeight: 199
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 195
      ImageHeight: 195
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 199
      ImageHeight: 199
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 195
      ImageHeight: 195
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 198
      ImageHeight: 199
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 199
      ImageHeight: 199
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 198
      ImageHeight: 198
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 199
      ImageHeight: 199
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 195
      ImageHeight: 195
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 714
      ImageHeight: 316
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 199
      ImageHeight: 199
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 283
      ImageHeight: 403
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 199
      ImageHeight: 199
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 199
      ImageHeight: 199
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 289
      ImageHeight: 289
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 289
      ImageHeight: 289
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 289
      ImageHeight: 289
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 258
      ImageHeight: 258
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 258
      ImageHeight: 258
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 289
      ImageHeight: 289
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 258
      ImageHeight: 258
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 258
      ImageHeight: 258
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 283
      ImageHeight: 290
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 342
      ImageHeight: 334
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 427
      ImageHeight: 504
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 342
      ImageHeight: 334
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 372
      ImageHeight: 375
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 168
      ImageHeight: 164
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 293
      ImageHeight: 293
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 293
      ImageHeight: 293
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 293
      ImageHeight: 293
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 293
      ImageHeight: 293
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 293
      ImageHeight: 293
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 350
      ImageHeight: 351
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 350
      ImageHeight: 351
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 293
      ImageHeight: 293
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 241
      ImageHeight: 241
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 241
      ImageHeight: 241
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 241
      ImageHeight: 241
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 241
      ImageHeight: 241
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 241
      ImageHeight: 241
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 241
      ImageHeight: 241
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 241
      ImageHeight: 241
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 241
      ImageHeight: 241
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 241
      ImageHeight: 238
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 241
      ImageHeight: 241
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 241
      ImageHeight: 241
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 241
      ImageHeight: 241
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 241
      ImageHeight: 241
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 241
      ImageHeight: 238
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 241
      ImageHeight: 238
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 294
      ImageHeight: 252
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 294
      ImageHeight: 222
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 241
      ImageHeight: 241
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 294
      ImageHeight: 252
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 241
      ImageHeight: 241
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 241
      ImageHeight: 241
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 241
      ImageHeight: 241
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 241
      ImageHeight: 241
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 241
      ImageHeight: 241
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 241
      ImageHeight: 241
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 241
      ImageHeight: 241
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 294
      ImageHeight: 222
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MPNGJB+AdvPSHN-MI
      FontSubset: true
      FirstChar: 50
      LastChar: 52
      FontDescriptor: 
       FontName: MPNGJB+AdvPSHN-MI
       Flags: Nonsymbolic
       FontBBox: -156, -208, 1125, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPNEIL+AdvPSHN-H
      FontSubset: true
      FirstChar: 40
      LastChar: 122
      FontDescriptor: 
       FontName: MPNEIL+AdvPSHN-H
       Flags: Nonsymbolic
       FontBBox: -166, -229, 1093, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPNGJC+AdvPSSym
      FontSubset: true
      FirstChar: 170
      LastChar: 170
      FontDescriptor: 
       FontName: MPNGJC+AdvPSSym
       Flags: Nonsymbolic
       FontBBox: -177, -291, 1083, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPNEJM+AdvPSMPi6
      FontSubset: true
      FirstChar: 100
      LastChar: 100
      FontDescriptor: 
       FontName: MPNEJM+AdvPSMPi6
       Flags: Nonsymbolic
       FontBBox: 0, -177, 989, 739
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPNGJD+Helvetica-Bold
      FontSubset: true
      FirstChar: 108
      LastChar: 108
      FontDescriptor: 
       FontName: MPNGJD+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPBEHK+AdvPSA183
      FontSubset: true
      FirstChar: 35
      LastChar: 252
      FontDescriptor: 
       FontName: MPBEHK+AdvPSA183
       Flags: Nonsymbolic
       FontBBox: -156, -208, 1072, 791
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: MPCPBO+AdvPS480274
      FontSubset: true
      FirstChar: 43
      LastChar: 66
      FontDescriptor: 
       FontName: MPCPBO+AdvPS480274
       Flags: Nonsymbolic
       FontBBox: 0, -208, 1354, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPBEJK+Advhelvneue-italic
      FontSubset: true
      FirstChar: 40
      LastChar: 223
      FontDescriptor: 
       FontName: MPBEJK+Advhelvneue-italic
       Flags: Nonsymbolic
       FontBBox: -156, -208, 1104, 791
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: MPCPGO+AdvP4C4E59
      FontSubset: true
      FirstChar: 128
      LastChar: 128
      FontDescriptor: 
       FontName: MPCPGO+AdvP4C4E59
       Flags: Nonsymbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPCCGI+AdvPS3F4C13
      FontSubset: true
      FirstChar: 89
      LastChar: 109
      FontDescriptor: 
       FontName: MPCCGI+AdvPS3F4C13
       Flags: Nonsymbolic
       FontBBox: 0, -291, 875, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPDAAM+AdvPSHN-HI
      FontSubset: true
      FirstChar: 45
      LastChar: 118
      FontDescriptor: 
       FontName: MPDAAM+AdvPSHN-HI
       Flags: Nonsymbolic
       FontBBox: -156, -218, 1135, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPBEHI+AdvPSA189
      FontSubset: true
      FirstChar: 45
      LastChar: 222
      FontDescriptor: 
       FontName: MPBEHI+AdvPSA189
       Flags: Nonsymbolic
       FontBBox: -156, -208, 1072, 802
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: MPCHAO+AdvHelN-L
      FontSubset: true
      FirstChar: 43
      LastChar: 177
      FontDescriptor: 
       FontName: MPCHAO+AdvHelN-L
       Flags: Nonsymbolic
       FontBBox: -156, -208, 1041, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPNGJD+Helvetica-Bold
      FontSubset: true
      FirstChar: 65
      LastChar: 108
      FontDescriptor: 
       FontName: MPNGJD+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPDAFL+AdvP7DED
      FontSubset: true
      FirstChar: 51
      LastChar: 51
      FontDescriptor: 
       FontName: MPDAFL+AdvP7DED
       Flags: Nonsymbolic
       FontBBox: -20, -229, 927, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPCHAN+AdvTT2876772e+20
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: MPCHAN+AdvTT2876772e+20
       Flags: Symbolic
       FontBBox: -218, -197, 1302, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MPNEJL+AdvPSHN-M
      FontSubset: true
      FirstChar: 30
      LastChar: 168
      FontDescriptor: 
       FontName: MPNEJL+AdvPSHN-M
       Flags: Nonsymbolic
       FontBBox: -156, -218, 1062, 802
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: MPCIGH+AdvP4C4E74
      FontSubset: true
      FirstChar: 1
      LastChar: 240
      FontDescriptor: 
       FontName: MPCIGH+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MPDBCH+AdvPS4721B4
      FontSubset: true
      FirstChar: 100
      LastChar: 100
      FontDescriptor: 
       FontName: MPDBCH+AdvPS4721B4
       Flags: Nonsymbolic
       FontBBox: 0, -208, 843, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPDBCI+AdvP4C4E46
      FontSubset: true
      FirstChar: 48
      LastChar: 80
      FontDescriptor: 
       FontName: MPDBCI+AdvP4C4E46
       Flags: Nonsymbolic
       FontBBox: 31, -1770, 999, 50
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPDBDJ+AdvPS4BD310
      FontSubset: true
      FirstChar: 100
      LastChar: 100
      FontDescriptor: 
       FontName: MPDBDJ+AdvPS4BD310
       Flags: Nonsymbolic
       FontBBox: 0, -208, 989, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPNEIL+AdvPSHN-H
      FontSubset: true
      FirstChar: 65
      LastChar: 222
      FontDescriptor: 
       FontName: MPNEIL+AdvPSHN-H
       Flags: Nonsymbolic
       FontBBox: -166, -229, 1093, 812
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: MPNEJL+AdvPSHN-M
      FontSubset: true
      FirstChar: 40
      LastChar: 168
      FontDescriptor: 
       FontName: MPNEJL+AdvPSHN-M
       Flags: Nonsymbolic
       FontBBox: -156, -218, 1062, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPNEJM+AdvPSMPi6
      FontSubset: true
      FirstChar: 100
      LastChar: 100
      FontDescriptor: 
       FontName: MPNEJM+AdvPSMPi6
       Flags: Nonsymbolic
       FontBBox: 0, -177, 989, 739
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MPNGJC+AdvPSSym
      FontSubset: true
      FirstChar: 170
      LastChar: 170
      FontDescriptor: 
       FontName: MPNGJC+AdvPSSym
       Flags: Nonsymbolic
       FontBBox: -177, -291, 1083, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.celrep.2023.112472</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Claudia Garcia-Diaz</rdf:li>
               <rdf:li>Anni Pöysti</rdf:li>
               <rdf:li>Elisabetta Mereu</rdf:li>
               <rdf:li>Melanie P. Clements</rdf:li>
               <rdf:li>Lucy J. Brooks</rdf:li>
               <rdf:li>Felipe Galvez-Cancino</rdf:li>
               <rdf:li>Simon P. Castillo</rdf:li>
               <rdf:li>Wenhao Tang</rdf:li>
               <rdf:li>Gordon Beattie</rdf:li>
               <rdf:li>Lilas Courtot</rdf:li>
               <rdf:li>Sara Ruiz</rdf:li>
               <rdf:li>Federico Roncaroli</rdf:li>
               <rdf:li>Yinyin Yuan</rdf:li>
               <rdf:li>Samuel Marguerat</rdf:li>
               <rdf:li>Sergio A. Quezada</rdf:li>
               <rdf:li>Holger Heyn</rdf:li>
               <rdf:li>Simona Parrinello</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>glioblastoma</rdf:li>
               <rdf:li>somatic mouse models</rdf:li>
               <rdf:li>tumor margin</rdf:li>
               <rdf:li>tumor microenvironment</rdf:li>
               <rdf:li>dormancy</rdf:li>
               <rdf:li>invasion</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">CellReports, 42 (2023) 112472. doi:10.1016/j.celrep.2023.112472</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>The Author(s)</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>CellReports</prism:publicationName>
         <prism:copyright>© 2023 The Author(s).</prism:copyright>
         <prism:issn>2211-1247</prism:issn>
         <prism:volume>42</prism:volume>
         <prism:number>5</prism:number>
         <prism:coverDisplayDate>30 May 2023</prism:coverDisplayDate>
         <prism:coverDate>2023-05-30</prism:coverDate>
         <prism:pageRange>112472</prism:pageRange>
         <prism:startingPage>112472</prism:startingPage>
         <prism:doi>10.1016/j.celrep.2023.112472</prism:doi>
         <prism:url>https://doi.org/10.1016/j.celrep.2023.112472</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.celrep.2023.112472</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>7.0</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1016/j.celrep.2023.112472</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:grabs>true</pdfx:grabs>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:CreateDate>2023-05-23T14:58:58+05:30</xap:CreateDate>
         <xap:ModifyDate>2023-05-23T17:29:54+05:30</xap:ModifyDate>
         <xap:MetadataDate>2023-05-23T17:29:54+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:64d28a60-7a49-48c6-9975-47d0c5cf97bd</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:7f40671a-e750-4fd7-aa03-ac3ab0bff9b0</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 354, 510, 455, 520
      Annotation: 
       Subtype: Link
       Rect: 100, 48, 273, 56
      Annotation: 
       Subtype: Link
       Rect: 53, 58, 69, 74
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 137, 584, 143, 593
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 143, 584, 150, 593
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 202, 584, 208, 593
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 208, 584, 215, 593
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 290, 584, 295, 593
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 295, 584, 301, 593
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 301, 584, 308, 593
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 398, 584, 404, 593
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 404, 584, 411, 593
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 478, 584, 484, 593
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 484, 584, 491, 593
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 148, 574, 152, 583
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 228, 574, 231, 583
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 294, 574, 297, 583
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 365, 574, 371, 583
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 371, 574, 375, 583
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 433, 574, 436, 583
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 481, 574, 485, 583
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 133, 564, 137, 573
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 190, 564, 194, 573
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 274, 564, 278, 573
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 359, 564, 363, 573
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 419, 564, 424, 573
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 424, 564, 432, 573
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 524, 564, 530, 573
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 530, 564, 539, 573
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 539, 564, 543, 573
       Destination: 1
      Annotation: 
       Subtype: Link
       Rect: 119, 415, 197, 423
      Annotation: 
       Subtype: Link
       Rect: 53, 405, 211, 413
      Annotation: 
       Subtype: Link
       Rect: 124, 174, 127, 182
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 129, 174, 132, 182
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 168, 141, 171, 149
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 172, 119, 176, 128
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 178, 119, 181, 128
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 155, 97, 159, 106
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 160, 97, 164, 106
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 175, 64, 178, 73
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 322, 141, 325, 149
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 358, 119, 371, 128
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 448, 64, 451, 73
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 453, 64, 460, 73
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 53, 16, 69, 32
      Annotation: 
       Subtype: Link
       Rect: 380, 10, 538, 18
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 147, 665, 154, 674
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 156, 665, 173, 674
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 132, 644, 139, 652
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 140, 644, 148, 652
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 149, 644, 156, 652
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 215, 622, 232, 630
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 102, 578, 109, 586
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 111, 578, 118, 586
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 165, 534, 172, 542
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 174, 534, 181, 542
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 182, 534, 189, 542
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 248, 490, 255, 499
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 130, 435, 148, 444
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 144, 172, 148, 181
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 150, 172, 157, 181
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 283, 85, 290, 93
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 291, 85, 298, 93
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 480, 585, 510, 593
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 520, 589, 527, 597
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 411, 512, 418, 521
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 341, 475, 381, 484
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 454, 432, 488, 440
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 335, 410, 367, 418
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 339, 388, 376, 396
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 352, 256, 387, 265
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 411, 256, 421, 265
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 431, 260, 438, 268
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 436, 234, 475, 243
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 434, 212, 465, 221
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 475, 216, 482, 225
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 392, 136, 422, 144
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 449, 128, 456, 137
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 458, 128, 464, 137
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 382, 70, 416, 78
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 431, 70, 441, 78
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 489, 74, 496, 82
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 497, 74, 504, 82
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 506, 74, 513, 82
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 514, 74, 521, 82
       Destination: 697
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 83, 48, 124, 56
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 155, 48, 189, 56
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 193, 52, 210, 60
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 306, 81, 341, 89
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 371, 81, 381, 89
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 81, 128, 111, 135
       Destination: 586
    Page: 
     Label: 5
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 276, 665, 283, 674
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 285, 665, 292, 674
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 201, 651, 238, 659
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 72, 633, 79, 641
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 250, 607, 286, 615
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 250, 541, 286, 550
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 87, 534, 94, 542
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 96, 534, 103, 542
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 214, 497, 250, 506
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 194, 468, 201, 477
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 75, 424, 82, 433
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 139, 366, 175, 374
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 106, 300, 144, 309
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 306, 596, 339, 604
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 474, 600, 481, 608
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 498, 574, 535, 582
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 500, 563, 536, 572
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 374, 530, 409, 539
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 514, 501, 521, 510
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 528, 497, 543, 506
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 304, 486, 328, 495
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 332, 442, 368, 451
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 306, 377, 342, 385
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 353, 377, 386, 385
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 306, 300, 341, 309
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 362, 300, 372, 309
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 403, 127, 409, 134
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 331, 108, 337, 115
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 81, 48, 115, 55
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 130, 48, 139, 55
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 154, 48, 182, 55
       Destination: 586
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 212, 654, 219, 663
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 136, 644, 143, 652
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 180, 618, 216, 626
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 76, 523, 83, 531
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 61, 497, 96, 506
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 133, 453, 165, 462
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 139, 421, 174, 429
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 138, 377, 174, 385
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 141, 304, 148, 312
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 190, 278, 221, 287
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 76, 238, 83, 247
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 120, 147, 151, 155
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 191, 114, 228, 122
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 284, 92, 298, 100
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 59, 81, 79, 89
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 148, 48, 188, 56
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 333, 629, 371, 637
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 538, 622, 545, 630
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 482, 530, 525, 539
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 376, 501, 383, 510
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 385, 501, 392, 510
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 493, 442, 528, 451
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 509, 432, 539, 440
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 399, 410, 435, 418
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 486, 377, 518, 385
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 534, 337, 541, 345
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 542, 337, 549, 345
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 416, 322, 452, 330
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 478, 322, 488, 330
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 313, 256, 348, 265
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 389, 256, 399, 265
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 368, 136, 404, 144
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 449, 136, 459, 144
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 470, 136, 504, 144
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 509, 139, 516, 148
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 344, 103, 380, 111
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 390, 107, 397, 115
       Destination: 697
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 208, 81, 245, 89
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 272, 81, 282, 89
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 306, 92, 347, 100
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 81, 125, 115, 132
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 130, 125, 139, 132
       Destination: 586
    Page: 
     Label: 9
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 153, 673, 188, 681
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 198, 673, 209, 681
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 235, 673, 245, 681
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 55, 596, 90, 604
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 100, 596, 111, 604
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 157, 596, 168, 604
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 277, 541, 292, 550
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 53, 530, 79, 539
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 119, 519, 155, 528
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 138, 486, 171, 495
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 182, 453, 217, 462
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 241, 453, 251, 462
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 227, 446, 234, 455
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 244, 432, 280, 440
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 425, 673, 457, 681
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 325, 651, 355, 659
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 442, 618, 474, 626
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 438, 497, 474, 506
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 331, 421, 366, 429
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 352, 377, 388, 385
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 81, 48, 115, 55
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 119, 48, 127, 55
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 145, 48, 153, 55
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 169, 48, 196, 55
       Destination: 586
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 160, 234, 190, 243
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 235, 201, 272, 210
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 221, 125, 255, 133
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 279, 125, 289, 133
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 207, 81, 238, 89
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 451, 267, 482, 276
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 494, 271, 501, 279
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 503, 271, 510, 279
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 313, 212, 347, 221
       Destination: 369
      Annotation: 
       Subtype: Link
       Rect: 480, 179, 517, 188
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 415, 48, 450, 56
       Destination: 445
      Annotation: 
       Subtype: Link
       Rect: 214, 377, 220, 384
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 222, 377, 227, 384
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 88, 299, 118, 306
       Destination: 586
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 186, 673, 221, 681
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 212, 640, 247, 648
       Destination: 307
      Annotation: 
       Subtype: Link
       Rect: 272, 640, 282, 648
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 264, 633, 271, 641
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 120, 596, 156, 604
       Destination: 445
      Annotation: 
       Subtype: Link
       Rect: 204, 596, 214, 604
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 72, 567, 79, 575
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 88, 563, 127, 572
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 179, 530, 210, 539
       Destination: 445
      Annotation: 
       Subtype: Link
       Rect: 220, 534, 227, 542
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 229, 534, 236, 542
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 230, 453, 267, 462
       Destination: 445
      Annotation: 
       Subtype: Link
       Rect: 208, 311, 239, 319
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 55, 278, 86, 287
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 55, 245, 93, 254
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 246, 212, 282, 221
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 161, 158, 193, 166
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 136, 150, 143, 159
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 499, 651, 532, 659
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 498, 640, 533, 648
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 502, 596, 538, 604
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 528, 552, 543, 561
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 304, 541, 323, 550
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 306, 508, 337, 517
       Destination: 534
      Annotation: 
       Subtype: Link
       Rect: 407, 388, 443, 396
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 388, 359, 395, 367
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 528, 344, 543, 352
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 304, 333, 329, 341
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 477, 315, 484, 323
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 393, 256, 428, 265
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 483, 172, 486, 181
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 488, 172, 492, 181
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 455, 139, 463, 148
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 325, 63, 332, 71
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 334, 63, 341, 71
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 343, 63, 350, 71
       Destination: 619
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 204, 85, 211, 93
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 213, 85, 220, 93
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 221, 85, 228, 93
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 230, 85, 237, 93
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 291, 63, 298, 71
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 542, 74, 549, 82
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 88, 153, 118, 160
       Destination: 586
    Page: 
     Label: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 166, 644, 173, 652
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 175, 644, 182, 652
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 75, 611, 82, 619
       Destination: 619
      Annotation: 
       Subtype: Link
       Rect: 83, 611, 90, 619
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 92, 611, 99, 619
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 79, 567, 97, 575
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 237, 468, 244, 477
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 276, 446, 283, 455
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 234, 315, 241, 323
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 388, 665, 395, 674
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 325, 586, 424, 595
       Destination: 968
      Annotation: 
       Subtype: Link
       Rect: 325, 575, 427, 584
       Destination: 1021
      Annotation: 
       Subtype: Link
       Rect: 325, 531, 543, 540
       Destination: 1021
      Annotation: 
       Subtype: Link
       Rect: 325, 520, 348, 529
       Destination: 1021
      Annotation: 
       Subtype: Link
       Rect: 325, 509, 397, 518
       Destination: 1021
      Annotation: 
       Subtype: Link
       Rect: 325, 159, 511, 167
       Destination: 1147
      Annotation: 
       Subtype: Link
       Rect: 465, 117, 543, 124
      Annotation: 
       Subtype: Link
       Rect: 304, 108, 366, 114
    Page: 
     Label: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 251, 598, 277, 605
       Destination: 167
      Annotation: 
       Subtype: Link
       Rect: 100, 589, 149, 596
      Annotation: 
       Subtype: Link
       Rect: 207, 243, 298, 250
      Annotation: 
       Subtype: Link
       Rect: 72, 234, 91, 241
      Annotation: 
       Subtype: Link
       Rect: 95, 202, 202, 209
      Annotation: 
       Subtype: Link
       Rect: 103, 171, 202, 178
      Annotation: 
       Subtype: Link
       Rect: 276, 149, 298, 156
      Annotation: 
       Subtype: Link
       Rect: 72, 140, 188, 147
      Annotation: 
       Subtype: Link
       Rect: 91, 99, 216, 106
      Annotation: 
       Subtype: Link
       Rect: 124, 48, 252, 55
      Annotation: 
       Subtype: Link
       Rect: 434, 655, 547, 662
      Annotation: 
       Subtype: Link
       Rect: 515, 615, 549, 622
      Annotation: 
       Subtype: Link
       Rect: 323, 606, 417, 613
      Annotation: 
       Subtype: Link
       Rect: 354, 566, 483, 573
      Annotation: 
       Subtype: Link
       Rect: 458, 526, 549, 533
      Annotation: 
       Subtype: Link
       Rect: 323, 516, 362, 523
      Annotation: 
       Subtype: Link
       Rect: 472, 476, 549, 483
      Annotation: 
       Subtype: Link
       Rect: 323, 467, 378, 474
      Annotation: 
       Subtype: Link
       Rect: 436, 427, 549, 434
      Annotation: 
       Subtype: Link
       Rect: 323, 417, 349, 424
      Annotation: 
       Subtype: Link
       Rect: 449, 378, 549, 385
      Annotation: 
       Subtype: Link
       Rect: 323, 368, 350, 375
      Annotation: 
       Subtype: Link
       Rect: 396, 328, 525, 335
      Annotation: 
       Subtype: Link
       Rect: 407, 288, 520, 295
      Annotation: 
       Subtype: Link
       Rect: 515, 258, 549, 265
      Annotation: 
       Subtype: Link
       Rect: 323, 248, 402, 255
      Annotation: 
       Subtype: Link
       Rect: 361, 218, 486, 225
      Annotation: 
       Subtype: Link
       Rect: 440, 178, 549, 185
      Annotation: 
       Subtype: Link
       Rect: 323, 168, 366, 175
      Annotation: 
       Subtype: Link
       Rect: 352, 119, 485, 126
      Annotation: 
       Subtype: Link
       Rect: 503, 98, 549, 105
      Annotation: 
       Subtype: Link
       Rect: 323, 88, 410, 95
      Annotation: 
       Subtype: Link
       Rect: 365, 48, 472, 55
    Page: 
     Label: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 217, 646, 292, 653
      Annotation: 
       Subtype: Link
       Rect: 65, 636, 98, 643
      Annotation: 
       Subtype: Link
       Rect: 217, 596, 292, 603
      Annotation: 
       Subtype: Link
       Rect: 65, 587, 130, 594
      Annotation: 
       Subtype: Link
       Rect: 156, 556, 263, 563
      Annotation: 
       Subtype: Link
       Rect: 170, 507, 283, 514
      Annotation: 
       Subtype: Link
       Rect: 245, 467, 292, 474
      Annotation: 
       Subtype: Link
       Rect: 65, 457, 151, 464
      Annotation: 
       Subtype: Link
       Rect: 245, 417, 292, 424
      Annotation: 
       Subtype: Link
       Rect: 65, 408, 136, 415
      Annotation: 
       Subtype: Link
       Rect: 146, 368, 275, 375
      Annotation: 
       Subtype: Link
       Rect: 235, 328, 292, 335
      Annotation: 
       Subtype: Link
       Rect: 65, 319, 146, 326
      Annotation: 
       Subtype: Link
       Rect: 185, 279, 292, 286
      Annotation: 
       Subtype: Link
       Rect: 65, 269, 87, 276
      Annotation: 
       Subtype: Link
       Rect: 125, 229, 261, 236
      Annotation: 
       Subtype: Link
       Rect: 183, 199, 292, 206
      Annotation: 
       Subtype: Link
       Rect: 65, 189, 104, 196
      Annotation: 
       Subtype: Link
       Rect: 107, 159, 214, 166
      Annotation: 
       Subtype: Link
       Rect: 144, 119, 285, 126
      Annotation: 
       Subtype: Link
       Rect: 162, 88, 284, 95
      Annotation: 
       Subtype: Link
       Rect: 96, 48, 221, 55
      Annotation: 
       Subtype: Link
       Rect: 316, 646, 431, 653
      Annotation: 
       Subtype: Link
       Rect: 316, 596, 446, 603
      Annotation: 
       Subtype: Link
       Rect: 391, 555, 524, 562
      Annotation: 
       Subtype: Link
       Rect: 452, 514, 543, 521
      Annotation: 
       Subtype: Link
       Rect: 316, 505, 355, 512
      Annotation: 
       Subtype: Link
       Rect: 385, 464, 522, 471
      Annotation: 
       Subtype: Link
       Rect: 316, 452, 543, 459
      Annotation: 
       Subtype: Link
       Rect: 316, 442, 543, 449
      Annotation: 
       Subtype: Link
       Rect: 316, 433, 366, 440
      Annotation: 
       Subtype: Link
       Rect: 316, 383, 427, 390
      Annotation: 
       Subtype: Link
       Rect: 496, 361, 543, 368
      Annotation: 
       Subtype: Link
       Rect: 316, 352, 383, 359
      Annotation: 
       Subtype: Link
       Rect: 336, 302, 475, 309
      Annotation: 
       Subtype: Link
       Rect: 316, 261, 450, 268
      Annotation: 
       Subtype: Link
       Rect: 339, 220, 441, 227
      Annotation: 
       Subtype: Link
       Rect: 465, 189, 543, 196
      Annotation: 
       Subtype: Link
       Rect: 316, 180, 391, 187
      Annotation: 
       Subtype: Link
       Rect: 451, 139, 543, 146
      Annotation: 
       Subtype: Link
       Rect: 316, 130, 339, 137
      Annotation: 
       Subtype: Link
       Rect: 486, 89, 543, 96
      Annotation: 
       Subtype: Link
       Rect: 316, 79, 390, 86
    Page: 
     Label: 17
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 264, 674, 298, 681
      Annotation: 
       Subtype: Link
       Rect: 72, 665, 177, 672
      Annotation: 
       Subtype: Link
       Rect: 172, 624, 296, 631
      Annotation: 
       Subtype: Link
       Rect: 213, 593, 298, 600
      Annotation: 
       Subtype: Link
       Rect: 72, 584, 116, 591
      Annotation: 
       Subtype: Link
       Rect: 72, 543, 199, 550
      Annotation: 
       Subtype: Link
       Rect: 150, 503, 280, 510
      Annotation: 
       Subtype: Link
       Rect: 264, 472, 298, 479
      Annotation: 
       Subtype: Link
       Rect: 72, 462, 166, 469
      Annotation: 
       Subtype: Link
       Rect: 103, 412, 236, 419
      Annotation: 
       Subtype: Link
       Rect: 210, 381, 298, 388
      Annotation: 
       Subtype: Link
       Rect: 72, 372, 111, 379
      Annotation: 
       Subtype: Link
       Rect: 154, 332, 253, 339
      Annotation: 
       Subtype: Link
       Rect: 276, 310, 298, 317
      Annotation: 
       Subtype: Link
       Rect: 72, 301, 171, 308
      Annotation: 
       Subtype: Link
       Rect: 172, 270, 287, 277
      Annotation: 
       Subtype: Link
       Rect: 72, 257, 298, 264
      Annotation: 
       Subtype: Link
       Rect: 72, 248, 298, 255
      Annotation: 
       Subtype: Link
       Rect: 72, 239, 298, 246
      Annotation: 
       Subtype: Link
       Rect: 72, 229, 298, 236
      Annotation: 
       Subtype: Link
       Rect: 72, 220, 192, 227
      Annotation: 
       Subtype: Link
       Rect: 221, 179, 298, 186
      Annotation: 
       Subtype: Link
       Rect: 72, 170, 127, 177
      Annotation: 
       Subtype: Link
       Rect: 184, 129, 298, 136
      Annotation: 
       Subtype: Link
       Rect: 72, 120, 94, 127
      Annotation: 
       Subtype: Link
       Rect: 105, 70, 234, 77
      Annotation: 
       Subtype: Link
       Rect: 377, 665, 481, 672
      Annotation: 
       Subtype: Link
       Rect: 475, 624, 549, 631
      Annotation: 
       Subtype: Link
       Rect: 323, 615, 369, 622
      Annotation: 
       Subtype: Link
       Rect: 323, 603, 549, 610
      Annotation: 
       Subtype: Link
       Rect: 323, 594, 549, 601
      Annotation: 
       Subtype: Link
       Rect: 323, 584, 549, 591
      Annotation: 
       Subtype: Link
       Rect: 323, 575, 459, 582
      Annotation: 
       Subtype: Link
       Rect: 408, 534, 547, 541
      Annotation: 
       Subtype: Link
       Rect: 472, 494, 549, 501
      Annotation: 
       Subtype: Link
       Rect: 323, 485, 374, 491
      Annotation: 
       Subtype: Link
       Rect: 420, 444, 539, 451
      Annotation: 
       Subtype: Link
       Rect: 323, 432, 549, 439
      Annotation: 
       Subtype: Link
       Rect: 323, 423, 549, 430
      Annotation: 
       Subtype: Link
       Rect: 323, 413, 549, 420
      Annotation: 
       Subtype: Link
       Rect: 323, 404, 403, 411
      Annotation: 
       Subtype: Link
       Rect: 438, 354, 549, 361
      Annotation: 
       Subtype: Link
       Rect: 323, 345, 344, 352
      Annotation: 
       Subtype: Link
       Rect: 527, 323, 549, 330
      Annotation: 
       Subtype: Link
       Rect: 323, 314, 412, 321
      Annotation: 
       Subtype: Link
       Rect: 493, 283, 549, 290
      Annotation: 
       Subtype: Link
       Rect: 323, 274, 368, 281
      Annotation: 
       Subtype: Link
       Rect: 435, 233, 549, 240
      Annotation: 
       Subtype: Link
       Rect: 323, 224, 349, 231
      Annotation: 
       Subtype: Link
       Rect: 323, 212, 549, 219
      Annotation: 
       Subtype: Link
       Rect: 323, 202, 377, 209
      Annotation: 
       Subtype: Link
       Rect: 527, 181, 549, 188
      Annotation: 
       Subtype: Link
       Rect: 323, 172, 415, 179
      Annotation: 
       Subtype: Link
       Rect: 411, 141, 516, 148
      Annotation: 
       Subtype: Link
       Rect: 475, 119, 549, 126
      Annotation: 
       Subtype: Link
       Rect: 323, 110, 342, 117
      Annotation: 
       Subtype: Link
       Rect: 373, 70, 474, 77
    Page: 
     Label: 18
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 148, 665, 284, 672
      Annotation: 
       Subtype: Link
       Rect: 146, 642, 239, 649
      Annotation: 
       Subtype: Link
       Rect: 85, 591, 201, 598
      Annotation: 
       Subtype: Link
       Rect: 88, 539, 218, 546
      Annotation: 
       Subtype: Link
       Rect: 235, 507, 292, 514
      Annotation: 
       Subtype: Link
       Rect: 65, 498, 110, 505
      Annotation: 
       Subtype: Link
       Rect: 65, 465, 197, 472
      Annotation: 
       Subtype: Link
       Rect: 362, 655, 474, 662
      Annotation: 
       Subtype: Link
       Rect: 332, 625, 470, 632
      Annotation: 
       Subtype: Link
       Rect: 395, 594, 531, 601
      Annotation: 
       Subtype: Link
       Rect: 443, 555, 543, 561
      Annotation: 
       Subtype: Link
       Rect: 316, 545, 353, 552
      Annotation: 
       Subtype: Link
       Rect: 469, 515, 543, 522
      Annotation: 
       Subtype: Link
       Rect: 316, 505, 378, 512
      Annotation: 
       Subtype: Link
       Rect: 509, 475, 543, 482
      Annotation: 
       Subtype: Link
       Rect: 316, 465, 419, 472
    Page: 
     Label: 19
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 291, 552, 297, 560
       Destination: 796
    Page: 
     Label: 20
    Page: 
     Label: 21
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 277, 418, 283, 425
       Destination: 697
      Annotation: 
       Subtype: Link
       Rect: 250, 402, 363, 410
      Annotation: 
       Subtype: Link
       Rect: 250, 392, 333, 400
      Annotation: 
       Subtype: Link
       Rect: 291, 311, 297, 318
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 297, 224, 303, 231
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 297, 211, 303, 219
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 302, 162, 308, 169
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 288, 114, 294, 122
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 302, 102, 308, 110
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 285, 90, 292, 98
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 287, 78, 293, 86
       Destination: 796
    Page: 
     Label: 22
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 93, 629, 198, 637
      Annotation: 
       Subtype: Link
       Rect: 319, 596, 365, 604
       Destination: 1021
      Annotation: 
       Subtype: Link
       Rect: 424, 563, 498, 572
       Destination: 968
      Annotation: 
       Subtype: Link
       Rect: 443, 541, 489, 550
       Destination: 1021
      Annotation: 
       Subtype: Link
       Rect: 339, 472, 346, 480
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 114, 461, 122, 469
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 291, 439, 298, 447
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 300, 439, 307, 447
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 536, 263, 543, 272
       Destination: 796
    Page: 
     Label: 23
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 540, 578, 547, 586
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 292, 468, 299, 477
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 416, 402, 424, 411
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 90, 326, 97, 334
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 138, 194, 145, 203
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 300, 117, 307, 126
       Destination: 923
    Page: 
     Label: 24
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 317, 442, 461, 451
      Annotation: 
       Subtype: Link
       Rect: 464, 446, 471, 455
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 102, 238, 109, 247
       Destination: 923
      Annotation: 
       Subtype: Link
       Rect: 382, 238, 389, 247
       Destination: 923
      Annotation: 
       Subtype: Link
       Rect: 327, 194, 334, 203
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 249, 150, 256, 159
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 76, 107, 83, 115
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 365, 63, 372, 71
       Destination: 923
    Page: 
     Label: 25
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 315, 348, 322, 356
       Destination: 923
      Annotation: 
       Subtype: Link
       Rect: 260, 212, 296, 221
       Destination: 586
      Annotation: 
       Subtype: Link
       Rect: 471, 85, 478, 93
       Destination: 697
    Page: 
     Label: 26
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 146, 435, 153, 444
       Destination: 923
      Annotation: 
       Subtype: Link
       Rect: 209, 370, 216, 378
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 308, 282, 315, 290
       Destination: 923
      Annotation: 
       Subtype: Link
       Rect: 115, 150, 123, 159
       Destination: 923
      Annotation: 
       Subtype: Link
       Rect: 417, 85, 424, 93
       Destination: 923
    Page: 
     Label: 27
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 471, 519, 549, 528
      Annotation: 
       Subtype: Link
       Rect: 59, 508, 204, 517
      Annotation: 
       Subtype: Link
       Rect: 456, 508, 549, 517
      Annotation: 
       Subtype: Link
       Rect: 59, 497, 110, 506
      Annotation: 
       Subtype: Link
       Rect: 252, 435, 259, 444
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 306, 435, 313, 444
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 97, 304, 104, 312
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 236, 183, 243, 192
       Destination: 923
      Annotation: 
       Subtype: Link
       Rect: 78, 107, 85, 115
       Destination: 796
      Annotation: 
       Subtype: Link
       Rect: 203, 48, 208, 56
    Page: 
     Label: 28
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 204, 673, 244, 681
       Destination: 1147
      Annotation: 
       Subtype: Link
       Rect: 209, 665, 216, 674
       Destination: 923
      Annotation: 
       Subtype: Link
       Rect: 306, 562, 346, 570
       Destination: 1147
      Annotation: 
       Subtype: Link
       Rect: 509, 341, 543, 349
       Destination: 1147
      Annotation: 
       Subtype: Link
       Rect: 53, 330, 57, 338
       Destination: 1147
  Checksum: d16e4b82
   Type: CRC32
  Checksum: 995f855617dd3a5f982102511b0817ba
   Type: MD5
  Checksum: 01c3d466c2f8d236ce0e82cada92976fdcdde2b5
   Type: SHA-1
  Checksum: e8bdaba15a566aeae2aec4547b806b82fa7b2319551ac48c42837efebaca3454
   Type: SHA-256