60b85f391294b20b4b391d2ca7f3da3c RHOA_Therapeutic.pdf 1c3ab0ca5b6e421fcaeab2c1a454e4853980d274 RHOA_Therapeutic.pdf ac92d62a69e81688ed1d25bc2d3c76868e0278dcb30f744a4f91c1f58419427a RHOA_Therapeutic.pdf Title: RHOA Therapeutic Targeting in Hematological Cancers Subject: Primarily identified as an important regulator of cytoskeletal dynamics, the small GTPase Ras homolog gene family member A (RHOA) has been implicated in the transduction of signals regulating a broad range of cellular functions such as cell survival, migration, adhesion and proliferation. Deregulated activity of RHOA has been linked to the growth, progression and metastasis of various cancer types. Recent cancer genome-wide sequencing studies have unveiled both RHOA gain and loss-of-function mutations in primary leukemia/lymphoma, suggesting that this GTPase may exert tumor-promoting or tumor-suppressive functions depending on the cellular context. Based on these observations, RHOA signaling represents an attractive therapeutic target for the development of selective anticancer strategies. In this review, we will summarize the molecular mechanisms underlying RHOA GTPase functions in immune regulation and in the development of hematological neoplasms and will discuss the current strategies aimed at modulating RHOA functions in these diseases. Keywords: small GTPase; RHOA; hematological cancers; lymphoma; tumor suppressor gene; oncogene; therapeutic target Author: Juliana Carvalho Santos, Núria Profitós-Pelejà, Salvador Sánchez-Vinces and Gaël Roué Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sat Jan 28 10:22:50 2023 CET ModDate: Sat Jan 28 11:16:59 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1200919 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- QOATDH+VnURWPalladioL Type 1 Custom yes yes no 10 0 QGYPPQ+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 LHWIHF+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 QSLEAG+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 IUYWSY+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 PFKOHU+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 AOPDMO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 78 0 AOPDNA+PalatinoLinotype TrueType WinAnsi yes yes no 81 0 AOPDNC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 84 0 FXXUVH+CMSY10 Type 1 Builtin yes yes no 91 0 AOPDMO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 108 0 AOPDNA+PalatinoLinotype TrueType WinAnsi yes yes no 111 0 AOPDNC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 114 0 LDSSDS+EURM10 Type 1 Builtin yes yes no 140 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-02-29 02:34:12 CET RepresentationInformation: RHOA_Therapeutic.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-02-28 16:19:45 CET Size: 1200919 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 687 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Physiological Functions of RHOA in the Immune System Destination: section.2 Children: Item: Title: RHOA GTPase Signaling in Myeloid Cells Destination: subsection.2.1 Item: Title: RHOA GTPase in the Control of Lymphoid Lineage Destination: subsection.2.2 Item: Title: RhoA in Hematopoietic Tissues: Oncogene or Tumor Suppressor? Destination: section.3 Item: Title: Bioinformatic Prediction of RHOA Therapeutic Agents Destination: section.4 Item: Title: Approaches to Modulate RHOA Signaling in Hematological Cancers Destination: section.5 Item: Title: Conclusions Destination: section.6 Item: Title: References Destination: section.6 Info: Title: RHOA Therapeutic Targeting in Hematological Cancers Author: Juliana Carvalho Santos, Núria Profitós-Pelejà, Salvador Sánchez-Vinces and Gaël Roué Subject: Primarily identified as an important regulator of cytoskeletal dynamics, the small GTPase Ras homolog gene family member A (RHOA) has been implicated in the transduction of signals regulating a broad range of cellular functions such as cell survival, migration, adhesion and proliferation. Deregulated activity of RHOA has been linked to the growth, progression and metastasis of various cancer types. Recent cancer genome-wide sequencing studies have unveiled both RHOA gain and loss-of-function mutations in primary leukemia/lymphoma, suggesting that this GTPase may exert tumor-promoting or tumor-suppressive functions depending on the cellular context. Based on these observations, RHOA signaling represents an attractive therapeutic target for the development of selective anticancer strategies. In this review, we will summarize the molecular mechanisms underlying RHOA GTPase functions in immune regulation and in the development of hematological neoplasms and will discuss the current strategies aimed at modulating RHOA functions in these diseases. 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